zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc
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inquiryStock products, own laboratory Product number PC00361 English Name (S)-(-)-Indoline-2-carboxylic acid CAS Number 79815-20-6 Purity 98%
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/901.html Product Name (S)-(-)-Indoline-2-carboxylic acid CAS No. 79815-20-6 Appearance White Powder Assay
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inquiryPerindopril Erbumine CAS:107133-36-8 (S)-(-)-Indoline-2-Carboxylic Acid CAS:79815-20-6 N-[(S)-1-Carbethoxy-1-Butyl]-(S)-Alanine CAS:82834-12-6 (2S,3aS,7aS)-2-Carboxyperhydroindole CAS:80875-98-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM
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inquiryhe company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: (S)-(-)-Indoline-2-carboxylic acid Synonyms: (S)-indoline-2-carboxylic acid CAS: 79815-20-6 MF: C9H9NO2 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application: APIs Transportation:
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryAppearance/Colour:white to light yellow crystal powder Vapor Pressure:1.88E-06mmHg at 25°C Melting Point:177 °C (dec.)(lit.) Refractive Index:-116 ° (C=1, 2mol/L HCl) Boiling Point:380 °C at 760 mmHg PKA:2.04±0.20(P
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryl-(S)-2,3-dihydro-1-[(S)-3-mercapto-2-methyl-1-oxopropyl]-1H-indole-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; | 100% |
(S)-2-amino-3-(2-bromophenyl)propanoic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 80 - 100℃; for 3.5 - 4h; Product distribution / selectivity; | 95.9% |
With potassium carbonate In water at 95℃; for 22h; Product distribution / selectivity; | 95.6% |
With potassium carbonate; copper(l) chloride In water at 95℃; for 1h; Inert atmosphere; enantioselective reaction; | 83% |
(S)-indoline-2-carboxylic acid methyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: (S)-indoline-2-carboxylic acid methyl ester With sodium hydroxide; water at 20℃; Stage #2: With hydrogenchloride; water at 20℃; pH=5; | 94.5% |
Indole-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With carbon disulfide; carbon dioxide; hydrogen iodide; hydrogen; potassium iodide In ethanol at 90℃; for 5h; Temperature; Solvent; Autoclave; Large scale; | 87.5% |
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran for 3h; Heating; | 87% |
(S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid; water Reflux; | 86.8% |
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate; copper(I) bromide In water at 100 - 105℃; Inert atmosphere; | 86.2% |
(2S)-2-amino-3-(2-chlorophenyl)propanoic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium carbonate; copper(l) chloride In water at 95℃; for 40h; Product distribution / selectivity; | 76.6% |
Stage #1: (2S)-2-amino-3-(2-chlorophenyl)propanoic acid With potassium carbonate; copper(l) chloride In water at 95℃; for 40h; Stage #2: With water at 25℃; pH=3.5; Product distribution / selectivity; Acidic conditions; | 76.6% |
(2S)-indoline-2-carboxylic acid (R)-α-methylbenzylamine salt
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water for 2h; Product distribution / selectivity; | 52.8% |
1-acetyl-2,3-indoline-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
1-benzhydryl-2,3-dihydro-1H-indole-2-carboxylic acid tert-butyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 2: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme |
2-(benzhydrylidene-amino)-3-(2-bromo-phenyl)-propionic acid tert-butyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 69 percent / nBu3SnH; AIBN / benzene / 5 h / 85 °C 2: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 3: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme |
1-Bromo-2-bromomethyl-benzene
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CsOH*H2O / cinchonine bromide derived chiral / 20 h 2: 69 percent / nBu3SnH; AIBN / benzene / 5 h / 85 °C 3: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 4: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 89 percent / CsOH*H2O / cinchonidinium bromide derived chiral / 20 h 2: 69 percent / nBu3SnH; AIBN / benzene / 5 h / 85 °C 3: 77 percent / H2 / Pd/C / methanol / 48 h / 5171.62 Torr 4: 87 percent / aq. HCl / tetrahydrofuran / 3 h / Heating View Scheme |
N-acetyl-indoline-2-carboxylic acid methyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 43 percent 2: aq. 2N HCl View Scheme |
indolin-2-yl carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 52 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C 3: 1.) 4-(dimethylamino)pyridine 5: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 6: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
