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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2,4-dichloro-5-fluoropyriMidine( 2927-71-1)

Cas:2927-71-1

Min.Order:100 Gram

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Manufacturer 2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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China Synchem Technology Co.,Ltd

2927-71-1 2,4-dichloro- 5-fluoropyrimidine Purity >98% new drug C4HCl2FN2 Customization Our Key Technology: 1. Low Temperature Reactions 2. Coupling Reactions 3. Fluorine Chemistry 4. Asymmetric

2,4-dichloro- 5-fluoropyrimidine

Cas:2927-71-1

Min.Order:100 Gram

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Nanjing Fred Technology Co.,Ltd.

factory supply 2,4-Dichloro-5-fluoropyrimidine with good price and high quality Appearance:white powder Application:Pharmaceutical intermediate

2,4-Dichloro-5-fluoropyrimidine with high quality and low price

Cas:2927-71-1

Min.Order:0 Metric Ton

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

FOB Price: $3.0

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Dichloro-5-Fluoropyrimidine supplier in China

Cas:2927-71-1

Min.Order:1 Metric Ton

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

2,4-Dichloro-5-fluoropyrimidine manufacturer with low price

Cas:2927-71-1

Min.Order:1 Gram

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1

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Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 2927-71-1 2,4-Dichloro-5-fluoropyrimidine (Abemaci Manufacturer

Cas:2927-71-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

FOB Price: $5.0

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:0

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Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2927-71-1 2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 2927-71-1 with fast shipping

Cas:2927-71-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,4-Dichloro-5-fluoropyrimidine 2927-71-1

Cas:2927-71-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,4-Dichloro-5-fluoropyrimidine CAS:2927-71-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or

2,4-Dichloro-5-fluoropyrimidine CAS:2927-71-1

Cas:2927-71-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2927-71-1

Cas:2927-71-1

Min.Order:0

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Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,4-Dichloro-5-Fluoropyrimidine

Cas:2927-71-1

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2927-71-1

Cas:2927-71-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,4-dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Best price/In stock 2,4-Dichloro-5-fluoropyrimidine 2927-71-1

Cas:2927-71-1

Min.Order:1 Gram

Negotiable

Type:Other

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Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g、5g、10g…1kg、5kg… Application:Pharmaceutical intermediates Trans

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,4-Dichloro-5-Fluoropyrimidine

Cas:2927-71-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,4-Dichloro-5-fluoropyrimidine

Cas:2927-71-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Synthetic route

2,4-dimethoxy-5-fluoropyrimidine
4330-22-7

2,4-dimethoxy-5-fluoropyrimidine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Conditions
ConditionsYield
Stage #1: 5-fluoro-2,4-dimethoxypyrimidine With thionyl chloride In chloroform at 0℃; for 0.5h; UV-irradiation;
Stage #2: With chlorine In chloroform at 20℃; for 12h; Solvent; Wavelength; UV-irradiation;
98%
5-fluoropyrimidine-2,4-diol
51-21-8

5-fluoropyrimidine-2,4-diol

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Conditions
ConditionsYield
With trichlorophosphate In N,N-dimethyl-aniline at 100℃; for 13h; Inert atmosphere; Large scale;95%
With pyridine; trichlorophosphate at 180℃; under 150.015 - 900.09 Torr; for 2h; Neat (no solvent);93%
With dimethyl amine; trichlorophosphate at 95 - 120℃; for 4h;92%
5-fluorouracil
51-21-8

5-fluorouracil

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Conditions
ConditionsYield
With dimethyl amine; trichlorophosphate at 95 - 120℃; for 4h;94%
With phosphorus pentachloride for 4h; Heating;91%
Stage #1: 5-fluorouracil With trichlorophosphate at 95℃; for 3.5h;
Stage #2: With hydrogenchloride In water at 0 - 20℃;
87%
2,4,6-trichloro-5-fluoropyrimidine
6693-08-9

