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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-[2-(3-Chlorophenyl)-ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1127.html Product Name 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile CAS

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM-- 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 31255-57-9 with best quality

Cas:31255-57-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]- 31255-57-9

Cas:31255-57-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]-

Cas:31255-57-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]-

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile Synonyms: 3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE-2-CARBONITRILE;3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE CARBONITRILE;3-[2-(3-CHLOROPHENYL)ETHYL]-2-CYANOPYRIDINE;3-(2-(3-CHLORO PHENYL)

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile supplier best quality

Cas:31255-57-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3(2-(3-CHLORO PHENYL)ETHYL) CYANO PYRIDINE (LORANITRILE)

Cas:31255-57-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

2-Cyano-3-(3-chlorophenylethyl)pyridine

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Trading Company

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

31255-57-9 CAS NO.31255-57-9

Cas:31255-57-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-[2-(3-Chlorophenyl)-ethyl]-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2-Cyano-3-(3-Chlorophenylethyl)Pyridine

Cas:31255-57-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]-

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Manufacturers

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Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd

Independent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi

Loratadine Impurity 8

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Pyridinecarbonitrile,3-[2-(3-chlorophenyl)ethyl]-

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile CAS No.31255-57-9

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Trading Company

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3-(2-(3-CHLOROPHENYL)ETHYL)-2-PYRIDINECARBONITRILEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-(2-(3-CHLOROPHENYL)ETHYL)-2-PYRIDINECARBONITRILE

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:Light brown solid Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

31255-57-9

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

31255-57-9 Application:intermediate

3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile

Cas:31255-57-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3-[2-(3-chlorophenyl)vinyl]-2-pyridinecarbonitrile

3-[2-(3-chlorophenyl)vinyl]-2-pyridinecarbonitrile

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; under 760.051 Torr; for 24h; Reagent/catalyst; Solvent;96%
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
107285-30-3

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With trichlorophosphate In toluene for 4h; Reflux;74%
With trichlorophosphate at 80℃; for 2.5h;68.1%
With trichlorophosphate for 5h; Heating / reflux;63%
3-(3-chlorophenethyl)-pyridine N-oxide
31255-47-7

3-(3-chlorophenethyl)-pyridine N-oxide

sodium cyanide
143-33-9

sodium cyanide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-(3-chlorophenethyl)-pyridine N-oxide With N,N-Dimethylcarbamoyl chloride In acetonitrile at 35 - 40℃; for 1 - 3h;
Stage #2: sodium cyanide In water; acetonitrile at -5 - 0℃; for 3 - 4h;
Stage #3: With sodium hydroxide In water; acetonitrile for 2 - 3h;
73.5%
2-cyano-3-methylpyridine
20970-75-6

2-cyano-3-methylpyridine

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C
2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min
3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8
View Scheme
Multi-step reaction with 3 steps
1: N-chloro-succinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux
2: magnesium; iodine / tetrahydrofuran / 1 h / 35 - 40 °C / Inert atmosphere
3: palladium 10% on activated carbon / tetrahydrofuran / 12 h / 25 - 35 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid / 0.5 h / 70 - 75 °C
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere
2.2: 1 h / -10 °C / Inert atmosphere
3.1: trichlorophosphate / 4 h / 110 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfuric acid; water; acetic acid / 60 °C
1.2: 2.5 h / 70 - 80 °C
2.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 2 h / Inert atmosphere
3.1: trichlorophosphate / 2.5 h / 80 °C
View Scheme
N-tert-butyl-3-methylpyridine-2-carboxamide
32998-95-1

N-tert-butyl-3-methylpyridine-2-carboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min
2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8
View Scheme
Multi-step reaction with 2 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere
1.2: 1 h / -10 °C / Inert atmosphere
2.1: trichlorophosphate / 4 h / 110 °C
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / Inert atmosphere
2.1: trichlorophosphate / 2.5 h / 80 °C
View Scheme
1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
View Scheme
3-[2-(3-Chlorophenyl)Ethyl]-1,1-Dimethylethyl)-2-Pyridine Carboxamide

