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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Sunitinib Malate

Cas:341031-54-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Yangzhou Qinyuan Pharmatech Co.,Ltd

Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero

Sunitinib Malate

Cas:341031-54-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hangzhou ZeErRui Chemical Co., Ltd.

roduct Name: Sunitinib Malate Assay: 99.0% Cas No.: 341031-54-7 usage:It has multiple effects of inhibiting angiogenesis and anti-tumor cell growth. Appearance:light yellow cr

Sunitinib Malate manufacture

Cas:341031-54-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Anti-tumor

Sunitinib Malate

Cas:341031-54-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Hangzhou Hysen Pharma co.,Ltd.

we are professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in Hangzho

Sunitinib malate CAS:341031-54-7

Cas:341031-54-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

We are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical CAS 341031-54-7

Sunitinib Malate high purity 98%

Cas:341031-54-7

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Characters Brown to reddish brown powder confirms Single impurity ≤

High purity Various Specifications Sunitinib malate CAS:341031-54-7

Cas:341031-54-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Sunitinib Malate 341031-54-7 API

Cas:341031-54-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Sunitinib malate CAS 341031-54-7 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distrib

Sunitinib malate CAS 341031-54-7

Cas:341031-54-7

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Sunitinib malate CAS No.:341031-54-7 Name: Sunitinib malate Synonyms: N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydrox

High purity Sunitinib malate CAS No.:341031-54-7

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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EAST CHEMSOURCES LIMITED

Sunitinib Malate English name: Sunitinib Malate Chemical name: N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybut

Sunitinib Malate

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Sunitinib Malate

Cas:341031-54-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Sunitinib Malate 341031-54-7 GMP Manufacturer

Cas:341031-54-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

Basic information Product Name: Sunitinib Malate Synonyms: Malic acid Shu;N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1

Sunitinib Malate

Cas:341031-54-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Sunitinib malate

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Sunitinib Malate

Cas:341031-54-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Sunitinib Malate CAS NO.341031-54-7

Cas:341031-54-7

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:Sunitinib malate The alias:SUNITINIB MALEATE; 1H-Pyrrole-3-carboxamide, CAS NO: 341031-54-7 Molecular formula:C28H38N4O7 Molecular weight:542.62392 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst

Sunitinib malate/CAS:341031-54-7/Raw material supply

Cas:341031-54-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Sunitinib Malate

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Sunitinib Malate Basic information Anticancer drug Application Product Name: Sunitinib Malate Synonyms: SUNITINIB MALATE;N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihy

TIANFU-CHEM -Sunitinib Malate

Cas:341031-54-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Sunitinib Malate

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 341031-54-7 with competitive price

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Sunitinib Malate

Cas:341031-54-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Sunitinib malate Synonyms Sunitinib malate;4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybu CAS: 341031-54-7 MF: C22H27FN4O2.C4H6O5 M

Sunitinib Malate CAS No 341031-54-7

Cas:341031-54-7

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 341031-54-7 Sunitinib Malate with best price

Cas:341031-54-7

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.More than 8years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specialized in API

Sunitinib malate99%(lower price)

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

99% Assay Chemical Powder Pharmaceutical Intermediate Sunitinib Malate raw powder

Cas:341031-54-7

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

professionally supply Intermediate 5-Chloroindole CAS 17422-32-1

Cas:341031-54-7

Min.Order:1 Kilogram

FOB Price: $2600.0 / 2700.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Sunitinib Malate CAS:341031-54-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Sunitinib Malate CAS:341031-54-7

Cas:341031-54-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-Malic acid
97-67-6

(S)-Malic acid

sunitinib
557795-19-4

sunitinib

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; ethanol at 20℃; for 2h; Darkness;100%
In ethanol for 2 - 4h; Product distribution / selectivity; Reflux; Industry scale;93.6%
In ethanol for 2 - 4h; Product distribution / selectivity; Reflux;93.6%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(S)-Malic acid
97-67-6

(S)-Malic acid

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
With pyrrolidine In ethanol at 78℃; for 3h;80%
With pyrrolidine In ethanol at 78℃; for 3h;80%
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In butan-1-ol at 48℃;
Stage #2: 5-fluoroindol-2(3H)-one With pyrrolidine In butan-1-ol at 94℃; Product distribution / selectivity;
71.2%
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In ethanol at 8 - 10℃; Reflux;
Stage #2: (S)-Malic acid In ethanol for 4 - 6h; Product distribution / selectivity; Reflux;
71%
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 4 - 6h;
Stage #2: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux;
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2-(N,N-diethylamino)ethyl ammonium di(L-malate)