2,4,6-trichloro-5-fluoropyrimidine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Conditions
ConditionsYield
With hydrogen; triethylamine; palladium on activated charcoal In ethyl acetate at 30℃; under 2625.2 Torr;87%
ethyl bromide
74-96-4

ethyl bromide

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Conditions
ConditionsYield
With magnesium In tetrahydrofuran
morpholine
110-91-8

morpholine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

4-(2-chloro-5-fluoro-pyrimidin-4-yl)morpholine
31646-53-4

4-(2-chloro-5-fluoro-pyrimidin-4-yl)morpholine

Conditions
ConditionsYield
In water at 60 - 70℃; for 2.5h;100%
With N-ethyl-N,N-diisopropylamine In ethanol Reflux; regioselective reaction;95%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 1h; Inert atmosphere; Reflux;85%
piperidine
110-89-4

piperidine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-chloro-5-fluoro-4-piperidin-1-yl-pyrimidine
40423-82-3

2-chloro-5-fluoro-4-piperidin-1-yl-pyrimidine

Conditions
ConditionsYield
In water at 60 - 70℃; for 2.5h;100%
1-n-propylpiperazine
21867-64-1

1-n-propylpiperazine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-Chloro-5-fluoro-4-(4-propyl-piperazin-1-yl)-pyrimidine

2-Chloro-5-fluoro-4-(4-propyl-piperazin-1-yl)-pyrimidine

Conditions
ConditionsYield
In water at 60 - 70℃; for 2.5h;100%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-chloro-5-fluoropyrimidin-4-amine
155-10-2

2-chloro-5-fluoropyrimidin-4-amine

Conditions
ConditionsYield
With ammonium hydroxide at 60 - 70℃; for 2.5h;100%
With ammonia In water Substitution;
With ammonium hydroxide In ethanol at 25 - 35℃; for 3.5h;
(R)-tert-butyl (1-aminobutan-2-yl)carbamate
956125-05-6

(R)-tert-butyl (1-aminobutan-2-yl)carbamate

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

{(R)-1-[(2-Chloro-5-fluoro-pyrimidin-4-ylamino)-methyl]-propyl}-carbamic acid tert-butyl ester
956125-24-9

{(R)-1-[(2-Chloro-5-fluoro-pyrimidin-4-ylamino)-methyl]-propyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0℃; for 3h;100%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

5-fluoro-N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine diformate

5-fluoro-N2,N4-bis(4-methoxyphenyl)pyrimidine-2,4-diamine diformate

Conditions
ConditionsYield
Stage #1: 4-methoxy-aniline; 2,4-dichloro-5-fluoropyrimidine With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 160℃; for 0.333333h; Microwave irradiation;
Stage #2: With formic acid In water; acetonitrile
100%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine
1341200-71-2

2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine

Conditions
ConditionsYield
With palladium diacetate; sodium carbonate; triphenylphosphine In tetrahydrofuran; water for 12h; Suzuki coupling; Reflux;100%
(S)-1-(1-methyl-6-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine
1537256-09-9

(S)-1-(1-methyl-6-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

(S)-2-chloro-5-fluoro-N-(1-(1-methyl-6-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidin-4-amine
1537207-28-5

(S)-2-chloro-5-fluoro-N-(1-(1-methyl-6-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 120℃; for 1h; Microwave irradiation;100%
n-propylmagnesium bromide
927-77-5

n-propylmagnesium bromide

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2,4-dichloro-5-fluoro-6-propylpyrimidine

2,4-dichloro-5-fluoro-6-propylpyrimidine

Conditions
ConditionsYield
Stage #1: n-propylmagnesium bromide; 2,4-dichloro-5-fluoropyrimidine In tetrahydrofuran; 1,2-dimethoxyethane at 15℃; for 1h;
Stage #2: With iodine; triethylamine In tetrahydrofuran; 1,2-dimethoxyethane at 5℃;
100%
cyclopropanol
16545-68-9

cyclopropanol

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-chloro-4-cyclopropoxy-5-fluoropyrimidine

