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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct description: Product name 5-Fluoro-2-oxindole CAS number 56341-41-4 Assay ≥98% Appearance Yellowish crystalline Capacity 200mt/year Application Pharmaceutical interme
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inquiryMaufacturer supply 5-Fluoro-2-oxindole CAS 56341-41-4 at reasonable price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/
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inquiryPurity 98% with good quality Competitive price Fast delivery Prompt shipment Appearance:Light yellow crystalline Storage:Store in cool dry place Package:25 kg/drum Application:Pharmaceutical intermediates Port:Shanghai, Nanjing
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inquiryGood quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name 5-Fluoro-2-oxindole Appearance Light Yellow Crystalline CAS NO. 56341-41-4 Molecular Formula C8H6FNO Molecular Weight 151.14
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inquiryProduct: Sunitinib Intermrdiate Chemical name:5-Fluoro-2-Oxindole Batch NO: 20210331 Analysis Date: 2021-03-31 Expiry Date: 2023-03-30 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
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inquiry5-Fluoro-2-oxindole CAS:56341-41-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Detail Minimum Order Qty. 10 Gram
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Wuhan BJM Pharm Inc. was found in 2013, located in Hubei Province, where has long history, rich culture, convenient traffic, beautiful environment and preferential policy. We have two factories in Dezhou , Shandong and Xianning, Hubei. The factory c
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
5-Fluoro-2-oxindole is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:White to light brown solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:Pharma
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryName 5-Fluoro-2-oxindole Synonyms 5-Fluorooxindole Molecular Structure Molecular Formula C
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiry5-fluoro-1H-indole-2,3-dione
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction; | 99.1% |
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere; | 87% |
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h; Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2; | 81.9% |
5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux; | 92.1% |
Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h; Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h; |
Conditions | Yield |
---|---|
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent); | 88% |
methyl 2-(5-fluoro-2-nitrophenyl)acetate
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With iron In acetic acid at 100℃; for 1h; | 87% |
1,3-dihydro-1-hydroxyindole-2-one
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h; | 81% |
5-fluoro-3-hydrazonoindolin-2-one
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 5h; Reflux; | 80.4% |
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere; | |
With sodium ethanolate |
Conditions | Yield |
---|---|
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; | 78% |
(5-Fluoro-2-nitro-phenyl)-acetic Acid
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2; | 76% |
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 6h; Reflux; | 73.6% |
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
In water | 73% |
In water | 73% |
With hydrogenchloride In water at 20℃; for 12h; pH=3; | 73% |
Conditions | Yield |
---|---|
In water | A 73% B n/a |
In water | A 73% B n/a |
molybdenum hexacarbonyl
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h; | 55% |
2-chloro-N-(4-fluorophenyl)acetamide
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With aluminium trichloride at 220 - 225℃; for 0.5h; | 54% |
With aluminum (III) chloride at 220℃; for 1h; |
3,3-dibromo-5-fluoro-2-oxindole
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With acetic acid; zinc Ambient temperature; |
(2-tert-Butoxycarbonylamino-5-fluoro-phenyl)-acetic acid
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 0.25h; Heating; Yield given; |
4-fluoroaniline
