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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to off white powder White powder Identification (HPLC)

High quality 949-99-5 4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality L-4-Nitro-Phenylalanine supplier in China

Cas:949-99-5

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply L-4-Nitro-Phenylalanine

Cas:949-99-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 949-99-5 4-nitro-L-phenylalanine Manufacturer

Cas:949-99-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-(4-Nitrophenyl)-L-alanine

Cas:949-99-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 949-99-5 with best quality

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Nitro-3-phenyl-L-alanine/ LIDE PHARMA- Factory supply / Best price

Cas:949-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: L-4-Nitrophe Synonyms: 4-nitro-L-phenylalanine CAS: 949-99-5 MF: C9H10N2O4 Appearance: White powder Storage:Store in cool and dry place, away from sun light. Package:25KG/Drum Application: Organic Chemicals Transportation:By sea or by air

L-4-Nitrophe

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:powder Storage:room temperature Package:25kg/drum Application:4-Nitro-L-phenylalanine is used in the studies on the rational manipulation of protein structures for the expansion of the genetic code with non natural amino acids into prote

4-Nitro-3-phenyl-L-alanine factory price

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Nitro-3-phenyl-L-alanine 949-99-5

Cas:949-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Anesthetic Agents, 4-Nitro-3-phenyl-L-alanine CAS:949-99-5

Cas:949-99-5

Min.Order:1 Gram

FOB Price: $1.6 / 2.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Nitro-3-phenyl-L-alanine CAS:949-99-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4-Nitro-3-phenyl-L-alanine CAS:949-99-5

Cas:949-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:949-99-5

Cas:949-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

4-Nitro-3-phenyl-L-alanine cas:949-99-5

Cas:949-99-5

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $40.0 / 80.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Nitro-L-Phenylalanine

Cas:949-99-5

Min.Order:0

Negotiable

Type:Manufacturers

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

L-Phe(4-NO2)-OH cas no.949-99-5 0.98

Cas:949-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-NITRO-3-PHENYL-L-ALANINE

Cas:949-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Gram

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Nitro-L-Phenylalanine

Cas:949-99-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality L-4-Nitro-Phenylalanine

Cas:949-99-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name:4-Nitro-3-phenyl-L-alanineSynonyms:P-NITRO-PHENYLALANINE;P-NITRO-L-PHENYLALANINE;P-NITRO-2-PHENYLALANINE;(P-NO2)PHE-OH;(S)-4-NITROPHENYLALANINE;(S)-4-NITROPHENYLALANINE HYDRATE;(S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID;RARECH

TIANFUCHEM--949-99-5---4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Nitro-L-Phenylalanine Hydrate CAS No.: 949-99-5 Molecule Formula:C9H10N2O4 Molecule Weight:210.19 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

Lower Price 4-Nitro-L-Phenylalanine Hydrate

Cas:949-99-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Enke 4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Kilogram

FOB Price: $300.0 / 400.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Nitro-3-phenyl-L-alanine

Cas:949-99-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

L-phenylalanine
63-91-2

L-phenylalanine

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
Stage #1: L-phenylalanine With sulfuric acid; nitric acid at 20℃; for 5h;
Stage #2: With sodium hydroxide pH=2 - 3;
95.2%
Stage #1: L-phenylalanine With sulfuric acid; nitric acid In water at 20℃;
Stage #2: With sodium hydroxide In water pH=2 - 3;
95.2%
Stage #1: L-phenylalanine With sulfuric acid; nitric acid at 10℃; for 2.5h;
Stage #2: With ammonia In water pH=5 - 6;
94%
N-acetyl-4-nitro-L-phenylalanine
17363-92-7

N-acetyl-4-nitro-L-phenylalanine

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With Acylase I enzyme from porcine kidney; water at 24.9℃; Rate constant;83%
With hydrogenchloride
p-nitrocinnamic acid
619-89-6

p-nitrocinnamic acid

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With ammonium hydroxide; borane-ammonia complex In aq. buffer at 37℃; pH=9.6; Enzymatic reaction;57%
With ammonium bisulphate; EncP-R299K variant at 55℃; for 22h; pH=8.3; Enzymatic reaction; stereoselective reaction;n/a
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With sodium hydroxide; oxygen at 30℃; for 42h; pH=7.3; aq. buffer; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;51%
p-nitrocinnamic acid
619-89-6

p-nitrocinnamic acid

A

(R)-3-amino-3-(4'-nitrophenyl)propanoic acid
501120-99-6

(R)-3-amino-3-(4'-nitrophenyl)propanoic acid

B

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With ammonia at 25℃; pH=9; Kinetics; aq. buffer; Enzymatic reaction; regioselective reaction;A 8%
B n/a
N-benzoyl-(4'-nitro)phenylalanine
101468-97-7

