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Zhejiang Huili Pharmaceutical Co., Ltd

ProName: Favorable Doxycycline Price Pure Doxyc... CasNo: 564-25-0 Molecular Formula: C22H24N2O8 Appearance: Yellow powder Application: 1.Diosmin has antioxidant, antiinflamm... DeliveryTime: 3-5 days PackAge: 1-5kg Bag 5-25kg Carton 25kg Dru

Doxycycline

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Doxycycline Manufacturer/High quality/Best price/In stock

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Doxycycline 564-25-0

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications doxycycline CAS:564-25-0

Cas:564-25-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

Xi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi

High quality 99% Doxycycline powder CAS:564-25-0

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $79.0 / 99.0

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Doxycycline 564-25-0 GMP Manufacturer

Cas:564-25-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Doxycycline CAS NO:564-25-0 Grade:Medical scientific research and export Molecular formula: C22H24N2O8 Molecular weight:444.44 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

Doxycycline/ CAS:564-25-0/raw material/ high-quality

Cas:564-25-0

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

564-25-0 Doxycycline

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM Doxycycline

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 564-25-0 with best quality

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

DoxycyclineCAS564-25-0

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 564-25-0 Doxycycline with best price

Cas:564-25-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Doxycycline at Factory Price

Cas:564-25-0

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of Cefquinome sulfate from Wuhan, Hubei, China. It is made obtainable from us

high quality Doxycycline

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Tetracycline antibiotics DoxycyclineCAS:564-25-0

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $42.0 / 55.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Doxycycline CAS:564-25-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Doxycycline CAS:564-25-0

Cas:564-25-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Doxycycline hyclate CAS NO.: 564-25-0

Cas:564-25-0

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tr

Factory Supply Veterinary medicine cas 564-25-0 Doxycycline

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

High quality 99% Doxycycline CAS 564-25-0 AKS

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

High quality Doxycycline powder with factory price

Cas:564-25-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Doxycycline is a sem

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

we have GMP USP/BP/EP Appearance:A yellow crystalline powder Storage:Room temperature Package:25kg/drum or as required Application:used in medicine Transportation:by sea by air express Port:China main port

Doxycycline USP/BP/EP 98%min supplier Pharmaceutical API Antibiotics GMP made in china

Cas:564-25-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Doxycycline

Cas:564-25-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DOXYCYCLINE

Cas:564-25-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Doxycycline

Cas:564-25-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Doxycycline CAS 564-25-0 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2

Doxycycline CAS 564-25-0

Cas:564-25-0

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply doxycycline

Cas:564-25-0

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Synthetic route

methacycline hydrochloride
3963-95-9

methacycline hydrochloride

A

doxycycline
564-25-0

doxycycline

B

6-epidoxycycline
3219-99-6

6-epidoxycycline

Conditions
ConditionsYield
With hydrogen; closo-3,3-(η2,η3-C7H7CH2)-3,1,2-RhC2B9H11 In methanol at 43℃; under 76000 Torr; for 4h;A 95.5%
B 2%
With hydrogen; rhodium-carborane complex B In methanol at 100℃; under 76000 Torr; for 4h;A 41%
B 52.5%
With hydrogen; In methanol at 60℃; under 76000 Torr; for 4h;A 96 % Chromat.
B 2.5 % Chromat.
With hydrogen; In methanol at 60℃; under 76000 Torr; for 4h; Yield given. Yields of byproduct given;
With hydrogen; closo-(ϖ-cyclodienyl)rhodacarborane In methanol at 60℃; under 76000 Torr; for 4h; Product distribution; various catalyst;A 96 % Chromat.
B 2.5 % Chromat.
C37H34N2O10

C37H34N2O10

doxycycline
564-25-0

doxycycline

Conditions
ConditionsYield
With hydrogen; palladium In tetrahydrofuran; methanol at 23℃; under 760.051 Torr; for 2h;
doxycycline hydrochloride
10592-13-9, 41411-66-9, 564-25-0

doxycycline hydrochloride

doxycycline
564-25-0

doxycycline

Conditions
ConditionsYield
With sodium hydroxide In water at 90℃;
C22H21ClN2O8

C22H21ClN2O8

doxycycline
564-25-0

doxycycline

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol; water at 45 - 65℃; under 2625.26 - 3375.34 Torr; Pressure; Inert atmosphere;
doxycycline
564-25-0

doxycycline

doxycycline hydrochloride
10592-13-9, 41411-66-9, 564-25-0

doxycycline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water90%
doxycycline
564-25-0

doxycycline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

[4S-(4α, 12aα)]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-9-iodo-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide trifluoroacetate

[4S-(4α, 12aα)]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-9-iodo-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide trifluoroacetate

