CAS No.79794-75-5,Loratadine Suppliers

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Kind Pharma has its own laboratory, we can do analytical testing for API (Active Pharmaceutical Ingredient), pharmaceutical intermediate, pesticide intermediate, additive and other chemical products, so it

Loratadine 99%

Cas:79794-75-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Loratadine Manufacturer/High quality/Best price/In stock

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Loratadine 79794-75-5

Cas:79794-75-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white crystalline powder Complies Solubility F

High purity Various Specifications Loratadine CAS:79794-75-5

Cas:79794-75-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Loratadine/79794-75-5/with high purity 99%

Cas:79794-75-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai P

LORATIDINE

Cas:79794-75-5

Min.Order:100 Gram

FOB Price: $1900.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Loratadine Cas 79794-75-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white powder Storage:Store in 2-8℃ Package:1kg/foil bag;25kg

Factory supply high quality Loratadine Cas 79794-75-5 with best price and fast delivery

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $295.0 / 300.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

Quanao supply API Loratadine powder cas 79794-75-5

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $269.0 / 289.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Loratadine

Cas:79794-75-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

EAST CHEMSOURCES LIMITED

Loratadine English name： Loratadine Chemical name： Ethyl4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate Category involved： bulk ph

Loratadine

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Cas:79794-75-5

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Loratadine 79794-75-5 GMP Manufacturer

Cas:79794-75-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Loratadine

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Loratadine

Cas:79794-75-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--79794-75-5--Loratadine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business relationsh

TIANFUCHEM--79794-75-5--Loratadine factory price

Cas:79794-75-5

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturing

Loratadine CAS:79794-75-5

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 79794-75-5 with best quality

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.，Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Loratadine

Cas:79794-75-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages &diams; High purity, all above 98.5%, no impurities after dissolution &diams; We will test each batch to ensure quality &diams; OEM and private brand services designed for free &diams; Various cap colors available &diams; W

Loratadine CAS79794-75-5

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Loratadine/ LIDE PHARMA- Factory supply / Best price

Cas:79794-75-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Loratadine Assay: 99% min CAS:79794-75-5 Molecular formula:C22H23ClN2O2 Molecular weight: 382.89 Purity: 99% Appearance: White crystalline powder Loratidine; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylid

Loratadine

Cas:79794-75-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed containers

China Supply 99% Purity Pharma Raw Materials White Crystal Powder CAS 79794-75-5 Loratadine

Cas:79794-75-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical inte

Loratadine 99%

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Loratadine Structure: Formula: C22H23ClN2O2 Molecular Weight : 382.88 Synonyms: LORATADINE;LORATADINE-D5;LORATIDINE;CLARATYNE;CLARITIN;ethyl4-(8-chloro-5,6

Loratadine

Cas:79794-75-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality Pure Antiallergic Loratadine 99% Raw Material Purity Loratadine Powder Pharmaceutical Loratadine Factory Floor Price Free Custom Clearance Door to Door

Cas:79794-75-5

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Appearance: White Crystalline Solid Storage:2 Years Package: according to customers' requirements Application:anti inflammatory, analgesic, antipyretic, analgesic, antipyretic Transportation:International express delivery Port: China main port

Loratadine WITH BEST PRICE

Cas:79794-75-5

Min.Order:1 Kilogram

FOB Price: $600.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Loratadine CAS:79794-75-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Loratadine CAS:79794-75-5

Cas:79794-75-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 79794-75-5 Loratadine

Cas:79794-75-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Loratadine

Cas:79794-75-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:79794-75-5

Cas:79794-75-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

: 541-41-3
chloroformic acid ethyl ester

: 38092-89-6
N-methyldesloratadine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In toluene at 60 - 75℃; for 1 - 2h;	90%
Stage #1: chloroformic acid ethyl ester; N-methyldesloratadine With N-ethyl-N,N-diisopropylamine In toluene at 60 - 75℃; for 1 - 2h; Stage #2: With hydrogenchloride In water; toluene	73%
With triethylamine In toluene for 3h; Reflux;	72%

: 216870-24-5
diethyl N-ethoxycarbonylpiperidine-4-phosphonate

: 79794-75-5
loratadine

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl acetamide; isopropyl alcohol at 20 - 140℃; under 760.051 Torr; for 2h;	82%

