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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications 5-Fluoroisatin CAS:443-69-6

Cas:443-69-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

1, Full experience of large numbers containers loading in main Chinese seaports 2, Packing with pallet as buyer's special request 3, Best service after shipment with e-mail 4, Cargoes together with container sales service ava

5-Fluoroisatin CAS 443-69-6

Cas:443-69-6

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

443-69-65-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours; 2.Best quality in your requirement; 3.We pay more attention on delivery time, and usually ship on time; 4.Under the premise of safety and effectiveness, we can pr

CAS:443-69-6/High quality/Factory supply

Cas:443-69-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Fluoroisatin

Cas:443-69-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/788.html Product Name

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

5-Fluoroisatin Basic information Product Name: 5-Fluoroisatin Synonyms: BUTTPARK 24\07-36;AKOS BBS-00006537;5-FLUOROINDOLINE-2,3-DIONE;5-FLUOROISATIN;5-FLUOROISATINE;5-FLUOROINDOLE-2

443-69-6

Cas:443-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 443-69-6 with best quality

Cas:443-69-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Chemical raw material high purity 99% 5-Fluoroisatin 443-69-6

Cas:443-69-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Fluoroisatin 443-69-6

Cas:443-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

5-Fluoroisatin Chemical Properties Melting point 224-227 °C (lit.) density 1.477±0.06 g/cm3(Predicted) storage temp. Refrigerator pka 8.51±0.20(Predicted) form Powder color Red BRN 131241 InChIKey GKODD

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

5-Fluoroisatin CAS:443-69-6

Cas:443-69-6

Min.Order:25 Gram

FOB Price: $15.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

5-Fluoroisatin CAS:443-69-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

5-Fluoroisatin CAS:443-69-6

Cas:443-69-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

FOB Price: $160.0 / 200.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-Fluoroisatin

Cas:443-69-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-Fluoroisatin

Cas:443-69-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan BJM Pharm Inc.

product name 5-fluoroisatin synonyms 5-fluoroindoline-2,3-dione cas no. 443-69-6 molecular weight 165.12 molecular formula c8h4fno2 melting point 224-227 ºc appeara

443-69-6 5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

5-Fluoro Isatin

Cas:443-69-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-Fluoroisatin

Cas:443-69-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-FLUOROISATIN

Cas:443-69-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Fluoroisatin

Cas:443-69-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-Fluoroisatin

Cas:443-69-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Various Specifications 5-Fluoroisatin

Cas:443-69-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

5-Fluoroisatin

Cas:443-69-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

5-Fluoroisatin

Cas:443-69-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Synthetic route

N-(4-fluorophenyl)-2-(hydroxyimino) acetamide
351-09-7

N-(4-fluorophenyl)-2-(hydroxyimino) acetamide

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With sulfuric acid In water at 80℃; for 0.333333h;88.6%
With sulfuric acid In water at 50 - 75℃; Temperature;88.2%
With sulfuric acid at 20℃;85%
N-(4-fluorophenyl)-2-(hydroxyimino)acetamide

N-(4-fluorophenyl)-2-(hydroxyimino)acetamide

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With sulfuric acid at 50 - 75℃; for 0.333333h;88.2%
5-fluoroindoline
2343-22-8

5-fluoroindoline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With iodine pentoxide In dimethyl sulfoxide at 80℃;87%
With o-iodosobenzoic acid; oxygen In dimethyl sulfoxide at 80℃; for 12h; Green chemistry;72%
3-(4-fluorophenylimino)-5-fluoro-N-(4-fluorophenyl)-3H-indole-2-amine
1174558-44-1

3-(4-fluorophenylimino)-5-fluoro-N-(4-fluorophenyl)-3H-indole-2-amine

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water for 0.333333h; Reflux;85%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

