Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryItems Standard Result Appearance White to off white powder White powder Identification (HPLC)
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryName: L-4-Nitrophe Synonyms: 4-nitro-L-phenylalanine CAS: 949-99-5 MF: C9H10N2O4 Appearance: White powder Storage:Store in cool and dry place, away from sun light. Package:25KG/Drum Application: Organic Chemicals Transportation:By sea or by air
Appearance:powder Storage:room temperature Package:25kg/drum Application:4-Nitro-L-phenylalanine is used in the studies on the rational manipulation of protein structures for the expansion of the genetic code with non natural amino acids into prote
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiry4-Nitro-3-phenyl-L-alanine CAS:949-99-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Cas:949-99-5
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Name:4-Nitro-3-phenyl-L-alanineSynonyms:P-NITRO-PHENYLALANINE;P-NITRO-L-PHENYLALANINE;P-NITRO-2-PHENYLALANINE;(P-NO2)PHE-OH;(S)-4-NITROPHENYLALANINE;(S)-4-NITROPHENYLALANINE HYDRATE;(S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID;RARECH
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inquiryProduct name: 4-Nitro-L-Phenylalanine Hydrate CAS No.: 949-99-5 Molecule Formula:C9H10N2O4 Molecule Weight:210.19 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryConditions | Yield |
---|---|
Stage #1: L-phenylalanine With sulfuric acid; nitric acid at 20℃; for 5h; Stage #2: With sodium hydroxide pH=2 - 3; | 95.2% |
Stage #1: L-phenylalanine With sulfuric acid; nitric acid In water at 20℃; Stage #2: With sodium hydroxide In water pH=2 - 3; | 95.2% |
Stage #1: L-phenylalanine With sulfuric acid; nitric acid at 10℃; for 2.5h; Stage #2: With ammonia In water pH=5 - 6; | 94% |
N-acetyl-4-nitro-L-phenylalanine
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With Acylase I enzyme from porcine kidney; water at 24.9℃; Rate constant; | 83% |
With hydrogenchloride |
Conditions | Yield |
---|---|
With ammonium hydroxide; borane-ammonia complex In aq. buffer at 37℃; pH=9.6; Enzymatic reaction; | 57% |
With ammonium bisulphate; EncP-R299K variant at 55℃; for 22h; pH=8.3; Enzymatic reaction; stereoselective reaction; | n/a |
4-nitrophenylalanine
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With sodium hydroxide; oxygen at 30℃; for 42h; pH=7.3; aq. buffer; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; | 51% |
p-nitrocinnamic acid
A
(R)-3-amino-3-(4'-nitrophenyl)propanoic acid
B
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With ammonia at 25℃; pH=9; Kinetics; aq. buffer; Enzymatic reaction; regioselective reaction; | A 8% B n/a |
N-benzoyl-(4'-nitro)phenylalanine
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With acylase-substance from pseudomonas |
(L)-p-Nitrophenylalanine methyl ester
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With water; chymotrypsin at 25℃; Rate constant; |
N-acetyl-4-nitro-DL-phenylalanine
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With phosphate buffer; acylase I from porcine kidney at 24.9℃; for 2h; |
glycine
1-bromomethyl-4-nitro-benzene
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Stage #1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate In methanol for 0.333333h; Heating; Stage #2: 1-bromomethyl-4-nitro-benzene With sodium hydroxide; (R)-2-amino-2'-hydroxy-1,1'-binaphthyl In dichloromethane at 20℃; for 0.0666667h; Stage #3: With hydrogenchloride In methanol; water Heating; |
3-(4-nitrophenyl)-2-oxopropanoic acid
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With Celite; phenylalanine dehydrogenase N145A; potassium chloride; ammonium chloride; 1,4-dihydronicotinamide adenine dinucleotide In ethanol at 20℃; for 18h; pH=8.5; |
Boc-Phe(p-NO2)-OH
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol at 0 - 20℃; for 5h; | |
With trifluoroacetic acid In dichloromethane |
Conditions | Yield |
---|---|
With carbon dioxide; Taxus chinensis phenylalanine aminomutase; ammonia In water pH=10; Kinetics; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; | |
With ammonium carbamate at 30℃; for 168h; pH=9.1; Time; | n/a |