N-benzoyl-(4'-nitro)phenylalanine

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With acylase-substance from pseudomonas
(L)-p-Nitrophenylalanine methyl ester
81677-60-3

(L)-p-Nitrophenylalanine methyl ester

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With water; chymotrypsin at 25℃; Rate constant;
N-acetyl-4-nitro-DL-phenylalanine
62561-97-1

N-acetyl-4-nitro-DL-phenylalanine

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With phosphate buffer; acylase I from porcine kidney at 24.9℃; for 2h;
glycine
56-40-6

glycine

1-bromomethyl-4-nitro-benzene
100-11-8

1-bromomethyl-4-nitro-benzene

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Stage #1: glycine With pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide; sodium methylate; nickel(II) nitrate In methanol for 0.333333h; Heating;
Stage #2: 1-bromomethyl-4-nitro-benzene With sodium hydroxide; (R)-2-amino-2'-hydroxy-1,1'-binaphthyl In dichloromethane at 20℃; for 0.0666667h;
Stage #3: With hydrogenchloride In methanol; water Heating;
3-(4-nitrophenyl)-2-oxopropanoic acid
38335-24-9

3-(4-nitrophenyl)-2-oxopropanoic acid

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With Celite; phenylalanine dehydrogenase N145A; potassium chloride; ammonium chloride; 1,4-dihydronicotinamide adenine dinucleotide In ethanol at 20℃; for 18h; pH=8.5;
Boc-Phe(p-NO2)-OH
33305-77-0

Boc-Phe(p-NO2)-OH

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With hydrogenchloride In methanol at 0 - 20℃; for 5h;
With trifluoroacetic acid In dichloromethane
4-nitro-trans-cinnamic acid
882-06-4

4-nitro-trans-cinnamic acid

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With carbon dioxide; Taxus chinensis phenylalanine aminomutase; ammonia In water pH=10; Kinetics; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;
With ammonium carbamate at 30℃; for 168h; pH=9.1; Time;n/a

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 0℃; Purification / work up; Resolution of racemate;
With dichloro bis(acetonitrile) palladium(II); (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) In aq. phosphate buffer; dichloromethane at 25℃; pH=7; Equilibrium constant; Reagent/catalyst; Solvent; Temperature; Resolution of racemate; enantioselective reaction;
With (S)-2-hydroxy-2'-(3-(N-phenylcarbamoylamino)benzyl)-1,1'-binaphthyl-3-carboxaldehyde In dimethyl sulfoxide Resolution of racemate; stereoselective reaction;A n/a
B n/a
4-amino-L-phenylalanine
943-80-6

4-amino-L-phenylalanine

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With CmII Enzymatic reaction;
With Streptomyces venezuelae CmlI; oxygen In aq. buffer at 4℃; pH=9; Kinetics; Enzymatic reaction;
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
17224-90-7

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction;
N-acetyl-4-nitro-DL-phenylalanine
62561-97-1

N-acetyl-4-nitro-DL-phenylalanine

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

N-acetyl-4-nitro-D-phenylalanine
89615-73-6

N-acetyl-4-nitro-D-phenylalanine

Conditions
ConditionsYield
With lipase AS 'Amano' at 35℃; for 24h; pH=6.5; Enzymatic reaction; enantioselective reaction;A n/a
B n/a

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

N-acetyl-4-nitro-D-phenylalanine
89615-73-6

N-acetyl-4-nitro-D-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / water; N,N-dimethyl-formamide / 20 °C
2: lipase AS 'Amano' / 24 h / 35 °C / pH 6.5 / Enzymatic reaction
View Scheme
4-nitro-trans-cinnamic acid
882-06-4

4-nitro-trans-cinnamic acid

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
With ammonium hydroxide at 30℃; for 0.33h; pH=9.5; Reagent/catalyst; Enzymatic reaction;A n/a
B n/a
With ammonium hydroxide at 30℃; for 22h; pH=9.5; Enzymatic reaction;A n/a
B n/a
With ammonia at 30℃; for 17h; pH=10; Time;A n/a
B n/a
(R)-2-amino-3[(R)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride
1627101-69-2

