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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality Perindopril erbumine 107133-36-8 Manufacturer

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price Perindopril powder

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 55.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Perindopril erbumine CAS 107133-36-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in dis

Perindopril erbumine CAS 107133-36-8

Cas:107133-36-8

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Perindopril Erbumine CAS:107133-36-8 white or off-white crystalline powder HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of busines

competitive price Perindopril Erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Perindoril

Cas:107133-36-8

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Perindopril erbumine 107133-36-8 GMP manufacturer

Cas:107133-36-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Perindopril erbumine

Cas:107133-36-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Factory Price Perindopril Erbumine Chemical / Pharmaceutical Chemical CAS 107133-36-8

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 107133-36-8 with fast shipping

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Perindopril erbumine/ LIDE PHARMA- Factory supply / Best price

Cas:107133-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: Perindopril erbumine Synonyms: 1-[2-(1-Ethoxycarbonylbutylamino)propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid 2-methyl-2-propanamine (1:1) CAS:107133-36-8 MF: C19H32N2O5·C4H11N Appearance:White powder Storage:Sto

Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White or almost white crystalline powder Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port of china

API Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Perindopril erbumine 107133-36-8

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Top quality Antibacterial Perindopril erbumine CAS:107133-36-8

Cas:107133-36-8

Min.Order:25 Kilogram

FOB Price: $2264.0 / 2384.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Perindopril erbumine CAS:107133-36-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

Perindopril erbumine CAS:107133-36-8

Cas:107133-36-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Perindopril erbumine

Cas:107133-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Cefquinome sulfate from Wuhan, Hubei, China. It is made obtainable from us

high quality Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Perindopril Erbumine CAS 107133-36-8

Cas:107133-36-8

Min.Order:1 Gram

FOB Price: $5000.0

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $460.0 / 500.0

Type:Lab/Research institutions

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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

99% Perindopril Erbumine CAS 107133-36-8 with Best Price

Cas:107133-36-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Perindopril erbumine

Cas:107133-36-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Perindopril erbumine

Cas:107133-36-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Perindopril erbumine

Cas:107133-36-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Perindoril

Cas:107133-36-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

107133-36-8 Perindopril erbumineAppearance:White powder Storage:Store in cool & dry place Package:according to customers' requirements Application:Medicine Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or

107133-36-8 Perindopril erbumine

Cas:107133-36-8

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Perindopril erbumine

Cas:107133-36-8

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package: 1g/bag, 5g/bag, 10g/bag, 100g/bag, 1kg/bag or as per your request Application:An angio

Perindopril

Cas:107133-36-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

Perindopril
82834-16-0

Perindopril

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
In ethyl acetate Heating / reflux;95%
In ethyl acetate Heating / reflux;95%
In ethyl acetate Heating / reflux;95%
Perindopril
82834-16-0

Perindopril

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
With tert-butylamine In ethyl acetate; acetonitrile Heating / reflux;95%
With tert-butylamine In ethyl acetate at 20℃; for 1 - 1.5h;65%
tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With tert-butylimino-tri(pyrrolidino)phosphorane In acetonitrile
Stage #2: N-[1(S)-(ethoxycarbonyl)butyl]-L-alanine ester of acetonoxime In acetonitrile at 50℃; for 0.5h;
Stage #3: tert-butylamine In dichloromethane at 0 - 10℃; for 0.5h; Product distribution / selectivity;
90%
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile
Stage #2: N-[1(S)-(ethoxycarbonyl)butyl]-L-alanine ester of acetonoxime In acetonitrile at 40 - 45℃;
Stage #3: tert-butylamine With hydrogenchloride In acetonitrile at 50 - 60℃; Product distribution / selectivity;
90%
Stage #1: benzylperindopril oxalate With hydrogen; 5%-palladium/activated carbon In ethanol at 30℃; under 3677.86 Torr; for 3h;
Stage #2: tert-butylamine In ethanol Product distribution / selectivity;
N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride

N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h;
Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h;
Stage #3: tert-butylamine In Isopropyl acetate Product distribution / selectivity;
86%
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h;
Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h;
Stage #3: tert-butylamine In ethyl acetate Product distribution / selectivity;
80%
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h;
Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h;
Stage #3: tert-butylamine In DMF (N,N-dimethyl-formamide) Product distribution / selectivity;
78%
2,5-dioxo-3-[1-(S)-ethoxycarbonyl-butyl]-4-(S)-methyl-oxazolidine

2,5-dioxo-3-[1-(S)-ethoxycarbonyl-butyl]-4-(S)-methyl-oxazolidine

octahydro-1H-indole-2-carboxylic acid
82717-40-6

octahydro-1H-indole-2-carboxylic acid

A

tert-butylamine (2S,3AS,7AS)-1-{2-[1-ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl}-octahydroindol-2-carboxylate

tert-butylamine (2S,3AS,7AS)-1-{2-[1-ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl}-octahydroindol-2-carboxylate

