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hangzhou verychem science and technology co.ltd

Product name:(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide Cas No:356068-86-5 Assay: 98%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Yangzhou Qinyuan Pharmatech Co.,Ltd

Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H- pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Manufacturer/High quality/Best price/In stock

Cas:356068-86-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H- pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

N-[2-(diethylamino)ethyl]-5-formyl-2,4-dimethyl-1h-pyrrole-3-carboxamideCAS NO.: 356068-86-5

Cas:356068-86-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-[2-(Diethylamino)-ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 356068-86-5 with competitive price

Cas:356068-86-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Product: Sunitinib Intermediate Chemical name:N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Batch NO: 20210129 Analysis Date: 2021-01-29 Expiry Date: 2023-01-28 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is a

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1350.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time . Appearance:Refer to COA Storage:Store in dry, cool and ventilated place Package:A

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide CAS:356068-86-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide CAS:356068-86-5

Cas:356068-86-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3- CAS: 356068-86-5 Specification Inspection Standard Test Results Appearance Light yellow to brown color so

Factory supply N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

N-(2-(Diethylamino)Ethyl)-5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxamide

Cas:356068-86-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan BJM Pharm Inc.

Sunitinib intermediate CAS No: 356068-86-5 Product Name: N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide CAS No: 356068-86-5 Molecular Formula: C14H23N3O2 Molecular Weight: 265.355 Usage: Sunitinib intermediate A

CAS NO.356068-86-5 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Sunitinib Impurity 356068-86-5

Cas:356068-86-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 356068-86-5 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

N-(-2((Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality N-(2-(Diethylamino)Ethyl)-5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxamide

Cas:356068-86-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Pale brown or Off-white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Cas:356068-86-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Synthetic route

5-[(2-diethylamino-ethylimino)-methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-[(2-diethylamino-ethylimino)-methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With water100%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h;86.3%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide84%
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: N,N-diethylethylenediamine With triethylamine In N,N-dimethyl-formamide at 20℃;
80%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N,N-diethylhydrazine
616-40-0

N,N-diethylhydrazine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h;86.3%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

1-(3-dimethyl-aminopropyl-3-ethylcarbodiimide hydrochloride

1-(3-dimethyl-aminopropyl-3-ethylcarbodiimide hydrochloride

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene43%
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene43%
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene43%
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 45 °C
2: imidazole / carbon dioxide / tetrahydrofuran / 45 °C
3: 100 percent / H2O
View Scheme
4-(imidazole-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde
452105-37-2

4-(imidazole-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: imidazole / carbon dioxide / tetrahydrofuran / 45 °C
2: 100 percent / H2O
View Scheme
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / aq. KOH / methanol / 3 h / Heating
2: 50 percent / EDC; HOBt; Et3N / dimethylformamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
2.2: 16 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1: water; potassium hydroxide / methanol / 3 h / Reflux
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C
View Scheme
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
86770-31-2

2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / TFA / -5 - 20 °C
2: 90 percent / aq. KOH / methanol / 3 h / Heating
3: 50 percent / EDC; HOBt; Et3N / dimethylformamide / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C
2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
2.2: 25 - 30 °C / pH 12 - 13
3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
4.2: 16 h / 25 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride; water / ethanol / 3 h / 70 °C
2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
3: water; potassium hydroxide / methanol / 3 h / Reflux
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / ethanol; water / 1 h / 60 °C
2: trichlorophosphate / dichloromethane / 2 h / Reflux
3: potassium hydroxide / methanol; water / 4 h / Reflux
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide
View Scheme
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

A

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylarnino-ethyl)-amide

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylarnino-ethyl)-amide

B

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
A 6.19g (78%)
B n/a
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
1.2: 25 - 30 °C / pH 12 - 13
2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
3.2: 16 h / 25 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux
2: water; potassium hydroxide / methanol / 3 h / Reflux
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux
1.2: 0.5 h / Reflux
2.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere
3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate / dichloromethane / 2 h / Reflux
2: potassium hydroxide / methanol; water / 4 h / Reflux
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide
View Scheme
Multi-step reaction with 3 steps
1.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C
1.2: 1.5 h / Reflux
2.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere
3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate
2436-79-5

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: water; potassium hydroxide / ethanol / 10 h / 50 - 60 °C
2.1: Inert atmosphere
3.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux
3.2: 0.5 h / Reflux
4.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere
5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium hydroxide / ethanol; water / 10 h / 50 °C
2.1: 0.08 h / 200 °C / Inert atmosphere
3.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C
3.2: 1.5 h / Reflux
4.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere
5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester
5442-91-1

