5-Fluoro-2-oxindole supplier | CasNO.56341-41-4

Name
5-Fluoro-2-oxindole
EINECS 446-540-4
CAS No. 56341-41-4
Article Data75
CAS DataBase
Density 1.311 g/cm³
Solubility
Melting Point 143-147 °C(lit.)
Formula C₈H₆FNO
Boiling Point 307.197 °C at 760 mmHg
Molecular Weight 151.14
Flash Point 139.588 °C
Transport Information
Appearance Light Yellow Crystalline
Safety 22-24/25-45-36/37/322-24/25-45-36/37/39-27-269-27-26
Risk Codes 36/37/38-34
Molecular Structure
Hazard Symbols Xi, C
Synonyms 5-Fluoro-1,3-dihydro-2H-indol-2-one;5-Fluoro-1,3-dihydroindol-2-one;5-Fluoro-2,3-dihydro-2-oxoindole;5-Fluoro-2-oxoindoline;5-Fluoroindolin-2-one;5-Fluoro-1,3-dihydro-indol-2-one;
PSA 29.10000
LogP 1.45830

Synthetic route

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;	99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;	87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h; Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;	81.9%

: 389571-36-2
5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2h; Reagent/catalyst; Temperature; Inert atmosphere; Reflux;	92.1%
Stage #1: 5-fluoro-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid methyl ester With hydrogenchloride In methanol; water at 80℃; for 5h; Stage #2: With potassium hydroxide In methanol; water at 40℃; for 0.5h;

: 79-04-9
chloroacetyl chloride

: 371-40-4
4-fluoroaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent);	88%

: 29640-99-1
methyl 2-(5-fluoro-2-nitrophenyl)acetate

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With iron In acetic acid at 100℃; for 1h;	87%

: 18108-55-9
1,3-dihydro-1-hydroxyindole-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With diethylamino-sulfur trifluoride In dichloromethane at 0℃; for 0.0833333h;	81%

: 283584-52-1
5-fluoro-3-hydrazonoindolin-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 5h; Reflux;	80.4%
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere;
With sodium ethanolate

: 351-83-7
4'-fluoroacetanilide

: 623-48-3
ethyl iodoacetae

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;	78%

: 29640-98-0
(5-Fluoro-2-nitro-phenyl)-acetic Acid

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With ammonium formate on silica gel; zinc In carbon dioxide at 50℃; under 90009 Torr; Autoclave; liquid CO2;	76%

: (E)-5-fluoro-3-hydrazonoindolin-2-one

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 6h; Reflux;	73.6%

: 356068-89-8
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
In water	73%
In water	73%
With hydrogenchloride In water at 20℃; for 12h; pH=3;	73%

: 356068-89-8
(2-amino-5-fluoro-phenyl)-acetic acid hydrazide

A 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide: 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide

B: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
In water	A 73% B n/a
In water	A 73% B n/a

: N'-(2-amino-5-fluorobenzylidene)-4-methylbenzenesulfonohydrazide

: 13939-06-5, 199620-15-0
molybdenum hexacarbonyl

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h;	55%

: 351-04-2
2-chloro-N-(4-fluorophenyl)acetamide

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With aluminium trichloride at 220 - 225℃; for 0.5h;	54%
With aluminum (III) chloride at 220℃; for 1h;

: 113423-50-0
3,3-dibromo-5-fluoro-2-oxindole

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With acetic acid; zinc Ambient temperature;

: 138343-99-4
(2-tert-Butoxycarbonylamino-5-fluoro-phenyl)-acetic acid

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 0.25h; Heating; Yield given;

: 371-40-4
4-fluoroaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 54 percent / AlCl3 / 0.5 h / 220 - 225 °C View Scheme
Multi-step reaction with 4 steps 1.1: hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate / water / 60 - 70 °C 2.1: sulfuric acid / 80 - 90 °C 3.1: sulfuric acid; water 4.1: hydrazine hydrate / ethanol / Reflux 4.2: Reflux View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / dichloromethane / 20 °C 2: aluminum (III) chloride / 1 h / 220 °C View Scheme

: 446-35-5
2,4-Difluoronitrobenzene

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1) NaH / 1) DMSO, 100 deg C, 40 min, 2a) RT, 30 min, 2b) 100 deg C, 1 h 2: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C 3: 87 percent / Fe powder / acetic acid / 1 h / 100 °C View Scheme
Multi-step reaction with 3 steps 1: sodium methylate / N,N-dimethyl acetamide / 10 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate; water / 20 °C 3: hydrogenchloride / water; methanol / 2 h / Inert atmosphere; Reflux View Scheme