(S)-2,3-dihydro-1H-indole-2-carboxylic acid,ethyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 100 percent / KOH / dimethylsulfoxide; H2O / Ambient temperature 2: 52 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C 4: 1.) 4-(dimethylamino)pyridine 6: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 7: 100 percent / 6 N HCl / 3 h / Heating View Scheme | |
Multi-step reaction with 7 steps 1: 100 percent / Et3N / diethyl ether / 4 h / Ambient temperature 2: 95 percent / NaOH / methanol; H2O / 1 h / Ambient temperature 4: 1.) 4-(dimethylamino)pyridine 6: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 7: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
2,3-dihydro-1-(2-methyl-1-oxo-2-propenyl)-1H-indole-2-carboxylic acid ethyl ester
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 95 percent / NaOH / methanol; H2O / 1 h / Ambient temperature 3: 1.) 4-(dimethylamino)pyridine 5: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 6: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
2,3-Dihydro-1-(2-methyl-1-oxo-2-propenyl)-1H-indole-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 2: 1.) 4-(dimethylamino)pyridine 4: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 5: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
(-)-1-(2-methyl-1-oxo-2-propenyl)indoline-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) 4-(dimethylamino)pyridine 3: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 4: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
(S)-1-<3-(benzoylthio)-2-methyl-1-oxopropyl>indoline-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 2: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 3: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
Wy-44,088
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 82 percent / 2-methoxyethylamine / 0.42 h / 0 - 20 °C 2: 100 percent / 6 N HCl / 3 h / Heating View Scheme |
A
(S)-indoline-2-carboxylic acid
B
(R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid
Conditions | Yield |
---|---|
With hydrogenchloride In water for 2h; |
(S)-indoline-2-carboxylic acid (1S)-10-camphorsulfonic acid salt
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 0 - 5℃; pH=2.9; |
(+)-α-Chloro-2-aminobenzenepropanoic acid, 2,6-dimethylpiperidine salt
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With phosphorus pentaoxide; sodium hydroxide |
C9H9NO2*C17H17Cl2N
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: C9H9NO2*C17H17Cl2N With sodium hydroxide In water; ethyl acetate pH=> 10; Stage #2: With hydrogenchloride In water pH=4 - 5; |
6-amino-(S)-indoline-2-carboxylic acid
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 6-amino-(S)-indoline-2-carboxylic acid With hydrogenchloride In water at 0℃; for 0.5h; Stage #2: With sodium nitrite In water for 1h; Stage #3: With ethanol In water at 55℃; for 3h; | 7 g |
4-nitro-3-phenyl-L-alanine
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid; uronium nitrate / 5 h / 0 - 60 °C 2.1: oxygen; potassium carbonate / water / 5 h / 120 °C / 3000.3 Torr / Autoclave 3.1: 5%-palladium/activated carbon; hydrogen / water / 4 h / 60 °C / 3750.38 Torr / Autoclave 4.1: hydrogenchloride / water / 0.5 h / 0 °C 4.2: 1 h 4.3: 3 h / 55 °C View Scheme |
ethanol
(S)-indoline-2-carboxylic acid
Ethyl (S)-indoline-2-carboxylate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; for 16h; | 100% |
With thionyl chloride In ethanol at 0 - 20℃; for 16h; | 100% |
With thionyl chloride at 0 - 20℃; for 16h; | 100% |
With thionyl chloride |
methanol
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; | 100% |
With thionyl chloride at -10 - 20℃; | 99% |
With thionyl chloride at 20℃; for 53h; Esterification; | 99% |
methanol
(S)-indoline-2-carboxylic acid
(S)-indoline-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 40℃; for 3h; | 99% |
With sulfuric acid at 80℃; for 16h; | 89.01% |
With thionyl chloride at 0 - 70℃; for 16h; Cooling with ice; | 82% |
(S)-indoline-2-carboxylic acid
benzyl chloroformate
(S)-1-(benzyloxycarbonyl)indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 0℃; for 1h; | 99% |
With sodium hydrogencarbonate In water; toluene Ambient temperature; | 96% |
With sodium hydroxide at 5 - 20℃; for 5h; | 93% |
di-tert-butyl dicarbonate
(S)-indoline-2-carboxylic acid
(S)-N-tert-butoxycarbonylindoline-2-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane at 20℃; for 12h; | 98% |
With sodium carbonate In tert-butyl alcohol at 20℃; for 12h; | 96% |
With sodium hydroxide In 1,4-dioxane at 0 - 20℃; | 90% |
(S)-indoline-2-carboxylic acid
(2S)-2,3-dihydro-1H-indole-2-ylmethanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether Inert atmosphere; | 96% |
Stage #1: (S)-indoline-2-carboxylic acid With dimethylsulfide borane complex; boron trifluoride diethyl etherate In tetrahydrofuran Reflux; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran Reflux; Stage #3: With sodium hydroxide In water | 87% |