B

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
With hydrogenchloride; tert-butylamine; triethylamine In dichloromethane; water; acetonitrileA 81%
B n/a
C12H23NO2Si
1159491-00-5

C12H23NO2Si

N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine
82834-12-6

N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine With 1H-imidazole; thionyl chloride In dichloromethane at -10℃; for 2h;
Stage #2: C12H23NO2Si In dichloromethane at -10 - 25℃; for 21h;
Stage #3: tert-butylamine In acetonitrile Heating / reflux;
61%
(2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamine]-(S)-propionyl}octahydroindole-2-carboxylic acid 4-chlorobenzyl ester

(2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamine]-(S)-propionyl}octahydroindole-2-carboxylic acid 4-chlorobenzyl ester

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate under 2068.65 Torr; for 8h;
perindopril oxalate

perindopril oxalate

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
In dichloromethane Product distribution / selectivity;
In water Product distribution / selectivity;
phosphate salt of perindopril

phosphate salt of perindopril

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
In water at 20℃; for 1h; Product distribution / selectivity;
benzylperindopril oxalate

benzylperindopril oxalate

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In ethanol at 30℃; under 3677.86 Torr; for 3h; Product distribution / selectivity;
(-)-di-p-toluoyl tartaric acid salt of perindopril

(-)-di-p-toluoyl tartaric acid salt of perindopril

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
In water Product distribution / selectivity;
(2S)-2-[(1S)-1-carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid dicyclohexylamine salt

(2S)-2-[(1S)-1-carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid dicyclohexylamine salt

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
In 2,2-dimethoxy-propane at 25 - 30℃; for 4 - 5h; Product distribution / selectivity;
at 25 - 30℃; for 4 - 5h; Product distribution / selectivity;
(2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamine]-(S)-propionyl}octahydroindole-2-carboxylic acid 4-methoxybenzyl ester

(2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamine]-(S)-propionyl}octahydroindole-2-carboxylic acid 4-methoxybenzyl ester

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamine]-(S)-propionyl}octahydroindole-2-carboxylic acid 4-methoxybenzyl ester With hydrogen; palladium on activated charcoal In ethyl acetate under 2068.65 Torr; for 5h;
Stage #2: tert-butylamine In ethyl acetate at 45℃; for 2h;
(2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester
200423-22-9

(2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester

N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride
869877-95-2

N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride With 1H-imidazole In dichloromethane at 10 - 15℃; for 1h;
Stage #2: (2S,3aS,7aS)-octahydroindole-2-carboxylic acid trimethylsilyl ester In dichloromethane at 10℃; for 3h;
Stage #3: tert-butylamine In dichloromethane at 10 - 40℃; for 1h; Product distribution / selectivity;
N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride
869877-95-2

N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: N-[1(S)-ethoxycarbonyl-1-butyl]-(S)-alanyl chloride hydrochloride With 1H-imidazole In dichloromethane at -5 - 0℃; for 1h;
Stage #2: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid In dichloromethane at -5 - 25℃; for 4.75h;
Stage #3: tert-butylamine In dichloromethane at 10 - 40℃; for 1h; Product distribution / selectivity;
(2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride
86647-57-6

(2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride

N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine
82834-12-6

N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine

tert-butylamine
75-64-9

tert-butylamine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Stage #1: (2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride; N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine With triethylamine In Isopropyl acetate at 10 - 15℃; for 0.25h;
Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In Isopropyl acetate at -10 - 30℃; for 6h;
Stage #3: tert-butylamine With hydrogen; 5% palladium over charcoal In ethanol
(S)-indoline-2-carboxylic acid
79815-20-6

(S)-indoline-2-carboxylic acid

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
2.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.2: 4 h / -5 - 5 °C
3.1: ethyl acetate / 0.5 h
View Scheme
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium acetate; acetic anhydride / 0.5 h / 20 °C / Inert atmosphere
1.2: 90 - 100 °C
2.1: sodium / 40 - 50 °C / Inert atmosphere
3.1: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
4.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
5.1: sulfuric acid; water / Reflux
6.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
7.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
7.2: 4 h / -5 - 5 °C
8.1: ethyl acetate / 0.5 h
View Scheme
(4Z)-4-[(2-chlorophenyl)methylene]-2-methyl-1,3-oxazol-5-one

(4Z)-4-[(2-chlorophenyl)methylene]-2-methyl-1,3-oxazol-5-one

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium / 40 - 50 °C / Inert atmosphere
2.1: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
3.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
4.1: sulfuric acid; water / Reflux
5.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
6.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
6.2: 4 h / -5 - 5 °C
7.1: ethyl acetate / 0.5 h
View Scheme
(Z)-2-acetylamino-3-(2-chlorophenyl)acrylic acid methyl ester

