Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:341031-54-7
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inquiryOur products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional team. 3.Track record of quality, Lot to lot consistency. 4.Zero
roduct Name: Sunitinib Malate Assay: 99.0% Cas No.: 341031-54-7 usage:It has multiple effects of inhibiting angiogenesis and anti-tumor cell growth. Appearance:light yellow cr
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inquiry1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Anti-tumor
we are professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in Hangzho
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inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical CAS 341031-54-7
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inquiryItems Standard Result Characters Brown to reddish brown powder confirms Single impurity ≤
Cas:341031-54-7
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Type:Manufacturers
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
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inquirySunitinib malate CAS 341031-54-7 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distrib
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inquirySunitinib malate CAS No.:341031-54-7 Name: Sunitinib malate Synonyms: N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydrox
Cas:341031-54-7
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inquirySunitinib Malate English name: Sunitinib Malate Chemical name: N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybut
Cas:341031-54-7
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryBasic information Product Name: Sunitinib Malate Synonyms: Malic acid Shu;N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:341031-54-7
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inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cas:341031-54-7
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inquiryName:Sunitinib malate The alias:SUNITINIB MALEATE; 1H-Pyrrole-3-carboxamide, CAS NO: 341031-54-7 Molecular formula:C28H38N4O7 Molecular weight:542.62392 Product Quality 12 years of chemical raw materials Mature operation of the industry Syst
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
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inquirySunitinib Malate Basic information Anticancer drug Application Product Name: Sunitinib Malate Synonyms: SUNITINIB MALATE;N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihy
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:341031-54-7
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Product Name Sunitinib malate Synonyms Sunitinib malate;4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybu CAS: 341031-54-7 MF: C22H27FN4O2.C4H6O5 M
Cas:341031-54-7
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inquiry1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:341031-54-7
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inquiry1.More than 8years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specialized in API
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:341031-54-7
Min.Order:10 Gram
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Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:341031-54-7
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Type:Trading Company
inquirySunitinib Malate CAS:341031-54-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in
Cas:341031-54-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
In methanol; ethanol at 20℃; for 2h; Darkness; | 100% |
In ethanol for 2 - 4h; Product distribution / selectivity; Reflux; Industry scale; | 93.6% |
In ethanol for 2 - 4h; Product distribution / selectivity; Reflux; | 93.6% |
5-fluoroindol-2(3H)-one
(S)-Malic acid
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
With pyrrolidine In ethanol at 78℃; for 3h; | 80% |
With pyrrolidine In ethanol at 78℃; for 3h; | 80% |
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In butan-1-ol at 48℃; Stage #2: 5-fluoroindol-2(3H)-one With pyrrolidine In butan-1-ol at 94℃; Product distribution / selectivity; | 71.2% |
Stage #1: 5-fluoroindol-2(3H)-one; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In ethanol at 8 - 10℃; Reflux; Stage #2: (S)-Malic acid In ethanol for 4 - 6h; Product distribution / selectivity; Reflux; | 71% |
Stage #1: (S)-Malic acid; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide In tetrahydrofuran for 4 - 6h; Stage #2: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux; |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 80% |
5-fluoroindol-2(3H)-one
