img _fcksaAppearance:Light Yellow powder Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochem
Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:59-48-3
Min.Order:1 Metric Ton
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
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1. Direct manufacturer 2. Stock available 3. Stable and fine quality 4. Premium service Appearance:white to light yellow crystalline Storage:Refrigerator Package:bag/bottle/drum Application:pharmaceutical intermediate
Oxindole Basic information Product Name: Oxindole Synonyms: OXINDOL;OXINDOLE;O-(AMINOPHENYL)ACETIC ACID LACTAM;TIMTEC-BB SBB004215;1,3-dihydro-2h-indol-2-on;1,3-Dihydro-indol-2-one;1,3-D
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:59-48-3
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:59-48-3
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:59-48-3
Min.Order:10 Kilogram
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inquiryProduct Name: Oxindole Synonyms: Diclofenac Sodium Impurity E;AKOS B028811;1,3-DIHYDRO-2H-INDOL-2-ONE;1,3-DIHYDRO-INDOLE-2-ONE;2-(AMINOPHENYL)ACETIC ACID LACTAM;2-HYDROXYINDOLE;2-INDOLINONE;2-KETOINDOLINE
We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:59-48-3
Min.Order:1 Gram
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla
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Cas:59-48-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryProduct Name: Oxindole CAS: 59-48-3 MF: C8H7NO MW: 133.15 EINECS: 200-429-5 Mol File: 59-48-3.mol Oxindole Structure Oxindole Chemical Properties Melting point 123-128 °C(lit.) Boiling point 227 °C73 mm Hg(lit.) d
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. A
Oxindole CAS:59-48-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste
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Cas:59-48-3
Min.Order:1 Kilogram
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:59-48-3
Min.Order:1 Gram
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Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:59-48-3
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:59-48-3
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct name: Oxindole CAS No.:59-48-3 Molecule Formula:C8H7NO Molecule Weight:133.15 Purity: 98.0% Package: 25kg/drum Description:Light yellow crystalline powder Manufacture Standards:Enterprise Standard TESTING I
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:59-48-3
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Conditions | Yield |
---|---|
Stage #1: indole-2,3-dione With hydrazine In methanol Heating; Stage #2: With sodium ethanolate In ethanol Wolff-Kishner reduction; Heating; Further stages.; | 98% |
With hydrogen In ethanol at 70℃; under 1875.19 Torr; for 0.333333h; | 96.5% |
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.0833333h; Temperature; Reagent/catalyst; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With iron; acetic acid at 100℃; | 95% |
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; for 4h; | 88% |
With 5%-palladium/activated carbon; hydrogen In ethanol; water under 7500.75 Torr; for 24h; Autoclave; | 88% |
methyl (2-nitrophenyl)acetate
2-oxoindole
Conditions | Yield |
---|---|
Stage #1: methyl (2-nitrophenyl)acetate With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 24h; Autoclave; Stage #2: In ethyl acetate for 6h; Reflux; Molecular sieve; | 99% |
With iron; ammonium chloride; acetic acid at 100℃; for 24h; | 87.8% |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 2280.15 Torr / Sealed tube 2: ethyl acetate / 6 h / Reflux; Molecular sieve View Scheme |
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 1h; | A 44% B 8% |
With oxygen; titanium(IV) oxide In water for 4h; Irradiation; | |
With D-glucose; GDH; cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata; nicotinamide adenine dinucleotide phosphate In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction; | |
With nicotinamide adenine dinucleotide phosphate; cytochrome P450 monooxygenase from Labrenzia aggregata In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction; enantioselective reaction; |