(R)-2-amino-3[(R)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
2: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: lithium aluminium deuteride / diethylene glycol dimethyl ether; tert-butyl alcohol / 0.5 h / -78 °C
2: sodium acetate / acetic anhydride / 100 °C
3: methanol / 0.5 h / 20 °C
4: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
5: hydrogenchloride / water; acetone / 7 h / Reflux
6: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
7: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 8 steps
1: lithium aluminium deuteride / diethylene glycol dimethyl ether; tert-butyl alcohol / 0.5 h / -78 °C
2: sodium acetate / acetic anhydride / 100 °C
3: methanol / 0.5 h / 20 °C
4: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
5: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C
6: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
7: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
8: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
α-deuterio-4-nitro-benzaldehyde
94781-50-7

α-deuterio-4-nitro-benzaldehyde

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium acetate / acetic anhydride / 100 °C
2: methanol / 0.5 h / 20 °C
3: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
4: hydrogenchloride / water; acetone / 7 h / Reflux
5: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
6: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 7 steps
1: sodium acetate / acetic anhydride / 100 °C
2: methanol / 0.5 h / 20 °C
3: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
4: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C
5: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
6: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
7: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
[4-2H]-4(4-nitrobenzylidene)-2-methyloxazol-5(4H)-one
1627096-62-1

[4-2H]-4(4-nitrobenzylidene)-2-methyloxazol-5(4H)-one

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: methanol / 0.5 h / 20 °C
2: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
3: hydrogenchloride / water; acetone / 7 h / Reflux
4: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
5: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 6 steps
1: methanol / 0.5 h / 20 °C
2: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
3: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C
4: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
5: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
6: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
[4-2H]-methyl 2-acetamido-3(4-nitrophenyl)acrylate
1627098-43-4

[4-2H]-methyl 2-acetamido-3(4-nitrophenyl)acrylate

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen; (-)-1,2-bis-[(2R,5R)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
2: hydrogenchloride / water; acetone / 7 h / Reflux
3: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
4: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
Multi-step reaction with 5 steps
1: hydrogen; (+)-1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 1.5 h / 5171.62 Torr
2: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C
3: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
4: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
5: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
(R)-methyl 2-acetamido-3[2H]-3(4-nitrophenyl)propanoate
1627099-40-4

(R)-methyl 2-acetamido-3[2H]-3(4-nitrophenyl)propanoate

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; acetone / 7 h / Reflux
2: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
3: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
(S)-methyl 2-acetamido-3-[2H]-3(4-nitrophenyl)propanoate
1627099-66-4

(S)-methyl 2-acetamido-3-[2H]-3(4-nitrophenyl)propanoate

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium hydroxide / methanol; water; tetrahydrofuran / 2 h / 20 °C
2: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
3: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
4: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
(R)-2-amino-3[(S)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride
1627100-30-4

(R)-2-amino-3[(S)-2H]-3(4-nitrophenyl)propanoic acid hydrochloride

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
2: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
(S)-2-acetamido-3-[2H]-3(4-nitrophenyl)propanoic acid
1627100-31-5

(S)-2-acetamido-3-[2H]-3(4-nitrophenyl)propanoic acid

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cobalt(II) chloride hexahydrate; N-acetyl amino acid racemase G291D/F323Y; D-acylase / aq. buffer / 23 h / 37 °C / pH 8.0 / Enzymatic reaction
2: E. coli BL21(DE3) whole cells expressing Anabaena variabilis phenylalanine ammonia lyase / aq. buffer / 48 h / 30 °C / pH 8.3 / Enzymatic reaction
3: ammonium hydroxide / 22 h / 30 °C / pH 9.5 / Enzymatic reaction
View Scheme
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoate
65615-89-6

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoate

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide / tetrahydrofuran; water / 20 °C
2: trifluoroacetic acid / dichloromethane
View Scheme
C9H8N2O4

C9H8N2O4

A

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

B

(R)-4-nitro-phenylalanine
56613-61-7

(R)-4-nitro-phenylalanine

Conditions
ConditionsYield
With borane-ammonia complex Enzymatic reaction;
methanol
67-56-1

methanol

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(S)-4-nitrophenylalanine methyl ester hydrochloride
17193-40-7

(S)-4-nitrophenylalanine methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 20℃;100%
With thionyl chloride at 5 - 45℃;100%
With thionyl chloride Ambient temperature;99%
N-(Benzyloxycarbonyloxy)succinimide
13139-17-8

N-(Benzyloxycarbonyloxy)succinimide

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
17224-90-7

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetonitrile at 20℃;100%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

benzyl chloroformate
501-53-1

benzyl chloroformate

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
17224-90-7

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid

Conditions
ConditionsYield
With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h;99.5%
With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h;99.5%
Stage #1: 4-nitro-3-phenyl-L-alanine; benzyl chloroformate With sodium hydroxide; sodium carbonate In water at 6 - 9℃; for 1h;
Stage #2: With hydrogenchloride In water pH=2;
99.5%
methanol
67-56-1

methanol

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(L)-p-Nitrophenylalanine methyl ester
81677-60-3