2-(N,N-diethylamino)ethyl ammonium di(L-malate)

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;80%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
1200435-83-1

L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
With pyrrolidine In butan-1-ol at 20℃; Reflux;75.1%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;75%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

di-(n-propyl ammonium) L-malate

di-(n-propyl ammonium) L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;75%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

di-(diisopropyl ammonium) L-malate

di-(diisopropyl ammonium) L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;72.5%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

2-(N,N-diethylamino)ethyl ammonium L-malate
1332307-07-9

2-(N,N-diethylamino)ethyl ammonium L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;72%
(S)-Malic acid
97-67-6

(S)-Malic acid

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
1374685-40-1

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux;
Stage #2: (S)-Malic acid In methanol; acetonitrile at 20℃; for 22h;
70%
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux;
Stage #2: (S)-Malic acid In methanol for 24h;
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 9.5h; Reflux;
Stage #2: (S)-Malic acid In methanol for 24h;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

(S)-Malic acid
97-67-6

(S)-Malic acid

N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; N,N-diethylethylenediamine With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran for 20h;
Stage #2: (S)-Malic acid In tetrahydrofuran for 4 - 6h; Reflux;
Stage #3: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux;
67%
2-(N,N-diethylamino)ethyl ammonium L-malate
1332307-07-9

2-(N,N-diethylamino)ethyl ammonium L-malate

5-fluoro-2-oxindole
1032268-12-4

5-fluoro-2-oxindole

C14H24N3O5S(1-)*Na(1+)
1338703-87-9

C14H24N3O5S(1-)*Na(1+)

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;67%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

dipyrrolidine L-malate

dipyrrolidine L-malate

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
In methanol; acetonitrile at 25 - 30℃; for 3h;32%
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyrrolidine / methanol / 5 - 7 h / Reflux
2: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 7 h / Reflux
1.2: 3 h / 20 - 60 °C
2.1: methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: 25 °C
View Scheme
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2199-59-9

ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
2.2: 16 h / 25 - 30 °C
3.1: pyrrolidine / methanol / 5 - 7 h / Reflux
4.1: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
2.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h
2.2: 4 - 6 h / Reflux
2.3: 4 - 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
2.2: 16 h / 25 - 30 °C
3.1: ethanol / 8 - 10 °C / Reflux
3.2: 4 - 6 h / Reflux
View Scheme
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
86770-31-2

2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C
2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
2.2: 25 - 30 °C / pH 12 - 13
3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
4.2: 16 h / 25 - 30 °C
5.1: pyrrolidine / methanol / 5 - 7 h / Reflux
6.1: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C
2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
2.2: 25 - 30 °C / pH 12 - 13
3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
4.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h
4.2: 4 - 6 h / Reflux
4.3: 4 - 6 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C
2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
2.2: 25 - 30 °C / pH 12 - 13
3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
4.2: 16 h / 25 - 30 °C
5.1: ethanol / 8 - 10 °C / Reflux
5.2: 4 - 6 h / Reflux
View Scheme
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9

5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
1.2: 16 h / 25 - 30 °C
2.1: pyrrolidine / methanol / 5 - 7 h / Reflux
3.1: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
1.2: 16 h / 25 - 30 °C
2.1: ethanol / 8 - 10 °C / Reflux
2.2: 4 - 6 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h
2.2: 25 °C
3.1: N,N-dimethyl-formamide / 25 °C
4.1: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / 5 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 25 °C
2.2: 1 h / 40 °C
3.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C
4.1: methanol / 0.5 h / 20 °C / Inert atmosphere
4.2: 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 35 °C / Large scale
1.2: 2 h / 35 °C / Large scale
2.1: triethylamine / 2 h / 60 °C / Large scale
3.1: methanol / 1 h / 40 °C / Large scale
View Scheme
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine / 5.5 h / 100 - 130 °C
2: pyrrolidine / methanol / 5 - 7 h / Reflux
3: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: hydrazine / 5.5 h / 100 - 130 °C
2.1: ethanol / 8 - 10 °C / Reflux
2.2: 4 - 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: hydrazine / 5.5 h / 100 - 130 °C
2.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h
2.2: 4 - 6 h / Reflux
2.3: 4 - 6 h / Reflux
View Scheme
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
2199-51-1