1-(toluene-4-sulfonyl)-1,3-dihydro-indol-2-one
2-oxoindole
Conditions | Yield |
---|---|
With naphthalene radical anion sodium salt In 1,2-dimethoxyethane at -78 - 18℃; Reagent/catalyst; | 90% |
Conditions | Yield |
---|---|
With chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III); chloro[5,10,15,20-tetrakis(4-dimethy-lamino-2,3,5,6-tetrafluorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h; | A 35% B 7% |
With ammonium persulfate; phosphoric acid In water pH=1.4; Oxidation; | A 26% B 32% |
ethyl 2-nitrophenylacetate
2-oxoindole
Conditions | Yield |
---|---|
With acetic acid; zinc In ethanol at 70℃; for 4h; Inert atmosphere; | 93% |
With acetic acid; zinc In ethanol at 70℃; for 4h; | 66% |
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 0.5h; | A 64% B 7% C 6% |
indole
A
2-oxoindole
B
indole-2,3-dione
C
2,2-di(3-indolyl)-3-indolone
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h; | A 50% B 6% C 6% |
N'-(2-aminobenzylidene)-4-methylbenzenesulfonohydrazide
molybdenum hexacarbonyl
2-oxoindole
Conditions | Yield |
---|---|
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h; Solvent; Reagent/catalyst; | 83% |
2-(2-nitrophenyl)acetic acid
A
2-oxoindole
B
1,3-dihydro-1-hydroxyindole-2-one
Conditions | Yield |
---|---|
Stage #1: 2-(2-nitrophenyl)acetic acid With 1,10-Phenanthroline; platinum on carbon; hydrogen In ethanol at 20℃; under 7500.75 Torr; Flow reactor; Green chemistry; Stage #2: With acetic acid In ethanol at 20℃; Catalytic behavior; Reagent/catalyst; Solvent; Pressure; Green chemistry; | A n/a B 83% |
With sulfuric acid; zinc at 30℃; | |
With acetic acid; platinum Hydrogenation; |
Conditions | Yield |
---|---|
With potassium carbonate; [pentamethylcyclopentadienylRhCl2]2 In acetone at 100℃; for 8h; | 74% |
Multi-step reaction with 3 steps 1: 1.) aq. HCl, NaNO2, 2.) NaN3 2: 50 percent / Pyridine, CF3COOH, Dicyclohexylcarbodiimide / dimethylsulfoxide; benzene / 0.5 h / 50 °C 3: 85 percent / decahydronaphthalene / 2 h / 190 - 200 °C View Scheme |
Conditions | Yield |
---|---|
With sodium In ethanol Reflux; | 69% |
1,4-diaza-bicyclo[2.2.2]octane In 2-Ethylhexyl alcohol; water at 130 - 145℃; for 3.5 - 5h; Heating / reflux; | 66.5% |
1,4-diaza-bicyclo[2.2.2]octane In 2-Ethylhexyl alcohol; hexan-1-ol at 130℃; for 2.5h; | 66.5% |
at 255℃; under 90 Torr; | |
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere; |
Conditions | Yield |
---|---|
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; | 84% |
1,4-Diiodobutane
n-butyllithium
N,N,N,N,-tetramethylethylenediamine
2-oxoindole
Conditions | Yield |
---|---|
Stage #1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine With diphosphorus pentasulfide In tetrahydrofuran; hexane at -25℃; for 0.5h; Nitrogen atmosphere; Stage #2: 1,4-Diiodobutane In tetrahydrofuran; hexane at -25 - 20℃; for 14h; | 50% |
1-methoxyindolin-2-one
2-oxoindole
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 1h; | 95% |
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 80℃; for 8h; | 13% |
2-aminophenylacetic acid methyl ester
2-oxoindole
Conditions | Yield |
---|---|
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; diphenylsilane; phenylboronic acid In m-xylene at 120℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube; | 92% |
for 0.333333h; Heating; under reduced pressure; | |
With water; trimethylamine at 30℃; Rate constant; dependency of rate constants on the nature of general base catalyst; |
Conditions | Yield |
---|---|
With rhodium(II) pivalate In water; chlorobenzene at 140℃; for 5h; Reagent/catalyst; Inert atmosphere; | 78% |
dirhodium tetraacetate In acetonitrile Rearrangement; Wolff; Heating; | 40% |
With water; acetic acid at 0℃; Irradiation.Mit der Licht einer Bogenlampe; |
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran for 3h; Ambient temperature; Irradiation; | 74% |
With lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 2.) 25 deg C, irradiation, 3 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With 1-fluoro-1,2-phenyliodohydrin-3-(1H)-one In 1,4-dioxane; water at 140℃; for 5h; Reagent/catalyst; | 81% |
With silica-gel-supported sulfuric acid In dichloromethane at 25℃; for 10h; Reagent/catalyst; Solvent; regioselective reaction; | 78% |