: 147124-34-3
dimethyl 2-(5-fluoro-2-nitrophenyl)malonate

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 56 percent / LiCl / dimethylsulfoxide; H2O / 3 h / 100 °C 2: 87 percent / Fe powder / acetic acid / 1 h / 100 °C View Scheme

: 452-71-1
4-fluor-2-methylaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / Heating 2: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min 3: 10percent HCl / ethanol / 0.25 h / Heating View Scheme

: 129822-40-8
tert-butyl (4-fluoro-2-methylphenyl)carbamate

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) s-BuLi / 1) THF, cyclohexane, -40 to -20 deg C, 2) -40 deg C, 1 min 2: 10percent HCl / ethanol / 0.25 h / Heating View Scheme

: 399-52-0
5-fluoro-1H-indole

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 48 percent / pyridinium bromide perbromide / 2-methyl-propan-2-ol / 20 h / 25 °C 2: Zn, AcOH / Ambient temperature View Scheme

glacial acid: glacial acid

: 29640-98-0
(5-Fluoro-2-nitro-phenyl)-acetic Acid

: 56341-41-4
5-fluoroindol-2(3H)-one

: 5-fluoro-3-methylthiooxindole

: 507-40-4
tert-butylhypochlorite

: 4455-13-4
methylthioacetic acid ethyl ester

: 371-40-4
4-fluoroaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water

...Expand

5-fluoro-3-methylthio-2-oxindole: 5-fluoro-3-methylthio-2-oxindole

: 507-40-4
tert-butylhypochlorite

: 4455-13-4
methylthioacetic acid ethyl ester

: 371-40-4
4-fluoroaniline

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In diethyl ether; ethanol; dichloromethane; water

...Expand

: 1261152-93-5
C8H5FN2O

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sulfuric acid; water 2.1: hydrazine hydrate / ethanol / Reflux 2.2: Reflux View Scheme

: 351-09-7
N-(4-fluorophenyl)-2-(hydroxyimino) acetamide

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid / 80 - 90 °C 2.1: sulfuric acid; water 3.1: hydrazine hydrate / ethanol / Reflux 3.2: Reflux View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid / 1 h / 50 - 70 °C 2: hydrazine hydrate / ethanol / 0.5 h / Inert atmosphere; Reflux 3: potassium tert-butylate / ethanol / 2 h / Reflux; Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / 0.17 h / Inert atmosphere 2: titanium tetrachloride; zinc / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / water / 50 - 75 °C 2: hydrazine hydrate / water / 6 h / 140 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / 2 h / 60 - 90 °C 2: hydrazine hydrate / water; ethanol / 10 h / 100 °C View Scheme

: 56341-41-4
5-fluoroindol-2(3H)-one

: 42081-15-2
3-bromoazulene-1-carbaldehyde

: 1022916-57-9
(3E)-3-(((4Z,6Z,8E)-1-bromoazulen-3-yl)methylene)-5-fluoroindolin-2-one

Conditions

Conditions	Yield
With piperidine In ethanol for 2h; Heating / reflux;	100%

: 253870-02-9
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 56341-41-4
5-fluoroindol-2(3H)-one

: 452105-33-8
5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions

Conditions	Yield
With pyrrolidine In ethanol for 3h; Reflux;	98%
With pyrrolidine In ethanol for 3h; Reflux;	98.2%
With piperidine In ethanol Inert atmosphere;	90%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 109-94-4
formic acid ethyl ester

: 5-fluoro-3-formyl-1H-indole-2-one

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;	98%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 538-58-9
1,5-diphenyl-1,4-pentadiene-3-one

: 1374637-27-0
5'-fluoro-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione

Conditions

Conditions	Yield
With Boc-D-Phg-OH; 9-amino-9-deoxy-epiquinine In toluene at 40℃; for 72h; Air; optical yield given as %ee; enantioselective reaction;	98%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 356068-86-5
N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

: 557795-19-4
sunitinib

Conditions

Conditions	Yield
With piperidine In toluene for 3h; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux;	97.3%
With piperidine In toluene for 3h; Reagent/catalyst; Solvent; Reflux;	97.3%
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 3.5h; Aldol Condensation; Darkness; Inert atmosphere;	94%

: 253870-02-9
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 56341-41-4
5-fluoroindol-2(3H)-one

