Product Name

  • Name

    3,5-dichloro-4-fluoroaniline

  • EINECS 220-345-2
  • CAS No. 2729-34-2
  • Density 1.502 g/cm3
  • Solubility
  • Melting Point 100-101°C
  • Formula C6H4Cl2FN
  • Boiling Point 287.172 °C at 760 mmHg
  • Molecular Weight 180.009
  • Flash Point 127.477 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 2729-34-2 (3,5-dichloro-4-fluoroaniline)
  • Hazard Symbols
  • Synonyms Aniline,3,5-dichloro-4-fluoro- (6CI,8CI);3,5-Dichloro-4-fluoro-phenylamine;
  • PSA 26.02000
  • LogP 3.29590

Synthetic route

3,5-dichloro-4-fluoro-nitrobenzene
3107-19-5

3,5-dichloro-4-fluoro-nitrobenzene

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Conditions
ConditionsYield
With hydrogen In methanol Inert atmosphere;90%
With hydrogenchloride; tin(ll) chloride
With ammonium formate; zinc In methanol; water for 1.33333h;
3,4,5-trichloronitrobenzen
20098-48-0

3,4,5-trichloronitrobenzen

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide; potassium fluoride / 150 °C
2: SnCl2; aqueous HCl
View Scheme
Multi-step reaction with 2 steps
1: potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride / 11 h / 140 - 175 °C
2: hydrogen / methanol / Inert atmosphere
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1,3-dichloro-2-fluorobenzene
2268-05-5

1,3-dichloro-2-fluorobenzene

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With nitrosylsulfuric acid at 10 - 15℃; for 6h;
Stage #2: With copper(I) oxide; sodium hypophosphite; sulfuric acid; water for 1h;		86%
2-amino-6-methyl-4-chloropyrimidine
5600-21-5

2-amino-6-methyl-4-chloropyrimidine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine

N4-(3,5-dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 140℃; for 1.5h; Microwave irradiation; Sealed tube;81%
2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-(morpholinosulfonyl)benzamide

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-(morpholinosulfonyl)benzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;76%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

2,4-dichloro-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoyl chloride

2,4-dichloro-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoyl chloride

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-((4-methylpiperazin-1-yl)sulfonyl)benzamide

2,4-dichloro-N-(3,5-dichloro-4-fluorophenyl)-5-((4-methylpiperazin-1-yl)sulfonyl)benzamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 12h; Inert atmosphere;64%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

O-ehyl (3,5-dichloro-4-fluorophenyl)sulfanylmethanethioate

O-ehyl (3,5-dichloro-4-fluorophenyl)sulfanylmethanethioate

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at -5℃;
Stage #2: potassium ethyl xanthogenate In water at 50℃; for 3h;		60%
With hydrogenchloride; sodium nitrite In water at 0 - 70℃; for 2h;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

phenyl chloroformate
1885-14-9

phenyl chloroformate

phenyl (3,5-dichloro-4-fluorophenyl)carbamate

phenyl (3,5-dichloro-4-fluorophenyl)carbamate

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;55%
With sodium hydrogencarbonate In water; ethyl acetate
4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(3,5-dichloro-4-fluorophenyl)-[1-(4-methoxybenzyl)-5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl]amine

(3,5-dichloro-4-fluorophenyl)-[1-(4-methoxybenzyl)-5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl]amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 20 - 85℃; for 15.0833h; Inert atmosphere;53%
1-benzyl-5-bromo-1H-[1,2,4]triazole

1-benzyl-5-bromo-1H-[1,2,4]triazole

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(2-benzyl-2H-[1,2,4]triazol-3-yl)(3,5-dichloro-4-fluorophenyl)amine

(2-benzyl-2H-[1,2,4]triazol-3-yl)(3,5-dichloro-4-fluorophenyl)amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 18h; Inert atmosphere;15%
2-acetylpropanoic acid ethyl ester
609-14-3

2-acetylpropanoic acid ethyl ester

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

ethyl (2Z)-2-[2-(3,5-dichloro-4-fluorophenyl)hydrazin-1-ylidene]propanoate

ethyl (2Z)-2-[2-(3,5-dichloro-4-fluorophenyl)hydrazin-1-ylidene]propanoate

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In ethanol; water at 0℃; for 0.0833333h;
Stage #2: 2-acetylpropanoic acid ethyl ester In ethanol; water at -10℃; for 0.05h;		14.7%
1-benzyl-3-bromo-1H-[1,2,4]triazole

1-benzyl-3-bromo-1H-[1,2,4]triazole

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(1-benzyl-1H-[1,2,4]triazol-3-yl)-(3,5-dichloro-4-fluorophenyl)amine

(1-benzyl-1H-[1,2,4]triazol-3-yl)-(3,5-dichloro-4-fluorophenyl)amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 110℃; for 19h; Inert atmosphere;7%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

ethyl cyanoacetimidate hydrochloride
55244-11-6

ethyl cyanoacetimidate hydrochloride

N5-(3,5-dichloro-4-fluoro-phenyl)-1H-pyrazole-3,5-diamine

N5-(3,5-dichloro-4-fluoro-phenyl)-1H-pyrazole-3,5-diamine

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine; ethyl cyanoacetimidate hydrochloride In ethanol at 20℃; under 760.051 Torr; Inert atmosphere;
Stage #2: With hydrazine In ethanol; water under 760.051 Torr; for 4.5h; Inert atmosphere; Heating;		5%
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