2-chloro-4-cyclopropoxy-5-fluoropyrimidine

Conditions
ConditionsYield
Stage #1: cyclopropanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.333333h;
Stage #2: 2,4-dichloro-5-fluoropyrimidine In tetrahydrofuran; mineral oil at 0℃; for 4h;
100%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

4-fluoroaniline
371-40-4

4-fluoroaniline

2-chloro-5-fluoro-N-(4-fluorophenyl)pyrimidin-4-amine
1049666-34-3

2-chloro-5-fluoro-N-(4-fluorophenyl)pyrimidin-4-amine

Conditions
ConditionsYield
With trifluoroacetic acid In ethanol at 20℃; for 24h; regioselective reaction;99%
In methanol; water at 50℃; for 5h;68%
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 1.5h;
Nα-isobutyl-Nβ-Boc-hydrazine
57699-53-3

Nα-isobutyl-Nβ-Boc-hydrazine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

C13H20ClFN4O2
929016-08-0

C13H20ClFN4O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol Reflux;99%
7-fluoro-2,3,3-trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indole

7-fluoro-2,3,3-trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indole

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

5-(2-chloro-5-fluoropyrimidin-4-yl)-7-fluoro-2,3,3-trimethyl-3H-indole

5-(2-chloro-5-fluoropyrimidin-4-yl)-7-fluoro-2,3,3-trimethyl-3H-indole

Conditions
ConditionsYield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 130℃; for 1h; Suzuki Coupling; Inert atmosphere; Microwave irradiation;99%
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 130℃; for 1h; Microwave irradiation; Inert atmosphere;301.2 mg
2-pyridylmethyl 4-tolyl sulfone
58414-96-3

2-pyridylmethyl 4-tolyl sulfone

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-Chloro-10-(toluene-4-sulfonyl)-pyrimido[4,5-b]indolizine
137890-00-7

2-Chloro-10-(toluene-4-sulfonyl)-pyrimido[4,5-b]indolizine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Heating;98%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

Diethyl methylmalonate
609-08-5

Diethyl methylmalonate

2-methyl-2-(2-chloro-5-fluoropyrimidinyl-4-yl)-1,3-propanedioic acid diethyl ester
137234-89-0

2-methyl-2-(2-chloro-5-fluoropyrimidinyl-4-yl)-1,3-propanedioic acid diethyl ester

Conditions
ConditionsYield
Stage #1: Diethyl methylmalonate With sodium hydride In tetrahydrofuran; mineral oil at -10℃; for 0.5h;
Stage #2: 2,4-dichloro-5-fluoropyrimidine In tetrahydrofuran; mineral oil at -10℃; for 0.5h;
98%
With sodium hydride In tetrahydrofuran; mineral oil at -10℃; for 0.5h;83%
1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one
1021426-42-5

1-(4-{4-amino-3-methoxyphenyl}piperazine-1-yl)ethan-1-one

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

1-(4-(4-((2-chloro-5-fluoropyrimidin-4-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethanone
1474014-16-8

1-(4-(4-((2-chloro-5-fluoropyrimidin-4-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethanone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; Temperature;98%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;68%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole
847818-74-0

1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

2-chloro-5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)pyrimidine

2-chloro-5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)pyrimidine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In tetrahydrofuran; water Reflux;98%
N-(1,3-benzodioxol-5-ylmethyl)-2-(tetrahydro-2H-pyran-4-yl)ethanamine

N-(1,3-benzodioxol-5-ylmethyl)-2-(tetrahydro-2H-pyran-4-yl)ethanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]pyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[2-(tetrahydro-2H-pyran-4-yl)ethyl]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 85℃;98%
methyl 6-azaspiro[2.5]octane-1-carboxylate hydrochloride

methyl 6-azaspiro[2.5]octane-1-carboxylate hydrochloride

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

methyl 6-(2-chloro-5-fluoropyrimidin-4-yl)-6-azaspiro[2.5]octane-1-carboxylate

methyl 6-(2-chloro-5-fluoropyrimidin-4-yl)-6-azaspiro[2.5]octane-1-carboxylate

Conditions
ConditionsYield
With triethylamine In methanol at 30℃; for 16h;98%
3-methyl-5-aminopyrazole
31230-17-8