4-nitrophenylalanine
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 0℃; Purification / work up; Resolution of racemate; | |
With dichloro bis(acetonitrile) palladium(II); (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) In aq. phosphate buffer; dichloromethane at 25℃; pH=7; Equilibrium constant; Reagent/catalyst; Solvent; Temperature; Resolution of racemate; enantioselective reaction; | |
With (S)-2-hydroxy-2'-(3-(N-phenylcarbamoylamino)benzyl)-1,1'-binaphthyl-3-carboxaldehyde In dimethyl sulfoxide Resolution of racemate; stereoselective reaction; | A n/a B n/a |
Conditions | Yield |
---|---|
With CmII Enzymatic reaction; | |
With Streptomyces venezuelae CmlI; oxygen In aq. buffer at 4℃; pH=9; Kinetics; Enzymatic reaction; |
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction; |
N-acetyl-4-nitro-DL-phenylalanine
A
4-nitro-3-phenyl-L-alanine
B
N-acetyl-4-nitro-D-phenylalanine
Conditions | Yield |
---|---|
With lipase AS 'Amano' at 35℃; for 24h; pH=6.5; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
4-nitrophenylalanine
A
4-nitro-3-phenyl-L-alanine
B
N-acetyl-4-nitro-D-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / water; N,N-dimethyl-formamide / 20 °C 2: lipase AS 'Amano' / 24 h / 35 °C / pH 6.5 / Enzymatic reaction View Scheme |
4-nitro-trans-cinnamic acid
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
With ammonium hydroxide at 30℃; for 0.33h; pH=9.5; Reagent/catalyst; Enzymatic reaction; | A n/a B n/a |
With ammonium hydroxide at 30℃; for 22h; pH=9.5; Enzymatic reaction; | A n/a B n/a |
With ammonia at 30℃; for 17h; pH=10; Time; | A n/a B n/a |
(R)-2-amino-3[(R)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 2: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
4-nitro-benzoyl chloride
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: lithium aluminium deuteride / diethylene glycol dimethyl ether; tert-butyl alcohol / 0.5 h / -78 °C 2: sodium acetate / acetic anhydride / 100 °C 3: methanol / 0.5 h / 20 °C 4: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 5: hydrogenchloride / water; acetone / 7 h / Reflux 6: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 7: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme | |
Multi-step reaction with 8 steps 1: lithium aluminium deuteride / diethylene glycol dimethyl ether; tert-butyl alcohol / 0.5 h / -78 °C 2: sodium acetate / acetic anhydride / 100 °C 3: methanol / 0.5 h / 20 °C 4: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 5: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C 6: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 7: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 8: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
α-deuterio-4-nitro-benzaldehyde
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium acetate / acetic anhydride / 100 °C 2: methanol / 0.5 h / 20 °C 3: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 4: hydrogenchloride / water; acetone / 7 h / Reflux 5: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 6: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme | |
Multi-step reaction with 7 steps 1: sodium acetate / acetic anhydride / 100 °C 2: methanol / 0.5 h / 20 °C 3: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 4: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C 5: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 6: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 7: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
[4-2H]-4(4-nitrobenzylidene)-2-methyloxazol-5(4H)-one
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: methanol / 0.5 h / 20 °C 2: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 3: hydrogenchloride / water; acetone / 7 h / Reflux 4: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 5: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme | |
Multi-step reaction with 6 steps 1: methanol / 0.5 h / 20 °C 2: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 3: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C 4: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 5: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 6: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