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 54 percent / AlCl3 / 0.5 h / 220 - 225 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 60 - 70 °C 2.1: sulfuric acid / 80 - 90 °C 3.1: sulfuric acid; water 4.1: hydrazine hydrate / ethanol / Reflux 4.2: Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / dichloromethane / 20 °C 2: aluminum (III) chloride / 1 h / 220 °C View Scheme |
2,4-Difluoronitrobenzene
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1) NaH / 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h 2: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C 3: 87 percent / Fe powder / acetic acid / 1 h / 100 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium methylate / N,N-dimethyl acetamide / 10 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 20 °C 3: hydrogenchloride / water; methanol / 2 h / Inert atmosphere; Reflux View Scheme |
dimethyl 2-(5-fluoro-2-nitrophenyl)malonate
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C 2: 87 percent / Fe powder / acetic acid / 1 h / 100 °C View Scheme |
4-fluor-2-methylaniline
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / Heating 2: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min 3: 10percent HCl / ethanol / 0.25 h / Heating View Scheme |
tert-butyl (4-fluoro-2-methylphenyl)carbamate
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min 2: 10percent HCl / ethanol / 0.25 h / Heating View Scheme |
5-fluoro-1H-indole
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 48 percent / pyridinium bromide perbromide / 2-methyl-propan-2-ol / 20 h / 25 °C 2: Zn, AcOH / Ambient temperature View Scheme |
(5-Fluoro-2-nitro-phenyl)-acetic Acid
5-fluoroindol-2(3H)-one
tert-butylhypochlorite
methylthioacetic acid ethyl ester
4-fluoroaniline
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water |
tert-butylhypochlorite
methylthioacetic acid ethyl ester
4-fluoroaniline
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water |
C8H5FN2O
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid; water 2.1: hydrazine hydrate / ethanol / Reflux 2.2: Reflux View Scheme |
N-(4-fluorophenyl)-2-(hydroxyimino) acetamide
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sulfuric acid / 80 - 90 °C 2.1: sulfuric acid; water 3.1: hydrazine hydrate / ethanol / Reflux 3.2: Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid / 1 h / 50 - 70 °C 2: hydrazine hydrate / ethanol / 0.5 h / Inert atmosphere; Reflux 3: potassium tert-butylate / ethanol / 2 h / Reflux; Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / 0.17 h / Inert atmosphere 2: titanium tetrachloride; zinc / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / water / 50 - 75 °C 2: hydrazine hydrate / water / 6 h / 140 °C View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / 2 h / 60 - 90 °C 2: hydrazine hydrate / water; ethanol / 10 h / 100 °C View Scheme |
5-fluoroindol-2(3H)-one
3-bromoazulene-1-carbaldehyde
(3E)-3-(((4Z,6Z,8E)-1-bromoazulen-3-yl)methylene)-5-fluoroindolin-2-one
Conditions | Yield |
---|---|
With piperidine In ethanol for 2h; Heating / reflux; | 100% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
Conditions | Yield |
---|---|
With pyrrolidine In ethanol for 3h; Reflux; | 98% |
With pyrrolidine In ethanol for 3h; Reflux; | 98.2% |
With piperidine In ethanol Inert atmosphere; | 90% |
5-fluoroindol-2(3H)-one
formic acid ethyl ester
Conditions | Yield |
---|---|
With sodium methylate In methanol Reflux; | 98% |
5-fluoroindol-2(3H)-one
1,5-diphenyl-1,4-pentadiene-3-one
5'-fluoro-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione
Conditions | Yield |
---|---|
With Boc-D-Phg-OH; 9-amino-9-deoxy-epiquinine In toluene at 40℃; for 72h; Air; optical yield given as %ee; enantioselective reaction; | 98% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib
Conditions | Yield |
---|---|
With piperidine In toluene for 3h; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux; | 97.3% |
With piperidine In toluene for 3h; Reagent/catalyst; Solvent; Reflux; | 97.3% |
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3.5h; Aldol Condensation; Darkness; Inert atmosphere; | 94% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-fluoroindol-2(3H)-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 5h; Reflux; Stage #2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With trimethylsilyl trifluoromethanesulfonate | 97% |