2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
1.2: 25 - 30 °C / pH 12 - 13
2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
3.2: 16 h / 25 - 30 °C
4.1: pyrrolidine / methanol / 5 - 7 h / Reflux
5.1: ethanol / 2 - 4 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
1.2: 25 - 30 °C / pH 12 - 13
2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
3.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h
3.2: 4 - 6 h / Reflux
3.3: 4 - 6 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C
1.2: 25 - 30 °C / pH 12 - 13
2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C
3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h
3.2: 16 h / 25 - 30 °C
4.1: ethanol / 8 - 10 °C / Reflux
4.2: 4 - 6 h / Reflux
View Scheme
N,N-diethylethylenediamine
100-36-7

N,N-diethylethylenediamine

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 1 h / 25 - 30 °C
2: acetonitrile; methanol / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1: methanol / 1 h / 25 - 30 °C
2: acetonitrile; methanol / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 15 - 19 °C
1.2: 15 - 19 °C
1.3: 0.67 h / 13 - 16 °C
2.1: methanol / 25 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dichloromethane / 0.5 h / 0 - 20 °C
2.1: zinc / methanol; acetic acid / 65 - 70 °C
3.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C
4.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere
4.2: 30 °C
5.1: potassium hydroxide / N,N-dimethyl-formamide / 3.5 h / 20 °C / Darkness; Inert atmosphere
6.1: methanol; ethanol / 2 h / 20 °C / Darkness
View Scheme
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 35 °C / Large scale
1.2: 2 h / 35 °C / Large scale
2.1: triethylamine / 2 h / 60 °C / Large scale
3.1: methanol / 1 h / 40 °C / Large scale
View Scheme
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5

N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogensulfite / ethanol; water / 10 - 20 °C
2: acetonitrile; methanol / 3 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux
1.2: 29.3 h / Reflux
2.1: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
5-fluoroindol-2(3H)-one
56341-41-4

5-fluoroindol-2(3H)-one

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux
1.2: 29.3 h / Reflux
2.1: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: ammonium sulfate / Inert atmosphere; Reflux
2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 13 h / Reflux
2.2: 22 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: ammonium sulfate / Inert atmosphere; Reflux
2: trimethylsilyl trifluoromethanesulfonate / N,N-dimethyl-formamide; acetonitrile / Reflux
3: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
356068-93-4

5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h
1.2: 25 °C
2.1: N,N-dimethyl-formamide / 25 °C
3.1: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 25 °C
1.2: 1 h / 40 °C
2.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C
3.1: methanol / 0.5 h / 20 °C / Inert atmosphere
3.2: 25 °C
View Scheme
Multi-step reaction with 2 steps
1.1: p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 15 - 19 °C
1.2: 15 - 19 °C
1.3: 0.67 h / 13 - 16 °C
2.1: methanol / 25 - 30 °C
View Scheme
(Z)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate
452105-55-4

(Z)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 25 °C
2: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C
2.1: methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: 25 °C
View Scheme
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, hydrochloride

N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, hydrochloride

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 90 °C / pH 8 - 9
2: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
sunitinib mesylate

sunitinib mesylate

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 80 °C / pH 8 - 9
2: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
1374685-40-1

5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trimethylsilyl trifluoromethanesulfonate / N,N-dimethyl-formamide; acetonitrile / Reflux
2: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane / trifluorormethanesulfonic acid / acetonitrile / 48 h / 20 - 65 °C
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h
2.2: 25 °C
3.1: N,N-dimethyl-formamide / 25 °C
4.1: methanol / 8 h / 25 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile; N,N-dimethyl-formamide / Reflux
2.1: methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: 25 °C
View Scheme
sunitinib hydrochloride
1327155-72-5

sunitinib hydrochloride

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water / 90 °C
2.1: methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: 25 °C
View Scheme
sunitinib methanesulfonic acid
1275588-72-1

sunitinib methanesulfonic acid

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water / 80 °C
2.1: methanol / 0.5 h / 20 °C / Inert atmosphere
2.2: 25 °C
View Scheme
N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
590424-05-8

N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

sunitinib malate
341031-54-7

sunitinib malate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere
1.2: 30 °C
2.1: potassium hydroxide / N,N-dimethyl-formamide / 3.5 h / 20 °C / Darkness; Inert atmosphere
3.1: methanol; ethanol / 2 h / 20 °C / Darkness
View Scheme
sunitinib malate
341031-54-7

sunitinib malate

(Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-yliden)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide L-malate

(Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-yliden)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide L-malate

Conditions
ConditionsYield
In ethanol Product distribution / selectivity; Reflux;
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