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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality L-Octahydroindole-2-carboxylic acid 80875-98-5 Manufacturer

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

L-Octahydroindole-2-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (2S,3As,7As)-Octahydro-1H-Indole-2-Carboxylic Acid supplier in China

Cas:80875-98-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Manufacturer high quality L-Octahydroindole-2-carboxylic acid Cas 80875-98-5 with good price

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Perindopril Erbumine CAS:107133-36-8 (S)-(-)-Indoline-2-Carboxylic Acid CAS:79815-20-6 N-[(S)-1-Carbethoxy-1-Butyl]-(S)-Alanine CAS:82834-12-6 (2S,3aS,7aS)-2-Carboxyperhydroindole CAS:80875-98-5 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM

(2S,3aS,7aS)-2-Carboxyperhydroindole for Perindopril

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2S,3aS,7aS)-Octahydro-2-indolecarboxylic acid

Cas:80875-98-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/898.html Product Name L-Octahydroindole-2-carboxylic acid CAS No.

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 80875-98-5 with best quality

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

L-Octahydroindole-2-carboxylic acid/ LIDE PHARMA- Factory supply / Best price

Cas:80875-98-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla

L-Octahydroindole-2-carboxylic acid CAS 80875-98-5

Cas:80875-98-5

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Indole-2-carboxylicacid, octahydro-, (2S,3aS,7aS)- 80875-98-5

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, L-Octahydroindole-2-carboxylic acid CAS:80875-98-5

Cas:80875-98-5

Min.Order:1 Kilogram

FOB Price: $32.0 / 35.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

L-Octahydroindole-2-carboxylic acid CAS:80875-98-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

L-Octahydroindole-2-carboxylic acid CAS:80875-98-5

Cas:80875-98-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2s,3as,7as)-Octahydro-1H-indole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indole-2-carboxylicacid, octahydro-, (2S,3aS,7aS)-

Cas:80875-98-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

(2s,3as,7as)-Octahydro-1H-indole-2-carboxylic acid

Cas:80875-98-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

L-OCTAHYDROINDOLE-2-CARBOXYLIC ACID

Cas:80875-98-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid

Cas:80875-98-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (2S,3As,7As)-Octahydro-1H-Indole-2-Carboxylic Acid

Cas:80875-98-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery Appearance:White solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:An intermediate in the synthesis of Pe

L-Octahydroindole-2-carboxylic acid-

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

L-Octahydroindole-2-carboxylic acid Basic information Product Name: L-Octahydroindole-2-carboxylic acid Synonyms

80875-98-5 C9H15NO2 L-Octahydroindole-2-carboxylic acid

Cas:80875-98-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (2S,3aS,7aS)-Octahydro-1H-Indole-2-Carboxylic Acid CAS No.: 80875-98-5 Molecule Formula:C9H15NO2 Molecule Weight:169.22 Purity: 98.0% Package: 25kg/drum Description:Off-white to white crystalline powder Manufacture Stand

Lower Price (2S,3aS,7aS)-Octahydro-1H-Indole-2-Carboxylic Acid

Cas:80875-98-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2S,3aS,7aS)-1-Benzoyl-octahydro-indole-2-carboxylic acid
80875-99-6

(2S,3aS,7aS)-1-Benzoyl-octahydro-indole-2-carboxylic acid

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 4h; Heating;87.8%
Benzyl (2S)-2,3,4,5,6,7-hexahydro-1H-indole-2-carboxylate
539820-41-2

Benzyl (2S)-2,3,4,5,6,7-hexahydro-1H-indole-2-carboxylate

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
With hydrogen; acetic acid; platinum on carbon at 20℃; under 3750.38 Torr;87%
(S)-indoline-2-carboxylic acid
79815-20-6

(S)-indoline-2-carboxylic acid

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
rhodium In 1,4-dioxane; methanol; water86.1%
With 8 % Pd/C; hydrogen In methanol at 55 - 65℃; under 37503.8 Torr; Autoclave;73.5%
With hydrogen; palladium on activated charcoal In acetic acid at 50℃; under 36775.4 Torr; for 18h;66%
(S)-indoline-2-carboxylic acid
79815-20-6