Stage #1: (S)-indoline-2-carboxylic acid With dimethylsulfide borane complex In tetrahydrofuran for 12h; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; methanol for 2h; Reflux; Stage #3: With sodium hydroxide In tetrahydrofuran; methanol; water | 87% |
ethanol
(S)-indoline-2-carboxylic acid
(S)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With thionyl chloride | 95% |
With thionyl chloride at 0 - 20℃; for 16h; |
(S)-indoline-2-carboxylic acid
methyl iodide
(2S)-1-methylindoline-2-carboxylic methyl ester
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 50℃; for 24h; Inert atmosphere; | 95% |
With potassium carbonate In DMF (N,N-dimethyl-formamide); acetone at 20℃; |
(S)-indoline-2-carboxylic acid
(6a,7,13a,14)-tetrahydropyrazino[1,2-a:4,5-a']diindol-6,13-dione
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 220℃; under 12901.3 Torr; for 0.416667h; Microwave irradiation; | 94% |
(S)-indoline-2-carboxylic acid
(6aS-cis)-6a,7,13a,14-tetrahydropyrazino<1,2-a:4,5-a'>diindole-6,13-dione
Conditions | Yield |
---|---|
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction; | 93% |
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; | 93% |
With triethylamine In toluene for 5h; Heating; | 83% |
With dicyclohexyl-carbodiimide In tetrahydrofuran for 1h; Ambient temperature; | 76% |
With dicyclohexyl-carbodiimide In tetrahydrofuran for 1h; Ambient temperature; | 76% |
Conditions | Yield |
---|---|
With triethylamine In diethyl ether for 24h; | 93% |
sarcosine
(S)-indoline-2-carboxylic acid
(S)-2-methyl-2,3,10,10a-tetrahydropyrazino[1,2-a]indole-1,4-dione
Conditions | Yield |
---|---|
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction; | 93% |
di-tert-butyl dicarbonate
(S)-indoline-2-carboxylic acid
methyl (S)-N-(tert-butoxycarbonyl)indoline-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: (S)-indoline-2-carboxylic acid With thionyl chloride In methanol Inert atmosphere; Stage #2: di-tert-butyl dicarbonate With triethylamine Inert atmosphere; | 91% |
With thionyl chloride; triethylamine 1.) MeOH, -10 deg C, 0.5 h; reflux, 3 h, 2.) CH2Cl2, room temperature, 24 h; Yield given. Multistep reaction; |
trifluorormethanesulfonic acid
(S)-indoline-2-carboxylic acid
3-phenyl-propenal
Conditions | Yield |
---|---|
Stage #1: (S)-indoline-2-carboxylic acid; 3-phenyl-propenal In methanol at 20℃; for 0.0333333h; Stage #2: trifluorormethanesulfonic acid In methanol | 91% |
(S)-indoline-2-carboxylic acid
(R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid
indolin-2-yl carboxylic acid
Conditions | Yield |
---|---|
Stage #1: (S)-indoline-2-carboxylic acid; (R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid With sodium hydroxide In water at 170℃; under 5250.53 Torr; for 3h; Racemisation; Stage #2: With hydrogenchloride In water at 20 - 25℃; pH=3.4; | 90% |
(S)-indoline-2-carboxylic acid
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
Conditions | Yield |
---|---|
rhodium In 1,4-dioxane; methanol; water | 86.1% |
With 8 % Pd/C; hydrogen In methanol at 55 - 65℃; under 37503.8 Torr; Autoclave; | 73.5% |
With hydrogen; palladium on activated charcoal In acetic acid at 50℃; under 36775.4 Torr; for 18h; | 66% |
(S)-indoline-2-carboxylic acid
A
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
B
(2S,3aR,7aR)-octahydroindole-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogen; acetic acid; platinum(IV) oxide at 60℃; for 24h; atmospheric pressure; | A 85% B n/a |
With platinum(IV) oxide; hydrogen at 60℃; optical yield given as %de; | A 85% B n/a |
acetic anhydride
(S)-indoline-2-carboxylic acid
1-acetyl-2,3-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 16h; | 85% |
(S)-indoline-2-carboxylic acid
L-proline
(5aS,12aS)-1,2,3,5a,6,12a-hexahydro-5H,12H-pyrrolo[1',2':4,5]pyrazino[1,2-a]indole-5,12-dione
Conditions | Yield |
---|---|
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction; | 83% |
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
(S)-indoline-2-carboxylic acid
(4aS,6aS,13aS,14aS)-1,2,3,4,4a,6a,7,13a,14,14a-decahydro-6H,13H-pyrazino[1,2-a:4,5-a']diindole-6,13-dione
Conditions | Yield |
---|---|
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction; | 81% |
L-N-Boc-Ala
(S)-indoline-2-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: (S)-indoline-2-carboxylic acid With triethylamine In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: L-N-Boc-Ala With dicyclohexyl-carbodiimide at 20℃; for 6h; | 81% |
(S)-indoline-2-carboxylic acid
B
Ethyl (S)-indoline-2-carboxylate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol | A n/a B 78% |
With hydrogenchloride In ethanol | A n/a B 78% |
With hydrogenchloride In ethanol | A n/a B 78% |
With hydrogenchloride In ethanol | A n/a B 78% |
With hydrogenchloride In ethanol | A n/a B 78% |
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