3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux
2.2: 0.5 h / Reflux
3.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere
4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 0.08 h / 200 °C / Inert atmosphere
2.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C
2.2: 1.5 h / Reflux
3.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere
4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C
View Scheme
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
590424-05-8

N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With oxalyl dichloride In dichloromethane at 0 - 10℃; for 2.5h; Inert atmosphere;
Stage #2: N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide In dichloromethane at 30℃;
tert-butyl 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate
590424-04-7

tert-butyl 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C
2.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere
2.2: 30 °C
View Scheme
N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dichloromethane / 0.5 h / 0 - 20 °C
2.1: zinc / methanol; acetic acid / 65 - 70 °C
3.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C
4.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere
4.2: 30 °C
View Scheme
N-(2-(diethylamino)ethyl)-3-oxobutanamide
590424-03-6

N-(2-(diethylamino)ethyl)-3-oxobutanamide

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: zinc / methanol; acetic acid / 65 - 70 °C
2.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C
3.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere
3.2: 30 °C
View Scheme
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib
557795-19-4

sunitinib

Conditions
ConditionsYield
With piperidine In toluene for 3h; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux;97.3%
With piperidine In toluene for 3h; Reagent/catalyst; Solvent; Reflux;97.3%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3.5h; Aldol Condensation; Darkness; Inert atmosphere;94%
5-bromo-2-indolin-2-one
20870-78-4

5-bromo-2-indolin-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

5-(5-Bromo-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)amide

5-(5-Bromo-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)amide

Conditions
ConditionsYield
With piperidine In ethanol at 90℃; for 6h; Knoevenagel condensation;96%
0.09 g (26%)
0.09 g (26%)
With piperidine In ethanol at 80℃; for 1h;368 mg
C43H37Br2NP2

C43H37Br2NP2

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

C35H51N7O2

C35H51N7O2

Conditions
ConditionsYield
Stage #1: C43H37Br2NP2 With n-butyllithium In tetrahydrofuran at -75℃; for 0.5h;
Stage #2: N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 2h;
91%
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide-α-d1

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide-α-d1

Conditions
ConditionsYield
With 1,3-bis-(2,4,6-trimethylphenyl)-4,5-dihydro-3H-imidazol-1-ium bromide; water-d2; potassium carbonate In dichloromethane at 80℃; for 12h;88%
(S)-Malic acid
97-67-6

(S)-Malic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
1200435-83-1

L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide

Conditions
ConditionsYield
In dichloromethane at 25 - 30℃;86%
In butan-1-ol at 57℃;
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(S)-Malic acid
97-67-6

(S)-Malic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib L-malate

sunitinib L-malate

Conditions
ConditionsYield
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In ethanol for 1.5h; Reflux;
Stage #2: (S)-Malic acid In ethanol Product distribution / selectivity;
84%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

tert-butyl-3-[(tert-butoxycarbonyl)(2-(diethylamino)ethyl)carbamoyl]-5-formyl-2,4-dimethyl-1H-pyrrole-1-carboxylate

tert-butyl-3-[(tert-butoxycarbonyl)(2-(diethylamino)ethyl)carbamoyl]-5-formyl-2,4-dimethyl-1H-pyrrole-1-carboxylate

Conditions
ConditionsYield
Stage #1: N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With dmap In dichloromethane at 20℃; for 0.166667h;
Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 50h;
84%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(S)-Malic acid
97-67-6

(S)-Malic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
With pyrrolidine In ethanol at 78℃; for 3h;80%
With pyrrolidine In ethanol at 78℃; for 3h;80%
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In butan-1-ol at 48℃;
Stage #2: 5-fluoroindol-2(3H)-one With pyrrolidine In butan-1-ol at 94℃; Product distribution / selectivity;
71.2%
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In ethanol at 8 - 10℃; Reflux;
Stage #2: (S)-Malic acid In ethanol for 4 - 6h; Product distribution / selectivity; Reflux;
71%
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 4 - 6h;
Stage #2: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux;
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2-(N,N-diethylamino)ethyl ammonium di(L-malate)

2-(N,N-diethylamino)ethyl ammonium di(L-malate)

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;80%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(S)-Malic acid
97-67-6

(S)-Malic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide L-malate

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide L-malate

Conditions
ConditionsYield
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In ethanol at 78℃; for 1.5h;
Stage #2: (S)-Malic acid In ethanol at 78℃; for 1h;
80%
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