pyrrolidine In ethanol for 3h; Heating / reflux; | 96% |
With pyrrolidine In ethanol for 3h; Heating / reflux; | 96% |
3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With pyrrolidine In ethanol Reflux; | 96% |
With pyrrolidine In ethanol Reflux; | 96% |
With pyrrolidine In ethanol Reflux; | 96% |
With piperidine In ethanol Knoevenagel condensation; Heating; | 87% |
With pyrrolidine In ethanol Reflux; |
5-fluoroindol-2(3H)-one
3-iodo-1H-indazole-6-carbaldehyde
Conditions | Yield |
---|---|
With piperidine In methanol at 60℃; for 3h; | 96% |
5-fluoroindol-2(3H)-one
5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
Conditions | Yield |
---|---|
With pyrrolidine In ethanol for 3h; Reflux; | 95% |
5-fluoroindol-2(3H)-one
malononitrile
2-(5-fluoro-2-oxoindolin-3-ylidene)malononitrile
Conditions | Yield |
---|---|
With iron(III) chloride hexahydrate; oxygen In N,N-dimethyl-formamide at 50℃; for 4h; Green chemistry; | 95% |
Conditions | Yield |
---|---|
With piperidine In methanol at 0 - 20℃; for 24h; | 93% |
6-fluoro-1H-indole-3-carbaldehyde
5-fluoroindol-2(3H)-one
(Z)-5-fluoro-3-((5-fluoro-1H-indol-3-yl)methylene)indolin-2-one
Conditions | Yield |
---|---|
With piperidine In methanol for 5h; Reflux; | 92% |
Conditions | Yield |
---|---|
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique; | 92% |
5-fluoroindol-2(3H)-one
2-bromo-4-methoxybenzaldehyde
Conditions | Yield |
---|---|
With piperidine In ethanol for 1.5h; Reflux; | 92% |
5-fluoroindol-2(3H)-one
5-fluoro-1H-indole
Conditions | Yield |
---|---|
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere; | 92% |
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
Stage #1: C18H22N4O4 With triethylamine In chloroform at 0℃; for 0.166667h; Stage #2: 5-fluoroindol-2(3H)-one In chloroform at 65℃; for 8h; Solvent; Temperature; | 92% |
5-fluoroindol-2(3H)-one
acetic anhydride
1,3-diacetyl-5-fluoro-1H-indol-2-yl acetate
Conditions | Yield |
---|---|
With dmap at 150℃; for 2h; | 91% |
Conditions | Yield |
---|---|
With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride In tetrahydrofuran at 20 - 65℃; for 2h; Molecular sieve; Inert atmosphere; optical yield given as %de; diastereoselective reaction; | A 5% B 91% |
Conditions | Yield |
---|---|
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique; | 91% |
2-methylquinoline
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With iron(II) acetate In N,N-dimethyl-formamide at 80℃; for 5h; Green chemistry; | 91% |
5-fluoroindol-2(3H)-one
5-fluoroindoline-2-thione
Conditions | Yield |
---|---|
With tetraphosphorus decasulfide; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 4h; | 90% |
With phosphorous (V) sulfide; sodium hydrogencarbonate In tetrahydrofuran for 3h; Ambient temperature; | 84% |
Stage #1: 5-fluoroindol-2(3H)-one With tetraphosphorus decasulfide In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran at 120℃; for 1h; | 75% |
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃; | |
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃; |
5-fluoroindol-2(3H)-one
(R)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde
(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one
Conditions | Yield |
---|---|
With piperidine In ethanol at 20 - 80℃; Darkness; | 90% |
With piperidine In ethanol at 20 - 80℃; for 2h; Darkness; | 90% |
With piperidine In ethanol at 20℃; |
1-methyl-2-formyl-1H-benzimidazole
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With piperidine In ethanol Knoevenagel Condensation; Reflux; stereoselective reaction; | 90% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h; Stage #2: 5-fluoroindol-2(3H)-one; C14H21NO5 With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h; | 90% |
5-fluoroindol-2(3H)-one
3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde
Conditions | Yield |
---|---|
With piperidine In ethanol for 12h; Reflux; | 90% |
5-fluoroindol-2(3H)-one
Conditions | Yield |
---|---|
With piperidine In ethanol at 60℃; | 90% |
5-fluoroindol-2(3H)-one
ethyl 3-(2-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate
(Z)-ethyl 3-{2-[(5-fluoro-2-oxoindolin-3-ylidene)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl}propanoate
Conditions | Yield |
---|---|
With piperidine In ethanol for 12h; Aldol condensation; Reflux; | 89% |
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