: 20970-75-6
2-cyano-3-methylpyridine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 20 g / BF3 / 4 h / 120 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 91 percent / hydrofluoric acid, BF3 / -35 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 7 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 4: tetrahydrofuran / 0.5 h / 40 - 50 °C 5: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 6: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 7: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 6 steps 1.1: sulfuric acid / 0.5 h / 70 - 75 °C 2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 2.2: 1 h / -10 °C / Inert atmosphere 3.1: trichlorophosphate / 4 h / 110 °C 4.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 4.2: 1 h / 40 - 50 °C / Inert atmosphere 4.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 5.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 6.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

: 32998-95-1
N-tert-butyl-3-methylpyridine-2-carboxamide

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 20 g / BF3 / 4 h / 120 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 91 percent / hydrofluoric acid, BF3 / -35 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 6 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 3: tetrahydrofuran / 0.5 h / 40 - 50 °C 4: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 5: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 6: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 5 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux 4: CF3SO3H / Heating 5: Et3N / toluene / Heating View Scheme
Multi-step reaction with 5 steps 1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 1.2: 1 h / -10 °C / Inert atmosphere 2.1: trichlorophosphate / 4 h / 110 °C 3.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 3.2: 1 h / 40 - 50 °C / Inert atmosphere 3.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 4.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 5.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

: 31255-57-9
3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating View Scheme
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

: 107285-30-3
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 20 g / BF3 / 4 h / 120 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 91 percent / hydrofluoric acid, BF3 / -35 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 5 steps 1: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 2: tetrahydrofuran / 0.5 h / 40 - 50 °C 3: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 4: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 5: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: POCl3 / Heating 2: 2.) aq. HCl / 1.) THF, reflux 3: CF3SO3H / Heating 4: Et3N / toluene / Heating View Scheme
Multi-step reaction with 4 steps 1.1: trichlorophosphate / 4 h / 110 °C 2.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 2.2: 1 h / 40 - 50 °C / Inert atmosphere 2.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 3.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 4.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

: 63463-36-5
(1-methyl-4-piperidyl)magnesium chloride

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: tetrahydrofuran / Reflux 2: sulfuric acid / 4.5 h / 20 °C 3: triethylamine / toluene / 3 h / Reflux View Scheme

: C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 20 g / BF3 / 4 h / 120 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 91 percent / hydrofluoric acid, BF3 / -35 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 2: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 3: 42.4 g / toluene / 1 h / 80 °C View Scheme

: 119770-60-4
1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 20 g / BF3 / 4 h / 120 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 2 steps 1: 91 percent / hydrofluoric acid, BF3 / -35 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 2 steps 1: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 2: 42.4 g / toluene / 1 h / 80 °C View Scheme

: 130642-50-1
{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CF3SO3H / Heating 2: Et3N / toluene / Heating View Scheme

: 620-20-2
1-Chloro-3-chloromethyl-benzene

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating 3: 2.) aq. HCl / 1.) THF, reflux 4: CF3SO3H / Heating 5: Et3N / toluene / Heating View Scheme

: 541-41-3
chloroformic acid ethyl ester

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 38092-89-6
N-methyldesloratadine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
In toluene; acetonitrile	42.4 g (HPLC purity 97.4%)
In toluene; acetonitrile	42.4 g (HPLC purity 97.4%)

...Expand

: 541-41-3
chloroformic acid ethyl ester

: 7440-44-0
pyrographite

: 38092-89-6
N-methyldesloratadine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
In toluene; acetonitrile

...Expand

: 31251-41-9
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / Reflux 2: sulfuric acid / 4.5 h / 20 °C 3: triethylamine / toluene / 3 h / Reflux View Scheme

: 38089-93-9
8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / 4.5 h / 20 °C 2: triethylamine / toluene / 3 h / Reflux View Scheme

: 100643-71-8
descarboethoxyloratadine

: 1609-47-8
diethyl dicarbonate

: 79794-75-5
loratadine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 2h;

: 5570-77-4
4-chloro-1-methylpiperidine

: 79794-75-5
loratadine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

: 79794-75-5
loratadine

: 100643-71-8
descarboethoxyloratadine

Conditions

Conditions	Yield
In ethanol; water Reflux; Inert atmosphere; Alkaline conditions;	98.5%
With C22H40N4(2+)*2BF4(1-) In toluene at 80℃; for 0.666667h;	98.5%
With sodium hydroxide In ethanol; water at 100 - 105℃; for 5h; Concentration; Solvent; Time; Temperature; Autoclave; Inert atmosphere; Large scale;	96%