(S)-indoline-2-carboxylic acid

A

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

B

(2S,3aR,7aR)-octahydroindole-2-carboxylic acid
145513-90-2

(2S,3aR,7aR)-octahydroindole-2-carboxylic acid

Conditions
ConditionsYield
With hydrogen; acetic acid; platinum(IV) oxide at 60℃; for 24h; atmospheric pressure;A 85%
B n/a
With platinum(IV) oxide; hydrogen at 60℃; optical yield given as %de;A 85%
B n/a
ethyl (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylate hydrochloride
82864-25-3

ethyl (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylate hydrochloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 25℃;
(2S,3aS,7aS)-1-Acetyl-octahydro-indole-2-carboxylic acid tert-butyl ester
116795-46-1

(2S,3aS,7aS)-1-Acetyl-octahydro-indole-2-carboxylic acid tert-butyl ester

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride
rac-3-bromocyclohexene
1521-51-3

rac-3-bromocyclohexene

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 89 percent / K2CO3 / acetonitrile / 48 h / Ambient temperature
2: 97 percent / K2CO3 / acetone / 48 h / Ambient temperature
3: 90 percent / 2N NaOH / dimethylformamide / 48 h / Ambient temperature
5: tetrahydrofuran / 0.5 h / Ambient temperature; Irradiation
6: Raney nickel
7: 6N HCl
View Scheme
Ethyl (S)-indoline-2-carboxylate hydrochloride
79854-42-5

Ethyl (S)-indoline-2-carboxylate hydrochloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / Pd/C / ethanol
2: NaOH / H2O; ethanol / 25 °C
View Scheme
benzyl (S)-(S)-(S)-perhydroindole-2-carboxylate
83508-14-9

benzyl (S)-(S)-(S)-perhydroindole-2-carboxylate

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: benzyl (S)-(S)-(S)-perhydroindole-2-carboxylate With methanol; sodium hydroxide; water for 2h; Heating / reflux;
Stage #2: With hydrogenchloride; water In methanol pH=6 - 7;
ethyl (2α, 3aβ, 7aβ)-octahydro-1H-indole-2-carboxylate
89083-53-4

ethyl (2α, 3aβ, 7aβ)-octahydro-1H-indole-2-carboxylate

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: ethyl (2α, 3aβ, 7aβ)-octahydro-1H-indole-2-carboxylate With sodium hydroxide; water at 30 - 35℃; for 5h;
Stage #2: With hydrogenchloride In water pH=4.5 - 4.8;
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium acetate; acetic anhydride / 0.5 h / 20 °C / Inert atmosphere
1.2: 90 - 100 °C
2.1: sodium / 40 - 50 °C / Inert atmosphere
3.1: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
4.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
5.1: sulfuric acid; water / Reflux
6.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
View Scheme
(4Z)-4-[(2-chlorophenyl)methylene]-2-methyl-1,3-oxazol-5-one

(4Z)-4-[(2-chlorophenyl)methylene]-2-methyl-1,3-oxazol-5-one

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium / 40 - 50 °C / Inert atmosphere
2: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
3: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
4: sulfuric acid; water / Reflux
5: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
View Scheme
(Z)-2-acetylamino-3-(2-chlorophenyl)acrylic acid methyl ester

(Z)-2-acetylamino-3-(2-chlorophenyl)acrylic acid methyl ester

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
2: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
3: sulfuric acid; water / Reflux
4: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
View Scheme
methyl (S)-2-acetamido-3-(2-chlorophenyl)propionate

methyl (S)-2-acetamido-3-(2-chlorophenyl)propionate

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
2: sulfuric acid; water / Reflux
3: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
View Scheme
(S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester
110592-39-7

(S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; water / Reflux
2: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S,3aS,7aS)-1-(tert-butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid
109523-13-9

(2S,3aS,7aS)-1-(tert-butoxycarbonyl)octahydro-1H-indole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With sodium hydroxide In tetrahydrofuran; water for 0.166667h;
Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 20℃; for 12h;
100%
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With sodium hydroxide In 1,4-dioxane; water at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃; Inert atmosphere;
99%
With triethylamine In tetrahydrofuran; water at 20℃;98%
(1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride
37107-48-5

(1R,2R)-trans-2-phenylcyclopropane-1-carboxyl chloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S,3aS,7aS)-1-((1R,2R)-2-Phenyl-cyclopropanecarbonyl)-octahydro-indole-2-carboxylic acid
176797-40-3

(2S,3aS,7aS)-1-((1R,2R)-2-Phenyl-cyclopropanecarbonyl)-octahydro-indole-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran Ambient temperature;100%
(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