L-(-)-malic acid of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
sunitinib malate
Conditions | Yield |
---|---|
With pyrrolidine In butan-1-ol at 20℃; Reflux; | 75.1% |
5-fluoroindol-2(3H)-one
L-malic acid ; ammonium-L malate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 75% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 75% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 72.5% |
5-fluoroindol-2(3H)-one
2-(N,N-diethylamino)ethyl ammonium L-malate
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 72% |
(S)-Malic acid
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux; Stage #2: (S)-Malic acid In methanol; acetonitrile at 20℃; for 22h; | 70% |
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 13h; Reflux; Stage #2: (S)-Malic acid In methanol for 24h; | |
Stage #1: 5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 9.5h; Reflux; Stage #2: (S)-Malic acid In methanol for 24h; |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
(S)-Malic acid
N,N-diethylethylenediamine
sunitinib malate
Conditions | Yield |
---|---|
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; N,N-diethylethylenediamine With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran for 20h; Stage #2: (S)-Malic acid In tetrahydrofuran for 4 - 6h; Reflux; Stage #3: 5-fluoroindol-2(3H)-one In tetrahydrofuran for 4 - 6h; Product distribution / selectivity; Reflux; | 67% |
2-(N,N-diethylamino)ethyl ammonium L-malate
5-fluoro-2-oxindole
C14H24N3O5S(1-)*Na(1+)
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 67% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
In methanol; acetonitrile at 25 - 30℃; for 3h; | 32% |
5-fluoroindol-2(3H)-one
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyrrolidine / methanol / 5 - 7 h / Reflux 2: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 7 h / Reflux 1.2: 3 h / 20 - 60 °C 2.1: methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: 25 °C View Scheme |
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 2.2: 16 h / 25 - 30 °C 3.1: pyrrolidine / methanol / 5 - 7 h / Reflux 4.1: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 2.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h 2.2: 4 - 6 h / Reflux 2.3: 4 - 6 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 2.2: 16 h / 25 - 30 °C 3.1: ethanol / 8 - 10 °C / Reflux 3.2: 4 - 6 h / Reflux View Scheme |
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C 2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 2.2: 25 - 30 °C / pH 12 - 13 3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 4.2: 16 h / 25 - 30 °C 5.1: pyrrolidine / methanol / 5 - 7 h / Reflux 6.1: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C 2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 2.2: 25 - 30 °C / pH 12 - 13 3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 4.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h 4.2: 4 - 6 h / Reflux 4.3: 4 - 6 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / isopropyl alcohol / 25 - 50 °C 2.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 2.2: 25 - 30 °C / pH 12 - 13 3.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 4.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 4.2: 16 h / 25 - 30 °C 5.1: ethanol / 8 - 10 °C / Reflux 5.2: 4 - 6 h / Reflux View Scheme |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 1.2: 16 h / 25 - 30 °C 2.1: pyrrolidine / methanol / 5 - 7 h / Reflux 3.1: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 1.2: 16 h / 25 - 30 °C 2.1: ethanol / 8 - 10 °C / Reflux 2.2: 4 - 6 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h 2.2: 25 °C 3.1: N,N-dimethyl-formamide / 25 °C 4.1: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane / 5 h / Reflux 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 25 °C 2.2: 1 h / 40 °C 3.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C 4.1: methanol / 0.5 h / 20 °C / Inert atmosphere 4.2: 25 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 35 °C / Large scale 1.2: 2 h / 35 °C / Large scale 2.1: triethylamine / 2 h / 60 °C / Large scale 3.1: methanol / 1 h / 40 °C / Large scale View Scheme |
5-fluoro-1H-indole-2,3-dione
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine / 5.5 h / 100 - 130 °C 2: pyrrolidine / methanol / 5 - 7 h / Reflux 3: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrazine / 5.5 h / 100 - 130 °C 2.1: ethanol / 8 - 10 °C / Reflux 2.2: 4 - 6 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrazine / 5.5 h / 100 - 130 °C 2.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h 2.2: 4 - 6 h / Reflux 2.3: 4 - 6 h / Reflux View Scheme |