: 3731-53-1
4-(aminomethyl)pyridine

: 79794-75-5
loratadine

: ethyl 4-(8-((pyridin-4-ylmethyl)amino)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With C47H70BrO4PPdSi; sodium t-butanolate In tetrahydrofuran at 20℃; for 1h; Schlenk technique; Inert atmosphere; Sealed tube;	98%

: 79794-75-5
loratadine

: potassium vinyltrifluoroborate

: ethyl 4-(8-vinyl-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 90℃; for 2h; Schlenk technique; Inert atmosphere;	91%

: 5764-82-9
bromo(2-ethoxy-2-oxoethyl)zinc

: 79794-75-5
loratadine

: ethyl 4-[13-(2-ethoxy-2-oxoethyl)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]piperidine-1-carboxylate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); N,N,N,N,-tetramethylethylenediamine; C38H62P2 In tetrahydrofuran at 20℃; for 16h; Negishi Coupling; Inert atmosphere;	90%

: 358-23-6
trifluoromethylsulfonic anhydride

: 79794-75-5
loratadine

: 603-35-0
triphenylphosphine

: (8-Chloro-11-(1-(ethoxycarbonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-4-yl)triphenylphosphonium trifluoromethanesulfonate

Conditions

Conditions	Yield
Stage #1: trifluoromethylsulfonic anhydride; loratadine at -78℃; Inert atmosphere; Stage #2: triphenylphosphine Inert atmosphere; Cooling; Stage #3: Alkaline conditions; Inert atmosphere; regioselective reaction;	88%
at -78 - 20℃; Alkaline conditions;	88%
Stage #1: trifluoromethylsulfonic anhydride; loratadine In dichloromethane at -78℃; Inert atmosphere; Stage #2: triphenylphosphine In dichloromethane at -78 - 20℃; Inert atmosphere; regioselective reaction;

...Expand

: 79794-75-5
loratadine

: ethyl 4-[8-hydroxy-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine carboxylate

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; boric acid; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 14h; Schlenk technique; Inert atmosphere;	87%

: 79794-75-5
loratadine

isopropyl halide: isopropyl halide

: C25H29ClN2O2

Conditions

Conditions	Yield
With tris-(trimethylsilyl)silane; [Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]2(4,4′-di-t-Bu-2,2′-bipyridine)]PF6; oxygen; trifluoroacetic acid In acetone at 20℃; for 24h; Minisci Aromatic Substitution; Irradiation; regioselective reaction;	83%

: 79794-75-5
loratadine

: 73183-34-3
bis(pinacol)diborane

: ethyl 4-(8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-11Hbenzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With potassium acetate; palladium diacetate; XPhos In 1,4-dioxane at 80℃; for 10h; Schlenk technique;	83%
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos In 1,4-dioxane at 110℃; for 12h; Inert atmosphere; Sealed tube;	705.4 mg

: 450-95-3
2-fluoroacetophenone

: 79794-75-5
loratadine

: (1-fluoro-2-oxo-2-phenylethyl)claritin

Conditions

Conditions	Yield
With chloro[(di(1-adamantyl)-N-butylphosphine)-2-(2-aminobiphenyl)]palladium(II); caesium carbonate In toluene at 100℃; for 14h; Schlenk technique; Inert atmosphere;	82%

: 358-23-6
trifluoromethylsulfonic anhydride

: 5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine

: 79794-75-5
loratadine

: (8-chloro-11-(1-(ethoxycarbonyl)piperidin-4-ylidene)-6,11-dihydro-5Hbenzo[5,6]cyclohepta[1,2-b]pyridin-4-yl)diphenyl(6-(trifluoromethyl)pyridin-3-yl)phosphonium trifluoromethanesulfonate

Conditions

Conditions	Yield
Stage #1: trifluoromethylsulfonic anhydride; 5-(diphenylphosphaneyl)-2-(trifluoromethyl)pyridine; loratadine In dichloromethane at -50℃; for 1h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; for 0.333333 - 0.5h; Inert atmosphere;	81%

...Expand

: 646-06-0
1,3-DIOXOLANE

: 79794-75-5
loratadine

A: ethyl 4-(8-formyl-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

B: ethyl 4-(8-(1,3-dioxolan-4-yl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1,3-DIOXOLANE; loratadine With potassium phosphate; (1,2-dimethoxyethane)dichloronickel(II); 4,4'-di-tert-butyl-2,2'-bipyridine for 0.166667h; Glovebox; Stage #2: With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate at 23℃; for 72h; Sealed tube; Irradiation; Stage #3: With hydrogenchloride In water; acetone at 23℃;	A 78% B n/a