1‐fluorenylmethoxycarbonyl-(2S,3aS,7aS)‐octahydroindole‐2‐carboxylic acid

1‐fluorenylmethoxycarbonyl-(2S,3aS,7aS)‐octahydroindole‐2‐carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water; acetone at 20℃; Cooling with ice;99%
With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Cooling with ice; Inert atmosphere;73%
methanol
67-56-1

methanol

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S,3aS,7aS)-methyl octahydro-1H-indole-2-carboxylate
192436-84-3

(2S,3aS,7aS)-methyl octahydro-1H-indole-2-carboxylate

Conditions
ConditionsYield
With thionyl chloride at 20℃; Inert atmosphere;98%
With thionyl chloride at 20℃; Cooling with ice;93%
With thionyl chloride at 20℃;
With thionyl chloride
methanol
67-56-1

methanol

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S,3aS,7aS)-1-ethyl 2-methyl hexahydro-1H-indole-1,2(2H,3H)-dicarboxylate
1213770-22-9

(2S,3aS,7aS)-1-ethyl 2-methyl hexahydro-1H-indole-1,2(2H,3H)-dicarboxylate

Conditions
ConditionsYield
With potassium carbonate at 20℃; for 48h; Inert atmosphere;98%
With potassium carbonate at 20℃; for 48h; Inert atmosphere;98%
With potassium carbonate at 20℃; for 48h; Inert atmosphere;96%
acetic anhydride
108-24-7

acetic anhydride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

1-acetyl-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid

1-acetyl-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid

Conditions
ConditionsYield
In dichloromethane for 0.5h;98%
In dichloromethane for 2.25h;
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(4aS,6aS,7aS,11aS,13aS,14aS)-hexadecahydropyrazino[1,2-a:4,5-a']diindol-6,13-dione

(4aS,6aS,7aS,11aS,13aS,14aS)-hexadecahydropyrazino[1,2-a:4,5-a']diindol-6,13-dione

Conditions
ConditionsYield
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction;97%
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

benzyl chloroformate
501-53-1

benzyl chloroformate

(2S,3aS,7aS)-1-(benzyloxycarbonyl)octahydro-1H-indole-2-carboxylic acid
107045-53-4

(2S,3aS,7aS)-1-(benzyloxycarbonyl)octahydro-1H-indole-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With potassium carbonate In tetrahydrofuran; water at 20℃; for 0.0833333h;
Stage #2: benzyl chloroformate In tetrahydrofuran; water at 0 - 20℃; for 2h;
Stage #3: pH=3; Acidic conditions;
96%
With sodium hydrogencarbonate In water; toluene at 0 - 20℃;95%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 4h;95%
formaldehyd
50-00-0

formaldehyd

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

C10H17NO2

C10H17NO2

Conditions
ConditionsYield
Stage #1: formaldehyd; (2S,3aS,7aS)-perhydroindole-2-carboxylic acid In water for 0.166667h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran at 20℃; for 3h;
96%
(E)-1-methyl-3-(2-nitrovinyl)-1H-indole
2731-00-2, 122631-39-4

(E)-1-methyl-3-(2-nitrovinyl)-1H-indole

6-bromoisatin
6326-79-0

6-bromoisatin

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

6-bromo-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

6-bromo-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;96%
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(2S,3aS,7aS)-(octahydro-indol-2-yl)-methanol

(2S,3aS,7aS)-(octahydro-indol-2-yl)-methanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether95%
Multi-step reaction with 2 steps
1: thionyl chloride / 20 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere
View Scheme
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether Inert atmosphere;
(E)-1-methyl-3-(2-nitrovinyl)-1H-indole
2731-00-2, 122631-39-4

(E)-1-methyl-3-(2-nitrovinyl)-1H-indole

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-fluoro-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-fluoro-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;95%
3-[(E)-2-nitroeth-1-enyl]-1H-indole
3156-51-2, 51870-94-1

3-[(E)-2-nitroeth-1-enyl]-1H-indole

indole-2,3-dione
91-56-5

indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;94%
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

benzyl alcohol
100-51-6

benzyl alcohol

(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate
94062-52-9

(2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid phenylmethyl ester 4-methylbenzenesulfonate

Conditions
ConditionsYield
In toluene for 4h; Heating;93%
In toluene Heating / reflux;91%
7-chloroisatin
7477-63-6