(Z)-2-acetylamino-3-(2-chlorophenyl)acrylic acid methyl ester

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogen; [Rhcod(S)-DuanPhos]BF4 / ethanol / 45 - 55 °C / 15001.5 Torr / Autoclave
2.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
3.1: sulfuric acid; water / Reflux
4.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
5.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
5.2: 4 h / -5 - 5 °C
6.1: ethyl acetate / 0.5 h
View Scheme
methyl (S)-2-acetamido-3-(2-chlorophenyl)propionate

methyl (S)-2-acetamido-3-(2-chlorophenyl)propionate

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate; copper(l) chloride / dimethyl sulfoxide / 100 - 105 °C / Inert atmosphere
2.1: sulfuric acid; water / Reflux
3.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
4.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.2: 4 h / -5 - 5 °C
5.1: ethyl acetate / 0.5 h
View Scheme
(S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester
110592-39-7

(S)-N-acetyl-2,3-dihydroindoline-2-carboxylic acid methyl ester

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid; water / Reflux
2.1: hydrogen; 8 % Pd/C / methanol / 55 - 65 °C / 37503.8 Torr / Autoclave
3.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.2: 4 h / -5 - 5 °C
4.1: ethyl acetate / 0.5 h
View Scheme
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
80875-98-5

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 2 h / 20 °C / Inert atmosphere
1.2: 4 h / -5 - 5 °C
2.1: ethyl acetate / 0.5 h
View Scheme
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate monohydrate

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate monohydrate

Conditions
ConditionsYield
With water In acetone at -80℃;100%
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate dihydrate

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate dihydrate

Conditions
ConditionsYield
With water at 30 - 40℃; for 240h; Product distribution / selectivity;100%
With water In acetonitrile at -50 - -45℃; Product distribution / selectivity;
L-arginine
74-79-3

L-arginine

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

perindopril L-arginine
612548-45-5

perindopril L-arginine

Conditions
ConditionsYield
With methanesulfonic acid In dimethyl sulfoxide at 70℃; for 1h;88%
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

Perindopril
82834-16-0

Perindopril

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 10 - 30℃; for 0.5h; Product distribution / selectivity;80%
With hydrogenchloride In dichloromethane; water pH=5.4; Product distribution / selectivity;
Stage #1: perindopril tert-butylamine With sulfuric acid In ethanol at 20 - 25℃; for 1.5h;
Stage #2: With sodium hydroxide In dichloromethane; water pH=4.2; Product distribution / selectivity;
With calcium chloride In ethyl acetate Product distribution / selectivity; Heating / reflux;
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

perindoprilat
95153-31-4

perindoprilat

Conditions
ConditionsYield
With sodium hydroxide for 72h; Ambient temperature;75%
With water; 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide at 59.84℃; for 120h; Kinetics;
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

A

ethyl (2S)-2-[(3S,5aS,9aS,10aS)-3-methyl-1,4-dioxo-5a,6,7,8,9,9a,10,10a-octahydro-3H-pyrazino[1,2-a]indol-2-yl]pentanoate
129970-98-5

ethyl (2S)-2-[(3S,5aS,9aS,10aS)-3-methyl-1,4-dioxo-5a,6,7,8,9,9a,10,10a-octahydro-3H-pyrazino[1,2-a]indol-2-yl]pentanoate

B

perindoprilat
95153-31-4

perindoprilat

Conditions
ConditionsYield
With water at 40℃; Conversion of starting material;A 0.04%
B 0.03%
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

C19H31N2O5*C8H9ClN2O5S

C19H31N2O5*C8H9ClN2O5S

Conditions
ConditionsYield
at 30℃; Activation energy; Further Variations:; Temperatures;
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate sesquihydrate

2-methylpropane-2-amine-(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-ethoxycarbonyl-butylamino]propanoyl]octahydro-1H-indole-2-carboxylate sesquihydrate

Conditions
ConditionsYield
With water at -15℃; for 1h; Product distribution / selectivity;
octanol
111-87-5

octanol

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt octanol solvate

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt octanol solvate

Conditions
ConditionsYield
In ethyl acetate at 30 - 60℃;
n-heptan1ol
111-70-6

n-heptan1ol

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt heptanol solvate

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt heptanol solvate

Conditions
ConditionsYield
In toluene at 20 - 55℃;
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

cyclohexanol
108-93-0

cyclohexanol

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt cyclohexanol solvate

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt cyclohexanol solvate

Conditions
ConditionsYield
In toluene at 20 - 65℃;
at 20 - 60℃; Product distribution / selectivity;
pentan-1-ol
71-41-0

pentan-1-ol

perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt pentanol solvate

(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt pentanol solvate

Conditions
ConditionsYield
In ethyl acetate at 20 - 60℃;
perindopril tert-butylamine
107133-36-8

perindopril tert-butylamine

calcium chloride

calcium chloride

calcium salt of perindopril

calcium salt of perindopril

Conditions
ConditionsYield
In ethyl acetate Heating / reflux;

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