: 356068-93-4
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 5-fluoroindol-2(3H)-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 5h; Reflux; Stage #2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With trimethylsilyl trifluoromethanesulfonate	97%
pyrrolidine In ethanol for 3h; Heating / reflux;	96%
With pyrrolidine In ethanol for 3h; Heating / reflux;	96%

: 40236-20-2
3,5-dimethyl-4-nitro-1H-pyrrole-2-carbaldehyde

: 56341-41-4
5-fluoroindol-2(3H)-one

: (3Z)-[(3,5-dimethyl-4-nitro-1-hydropyrrol-2-yl)methylene]-5-fluoro-indol-2-one

Conditions

Conditions	Yield
With pyrrolidine In ethanol Reflux;	96%
With pyrrolidine In ethanol Reflux;	96%
With pyrrolidine In ethanol Reflux;	96%
With piperidine In ethanol Knoevenagel condensation; Heating;	87%
With pyrrolidine In ethanol Reflux;

: 56341-41-4
5-fluoroindol-2(3H)-one

: 944904-42-1
3-iodo-1H-indazole-6-carbaldehyde

: (E)-5-fluoro-3-((3-iodo-1H-indazol-6-yl)methylene)indolin-2-one

Conditions

Conditions	Yield
With piperidine In methanol at 60℃; for 3h;	96%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1194048-25-3
5-[13C]formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-[13C]methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Conditions

Conditions	Yield
With pyrrolidine In ethanol for 3h; Reflux;	95%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 109-77-3
malononitrile

: 116719-42-7
2-(5-fluoro-2-oxoindolin-3-ylidene)malononitrile

Conditions

Conditions	Yield
With iron(III) chloride hexahydrate; oxygen In N,N-dimethyl-formamide at 50℃; for 4h; Green chemistry;	95%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 3952-66-7
methyl 2-oxobutanoate

: C13H14FNO4

Conditions

Conditions	Yield
With piperidine In methanol at 0 - 20℃; for 24h;	93%

: 2795-41-7
6-fluoro-1H-indole-3-carbaldehyde

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1350703-09-1
(Z)-5-fluoro-3-((5-fluoro-1H-indol-3-yl)methylene)indolin-2-one

Conditions

Conditions	Yield
With piperidine In methanol for 5h; Reflux;	92%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 6781-98-2
2,6-dimethyl-1-chlorobenzene

: 1426306-74-2
C16H14FNO

Conditions

Conditions	Yield
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique;	92%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 43192-31-0
2-bromo-4-methoxybenzaldehyde

: 3-(2-bromo-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one

Conditions

Conditions	Yield
With piperidine In ethanol for 1.5h; Reflux;	92%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 399-52-0
5-fluoro-1H-indole

Conditions

Conditions	Yield
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere;	92%
With bis(trimethylsilyl)amide yttrium(III); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Schlenk technique; Sealed tube; Inert atmosphere;	86%

: 56341-41-4
5-fluoroindol-2(3H)-one

: C18H22N4O4

: C34H30F2N6O4

Conditions

Conditions	Yield
Stage #1: C18H22N4O4 With triethylamine In chloroform at 0℃; for 0.166667h; Stage #2: 5-fluoroindol-2(3H)-one In chloroform at 65℃; for 8h; Solvent; Temperature;	92%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 108-24-7
acetic anhydride

: 1268630-22-3
1,3-diacetyl-5-fluoro-1H-indol-2-yl acetate

Conditions

Conditions	Yield
With dmap at 150℃; for 2h;	91%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 90696-21-2
3-(4-methoxyphenyl)propynal

A: C18H12FNO2

: C28H22FNO5

Conditions

Conditions	Yield
With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride In tetrahydrofuran at 20 - 65℃; for 2h; Molecular sieve; Inert atmosphere; optical yield given as %de; diastereoselective reaction;	A 5% B 91%

...Expand

: 56341-41-4
5-fluoroindol-2(3H)-one

: 623-12-1
4-chloromethoxybenzene

: 1426306-75-3
C15H12FNO2

Conditions

Conditions	Yield
With C31H43Cl2N4Pd; potassium tert-butylate In toluene at 100℃; for 12h; Inert atmosphere; Schlenk technique;	91%

: 91-63-4
2-methylquinoline

: 56341-41-4
5-fluoroindol-2(3H)-one

: 5-fluoro-3-hydroxy-3-(quinolin-2-ylmethyl)indolin-2-one

Conditions

Conditions	Yield
With iron(II) acetate In N,N-dimethyl-formamide at 80℃; for 5h; Green chemistry;	91%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 73425-13-5
5-fluoroindoline-2-thione