[4-2H]-methyl 2-acetamido-3(4-nitrophenyl)acrylate
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 2: hydrogenchloride / water; acetone / 7 h / Reflux 3: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 4: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme | |
Multi-step reaction with 5 steps 1: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr 2: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C 3: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 4: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 5: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
(R)-methyl 2-acetamido-3[2H]-3(4-nitrophenyl)propanoate
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water; acetone / 7 h / Reflux 2: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 3: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
(S)-methyl 2-acetamido-3-[2H]-3(4-nitrophenyl)propanoate
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C 2: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 3: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 4: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
(R)-2-amino-3[(S)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 2: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
(S)-2-acetamido-3-[2H]-3(4-nitrophenyl)propanoic acid
A
4-nitro-3-phenyl-L-alanine
B
(R)-4-nitro-phenylalanine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction 2: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction 3: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction View Scheme |
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoate
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hydroxide / tetrahydrofuran; water / 20 °C 2: trifluoroacetic acid / dichloromethane View Scheme |
Conditions | Yield |
---|---|
With borane-ammonia complex Enzymatic reaction; |
methanol
4-nitro-3-phenyl-L-alanine
(S)-4-nitrophenylalanine methyl ester hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; | 100% |
With thionyl chloride at 5 - 45℃; | 100% |
With thionyl chloride Ambient temperature; | 99% |
N-(Benzyloxycarbonyloxy)succinimide
4-nitro-3-phenyl-L-alanine
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetonitrile at 20℃; | 100% |
4-nitro-3-phenyl-L-alanine
benzyl chloroformate
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h; | 99.5% |
With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h; | 99.5% |
Stage #1: 4-nitro-3-phenyl-L-alanine; benzyl chloroformate With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h; Stage #2: With hydrogenchloride In water pH=2; | 99.5% |
methanol
4-nitro-3-phenyl-L-alanine
(L)-p-Nitrophenylalanine methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 0℃; for 2h; Inert atmosphere; Reflux; | 98.1% |
With thionyl chloride at 0℃; for 1h; Reflux; | 91% |
With thionyl chloride at 0℃; for 1h; Reflux; | 91% |
Conditions | Yield |
---|---|
In benzene at 120℃; for 12h; | 98% |
In benzene for 10h; Heating; Yield given; |
4-nitro-3-phenyl-L-alanine
2,6-Dichlorobenzoyl chloride
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 10 - 15℃; for 2h; pH=~ 14; | 97% |
Stage #1: 4-nitro-3-phenyl-L-alanine; 2,6-Dichlorobenzoyl chloride With sodium hydroxide In water; acetone at 15℃; pH=>= 13; Cooling in ice; Stage #2: With hydrogenchloride In water; acetone | 95% |
4-nitro-3-phenyl-L-alanine
(S)-3-(4-nitrophenyl)-2-hydroxypropionic acid
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite In water; acetone at -5 - 20℃; for 18h; | 96% |
With sulfuric acid; sodium nitrite In water; acetone at -5 - 20℃; for 18h; | 96% |
With sulfuric acid; water; sodium nitrite at 0 - 20℃; | 77% |
With sulfuric acid; sodium nitrite at 0 - 20℃; | 55% |
With sulfuric acid; sodium nitrite |
di-tert-butyl dicarbonate
4-nitro-3-phenyl-L-alanine
Boc-Phe(p-NO2)-OH
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane; water for 3h; Ambient temperature; | 96% |
In 1,4-dioxane; water at 0 - 20℃; for 24h; Substitution; | 92% |
In tetrahydrofuran; sodium hydroxide | 88% |
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With sodium methylate In methanol at 20℃; for 24h; Inert atmosphere; Schlenk technique; Darkness; | 94.7% |