A

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

B

(E)-5-fluoro-5'-methoxy-[3,3'-biindolinylidene]-2,2'-dione

(E)-5-fluoro-5'-methoxy-[3,3'-biindolinylidene]-2,2'-dione

Conditions
ConditionsYield
With oxygen; sodium iodide In tetrahydrofuran at 60℃; for 12h; Schlenk technique; chemoselective reaction;A 80%
B 8%
carbon monoxide
201230-82-2

carbon monoxide

N'-(2-bromo-4-fluorophenyl)-N,N-dimethylurea

N'-(2-bromo-4-fluorophenyl)-N,N-dimethylurea

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Stage #1: N'-(2-bromo-4-fluorophenyl)-N,N-dimethylurea With methyllithium In tetrahydrofuran; diethyl ether at 0℃;
Stage #2: With tert.-butyl lithium In tetrahydrofuran; diethyl ether; n-heptane at 0℃; for 1h;
Stage #3: carbon monoxide In tetrahydrofuran; diethyl ether; n-heptane at 0℃; for 0.5h;
79%
Yield given; Multistep reaction;
phenylglycine isopropyl ester

phenylglycine isopropyl ester

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
In acetonitrile at 60℃; for 16h;78.7%
5-fluoro-1H-indole
399-52-0

5-fluoro-1H-indole

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; oxygen In acetonitrile at 20℃; for 18h;68%
chloral hydrate
302-17-0

chloral hydrate

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Stage #1: chloral hydrate; 4-fluoroaniline With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water
Stage #2: With sulfuric acid at 60 - 80℃;
63%
Stage #1: chloral hydrate; 4-fluoroaniline With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate for 0.166667h; Heating;
Stage #2: With sulfuric acid for 1h; Heating;
Stage #1: chloral hydrate; 4-fluoroaniline With hydroxylamine hydrochloride; sodium sulfate In water Sandmeyer reaction;
Stage #2: With sulfuric acid In methanol Sandmeyer reaction;
4-Fluoroisonitrosoacetanilide

4-Fluoroisonitrosoacetanilide

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With sulfuric acid 1) 50 deg C, 30 min; 2) 80 deg C, 10 min;62%
chloral ethyl hemiacetal
515-83-3

chloral ethyl hemiacetal

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Stage #1: chloral ethyl hemiacetal; 4-fluoroaniline With hydrogenchloride; sodium sulfate In water for 1h;
Stage #2: With hydroxylamine hydrochloride In water at 10 - 80℃; for 1.5h;
Stage #3: With sulfuric acid at 60℃; for 6h;
61%
(E)-N-(4-fluorophenyl)-2-(hydroxyimino)acetamide
879274-72-3

(E)-N-(4-fluorophenyl)-2-(hydroxyimino)acetamide

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With sulfuric acid In water at 50 - 90℃;52%
With sulfuric acid In water at 50 - 90℃;52%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

A

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

B

(E)-5,5'-difluoro-[3,3'-biindolinylidene]-2,2'-dione

(E)-5,5'-difluoro-[3,3'-biindolinylidene]-2,2'-dione

Conditions
ConditionsYield
With oxygen; sodium iodide In dimethyl sulfoxide at 100℃; for 12h; Schlenk technique; chemoselective reaction;A 29%
B 52%
oxalyl dichloride
79-37-8

oxalyl dichloride

4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With H-β zeolite In 1,2-dichloro-ethane at 80℃; for 36h; Inert atmosphere;51%
3,3-dibromo-5-fluoro-2-oxindole
113423-50-0

3,3-dibromo-5-fluoro-2-oxindole

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With water In methanol for 2h; Heating;
4-fluoroaniline
371-40-4

4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine sulfate; sodium sulfate; HCl / ethanol; H2O
2: H2SO4
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / NH2OH*HCl; sodium sulfate / H2O / 0.05 h / microwave irradiation
2: 61 percent / H2SO4 (86 percent) / 0.01 h / microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: NH2OH
2: conc. H2SO4 / Heating
View Scheme
2-bromo-4-fluoroaniline
1003-98-1

2-bromo-4-fluoroaniline

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Et3N / tetrahydrofuran / 2 h / 0 °C
1.2: 71 percent / tetrahydrofuran / 1 h / 0 °C
2.1: MeLi / tetrahydrofuran; diethyl ether / 0 °C
2.2: t-BuLi / tetrahydrofuran; diethyl ether; heptane / 1 h / 0 °C
2.3: 79 percent / tetrahydrofuran; diethyl ether; heptane / 0.5 h / 0 °C
View Scheme
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CuBr2 / ethyl acetate / 80 °C
2: water / methanol / 2 h / Heating
View Scheme
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; oxygen In acetonitrile at 20℃; for 24h;
4-fluoroaniline
371-40-4