Conditions
ConditionsYield
With N-iodo-succinimide at 20℃; for 5h;80%
doxycycline
564-25-0

doxycycline

C22H22N2O8

C22H22N2O8

Conditions
ConditionsYield
With mercury(II) diacetate In N,N-dimethyl-formamide at 20℃; for 6h; Molecular sieve;76%
doxycycline
564-25-0

doxycycline

doxycycline-5-nitrate
1381789-22-5

doxycycline-5-nitrate

Conditions
ConditionsYield
With acetic anhydride; copper(II) nitrate In tetrahydrofuran at -10 - 20℃; for 5h;44%
With acetic anhydride; copper(II) nitrate In tetrahydrofuran at 20℃; for 2h;44%
bis-(2-nitryloxy-ethyl)-amine
20830-49-3

bis-(2-nitryloxy-ethyl)-amine

doxycycline
564-25-0

doxycycline

acetaldehyde
75-07-0

acetaldehyde

amido-N-[bis-(β-nitrooxyethyl)aminoethyl]-α-6-deoxy-5-oxytetracycline
1381789-28-1

amido-N-[bis-(β-nitrooxyethyl)aminoethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;35%
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;35%
formaldehyd
50-00-0

formaldehyd

doxycycline
564-25-0

doxycycline

4-nitrooxypiperidine
104963-85-1

4-nitrooxypiperidine

amido-N-[4-nitrooxypiperidinomethyl]-α-6-deoxy-5-oxytetracycline
1381789-24-7

amido-N-[4-nitrooxypiperidinomethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;32%
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;32%
formaldehyd
50-00-0

formaldehyd

N-methyl-2-ethanolamine O-nitrate
145459-15-0

N-methyl-2-ethanolamine O-nitrate

doxycycline
564-25-0

doxycycline

amido-N-[(β-nitrooxyethyl)aminomethyl]-α-6-deoxy-5-oxytetracycline
1381789-26-9

amido-N-[(β-nitrooxyethyl)aminomethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;30%
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;30%
formaldehyd
50-00-0

formaldehyd

bis-(2-nitryloxy-ethyl)-amine
20830-49-3

bis-(2-nitryloxy-ethyl)-amine

doxycycline
564-25-0

doxycycline

amido-N-[N,N-diethylnitrate-aminomethyl]-α-6-deoxy-5-oxytetracycline
1381789-20-3

amido-N-[N,N-diethylnitrate-aminomethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;25%
Stage #1: formaldehyd; bis-(2-nitryloxy-ethyl)-amine In isopropyl alcohol at 75℃; for 0.5h; Inert atmosphere;
Stage #2: doxycycline In methanol; isopropyl alcohol at 40℃; for 2.08333h; Product distribution / selectivity;
formaldehyd
50-00-0

formaldehyd

3-methylnitrate piperidine
104963-89-5

3-methylnitrate piperidine

doxycycline
564-25-0

doxycycline

amido-N-[3-methylnitratepiperidinomethyl]-α-6-deoxy-5-oxytetracycline
1381789-21-4

amido-N-[3-methylnitratepiperidinomethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;25%
In tetrahydrofuran; water at 40℃; for 16h; Product distribution / selectivity;
4-nitrooxymethyl piperidine

4-nitrooxymethyl piperidine

formaldehyd
50-00-0

formaldehyd

doxycycline
564-25-0

doxycycline

amido-N-[4-(nitrooxymethyl)piperidinomethyl]-α-6-deoxy-5-oxytetracycline
1381789-23-6

amido-N-[4-(nitrooxymethyl)piperidinomethyl]-α-6-deoxy-5-oxytetracycline

Conditions
ConditionsYield
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;21%
In tetrahydrofuran for 4h; Inert atmosphere; Reflux;21%
nitroveratryloxycarbonyl chloride
42855-00-5

nitroveratryloxycarbonyl chloride

doxycycline
564-25-0

doxycycline

NvOC-Dox
1207744-07-7

NvOC-Dox

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.0833333h; Molecular sieve;17%
doxycycline
564-25-0

doxycycline

4-epioxytetracycline
6543-77-7

4-epioxytetracycline

Conditions
ConditionsYield
With acetic acid for 24h; Ambient temperature;650 mg
doxycycline
564-25-0

doxycycline

<4S-(4α,12aα)>-4-(dimethylamino)-9-nitro-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
120793-45-5

<4S-(4α,12aα)>-4-(dimethylamino)-9-nitro-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Conditions
ConditionsYield
With sulfuric acid; potassium nitrate Nitration;
With sulfuric acid; potassium nitrate
With sodium nitrate; sulfuric acid at 4℃; under 760.051 Torr; for 3h;
doxycycline
564-25-0

doxycycline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

1-(4,5-dimethoxy-2-nitrophenyl)diazoethane
116271-29-5

1-(4,5-dimethoxy-2-nitrophenyl)diazoethane

(4S,4aR,5S,5aR,6R,12aS)-12-[1-(4,5-Dimethoxy-2-nitro-phenyl)-ethoxy]-4-dimethylamino-3,5,10,12a-tetrahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide; compound with trifluoro-acetic acid