With dihydrogen peroxide; iron(II) bromide In water at 20℃; Catalytic behavior; Reagent/catalyst; Fenton Reaction; Green chemistry; | 66% |
indole
A
2-oxoindole
C
indole-2,3-dione
D
2,2-di(3-indolyl)-3-indolone
E
dioxindol
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 6h; Overall yield = 99 %; |
1-(2-chloroacetyl)indolin-2-one
2-oxoindole
Conditions | Yield |
---|---|
With morpholine In ethanol at 20℃; Reagent/catalyst; |
2-(2-chlorophenyl)acetamide
2-oxoindole
Conditions | Yield |
---|---|
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h; | 75% |
1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate
2-oxoindole
Conditions | Yield |
---|---|
With acetic acid In methanol at 60℃; for 48h; Temperature; |
indole
A
2-oxoindole
B
indirubin
D
indole-2,3-dione
E
2,2-di(3-indolyl)-3-indolone
F
dioxindol
Conditions | Yield |
---|---|
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 3h; Overall yield = 91 %; |
Conditions | Yield |
---|---|
With ammonium hydroxide; copper In neat (no solvent) at 100℃; for 16h; Sealed tube; | 80% |
With ammonia; water; copper diacetate; copper at 165℃; Unter Druck; |
methyl (2-nitrophenyl)acetate
A
2-oxoindole
B
2-aminophenylacetic acid methyl ester
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate at 0℃; under 735.5 Torr; for 4h; Title compound not separated from byproducts; | |
With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 24h; Autoclave; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / benzene / Heating 2: hydrogen / PtO2 / methanol / 2 h / 2585.7 Torr 3: H2O, trimethylamine / 30 °C / dependency of rate constants on the nature of general base catalyst View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / PtO2 / methanol / 2 h / 2585.7 Torr 2: H2O, trimethylamine / 30 °C / dependency of rate constants on the nature of general base catalyst View Scheme |
2-oxoindole
Conditions | Yield |
---|---|
Stage #1: o'-(2,2-difluorovinyl)-p-toluenesulfonanilide With trimethylsilyl trifluoromethanesulfonate; palladium dichloride In 1,1,1,3,3,3-hexafluoropropan-2-ol at 60℃; for 2h; Stage #2: With water; sodium hydrogencarbonate In 1,1,1,3,3,3-hexafluoropropan-2-ol | 90% |
Conditions | Yield |
---|---|
With UiO-66 metal organic framework nanoparticles In neat (no solvent) at 80℃; for 2h; Friedel-Crafts Alkylation; Sealed tube; Darkness; | 100% |
With pyrrolidine In ethanol for 2h; Reflux; | 94% |
With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate at 80℃; for 1h; | 93% |
2-oxoindole
cis-7-azabicyclo<4.3.0>nonan-8-one
Conditions | Yield |
---|---|
With platinum(IV) oxide; hydrogen In acetic acid at 70℃; under 760.051 Torr; for 48h; | 100% |
With C33H49ClNRh; hydrogen In 2,2,2-trifluoroethanol at 20℃; under 30003 Torr; for 24h; Autoclave; Molecular sieve; | 99% |
With C31H47ClNRh; hydrogen In toluene at 25℃; under 37503.8 Torr; for 24h; Catalytic behavior; Solvent; Pressure; Concentration; Temperature; Molecular sieve; Autoclave; Schlenk technique; diastereoselective reaction; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride In acetic acid Heating; | 100% |
With zirconium(IV) chloride In ethanol Reagent/catalyst; Solvent; Temperature; Reflux; | 91% |
With hydrogenchloride In water; acetic acid for 3h; Reflux; | 88% |
2-oxoindole
4,6-dimethoxy-2,3-diphenyl-1H-indole
7-(indol-2'-yl)-4,6-dimethoxy-2,3-diphenylindole
Conditions | Yield |
---|---|
With trifluoromethylsulfonic anhydride In chloroform for 0.5h; Ambient temperature; | 100% |
With trichlorophosphate In chloroform Heating; | 56% |
With trichlorophosphate |
Conditions | Yield |
---|---|
With potassium phosphate; copper(I) thiophene-2-carboxylate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane In toluene at 85℃; for 6h; | 100% |
Conditions | Yield |
---|---|
piperidine In ethanol for 14h; Heating / reflux; | 100% |
2-oxoindole
5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid
Conditions | Yield |
---|---|
In ethanol at 90 - 100℃; | 100% |
268 mg (100%) | |
268 mg (100%) | |
268 mg (100%) |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With piperidine In ethanol for 12h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 1h; | |