4-fluoroaniline

alkali thiocyanate

alkali thiocyanate

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH2OH*HCl, Na2SO4
2: H2SO4
View Scheme
5-iodoisatin
20780-76-1

5-iodoisatin

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Stage #1: 5-iodoisatin With tetrakis(triphenylphosphine) palladium(0); bis(tri-n-butyltin); lithium chloride In 1,4-dioxane at 23 - 100℃; Inert atmosphere;
Stage #2: With silver trifluoromethanesulfonate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate) In acetone at 23℃; for 0.333333h; Inert atmosphere; regiospecific reaction;
11.9 mg
C8H5FN2O
1261152-93-5

C8H5FN2O

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
With sulfuric acid; water
p-fluoroaniline hydrochloride
2146-07-8

p-fluoroaniline hydrochloride

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; sulfuric acid; sodium sulfate; hydroxylamine hydrochloride / water / 100 °C
2: sulfuric acid / 85 °C
View Scheme
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

1-bromo-hexane
111-25-1

1-bromo-hexane

5-fluoro-1-hexyl-isatin
85511-62-2

5-fluoro-1-hexyl-isatin

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 140℃; Microwave irradiation;100%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

-CH2CH2CH(CH3)2 halide

-CH2CH2CH(CH3)2 halide

1-isopentyl-5-methylindoline-2,3-dione

1-isopentyl-5-methylindoline-2,3-dione

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;100%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

-CH2CH2CH(CH3)2 halide

-CH2CH2CH(CH3)2 halide

C13H14FNO2

C13H14FNO2

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;100%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

-CH2CH2CH3 halide

-CH2CH2CH3 halide

5-fluoro-1-n-propylisatin
445218-47-3

5-fluoro-1-n-propylisatin

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;100%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

-CH3 halide

-CH3 halide

5-fluoro-1-methylisatin
773-91-1

5-fluoro-1-methylisatin

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃;100%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

Conditions
ConditionsYield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h;
Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;
81.9%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3,3'-methylenedianiline
19471-12-6

3,3'-methylenedianiline

3,3'-[methylenebis(3,1-phenylenenitrilo)]bis[1,3-dihydro-5-fluoro-2H-indol-2-one]

3,3'-[methylenebis(3,1-phenylenenitrilo)]bis[1,3-dihydro-5-fluoro-2H-indol-2-one]

Conditions
ConditionsYield
In water at 20℃; for 22h;99%
With acetic acid In ethanol for 5h; Heating;68%
In ethanol Heating;
indole
120-72-9

indole

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5'-fluoro-1H,1''H-[3,3':3',3''-terindol]-2'(1'H)-one
695168-61-7

5'-fluoro-1H,1''H-[3,3':3',3''-terindol]-2'(1'H)-one

Conditions
ConditionsYield
With titanium(IV) oxide In water at 20℃; Green chemistry;99%
With bromine In acetonitrile at 20℃; for 7h;92%
With C14H32N2O6S2(2+)*2ClO4(1-) In neat (no solvent) at 110℃; for 0.166667h; Catalytic behavior; Reagent/catalyst;89%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-(trifluoromethyl)propiophenone
1533-03-5

3-(trifluoromethyl)propiophenone

6-fluoro-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
1335116-93-2

6-fluoro-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Conditions
ConditionsYield
Stage #1: 5-fluoro-1H-indole-2,3-dione; 3-(trifluoromethyl)propiophenone With potassium hydroxide In ethanol; water for 1h; Reflux;
Stage #2: With hydrogenchloride In water pH=~ 3; Product distribution / selectivity;
99%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide In ethanol; water for 0.25h;
Stage #2: 3-(trifluoromethyl)propiophenone In ethanol; water for 1h; Reflux;
Stage #3: With hydrogenchloride In water pH=6;
34%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

aminomalonic acid diethyl ester
6829-40-9

aminomalonic acid diethyl ester

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

5',5'-diethyl 3',4'-dimethyl 5-fluoro-2-oxospiro[indoline-3,2'-pyrrole]-3',4',5',5'(1'H)-tetracarboxylate
1459805-67-4