C14H24N3O5S(1-)*Na(1+)
1338703-87-9

C14H24N3O5S(1-)*Na(1+)

Conditions
ConditionsYield
With sodium hydrogensulfite In ethanol; water at 10 - 20℃;79%
piperidine
110-89-4

piperidine

4-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one
442562-94-9

4-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

5-[4-(3-Methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide

5-[4-(3-Methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide

Conditions
ConditionsYield
In ethanol78%
5-hydroxy-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

5-hydroxy-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-N-(2-(diethylamino)ethyl)-5-((5-hydroxy-4,6-dimethyl-2-oxo-1H-pyrrolo[2,3-b]pyridin-3(2H)-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-N-(2-(diethylamino)ethyl)-5-((5-hydroxy-4,6-dimethyl-2-oxo-1H-pyrrolo[2,3-b]pyridin-3(2H)-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With piperidine In ethanol for 20h; Knoevenagel Condensation; Reflux;77%
5-iodo-1,3-dihydro-indol-2-one
193354-13-1

5-iodo-1,3-dihydro-indol-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-iodo-1,2-dihydro-2-oxo-3H-indole-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
1372783-13-5

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-iodo-1,2-dihydro-2-oxo-3H-indole-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With piperidine In ethanol at 90℃; for 5h; Knoevenagel condensation;76%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

acetic acid
64-19-7

acetic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib acetate
1221149-36-5

sunitinib acetate

Conditions
ConditionsYield
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In butan-1-ol at 20℃; Reflux;
Stage #2: acetic acid In butan-1-ol Reflux;
75.3%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;75%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

di-(n-propyl ammonium) L-malate

di-(n-propyl ammonium) L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;75%
6-chloro-2-oxindole
56341-37-8

6-chloro-2-oxindole

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((6-chloro-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((6-chloro-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;74%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

di-(diisopropyl ammonium) L-malate

di-(diisopropyl ammonium) L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;72.5%
piperidine
110-89-4

piperidine

4-(4-methoxy-phenyl)-1,3-dihydro-indol-2-one
442562-93-8

4-(4-methoxy-phenyl)-1,3-dihydro-indol-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

5-[4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-[4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

Conditions
ConditionsYield
In ethanol72%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2-(N,N-diethylamino)ethyl ammonium L-malate
1332307-07-9

2-(N,N-diethylamino)ethyl ammonium L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;72%
piperidine
110-89-4

piperidine

4-(4-fluoro-phenyl)-1,3-dihydro-indol-2-one
442562-87-0

4-(4-fluoro-phenyl)-1,3-dihydro-indol-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

5-[4-(4-Fluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-[4-(4-Fluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

Conditions
ConditionsYield
In ethanol70%
(S)-Malic acid
97-67-6

(S)-Malic acid

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
1374685-40-1

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux;
Stage #2: (S)-Malic acid In methanol; acetonitrile at 20℃; for 22h;
70%
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux;
Stage #2: (S)-Malic acid In methanol for 24h;
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 9.5h; Reflux;
Stage #2: (S)-Malic acid In methanol for 24h;
5-(2-azidoethyl)indolin-2-one

5-(2-azidoethyl)indolin-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((5-(2-azidoethyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((5-(2-azidoethyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;68%
piperidine
110-89-4

piperidine

4-(3-bromo-phenyl)-1,3-dihydro-indol-2-one
442562-92-7

4-(3-bromo-phenyl)-1,3-dihydro-indol-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

A

5-l4-(3-Bromophenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-l4-(3-Bromophenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

B

5-[4-(3-bromo-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

5-[4-(3-bromo-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1 H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

Conditions
ConditionsYield
In ethanolA 67%
B n/a
5-azaindolin-2-one
134682-54-5

5-azaindolin-2-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-1H-pyrrolo[3,2-c]pyridin-3(2H)-ylidene)methyl)-1H-pyrrole-3-carboxamide
1350702-94-1

(Z)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-1H-pyrrolo[3,2-c]pyridin-3(2H)-ylidene)methyl)-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With piperidine In methanol for 5h; Reflux;62%
N-(2-(2-oxoindolin-5-yl)ethyl)acetamide

N-(2-(2-oxoindolin-5-yl)ethyl)acetamide

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((5-(2-acetamidoethyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

(Z)-5-((5-(2-acetamidoethyl)-2-oxoindolin-3-ylidene)methyl)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
With pyrrolidine In ethanol for 3h; Reflux;62%

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