3-[2-(3-Chlorophenyl)Ethyl]-1,1-Dimethylethyl)-2-Pyridine Carboxamide

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
107285-30-3

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With sodium hydroxide In water; isopropyl alcohol; trichlorophosphate118 g (HPLC purity 95.7%)
C7H5ClMgN2

C7H5ClMgN2

1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Conditions
ConditionsYield
With palladium 10% on activated carbon In tetrahydrofuran at 25 - 35℃; for 12h;8.65 g
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With sulfuric acid; water at 120 - 122℃; for 10 - 12h;
Stage #2: With sodium hydroxide In water at 90℃;
94.4%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h;
Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux;
94%
With PPA at 200℃;45%
With PPA Heating;
4-chloro-1-methylpiperidine
5570-77-4

4-chloro-1-methylpiperidine

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran; ethylene dibromide at 75℃; for 1h; Inert atmosphere;
Stage #2: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile In tetrahydrofuran; ethylene dibromide at 40 - 50℃; for 1h; Inert atmosphere;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; ethylene dibromide at 20℃; for 1h; pH=< 2; Inert atmosphere;
83.3%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
In tetrahydrofuran at 30 - 60℃; for 1.5h;48.6%
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone
130642-50-1

{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone

Conditions
ConditionsYield
With hydrogenchloride 1.) THF, reflux; Multistep reaction;
In pyridine
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

Conditions
ConditionsYield
In tetrahydrofuran at 40 - 50℃; for 0.5h;
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
244122-88-1

10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
170727-68-1

8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol
170727-67-0

{3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-[4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

1-[4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 5 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine
2: 99 percent / naBH4 / ethanol / 3 h
3: 3 percent / PPA / 3 h / 170 - 175 °C
4: NEt3 / benzene / 1.5 h / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

loratadine
79794-75-5

loratadine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 20 g / BF3 / 4 h / 120 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 91 percent / hydrofluoric acid, BF3 / -35 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C
4: 42.4 g / toluene / 1 h / 80 °C
View Scheme
Multi-step reaction with 3 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere
1.2: 1 h / 40 - 50 °C / Inert atmosphere
1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere
2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C
3.1: triethylamine / toluene / 2 h / 80 - 85 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine
119770-61-5

8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 0.85 g / polyphosphoric acid (PPA) / 8 h / 190 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene
119770-62-6

8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 0.3 g / BF3 / 4 h / 120 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE
119770-60-4

1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

N-methyldesloratadine
38092-89-6

N-methyldesloratadine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 20 g / BF3 / 4 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 91 percent / hydrofluoric acid, BF3 / -35 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 0.5 h / 40 - 50 °C
2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C
3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C
View Scheme
Multi-step reaction with 2 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere
1.2: 1 h / 40 - 50 °C / Inert atmosphere
1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere
2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-methyl-amine

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-methyl-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: PPA / Heating
2: tetrahydrofuran / -40 °C
3: H2SO4
4: Et3N / toluene / Heating
5: aq. KOH / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-dimethyl-amine

{3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-dimethyl-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PPA / Heating
2: tetrahydrofuran / -40 °C
3: H2SO4
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

descarboethoxyloratadine
100643-71-8

descarboethoxyloratadine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
4: aq. KOH / Heating
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone
130642-68-1

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PPA / Heating
2: diethyl ether; tetrahydrofuran
3: H2SO4 / H2O
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde
130642-70-5

4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: PPA / Heating
2: diethyl ether; tetrahydrofuran
3: H2SO4 / H2O
4: tetrahydrofuran
5: H2SO4 / tetrahydrofuran; H2O
View Scheme
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

N-formyldesloratadine
117810-61-4

N-formyldesloratadine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2.) aq. HCl / 1.) THF, reflux
2: CF3SO3H / Heating
3: Et3N / toluene / Heating
4: aq. KOH / Heating
5: C5H5N / CH2Cl2
View Scheme

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