5',5'-diethyl 3',4'-dimethyl 5-fluoro-2-oxospiro[indoline-3,2'-pyrrole]-3',4',5',5'(1'H)-tetracarboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In 1,2-dichloro-ethane at 60℃; for 36h; Time; Molecular sieve;99%
2,4-thiazolidinedion
2295-31-0

2,4-thiazolidinedion

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

C11H7FN2O4S

C11H7FN2O4S

Conditions
ConditionsYield
With water at 20℃; for 12h;99%
2-thioxo-4-thiazolidinone
141-84-4

2-thioxo-4-thiazolidinone

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5-(5-Fluoro-3-hydroxy-2-oxoindolin-3- yl)-2-thioxothiazolidin-4-one

5-(5-Fluoro-3-hydroxy-2-oxoindolin-3- yl)-2-thioxothiazolidin-4-one

Conditions
ConditionsYield
With water at 20℃; for 12h;99%
2-oxoindole
59-48-3

2-oxoindole

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5-fluoro-3-hydroxy-1,1',3,3'-tetrahydro-2H,2'H-3,3'-biindole-2,2'-dione

5-fluoro-3-hydroxy-1,1',3,3'-tetrahydro-2H,2'H-3,3'-biindole-2,2'-dione

Conditions
ConditionsYield
With water at 20℃; for 24h;99%
5-chloro-indolin-2-one
17630-75-0

5-chloro-indolin-2-one

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

C16H10ClFN2O3

C16H10ClFN2O3

Conditions
ConditionsYield
With water at 20℃; for 24h;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

1-Phenyl-3-methylindolin-2-one
23210-22-2

1-Phenyl-3-methylindolin-2-one

C23H17FN2O3

C23H17FN2O3

Conditions
ConditionsYield
With water at 20℃; for 24h;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-methyl-2-pyrazoline-5-one
108-26-9

3-methyl-2-pyrazoline-5-one

5-fluoro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

5-fluoro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

Conditions
ConditionsYield
With water at 20℃; for 0.166667h; Green chemistry;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

5-propyl-2,4-dihydro-3H-pyrazol-3-one
29211-70-9

5-propyl-2,4-dihydro-3H-pyrazol-3-one

5-fluoro-3-hydroxy-3-(3-hydroxy-5-propyl-1H-pyrazol-4-yl)indolin-2-one

5-fluoro-3-hydroxy-3-(3-hydroxy-5-propyl-1H-pyrazol-4-yl)indolin-2-one

Conditions
ConditionsYield
With water at 20℃; for 0.166667h; Green chemistry;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-phenyl-1-(1H-pyrazol-1-yl)but-3-en-1-one

3-phenyl-1-(1H-pyrazol-1-yl)but-3-en-1-one

(S)-5-fluoro-4'-phenylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione

(S)-5-fluoro-4'-phenylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione

Conditions
ConditionsYield
With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea In acetonitrile at 25℃; for 12h; enantioselective reaction;99%
1-(pyridin-2-yl)-butan-2-one
6303-73-7

1-(pyridin-2-yl)-butan-2-one

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

2-ethyl-6-fluoro-3-(pyridin-2-yl)quinoline-4-carboxylic acid
1259522-46-7

2-ethyl-6-fluoro-3-(pyridin-2-yl)quinoline-4-carboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 90℃;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

2,2-difluoro-2-(3-methyl-4-nitro-1,2-oxazol-5-yl)-1-phenylethan-1-one

2,2-difluoro-2-(3-methyl-4-nitro-1,2-oxazol-5-yl)-1-phenylethan-1-one

3-(difluoro(3-methyl-4-nitroisoxazol-5-yl)methyl)-5-fluoro-3-hydroxyindolin-2-one

3-(difluoro(3-methyl-4-nitroisoxazol-5-yl)methyl)-5-fluoro-3-hydroxyindolin-2-one

Conditions
ConditionsYield
With methanol; triethylamine at 20℃; for 24h;99%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

(E)-5-fluoro-3-hydrazonoindolin-2-one

(E)-5-fluoro-3-hydrazonoindolin-2-one

Conditions
ConditionsYield
With hydrazine hydrate In methanol at 20℃; for 12.5h; Reflux;98.3%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

