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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1127.html Product Name 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile CAS
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Name: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Synonyms: 3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE-2-CARBONITRILE;3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE CARBONITRILE;3-[2-(3-CHLOROPHENYL)ETHYL]-2-CYANOPYRIDINE;3-(2-(3-CHLORO PHENYL)
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryIndependent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi
Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
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inquiry3-(2-(3-CHLOROPHENYL)ETHYL)-2-PYRIDINECARBONITRILEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiryBest quality with low priceAppearance:Light brown solid Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai
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inquiry3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; under 760.051 Torr; for 24h; Reagent/catalyst; Solvent; | 96% |
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
With trichlorophosphate In toluene for 4h; Reflux; | 74% |
With trichlorophosphate at 80℃; for 2.5h; | 68.1% |
With trichlorophosphate for 5h; Heating / reflux; | 63% |
3-(3-chlorophenethyl)-pyridine N-oxide
sodium cyanide
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 3-(3-chlorophenethyl)-pyridine N-oxide With N,N-Dimethylcarbamoyl chloride In acetonitrile at 35 - 40℃; for 1 - 3h; Stage #2: sodium cyanide In water; acetonitrile at -5 - 0℃; for 3 - 4h; Stage #3: With sodium hydroxide In water; acetonitrile for 2 - 3h; | 73.5% |
2-cyano-3-methylpyridine
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme | |
Multi-step reaction with 3 steps 1: N-chloro-succinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux 2: magnesium; iodine / tetrahydrofuran / 1 h / 35 - 40 °C / Inert atmosphere 3: palladium 10% on activated carbon / tetrahydrofuran / 12 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid / 0.5 h / 70 - 75 °C 2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 2.2: 1 h / -10 °C / Inert atmosphere 3.1: trichlorophosphate / 4 h / 110 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; water; acetic acid / 60 °C 1.2: 2.5 h / 70 - 80 °C 2.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 2 h / Inert atmosphere 3.1: trichlorophosphate / 2.5 h / 80 °C View Scheme |
N-tert-butyl-3-methylpyridine-2-carboxamide
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme | |
Multi-step reaction with 2 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 1.2: 1 h / -10 °C / Inert atmosphere 2.1: trichlorophosphate / 4 h / 110 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 2 h / Inert atmosphere 2.1: trichlorophosphate / 2.5 h / 80 °C View Scheme |
1-Chloro-3-chloromethyl-benzene
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating View Scheme |
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
With sodium hydroxide In water; isopropyl alcohol; trichlorophosphate | 118 g (HPLC purity 95.7%) |
1-Chloro-3-chloromethyl-benzene
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
With palladium 10% on activated carbon In tetrahydrofuran at 25 - 35℃; for 12h; | 8.65 g |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With sulfuric acid; water at 120 - 122℃; for 10 - 12h; Stage #2: With sodium hydroxide In water at 90℃; | 94.4% |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Conditions | Yield |
---|---|
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h; Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux; | 94% |
With PPA at 200℃; | 45% |
With PPA Heating; |
4-chloro-1-methylpiperidine
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
Conditions | Yield |
---|---|
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran; ethylene dibromide at 75℃; for 1h; Inert atmosphere; Stage #2: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile In tetrahydrofuran; ethylene dibromide at 40 - 50℃; for 1h; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; ethylene dibromide at 20℃; for 1h; pH=< 2; Inert atmosphere; | 83.3% |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
(1-methyl-4-piperidyl)magnesium chloride
1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
Conditions | Yield |
---|---|
In tetrahydrofuran at 30 - 60℃; for 1.5h; | 48.6% |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
(1-methyl-4-piperidyl)magnesium chloride
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
Conditions | Yield |
---|---|
With hydrogenchloride 1.) THF, reflux; Multistep reaction; | |
In pyridine |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
(1-methyl-4-piperidyl)magnesium chloride
Conditions | Yield |
---|---|
In tetrahydrofuran at 40 - 50℃; for 0.5h; |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating 5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating 5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
loratadine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating View Scheme | |
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 0.85 g / polyphosphoric acid (PPA) / 8 h / 190 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 0.3 g / BF3 / 4 h / 120 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
N-methyldesloratadine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C View Scheme | |
Multi-step reaction with 2 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: PPA / Heating 2: tetrahydrofuran / -40 °C 3: H2SO4 4: Et3N / toluene / Heating 5: aq. KOH / Heating View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PPA / Heating 2: tetrahydrofuran / -40 °C 3: H2SO4 View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
descarboethoxyloratadine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating 4: aq. KOH / Heating View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PPA / Heating 2: diethyl ether; tetrahydrofuran 3: H2SO4 / H2O View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: PPA / Heating 2: diethyl ether; tetrahydrofuran 3: H2SO4 / H2O 4: tetrahydrofuran 5: H2SO4 / tetrahydrofuran; H2O View Scheme |
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
N-formyldesloratadine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating 4: aq. KOH / Heating 5: C5H5N / CH2Cl2 View Scheme |
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