(4S,4aR,5S,5aR,6R,12aS)-12-[1-(4,5-Dimethoxy-2-nitro-phenyl)-ethoxy]-4-dimethylamino-3,5,10,12a-tetrahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide; compound with trifluoro-acetic acid

Conditions
ConditionsYield
Stage #1: doxycycline; 1-(4,5-dimethoxy-2-nitrophenyl)diazoethane With potassium chloride In methanol; N,N-dimethyl-formamide at 20℃; for 24h;
Stage #2: trifluoroacetic acid In water; acetonitrile at 40℃; for 1h;
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-9-(carboxylic acid methyl ester)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-9-(carboxylic acid methyl ester)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 29 percent / NaOAc / Pd(dppf)2Cl2 / CH2Cl2 / 4 h / 70 °C / 23271.7 Torr
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-9-(1'-cyclopentenyl)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-9-(1'-cyclopentenyl)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 32 percent / CuI; triethylamine / Pd(OAc)2; P(o-tolyl)3 / acetonitrile
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-4-(dimethylamino)-9-(2-tert-butylcarbamoyl-vinyl)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-4-(dimethylamino)-9-(2-tert-butylcarbamoyl-vinyl)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 47 percent / CuI; triethylamine / Pd(OAc)2; P(o-tolyl)3 / acetonitrile / 2 h / 60 °C
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-4-(dimethylamino)-9-(3-formyl-4-methoxyphenyl)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-4-(dimethylamino)-9-(3-formyl-4-methoxyphenyl)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 29 percent / Na2CO3 / Pd(OAc)2 / methanol; H2O; dimethylformamide / 2 h / 70 °C
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-9-[3,4-methylenedioxophenyl]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-9-[3,4-methylenedioxophenyl]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 49 percent / Na2CO3 / Pd(OAc)2 / methanol; H2O; dimethylformamide / 2 h / 70 °C
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-9-(3-pirrolidin-1-ylmethyl-phenyl)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-9-(3-pirrolidin-1-ylmethyl-phenyl)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / N-iodosuccinimide / 5 h / 20 °C
2: 29 percent / Na2CO3 / Pd(OAc)2 / methanol; H2O; dimethylformamide / 2 h / 70 °C
3: 35 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 4 h / 20 °C
View Scheme
doxycycline
564-25-0

doxycycline

<4S-(4α,12aα)>-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
161321-34-2

<4S-(4α,12aα)>-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
View Scheme
Multi-step reaction with 2 steps
1: KNO3; H2SO4
2: H2 / Pd-C
View Scheme
doxycycline
564-25-0

doxycycline

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-9-vinyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-9-vinyl-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
4: 85 percent / Pd(OAc)2 / acetonitrile / 4 h
View Scheme
doxycycline
564-25-0

doxycycline

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-9-ethynyl-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-9-ethynyl-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
4: 88 percent / Pd(OAc)2 / acetonitrile / 4 h
View Scheme
doxycycline
564-25-0

doxycycline

[4S-(4α, 12aα)]-9-phenyl-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

[4S-(4α, 12aα)]-9-phenyl-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
4: 66 percent / Pd(OAc)2 / acetonitrile / 4 h
View Scheme
doxycycline
564-25-0

doxycycline

(4S,4aR,5S,5aR,6R,12aS)-9-(4-Amino-phenyl)-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

(4S,4aR,5S,5aR,6R,12aS)-9-(4-Amino-phenyl)-4-dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
4: 59 percent / Pd(OAc)2 / acetonitrile / 4 h
View Scheme
doxycycline
564-25-0

doxycycline

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-9-(4-nitro-phenyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

(4S,4aR,5S,5aR,6R,12aS)-4-Dimethylamino-3,5,10,12,12a-pentahydroxy-6-methyl-9-(4-nitro-phenyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
4: 73 percent / Pd(OAc)2 / acetonitrile / 4 h
View Scheme
doxycycline
564-25-0

doxycycline

C22H23N4O8(1+)*BF4(1-)

C22H23N4O8(1+)*BF4(1-)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KNO3; conc. H2SO4
2: H2 / Pd/C
3: 100 percent / n-BuONO; HBF4 / methanol / 0.5 h
View Scheme
doxycycline
564-25-0

doxycycline

9-azidodoxycycline
295356-11-5

9-azidodoxycycline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: KNO3; H2SO4
2.1: H2 / Pd-C
3.1: n-BuONO / methanol; HCl
3.2: NaN3
View Scheme

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