6-fluoroquinoline-2,4-dicarboxylic acid
220844-72-4

6-fluoroquinoline-2,4-dicarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide at 110℃; for 6h;98.15%
With sodium hydroxide at 110℃; for 4h;70%
With potassium hydroxide In water at 40℃; for 16h; Pfitzinger Quinoline Synthesis;65%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

cyanoacetic acid
372-09-8

cyanoacetic acid

cyano(5-fluoro-2-oxo-2,3-dihydroindol-3-ylidene)acetic acid

cyano(5-fluoro-2-oxo-2,3-dihydroindol-3-ylidene)acetic acid

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 20℃;98%
With piperdinium acetate In water at 100℃; Knoevenagel Condensation;90%
2-amino-6-nonadecyl-benzoic acid
934273-32-2

2-amino-6-nonadecyl-benzoic acid

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

C34H47FN2O3

C34H47FN2O3

Conditions
ConditionsYield
for 0.0333333h; microwave irradiation;98%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

5-fluoro-3-(1H-pyrrol-1-yl)-1,3-dihydroindol-2-one
1123858-19-4

5-fluoro-3-(1H-pyrrol-1-yl)-1,3-dihydroindol-2-one

Conditions
ConditionsYield
With cetyltrimethylammonim bromide In water at 80℃; for 0.5h; Green chemistry;98%
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 110℃; for 0.166667h; Microwave irradiation;96%
With scandium tris(dodecyl sulfate) In water at 80℃; for 0.5h; Green chemistry;96%
With β‐cyclodextrin In water at 60℃; for 1.5h;94%
With iodine In water; acetonitrile at 20℃; for 4h; Irradiation;
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

dimedone
126-81-8

dimedone

malononitrile
109-77-3

malononitrile

2-amino-5'-fluoro-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
352329-70-5

2-amino-5'-fluoro-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile

Conditions
ConditionsYield
With silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride In ethanol at 20℃; for 3.5h;98%
With 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydroxide In water at 80℃; for 0.166667h; Green chemistry;96%
In water at 80℃; for 0.133333h; Microwave irradiation; Green chemistry;95%
1H-indene-1,3(2H)-dione
606-23-5

1H-indene-1,3(2H)-dione

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

2-(3-(4-(dimethylamino)phenyl)-5-fluoro-2-oxoindolin-3-yl)-1H-indene-1,3(2H)-dione
1310937-72-4

2-(3-(4-(dimethylamino)phenyl)-5-fluoro-2-oxoindolin-3-yl)-1H-indene-1,3(2H)-dione

Conditions
ConditionsYield
With lithium perchlorate In ethanol for 4h; Friedel-Crafts type reaction; Reflux;98%
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

malononitrile
109-77-3

malononitrile

2'-amino-5-fluoro-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano[2,3-b]chromene]-3'-carbonitrile
1429936-36-6

2'-amino-5-fluoro-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano[2,3-b]chromene]-3'-carbonitrile

Conditions
ConditionsYield
With silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride In ethanol at 20℃; for 4.5h;98%
With tetrabutylammonium acetate In melt at 100℃;93%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

3-acetylcoumarin
3949-36-8

3-acetylcoumarin

(R)-5-fluoro-3-hydroxy-3-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl]indolin-2-one
1610544-12-1

(R)-5-fluoro-3-hydroxy-3-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl]indolin-2-one

Conditions
ConditionsYield
Stage #1: 3-acetylcoumarin With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R)-(6-methoxyquinolin-4-yl)(3-vinylquinuclidin-7-yl)methyl)urea In tetrahydrofuran at 5℃; for 0.333333h; Aldol Addition;
Stage #2: 5-fluoro-1H-indole-2,3-dione In tetrahydrofuran at 5℃; for 24h; Aldol Addition; enantioselective reaction;
98%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

4-((1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)oxy)-N-phenylbutanethioamide

4-((1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)oxy)-N-phenylbutanethioamide

5-fluoro-3-hydroxy-3-(2-oxido-1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)indolin-2-one

5-fluoro-3-hydroxy-3-(2-oxido-1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)indolin-2-one

Conditions
ConditionsYield
In chloroform at 61℃; for 15h; Inert atmosphere;98%

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