Conditions

Conditions	Yield
With tetraphosphorus decasulfide; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 4h;	90%
With phosphorous (V) sulfide; sodium hydrogencarbonate In tetrahydrofuran for 3h; Ambient temperature;	84%
Stage #1: 5-fluoroindol-2(3H)-one With tetraphosphorus decasulfide In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In tetrahydrofuran at 120℃; for 1h;	75%
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃;
Stage #1: 5-fluoroindol-2(3H)-one With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: With tetraphosphorus decasulfide In tetrahydrofuran at 20℃;

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1130138-32-7
(R)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

: 1130137-76-6
(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Conditions

Conditions	Yield
With piperidine In ethanol at 20 - 80℃; Darkness;	90%
With piperidine In ethanol at 20 - 80℃; for 2h; Darkness;	90%
With piperidine In ethanol at 20℃;

: 3012-80-4
1-methyl-2-formyl-1H-benzimidazole

: 56341-41-4
5-fluoroindol-2(3H)-one

: (E)-5-fluoro-3-((1-methyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-one

Conditions

Conditions	Yield
With piperidine In ethanol Knoevenagel Condensation; Reflux; stereoselective reaction;	90%

: 253870-02-9
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 56341-41-4
5-fluoroindol-2(3H)-one

: C14H21NO5

: C30H32FN3O7

Conditions

Conditions	Yield
Stage #1: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 35℃; for 3h; Stage #2: 5-fluoroindol-2(3H)-one; C14H21NO5 With triethylamine In tetrahydrofuran; acetonitrile at 60℃; for 24h;	90%

...Expand

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1239441-14-5
3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde

: (Z)-3-({3-[3-(diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-fluoroindolin-2-one

Conditions

Conditions	Yield
With piperidine In ethanol for 12h; Reflux;	90%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 4-(4-formylphenoxy)-3-(trifluoromethyl)benzonitrile

: 4-(4-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

Conditions

Conditions	Yield
With piperidine In ethanol at 60℃;	90%

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1235459-55-8
ethyl 3-(2-formyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate

: 1235458-09-9
(Z)-ethyl 3-{2-[(5-fluoro-2-oxoindolin-3-ylidene)methyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl}propanoate

Conditions

Conditions	Yield
With piperidine In ethanol for 12h; Aldol condensation; Reflux;	89%

5-Fluoro-2-oxindole Chemical Properties

IUPAC Name: 5-Fluoro-1,3-dihydroindol-2-one
Molecular Formula: C₈H₆FNO
Molecular Weight: 151.14 g/mol
Canonical SMILES: C1C2=C(C=CC(=C2)F)NC1=O
InChI: InChI=1S/C8H6FNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
Product Categories: INDOLE; blocks; FluoroCompounds; IndolesOxindoles; Indole/indoline/oxindole; Indole and Indoline; Heterocycles; Indoles and derivatives; Halides; Pyrroles & Indoles; ketone; Sunitinib; Aromatics Compounds; Intermediate of sunitinib malate; Aromatics; Pyrroles & Indoles; Boronic Acid;Heterocyclic Compounds; Building Blocks; Heterocyclic Building Blocks; Indoles; Fluorinated heterocyclic series
Index of Refraction: 1.56
Molar Refractivity: 37.28 cm³
Molar Volume: 115.2 cm³
Polarizability: 14.78×10^-24 cm³
Surface Tension: 41.8 dyne/cm
Density: 1.311 g/cm³
Flash Point: 139.6 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Boiling Point: 307.2 °C at 760 mmHg
Melting Point: 143-147 °C(lit.)
Storage temperature: Keep Cold
Vapour Pressure of 5-Fluorooxindole (CAS NO.56341-41-4): 0.000736 mmHg at 25 °C

5-Fluoro-2-oxindole Safety Profile

Safty informations of 5-Fluorooxindole (CAS NO.56341-41-4):
Hazard Codes: Irritant Xi Corrosive C
Risk Statements: 36/37/38-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R34:Causes burns.
Safety Statements: 22-24/25-45-36/37/39-27-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD

5-Fluoro-2-oxindole Specification

5-Fluorooxindole (CAS NO.56341-41-4), its Synonyms are 5-Fluoroindole-2-One ; 5-Fluoro-1,3-dihydro-indol-2-one ; 5-Fluorooxindole 98% . It is light yellow crystalline.

Product Name

5-Fluoro-2-oxindole

Synthetic route

5-Fluoro-2-oxindole Chemical Properties

5-Fluoro-2-oxindole Safety Profile

5-Fluoro-2-oxindole Specification

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