Product name:(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide Cas No:356068-86-5 Assay: 98%min Hangzhou Verychem Science And Technology Co. Ltd. was set up in year 2004, it’s a young but fast growing company. In
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero
Cas:356068-86-5
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:356068-86-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:356068-86-5
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:356068-86-5
Min.Order:1
Negotiable
Type:Other
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:356068-86-5
Min.Order:0
Negotiable
Type:Trading Company
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:356068-86-5
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:356068-86-5
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:356068-86-5
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:356068-86-5
Min.Order:1 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:356068-86-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryProduct: Sunitinib Intermediate Chemical name:N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Batch NO: 20210129 Analysis Date: 2021-01-29 Expiry Date: 2023-01-28 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is a
Cas:356068-86-5
Min.Order:1 Kilogram
FOB Price: $1300.0 / 1350.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:356068-86-5
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time . Appearance:Refer to COA Storage:Store in dry, cool and ventilated place Package:A
Cas:356068-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryN-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide CAS:356068-86-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int
Cas:356068-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryN-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3- CAS: 356068-86-5 Specification Inspection Standard Test Results Appearance Light yellow to brown color so
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:356068-86-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:356068-86-5
Min.Order:0
Negotiable
Type:Manufacturers
inquirySunitinib intermediate CAS No: 356068-86-5 Product Name: N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide CAS No: 356068-86-5 Molecular Formula: C14H23N3O2 Molecular Weight: 265.355 Usage: Sunitinib intermediate A
Cas:356068-86-5
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,
Cas:356068-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:356068-86-5
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:356068-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:356068-86-5
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:356068-86-5
Min.Order:1 Gram
Negotiable
Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:356068-86-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:356068-86-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Pale brown or Off-white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide
Cas:356068-86-5
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryN-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With water | 100% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
N,N-diethylethylenediamine
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h; | 86.3% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide | 84% |
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: N,N-diethylethylenediamine With triethylamine In N,N-dimethyl-formamide at 20℃; | 80% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
N,N-diethylhydrazine
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 59h; | 86.3% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
benzotriazol-1-ol
N,N-diethylethylenediamine
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene | 43% |
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene | 43% |
With sodium hydroxide; triethylamine In N-methyl-acetamide; methanol; dichloromethane; water; ethyl acetate; toluene | 43% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran / 45 °C 2: imidazole / carbon dioxide / tetrahydrofuran / 45 °C 3: 100 percent / H2O View Scheme |
4-(imidazole-1-carbonyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: imidazole / carbon dioxide / tetrahydrofuran / 45 °C 2: 100 percent / H2O View Scheme |
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / aq. KOH / methanol / 3 h / Heating 2: 50 percent / EDC; HOBt; Et3N / dimethylformamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 2.2: 16 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1: water; potassium hydroxide / methanol / 3 h / Reflux 2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C View Scheme |
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 81 percent / TFA / -5 - 20 °C 2: 90 percent / aq. KOH / methanol / 3 h / Heating 3: 50 percent / EDC; HOBt; Et3N / dimethylformamide / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C 2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 2.2: 25 - 30 °C / pH 12 - 13 3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 4.2: 16 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride; water / ethanol / 3 h / 70 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux 3: water; potassium hydroxide / methanol / 3 h / Reflux 4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / ethanol; water / 1 h / 60 °C 2: trichlorophosphate / dichloromethane / 2 h / Reflux 3: potassium hydroxide / methanol; water / 4 h / Reflux 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide View Scheme |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
N,N-diethylethylenediamine
B
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
A 6.19g (78%) B n/a |
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate / 1,2-dichloro-ethane / 2 h / Reflux 2: water; potassium hydroxide / methanol / 3 h / Reflux 3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux 1.2: 0.5 h / Reflux 2.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere 3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate / dichloromethane / 2 h / Reflux 2: potassium hydroxide / methanol; water / 4 h / Reflux 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide View Scheme | |
Multi-step reaction with 3 steps 1.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C 1.2: 1.5 h / Reflux 2.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere 3.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme |
diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: water; potassium hydroxide / ethanol / 10 h / 50 - 60 °C 2.1: Inert atmosphere 3.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux 3.2: 0.5 h / Reflux 4.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere 5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium hydroxide / ethanol; water / 10 h / 50 °C 2.1: 0.08 h / 200 °C / Inert atmosphere 3.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C 3.2: 1.5 h / Reflux 4.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere 5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme |
3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 4-ethyl ester
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Inert atmosphere 2.1: trichlorophosphate / dichloromethane / 1.5 h / Reflux 2.2: 0.5 h / Reflux 3.1: sodium hydroxide; water / methanol / 4.5 h / 82 - 83 °C / Inert atmosphere 4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 0.08 h / 200 °C / Inert atmosphere 2.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C 2.2: 1.5 h / Reflux 3.1: sodium hydroxide / water; methanol / 4.5 h / Reflux; Inert atmosphere 4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane; N,N-dimethyl-formamide / 59 h / 0 - 20 °C View Scheme |
N,N-dimethyl-formamide
N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: N,N-dimethyl-formamide With oxalyl dichloride In dichloromethane at 0 - 10℃; for 2.5h; Inert atmosphere; Stage #2: N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide In dichloromethane at 30℃; |
tert-butyl 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C 2.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere 2.2: 30 °C View Scheme |
N,N-diethylethylenediamine
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: dichloromethane / 0.5 h / 0 - 20 °C 2.1: zinc / methanol; acetic acid / 65 - 70 °C 3.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C 4.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere 4.2: 30 °C View Scheme |
N-(2-(diethylamino)ethyl)-3-oxobutanamide
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: zinc / methanol; acetic acid / 65 - 70 °C 2.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C 3.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere 3.2: 30 °C View Scheme |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib
Conditions | Yield |
---|---|
With piperidine In toluene for 3h; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux; | 97.3% |
With piperidine In toluene for 3h; Reagent/catalyst; Solvent; Reflux; | 97.3% |
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3.5h; Aldol Condensation; Darkness; Inert atmosphere; | 94% |
5-bromo-2-indolin-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With piperidine In ethanol at 90℃; for 6h; Knoevenagel condensation; | 96% |
0.09 g (26%) | |
0.09 g (26%) | |
With piperidine In ethanol at 80℃; for 1h; | 368 mg |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: C43H37Br2NP2 With n-butyllithium In tetrahydrofuran at -75℃; for 0.5h; Stage #2: N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 2h; | 91% |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With 1,3-bis-(2,4,6-trimethylphenyl)-4,5-dihydro-3H-imidazol-1-ium bromide; water-d2; potassium carbonate In dichloromethane at 80℃; for 12h; | 88% |
(S)-Malic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
Conditions | Yield |
---|---|
In dichloromethane at 25 - 30℃; | 86% |
In butan-1-ol at 57℃; |
5-fluoroindol-2(3H)-one
(S)-Malic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In ethanol for 1.5h; Reflux; Stage #2: (S)-Malic acid In ethanol Product distribution / selectivity; | 84% |
di-tert-butyl dicarbonate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With dmap In dichloromethane at 20℃; for 0.166667h; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 50h; | 84% |
5-fluoroindol-2(3H)-one
(S)-Malic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
With pyrrolidine In ethanol at 78℃; for 3h; | 80% |
With pyrrolidine In ethanol at 78℃; for 3h; | 80% |
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In butan-1-ol at 48℃; Stage #2: 5-fluoroindol-2(3H)-one With pyrrolidine In butan-1-ol at 94℃; Product distribution / selectivity; | 71.2% |
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In ethanol at 8 - 10℃; Reflux; Stage #2: (S)-Malic acid In ethanol for 4 - 6h; Product distribution / selectivity; Reflux; | 71% |
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 4 - 6h; Stage #2: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux; |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 80% |
5-fluoroindol-2(3H)-one
(S)-Malic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In ethanol at 78℃; for 1.5h; Stage #2: (S)-Malic acid In ethanol at 78℃; for 1h; | 80% |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
C14H24N3O5S(1-)*Na(1+)
Conditions | Yield |
---|---|
With sodium hydrogensulfite In ethanol; water at 10 - 20℃; | 79% |
piperidine
4-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
In ethanol | 78% |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With piperidine In ethanol for 20h; Knoevenagel Condensation; Reflux; | 77% |
5-iodo-1,3-dihydro-indol-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-iodo-1,2-dihydro-2-oxo-3H-indole-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With piperidine In ethanol at 90℃; for 5h; Knoevenagel condensation; | 76% |
5-fluoroindol-2(3H)-one
acetic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib acetate
Conditions | Yield |
---|---|
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With pyrrolidine In butan-1-ol at 20℃; Reflux; Stage #2: acetic acid In butan-1-ol Reflux; | 75.3% |
5-fluoroindol-2(3H)-one
L-malic acid ; ammonium-L malate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 75% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 75% |
6-chloro-2-oxindole
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With pyrrolidine In ethanol for 3h; Reflux; | 74% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 72.5% |
piperidine
4-(4-methoxy-phenyl)-1,3-dihydro-indol-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
In ethanol | 72% |
5-fluoroindol-2(3H)-one
2-(N,N-diethylamino)ethyl ammonium L-malate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 72% |
piperidine
4-(4-fluoro-phenyl)-1,3-dihydro-indol-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
In ethanol | 70% |
(S)-Malic acid
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux; Stage #2: (S)-Malic acid In methanol; acetonitrile at 20℃; for 22h; | 70% |
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux; Stage #2: (S)-Malic acid In methanol for 24h; | |
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 9.5h; Reflux; Stage #2: (S)-Malic acid In methanol for 24h; |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With pyrrolidine In ethanol for 3h; Reflux; | 68% |
piperidine
4-(3-bromo-phenyl)-1,3-dihydro-indol-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
In ethanol | A 67% B n/a |
5-azaindolin-2-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
(Z)-N-(2-(diethylamino)ethyl)-2,4-dimethyl-5-((2-oxo-1H-pyrrolo[3,2-c]pyridin-3(2H)-ylidene)methyl)-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With piperidine In methanol for 5h; Reflux; | 62% |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Conditions | Yield |
---|---|
With pyrrolidine In ethanol for 3h; Reflux; | 62% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View