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h; |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Stage #1: 2-oxoindole; benzaldehyde With piperidine In ethanol for 3h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; | 87% |
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In methanol for 3h; Reflux; Stage #2: With sodium tetrahydroborate In methanol | 82% |
2-oxoindole
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde
(E)-3-((3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)methylene)indolin-2-one
Conditions | Yield |
---|---|
With piperidine In ethanol at 20 - 70℃; for 2h; | 100% |
With piperidine In ethanol at 20 - 70℃; for 2h; | 100% |
Conditions | Yield |
---|---|
Reagent/catalyst; Aldol Condensation; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With piperidine In ethanol for 3h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 3h; | 48% |
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h; |
4-Trifluoromethylbenzaldehyde
2-oxoindole
3-(4-trifluoromethylbenzyl)-1,3-dihydroindol-2-one
Conditions | Yield |
---|---|
Stage #1: 4-Trifluoromethylbenzaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Stage #1: 4-Trifluoromethylbenzaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h; |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; 3,4-dimethoxy-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; β-naphthaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
2-oxoindole
4-methoxy-1-naphthaldehyde
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; 4-methoxy-1-naphthaldehyde With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
2-oxoindole
2-ethenyl-1-benzothiophene
Conditions | Yield |
---|---|
Stage #1: 2-oxoindole; 2-ethenyl-1-benzothiophene With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-furancarboxaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; | 100% |
2-oxoindole
5-methoxy-7-methoxyindole-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With trichlorophosphate at 60℃; for 2.5h; | 100% |
2-oxoindole
indole-2,3-dione
3-hydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione
Conditions | Yield |
---|---|
With water at 20℃; for 24h; | 99% |
In ethanol for 9h; Reflux; | 96% |
With Sulfonic-acid-functionalized nanoporous silica In water at 140℃; for 0.5h; Mechanism; Time; Solvent; | 95% |
Conditions | Yield |
---|---|
With morpholine for 16h; Knoevenagel Condensation; Reflux; | 99% |
With pyridine; titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Temperature; Knoevenagel Condensation; | 96% |
With piperidine In ethanol for 3h; Knoevenagel condensation; Reflux; | 92% |
2-oxoindole
3-(4-bromophenyl)-4,6-dimethoxy-1H-indole
Conditions | Yield |
---|---|
With trifluoromethylsulfonic anhydride In chloroform for 0.5h; Ambient temperature; | 99% |
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 99% |
Stage #1: 2-oxoindole With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: chloromethyl methyl ether In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0 - 23℃; for 24h; Inert atmosphere; | 79% |
Stage #1: 2-oxoindole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide at 20℃; for 3h; | 63% |
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.5h; | 52% |
2-oxoindole
5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
piperidine In ethanol Heating / reflux; | 99% |
With piperidine In ethanol Heating; | 1.98 g |
Conditions | Yield |
---|---|
With potassium hydroxide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] at 110℃; for 15h; Inert atmosphere; Neat (no solvent); | 99% |
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110℃; for 20h; Inert atmosphere; | 79% |
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110 - 115℃; Sealed tube; Inert atmosphere; | 74% |
2-oxoindole
1,3-diphenyl-3-hydroxypropene
(E)-1-(1,3-diphenylallyl)indolin-2-one
Conditions | Yield |
---|---|
With perrhenic acid anhydride In dichloromethane at 20℃; for 0.166667h; | 99% |
Conditions | Yield |
---|---|
With piperidine In ethanol at 20℃; for 3h; | 99% |
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