7-chloroisatin

3-[(E)-2-nitroeth-1-enyl]-1H-indole
3156-51-2, 51870-94-1

3-[(E)-2-nitroeth-1-enyl]-1H-indole

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

7-chloro-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

7-chloro-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;93%
3-[(E)-2-nitroeth-1-enyl]-1H-indole
3156-51-2, 51870-94-1

3-[(E)-2-nitroeth-1-enyl]-1H-indole

5-Bromo-1H-indole-2,3-dione
87-48-9

5-Bromo-1H-indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-bromo-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-bromo-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;93%
3-(β-nitro-β-methylvinyl)indole
64252-02-4

3-(β-nitro-β-methylvinyl)indole

5-Bromo-1H-indole-2,3-dione
87-48-9

5-Bromo-1H-indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-bromo-2'-(1-methyl-1H-indol-3-yl)-1'-methyl-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-bromo-2'-(1-methyl-1H-indol-3-yl)-1'-methyl-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;93%
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine
82717-96-2

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

ramipril

ramipril

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide); acetonitrile at 20℃; for 0.5h;92%
5-methyl-indole-2,3-dione
608-05-9

5-methyl-indole-2,3-dione

(E)-1-methyl-3-(2-nitrovinyl)-1H-indole
2731-00-2, 122631-39-4

(E)-1-methyl-3-(2-nitrovinyl)-1H-indole

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(E)-1-methyl-3-(2-nitroprop-1-en-1-yl)-1H-indole
110999-33-2

(E)-1-methyl-3-(2-nitroprop-1-en-1-yl)-1H-indole

5-fluoro-1'-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-fluoro-1'-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
5-chloroindole 2,3-dione
17630-76-1

5-chloroindole 2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(E)-1-methyl-3-(2-nitroprop-1-en-1-yl)-1H-indole
110999-33-2

(E)-1-methyl-3-(2-nitroprop-1-en-1-yl)-1H-indole

5-chloro-1'-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-chloro-1'-methyl-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
(E)-1-methyl-3-(2-nitrovinyl)-2-phenyl-1H-indole
122631-44-1

(E)-1-methyl-3-(2-nitrovinyl)-2-phenyl-1H-indole

5-Bromo-1H-indole-2,3-dione
87-48-9

5-Bromo-1H-indole-2,3-dione

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-bromo-2'-(1-methyl-2-phenyl-1H-indol-3-yl)-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-bromo-2'-(1-methyl-2-phenyl-1H-indol-3-yl)-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
5-methoxyisatine
39755-95-8

5-methoxyisatine

3-[(E)-2-nitroeth-1-enyl]-1H-indole
3156-51-2, 51870-94-1

3-[(E)-2-nitroeth-1-enyl]-1H-indole

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

2'-(1H-indol-3-yl)-5-methoxy-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

2'-(1H-indol-3-yl)-5-methoxy-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-[(E)-2-nitroeth-1-enyl]-1H-indole
3156-51-2, 51870-94-1

3-[(E)-2-nitroeth-1-enyl]-1H-indole

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-fluoro-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-fluoro-2'-(1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;92%
sarcosine
107-97-1

sarcosine

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

(5aS,9aS,10aS)-2-methyldecahydropyrazino[1,2-a]indole-1,4-dione
1110659-51-2

(5aS,9aS,10aS)-2-methyldecahydropyrazino[1,2-a]indole-1,4-dione

Conditions
ConditionsYield
With methyl dichlorophosphite; triethylamine; 1-methyl-3-methylimidazol-3-ium dimethyl phosphate In toluene at 145℃; for 1h; Microwave irradiation; stereoselective reaction;91%
(E)-1-methyl-3-(2-nitrovinyl)-1H-indole
2731-00-2, 122631-39-4

(E)-1-methyl-3-(2-nitrovinyl)-1H-indole

5-methoxyisatine
39755-95-8

5-methoxyisatine

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-methoxy-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-methoxy-2'-(1-methyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;91%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

(E)-1-methyl-3-(2-nitrovinyl)-2-phenyl-1H-indole
122631-44-1

(E)-1-methyl-3-(2-nitrovinyl)-2-phenyl-1H-indole

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

5-fluoro-2'-(1-methyl-2-phenyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

5-fluoro-2'-(1-methyl-2-phenyl-1H-indol-3-yl)-1'-nitro-1',2',4a',5',6',7',8',8a',9',9a'-decahydrospiro[indoline-3,3'-pyrrolo[1,2-a]indol]-2-one

Conditions
ConditionsYield
In ethanol; water at 20℃; for 6h; Green chemistry;91%
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