(L)-p-Nitrophenylalanine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 2h; Inert atmosphere; Reflux;98.1%
With thionyl chloride at 0℃; for 1h; Reflux;91%
With thionyl chloride at 0℃; for 1h; Reflux;91%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

benzyl alcohol
100-51-6

benzyl alcohol

p-nitro-L-phenylalanine benzyl ester toluene-p-sulfonate

p-nitro-L-phenylalanine benzyl ester toluene-p-sulfonate

Conditions
ConditionsYield
In benzene at 120℃; for 12h;98%
In benzene for 10h; Heating; Yield given;
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

2,6-Dichlorobenzoyl chloride
4659-45-4

2,6-Dichlorobenzoyl chloride

Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine
401906-14-7

Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 10 - 15℃; for 2h; pH=~ 14;97%
Stage #1: 4-nitro-3-phenyl-L-alanine; 2,6-Dichlorobenzoyl chloride With sodium hydroxide In water; acetone at 15℃; pH=>= 13; Cooling in ice;
Stage #2: With hydrogenchloride In water; acetone
95%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(S)-3-(4-nitrophenyl)-2-hydroxypropionic acid
33173-27-2

(S)-3-(4-nitrophenyl)-2-hydroxypropionic acid

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite In water; acetone at -5 - 20℃; for 18h;96%
With sulfuric acid; sodium nitrite In water; acetone at -5 - 20℃; for 18h;96%
With sulfuric acid; water; sodium nitrite at 0 - 20℃;77%
With sulfuric acid; sodium nitrite at 0 - 20℃;55%
With sulfuric acid; sodium nitrite
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Boc-Phe(p-NO2)-OH
33305-77-0

Boc-Phe(p-NO2)-OH

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water for 3h; Ambient temperature;96%
In 1,4-dioxane; water at 0 - 20℃; for 24h; Substitution;92%
In tetrahydrofuran; sodium hydroxide88%
dichlorotricarbonylruthenium(II) dimer

dichlorotricarbonylruthenium(II) dimer

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

tricarbonylchloro(4-nitrophenylalaninato)ruthenium(II)

tricarbonylchloro(4-nitrophenylalaninato)ruthenium(II)

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 24h; Inert atmosphere; Schlenk technique; Darkness;94.7%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride
58816-66-3

(S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: ethanol With thionyl chloride at 0 - 20℃; for 0.75h;
Stage #2: 4-nitro-3-phenyl-L-alanine Heating / reflux;
92%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(2S)-2-amino-3-(2,4-dinitrophenyl)propanoic acid
49607-21-8

(2S)-2-amino-3-(2,4-dinitrophenyl)propanoic acid

Conditions
ConditionsYield
With sulfuric acid; uronium nitrate at 0 - 60℃; for 5h; Temperature; Reagent/catalyst; Time; regioselective reaction;87.8%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

4-amino-L-phenylalanine
943-80-6

4-amino-L-phenylalanine

Conditions
ConditionsYield
With barium sulfate; hydrogen; palladium87%
With rosenmund catalyst; hydrogen In water at 20℃; for 3h;85%
With methanol; aluminum oxide; palladium/alumina Hydrogenation;
With hydrogen; palladium on barium sulfate In water
With hydrogen; Pd-BaSO4 In water
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

N-α-FMOC-4-nitro-L-phenylalanine
95753-55-2

N-α-FMOC-4-nitro-L-phenylalanine

Conditions
ConditionsYield
Acylation;87%
With sodium hydroxide In water; acetonitrile at 20℃; for 3h;67%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

N-(benzyloxycarbonyl)succinimide
75315-63-8

N-(benzyloxycarbonyl)succinimide

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid
17224-90-7

(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-nitrophenyl)propanoic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water87%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

N-α-FMOC-4-nitro-L-phenylalanine
95753-55-2

N-α-FMOC-4-nitro-L-phenylalanine

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane 0 deg C, then Rt 2 h.;86%
With sodium carbonate In 1,4-dioxane at 0℃; for 3h;64%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

(S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol
89288-22-2

(S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine In tetrahydrofuran at 70℃; for 18h;86%
With lithium borohydride; chloro-trimethyl-silane In tetrahydrofuran at 0 - 20℃;68%
With sodium tetrahydroborate; iodine In tetrahydrofuran at 60℃; for 20h;67%
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