Yield

Stage #1: 1,3-DIOXOLANE; loratadine With potassium phosphate; (1,2-dimethoxyethane)dichloronickel(II); 4,4'-di-tert-butyl-2,2'-bipyridine for 0.166667h; Glovebox;
Stage #2: With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate at 23℃; for 72h; Sealed tube; Irradiation;
Stage #3: With hydrogenchloride In water; acetone at 23℃;

A 78%
B n/a

...Expand

: 79794-75-5
loratadine

: 17997-47-6
2-tri-n-butylstannylpyridine

: ethyl 4-(8-(pyridin-2-yl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;	78%

: 358-23-6
trifluoromethylsulfonic anhydride

: 4-(diphenylphosphaneyl)-2,6-dimethylpyridine

: 79794-75-5
loratadine

: (8-chloro-11-(1-(ethoxycarbonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-4-yl)(2,6-dimethylpyridin-4-yl)diphenylphosphonium trifluoromethanesulfonate

Conditions

Conditions	Yield
Stage #1: trifluoromethylsulfonic anhydride; loratadine In dichloromethane at -78℃; for 0.583333h; Inert atmosphere; Stage #2: 4-(diphenylphosphaneyl)-2,6-dimethylpyridine In dichloromethane at -50℃; for 0.5h; Inert atmosphere; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; Inert atmosphere;	78%

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 79794-75-5
loratadine

: ethyl 4-(8-(2,2,2-trifluoroethyl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; nickel dibromide; zinc In N,N-dimethyl acetamide at 80℃; for 12h; Inert atmosphere; Schlenk technique;	78%

: 2-(allylsulfonyl)-5-(trifluoromethyl)pyridine

: 79794-75-5
loratadine

: ethyl 4-(8-(5-(trifluoromethyl)pyridin-2-yl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 18h; Inert atmosphere;	77%

: 79794-75-5
loratadine

A: 4-(8-Chloro-7-nitro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carboxylic acid ethyl ester

B: 4-(8-Chloro-9-nitro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at -5℃; for 16h;	A 12% B 76%

: 124-38-9
carbon dioxide

: 79794-75-5
loratadine

: 143540-41-4
8-cyano-11-(1-ethoxycarbonyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Conditions

Conditions	Yield
With nickel(II) acetylacetonate; potassium fluoride; phenylsilane; ammonia; zinc; bis(2-diphenylphosphinoethyl)phenylphosphine In 1-methyl-pyrrolidin-2-one at 90 - 140℃; under 760.051 Torr; for 20h; Sealed tube;	72%

: 762-51-6
1-fluoro-2-iodoethane

: 79794-75-5
loratadine

: C24H27FN2O2

Conditions

Conditions	Yield
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	70%
With manganese; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium chloride; nickel dibromide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Inert atmosphere; Sealed tube;	70%

: 79794-75-5
loratadine

A: 79779-58-1
ethyl 4-(5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

B: methyl 4-(5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With tert-Amyl alcohol; tetramethyl ammoniumhydroxide; 2-(2-ethylhexyl)-6,8,11-tris(4-methoxyphenyl)-1H-peryleno[1,12-efg]isoindole-1,3(2H)-dione In methanol at 20℃; for 48h; Birch Reduction; Sealed tube; Irradiation;	A 65% B 26%

: 127-19-5
N,N-dimethyl acetamide

: 79794-75-5
loratadine

: C26H31N3O3

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; [2,2]bipyridinyl; nickel(II) bromide dimethoxyethane at 30℃; for 48h; Inert atmosphere; Irradiation; regioselective reaction;	63%

: 1279123-63-5
potassium hydrogenfluoride

: 79794-75-5
loratadine

: 73183-34-3
bis(pinacol)diborane

: ethyl 4-(8-(trifluoro-λ4-boraneyl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate potassium salt

Conditions

Conditions	Yield
Stage #1: loratadine; bis(pinacol)diborane With 10H-phenothiazine; caesium carbonate In acetonitrile at 45℃; for 72h; Irradiation; Sealed tube; Inert atmosphere; Stage #2: With hydrogenchloride; dihydroxy-methyl-borane In water; acetone Stage #3: potassium hydrogenfluoride Further stages;	62%

...Expand

: 79794-75-5
loratadine

tert-butyl halide: tert-butyl halide

: C26H31ClN2O2

Conditions

Conditions	Yield
With tris-(trimethylsilyl)silane; [Ir[2-(2,4-difluorophenyl)-5-trifluoromethylpyridine]2(4,4′-di-t-Bu-2,2′-bipyridine)]PF6; oxygen; trifluoroacetic acid In acetone at 20℃; for 24h; Minisci Aromatic Substitution; Irradiation; regioselective reaction;	61%