4-nitro-3-phenyl-L-alanine
(S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: ethanol With thionyl chloride at 0 - 20℃; for 0.75h; Stage #2: 4-nitro-3-phenyl-L-alanine Heating / reflux; | 92% |
4-nitro-3-phenyl-L-alanine
(2S)-2-amino-3-(2,4-dinitrophenyl)propanoic acid
Conditions | Yield |
---|---|
With sulfuric acid; uronium nitrate at 0 - 60℃; for 5h; Temperature; Reagent/catalyst; Time; regioselective reaction; | 87.8% |
Conditions | Yield |
---|---|
With barium sulfate; hydrogen; palladium | 87% |
With rosenmund catalyst; hydrogen In water at 20℃; for 3h; | 85% |
With methanol; aluminum oxide; palladium/alumina Hydrogenation; | |
With hydrogen; palladium on barium sulfate In water | |
With hydrogen; Pd-BaSO4 In water |
4-nitro-3-phenyl-L-alanine
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
N-α-FMOC-4-nitro-L-phenylalanine
Conditions | Yield |
---|---|
Acylation; | 87% |
With sodium hydroxide In water; acetonitrile at 20℃; for 3h; | 67% |
4-nitro-3-phenyl-L-alanine
N-(benzyloxycarbonyl)succinimide
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water | 87% |
(fluorenylmethoxy)carbonyl chloride
4-nitro-3-phenyl-L-alanine
N-α-FMOC-4-nitro-L-phenylalanine
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane 0 deg C, then Rt 2 h.; | 86% |
With sodium carbonate In 1,4-dioxane at 0℃; for 3h; | 64% |
4-nitro-3-phenyl-L-alanine
(S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol
Conditions | Yield |
---|---|
With sodium tetrahydroborate; iodine In tetrahydrofuran at 70℃; for 18h; | 86% |
With lithium borohydride; chloro-trimethyl-silane In tetrahydrofuran at 0 - 20℃; | 68% |
With sodium tetrahydroborate; iodine In tetrahydrofuran at 60℃; for 20h; | 67% |
bromoacetic acid tert-butyl ester
4-nitro-3-phenyl-L-alanine
2-(bis-2-tert-butoxycarbonylmethylamino)-3-(4-nitrophenyl)propanoic acid
Conditions | Yield |
---|---|
Stage #1: 4-nitro-3-phenyl-L-alanine With potassium carbonate In acetonitrile for 0.5h; Inert atmosphere; Stage #2: bromoacetic acid tert-butyl ester In acetonitrile for 18h; Inert atmosphere; Reflux; | 85% |
N-tertiarybutoxycarbonyl-D-alanine N-hydroxysuccinimide ester
4-nitro-3-phenyl-L-alanine
Conditions | Yield |
---|---|
With 4-methyl-morpholine In N,N-dimethyl-formamide for 4h; Ambient temperature; | 80% |
ethanol
4-nitro-3-phenyl-L-alanine
ethyl (S)-2-amino-3-(4-nitrophenyl)propionate
Conditions | Yield |
---|---|
With hydrogenchloride for 3h; Heating; | 80% |
4-nitro-3-phenyl-L-alanine
p-[N-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl azide
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 20h; | 80% |
Conditions | Yield |
---|---|
In water at 80℃; for 24h; | 76% |
4-nitro-3-phenyl-L-alanine
2-Formyl-21,23-dihydro-5,10,15,20-tetraphenylporphyrin
Conditions | Yield |
---|---|
Stage #1: 4-nitro-3-phenyl-L-alanine; 2-Formyl-21,23-dihydro-5,10,15,20-tetraphenylporphyrin With sodium cyanoborohydride In tetrahydrofuran; methanol for 24h; Reflux; Stage #2: Heating; | 75% |
4-nitro-3-phenyl-L-alanine
acetic anhydride
N-acetyl-4-nitro-L-phenylalanine
Conditions | Yield |
---|---|
With sodium hydroxide In acetone for 1h; | 74% |
In water |
Conditions | Yield |
---|---|
Stage #1: ethylene glycol With hydrogenchloride at 20℃; Stage #2: 4-nitro-3-phenyl-L-alanine at 80 - 85℃; for 2h; | 73.9% |
4-nitro-3-phenyl-L-alanine
2-bromo-4-nitro-L-phenylalanine
Conditions | Yield |
---|---|
With tribromo-isocyanuric acid; sulfuric acid optical yield given as %ee; | 73% |
4-nitro-3-phenyl-L-alanine
benzoyl chloride
(S)-4-nitro-N-benzoyl-phenylalanine
Conditions | Yield |
---|---|
With sodium hydroxide In water at 0 - 23℃; | 68% |
With sodium hydroxide | |
Stage #1: 4-nitro-3-phenyl-L-alanine; benzoyl chloride With sodium hydroxide at 20℃; for 2h; Cooling with ice; Stage #2: With hydrogenchloride In water pH=5 - 6; |
4-nitro-3-phenyl-L-alanine
{[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile
Boc-Phe(p-NO2)-OH
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water Ambient temperature; | 67.2% |
Conditions | Yield |
---|---|
In water at 80℃; for 24h; | 67% |
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