2-(bis-2-tert-butoxycarbonylmethylamino)-3-(4-nitrophenyl)propanoic acid
1619224-40-6

2-(bis-2-tert-butoxycarbonylmethylamino)-3-(4-nitrophenyl)propanoic acid

Conditions
ConditionsYield
Stage #1: 4-nitro-3-phenyl-L-alanine With potassium carbonate In acetonitrile for 0.5h; Inert atmosphere;
Stage #2: bromoacetic acid tert-butyl ester In acetonitrile for 18h; Inert atmosphere; Reflux;
85%
N-tertiarybutoxycarbonyl-D-alanine N-hydroxysuccinimide ester
34404-33-6

N-tertiarybutoxycarbonyl-D-alanine N-hydroxysuccinimide ester

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

Boc-D-Ala-p-NO2Phe-OH

Boc-D-Ala-p-NO2Phe-OH

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide for 4h; Ambient temperature;80%
ethanol
64-17-5

ethanol

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

ethyl (S)-2-amino-3-(4-nitrophenyl)propionate
34276-53-4

ethyl (S)-2-amino-3-(4-nitrophenyl)propionate

Conditions
ConditionsYield
With hydrogenchloride for 3h; Heating;80%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

p-[N-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl azide
126513-13-1

p-[N-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl azide

N-<4--N-prop-2-ynylamino>benzoyl>-L-3-(4-nitrophenyl)alanine

N-<4--N-prop-2-ynylamino>benzoyl>-L-3-(4-nitrophenyl)alanine

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 20h;80%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

3-methyl-5-hydroxy-4-(4-nitrophenyl)-2(5H)-furanone

3-methyl-5-hydroxy-4-(4-nitrophenyl)-2(5H)-furanone

Conditions
ConditionsYield
In water at 80℃; for 24h;76%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

2-Formyl-21,23-dihydro-5,10,15,20-tetraphenylporphyrin
71159-98-3

2-Formyl-21,23-dihydro-5,10,15,20-tetraphenylporphyrin

3-(4-nitrophenyl)-2-[(5,10,15,20-tetraphenylporphyrin-2-ylmethyl)amino]propionic acid

3-(4-nitrophenyl)-2-[(5,10,15,20-tetraphenylporphyrin-2-ylmethyl)amino]propionic acid

Conditions
ConditionsYield
Stage #1: 4-nitro-3-phenyl-L-alanine; 2-Formyl-21,23-dihydro-5,10,15,20-tetraphenylporphyrin With sodium cyanoborohydride In tetrahydrofuran; methanol for 24h; Reflux;
Stage #2: Heating;
75%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

acetic anhydride
108-24-7

acetic anhydride

N-acetyl-4-nitro-L-phenylalanine
17363-92-7

N-acetyl-4-nitro-L-phenylalanine

Conditions
ConditionsYield
With sodium hydroxide In acetone for 1h;74%
In water
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

ethylene glycol
107-21-1

ethylene glycol

4-nitro-(S)-phenylalanine hydroxyethyl ester hydrochloride

4-nitro-(S)-phenylalanine hydroxyethyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: ethylene glycol With hydrogenchloride at 20℃;
Stage #2: 4-nitro-3-phenyl-L-alanine at 80 - 85℃; for 2h;
73.9%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

2-bromo-4-nitro-L-phenylalanine
1222073-44-0

2-bromo-4-nitro-L-phenylalanine

Conditions
ConditionsYield
With tribromo-isocyanuric acid; sulfuric acid optical yield given as %ee;73%
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

benzoyl chloride
98-88-4

benzoyl chloride

(S)-4-nitro-N-benzoyl-phenylalanine
69935-12-2

(S)-4-nitro-N-benzoyl-phenylalanine

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 23℃;68%
With sodium hydroxide
Stage #1: 4-nitro-3-phenyl-L-alanine; benzoyl chloride With sodium hydroxide at 20℃; for 2h; Cooling with ice;
Stage #2: With hydrogenchloride In water pH=5 - 6;
4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

{[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile
80994-44-1

{[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile

Boc-Phe(p-NO2)-OH
33305-77-0

Boc-Phe(p-NO2)-OH

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water Ambient temperature;67.2%
2-Oxobutyric acid
600-18-0

2-Oxobutyric acid

4-nitro-3-phenyl-L-alanine
949-99-5

4-nitro-3-phenyl-L-alanine

3-ethyl-5-hydroxy-4-(4-nitrophenyl)-2(5H)-furanone

3-ethyl-5-hydroxy-4-(4-nitrophenyl)-2(5H)-furanone

Conditions
ConditionsYield
In water at 80℃; for 24h;67%

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