: 79794-75-5
loratadine

: 4381-25-3
S-methyl-S-phenylsulfoximine

: ethyl 4-(8-((methyl(oxo)(phenyl)-λ6-sulfaneylidene)amino)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 8h; Inert atmosphere; Sealed tube; Electrochemical reaction;	60%

: 1768-64-5
4-chlorotetrahydro-2H-pyran

: 79794-75-5
loratadine

: ethyl 4-(8-(tetrahydro-2H-pyran-4-yl)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With 2,2'-biimidazole; (1,2-dimethoxyethane)dichloronickel(II); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; N-(adamantan-1-yl)-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilan-2-amine In tert-Amyl alcohol; N,N-dimethyl acetamide at 55℃; for 18h; Inert atmosphere; Irradiation;	58%

: 79794-75-5
loratadine

: 149-73-5
trimethyl orthoformate

: 130642-61-4
ethyl 4-(8-methyl-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: loratadine; trimethyl orthoformate With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube; Stage #2: With palladium on activated charcoal; hydrogen In methanol at 20℃; under 1551.49 Torr; for 10h;	57%
With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube;	51%

Yield

Stage #1: loratadine; trimethyl orthoformate With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube;
Stage #2: With palladium on activated charcoal; hydrogen In methanol at 20℃; under 1551.49 Torr; for 10h;

57%

With potassium phosphate; [nickel(II)dichloride(dimethoxyethane)]; [4,4'-bis(1,1-dimethylethyl)-2,2'-bipyridine-N1,N1]bis-{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C}iridium(III) hexafluorophosphate; 4,4'-di-tert-butyl-2,2'-bipyridine at 20℃; for 72h; Irradiation; Sealed tube;

51%

: 79794-75-5
loratadine

: 77970-95-7
S-(4-methoxyphenyl)-S-methylsulfoximine

: ethyl 4-(8-(((4-methoxyphenyl)(methyl)(oxo)-λ6-sulfaneylidene)amino)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl acetamide at 20℃; for 8h; Inert atmosphere; Sealed tube; Electrochemical reaction;	57%

: 10273-89-9
2-(2-methylphenyl)pyridine

: 79794-75-5
loratadine

: C34H33N3O2

Conditions

Conditions	Yield
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere;	56%
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 72h; Inert atmosphere; Glovebox;	56%

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 13675-18-8
tetrahydroxydiboron

: 79794-75-5
loratadine

: ethyl 4-(8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-11Hbenzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: tetrahydroxydiboron; loratadine With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate; XPhos In ethanol at 80℃; Stage #2: 2,3-dimethyl-2,3-butane diol In dichloromethane at 20℃; for 16h;	52%

...Expand

Related products

79799-05-6

3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, methyl ester, (3S)-

79803-73-9

4-Morpholinepropanesulfonicacid, b-hydroxy-, sodium salt (1:1)

79804-71-0

Corticotropin-releasingfactor (sheep)

79804-72-1

L-Glutamine,L-alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-a-aspartyl-L-alanylglycyl-L-seryl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-lysyl-L-a-glutamyl-L-a-aspartyl-L-asparaginyl-L-valyl-L-leucyl-L-valyl-L-a-glutamyl-L-seryl-L-histidyl-L-a-glutamyl-L-lysyl-L-seryl-L-leucylglycyl-L-a-glutamyl-L-alanyl-L-a-aspartyl-L-lysyl-L-alanyl-L-a-aspartyl-L-valyl-L-a-aspartyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-alanyl-L-lysyl-L-seryl-

79809-27-1

1,5-Naphthalenedisulfonicacid,2-[2-[6-[[4-chloro-6-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]-1-hydroxy-3-sulfo-2-naphthalenyl]diazenyl]-,sodium salt (1:4)

79-81-2

Vitamin A palmitate

79814-40-7

2,5-Furandione,3-(acetyloxy)dihydro-, (3R)-

79814-47-4

Pentanedioic acid,3-amino-2-(1-hydroxyethyl)-, 5-methyl ester, [2S-[2R*(R*),3S*]]- (9CI)

79815-20-6

(S)-(-)-Indoline-2-carboxylic acid

79817-55-3

1-Amino-4-(2-benzothiazol-ylthio)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonic acid