2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C 4.1: pyrrolidine / methanol / 5 - 7 h / Reflux 5.1: ethanol / 2 - 4 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 20 h 3.2: 4 - 6 h / Reflux 3.3: 4 - 6 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C 4.1: ethanol / 8 - 10 °C / Reflux 4.2: 4 - 6 h / Reflux View Scheme |
N,N-diethylethylenediamine
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol / 1 h / 25 - 30 °C 2: acetonitrile; methanol / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1: methanol / 1 h / 25 - 30 °C 2: acetonitrile; methanol / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 15 - 19 °C 1.2: 15 - 19 °C 1.3: 0.67 h / 13 - 16 °C 2.1: methanol / 25 - 30 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: dichloromethane / 0.5 h / 0 - 20 °C 2.1: zinc / methanol; acetic acid / 65 - 70 °C 3.1: sulfuric acid / water; methanol / 3.5 h / 60 - 65 °C 4.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere 4.2: 30 °C 5.1: potassium hydroxide / N,N-dimethyl-formamide / 3.5 h / 20 °C / Darkness; Inert atmosphere 6.1: methanol; ethanol / 2 h / 20 °C / Darkness View Scheme | |
Multi-step reaction with 3 steps 1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 2 h / 35 °C / Large scale 1.2: 2 h / 35 °C / Large scale 2.1: triethylamine / 2 h / 60 °C / Large scale 3.1: methanol / 1 h / 40 °C / Large scale View Scheme |
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogensulfite / ethanol; water / 10 - 20 °C 2: acetonitrile; methanol / 3 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux 1.2: 29.3 h / Reflux 2.1: methanol / 8 h / 25 °C / Inert atmosphere View Scheme |
5-fluoroindol-2(3H)-one
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1,1,1,3,3,3-hexamethyl-disilazane / ammonium sulfate / 5 h / Reflux 1.2: 29.3 h / Reflux 2.1: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium sulfate / Inert atmosphere; Reflux 2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 13 h / Reflux 2.2: 22 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: ammonium sulfate / Inert atmosphere; Reflux 2: trimethylsilyl trifluoromethanesulfonate / N,N-dimethyl-formamide; acetonitrile / Reflux 3: methanol / 8 h / 25 °C / Inert atmosphere View Scheme |
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h 1.2: 25 °C 2.1: N,N-dimethyl-formamide / 25 °C 3.1: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 25 °C 1.2: 1 h / 40 °C 2.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C 3.1: methanol / 0.5 h / 20 °C / Inert atmosphere 3.2: 25 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 15 - 19 °C 1.2: 15 - 19 °C 1.3: 0.67 h / 13 - 16 °C 2.1: methanol / 25 - 30 °C View Scheme |
(Z)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 25 °C 2: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: acetonitrile; N,N-dimethyl-formamide / 1 h / 25 °C 2.1: methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: 25 °C View Scheme |
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 90 °C / pH 8 - 9 2: methanol / 8 h / 25 °C / Inert atmosphere View Scheme |
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 80 °C / pH 8 - 9 2: methanol / 8 h / 25 °C / Inert atmosphere View Scheme |
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trimethylsilyl trifluoromethanesulfonate / N,N-dimethyl-formamide; acetonitrile / Reflux 2: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: 1,1,1,3,3,3-hexamethyl-disilazane / trifluorormethanesulfonic acid / acetonitrile / 48 h / 20 - 65 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h 2.2: 25 °C 3.1: N,N-dimethyl-formamide / 25 °C 4.1: methanol / 8 h / 25 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile; N,N-dimethyl-formamide / Reflux 2.1: methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: 25 °C View Scheme |
sunitinib hydrochloride
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: water / 90 °C 2.1: methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: 25 °C View Scheme |
sunitinib methanesulfonic acid
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: water / 80 °C 2.1: methanol / 0.5 h / 20 °C / Inert atmosphere 2.2: 25 °C View Scheme |
N-(2-(diethylamino)ethyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib malate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: oxalyl dichloride / dichloromethane / 2.5 h / 0 - 10 °C / Inert atmosphere 1.2: 30 °C 2.1: potassium hydroxide / N,N-dimethyl-formamide / 3.5 h / 20 °C / Darkness; Inert atmosphere 3.1: methanol; ethanol / 2 h / 20 °C / Darkness View Scheme |
sunitinib malate
Conditions | Yield |
---|---|
In ethanol Product distribution / selectivity; Reflux; |
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