3-methyl-5-aminopyrazole

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

2-chloro-5-fluoro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine
851434-99-6

2-chloro-5-fluoro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Conditions
ConditionsYield
With triethylamine In ethanol at 0 - 25℃; regioselective reaction;97%
With N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 48h; Inert atmosphere;86%
With N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 48h; Inert atmosphere;86%
With triethylamine In ethanol at 18 - 25℃; for 12h;
With triethylamine In ethanol at 18 - 25℃; for 12h;
2-fluorobenzylamine
89-99-6

2-fluorobenzylamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

(2-chloro-5-fluoropyrimidin-4-yl)-(2-fluorobenzyl)amine
1174385-80-8

(2-chloro-5-fluoropyrimidin-4-yl)-(2-fluorobenzyl)amine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 5h; Reflux;97%
With triethylamine In tetrahydrofuran at 80℃; for 5h;97%
N-(1,3-benzodioxol-5-ylmethyl)-3-(5-phenyl-1,2,4-oxadiazol-3-yl)propan-1-amine

N-(1,3-benzodioxol-5-ylmethyl)-3-(5-phenyl-1,2,4-oxadiazol-3-yl)propan-1-amine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[3-(5-phenyl-1,2,4-oxadiazol-3-yl)propyl]pyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[3-(5-phenyl-1,2,4-oxadiazol-3-yl)propyl]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 85℃;97%
tert-butyl 3-hydroxyphenylcarbamate
19962-06-2

tert-butyl 3-hydroxyphenylcarbamate

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

C15H15ClFN3O3
1246610-46-7

C15H15ClFN3O3

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 110℃; for 16h;96%
2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2-chloro-5-fluoro-4-methylthiopyrimidine

2-chloro-5-fluoro-4-methylthiopyrimidine

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 2h;96%
In tetrahydrofuran; water at -30℃; for 2h;93%
In tetrahydrofuran at 20℃; for 12h;
N-(1,3-benzodioxol-5-ylmethyl)-1-methylcyclopropanamine

N-(1,3-benzodioxol-5-ylmethyl)-1-methylcyclopropanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-(1-methylcyclopropyl)pyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-(1-methylcyclopropyl)pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 85℃;96%
N-(1,3-benzodioxol-5-ylmethyl)-2-(4-fluorophenyl)ethanamine

N-(1,3-benzodioxol-5-ylmethyl)-2-(4-fluorophenyl)ethanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[2-(4-fluorophenyl)ethyl]pyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-5-fluoro-N-[2-(4-fluorophenyl)ethyl]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 85℃;96%
1-(1,3-benzodioxol-5-yl)-N-(cyclopropylmethyl)methanamine

1-(1,3-benzodioxol-5-yl)-N-(cyclopropylmethyl)methanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-(cyclopropylmethyl)-5-fluoropyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-(cyclopropylmethyl)-5-fluoropyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol; isopropyl alcohol at 85℃;96%
N-(1,3-benzodioxol-5-ylmethyl)-2-(4-chloro-3,5-dimethylphenoxy)ethanamine

N-(1,3-benzodioxol-5-ylmethyl)-2-(4-chloro-3,5-dimethylphenoxy)ethanamine

2,4-dichloro-5-fluoropyrimidine
2927-71-1

2,4-dichloro-5-fluoropyrimidine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-[2-(4-chloro-3,5-dimethylphenoxy)ethyl]-5-fluoropyrimidin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-2-chloro-N-[2-(4-chloro-3,5-dimethylphenoxy)ethyl]-5-fluoropyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 85℃;96%

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