3,5-dichloro-4-fluorophenol
2995-04-2

3,5-dichloro-4-fluorophenol

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; sodium nitrite In water at 0℃; for 0.166667h;
Stage #2: With sulfuric acid; water; sodium sulfate at 90 - 120℃; for 2.5h; Enzymatic reaction;		5%
Boc-(R)-Ala
3744-87-4, 7764-95-6, 15761-38-3

Boc-(R)-Ala

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester
1159735-51-9

[(R)-1-(3,5-dichloro-4-fluoro-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h;
Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at 20℃; for 20h;
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - 20℃;
Stage #1: Boc-(R)-Ala With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20 - -15℃; for 0.833333h;
Stage #2: 3,5-dichloro-4-fluorophenylamine In tetrahydrofuran at -15 - 20℃;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

Kalium-ethyl-adipat
24356-36-3

Kalium-ethyl-adipat

C14H15Cl2FN2O4
1570075-05-6

C14H15Cl2FN2O4

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With hydrogenchloride; sodium nitrite In water at 0 - 8℃; for 0.333333h;
Stage #2: Kalium-ethyl-adipat In water at 0 - 40℃; for 1h; Japp-Klingemann Hydrazone Synthesis;
4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

4-[5-bromo-2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]morpholine

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

(3,5-dichloro-4-fluorophenyl)-(5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl)amine

(3,5-dichloro-4-fluorophenyl)-(5-morpholin-4-yl-1H-[1,2,4]triazol-3-yl)amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / toluene / 15.08 h / 20 - 85 °C / Inert atmosphere
2: trifluoroacetic acid / 2 h / 65 °C
View Scheme
4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride

4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride

3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride

5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride

Conditions
ConditionsYield
In toluene for 2h; Reflux;
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-cyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-cyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}cyclopropanecarbohydrazide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: triethylamine / tetrahydrofuran / 0.08 h / 20 °C
8.1: trifluoroacetic acid / 2 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-2-fluorocyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-2-fluorocyclopropylcarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-2-fluorocyclopropanecarbohydrazide

N'-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-2-fluorocyclopropanecarbohydrazide

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 50 °C
8.1: trifluoroacetic acid / 2 h / 20 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl 2,2-difluorocyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl 2,2-difluorocyclopropanecarbonyl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h / 50 - 70 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N'-isovaleryl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N'-isovaleryl-N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
7.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-2-butenoyl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-2-butenoyl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-3-hydroxy-butanoyl]phenyl}carbamate

tert-butyl N-{2-chloro-5-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluoro-3-hydroxy-butanoyl]phenyl}carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one
1190865-44-1

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
View Scheme
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

1,3-dichloro-2-fluoro-5-iodo-benzene

1,3-dichloro-2-fluoro-5-iodo-benzene

Conditions
ConditionsYield
Stage #1: 3,5-dichloro-4-fluorophenylamine With sulfuric acid; acetic acid; sodium nitrite at 20℃; for 4h; Cooling with ice;
Stage #2: With potassium iodide at 70℃; for 1h; Cooling with ice;		29.7 g
3,5-dichloro-4-fluorophenylamine
2729-34-2

3,5-dichloro-4-fluorophenylamine

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

tert-butyl N-{2-chloro-5-[5-(3,5-dichloro-4-fluorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium nitrite; acetic acid; sulfuric acid / 4 h / 20 °C / Cooling with ice
1.2: 1 h / 70 °C / Cooling with ice
2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.33 h / Cooling with ice
2.2: 1.83 h / Cooling with ice
3.1: triethylamine / tetrahydrofuran / 2 h / 60 - 80 °C
4.1: dmap; acetic anhydride; triethylamine / toluene / 3 h / 50 °C
5.1: sodium hydroxide; tetrabutylammomium bromide; hydroxylamine hydrochloride / water; tert-butyl methyl ether / 1 h / 20 °C / Cooling with ice
6.1: sodium hydroxide; ammonium hydroxide; ammonium chloride; Aliquat 336; sodium hypochlorite / tetrahydrofuran; water / 0.67 h / 20 °C
View Scheme

3,5-Dichloro-4-fluoroaniline Chemical Properties

 
IUPAC Name: 3,5-Dichloro-4-fluoroaniline
Molecular Formula: C6H4Cl2FN
Molecular Weight: 180.01 g/mol
Canonical SMILES: c1(c(cc(cc1Cl)N)Cl)F
InChI: InChI=1/C6H4Cl2FN/c7-4-1-3(10)2-5(8)6(4)9/h1-2H,10H2
EINECS: 220-345-2
Product Categories: Chiral chemicals
Index of Refraction: 1.587 
Molar Refractivity: 40.27 cm3 
Molar Volume: 119.8 cm3 
Polarizability: 15.96×10-24 cm3 
Surface Tension: 45.9 dyne/cm 
Density: 1.502 g/cm3 
Flash Point: 127.5 °C 
Enthalpy of Vaporization: 52.63 kJ/mol 
Boiling Point: 287.2 °C at 760 mmHg
Melting Point: 100-101 °C
Vapour Pressure of 3,5-Dichloro-4-fluoroaniline (CAS NO.2729-34-2): 0.00252 mmHg at 25 °C

3,5-Dichloro-4-fluoroaniline Specification

 3,5-Dichloro-4-fluoroaniline (CAS NO.2729-34-2), its Synonyms are 3,5-Dichloro-4-fluorobenzenamine ; 3,5-Dichloro-4-fluoro-phenylamine ; Benzenamine, 3,5-dichloro-4-fluoro- .

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