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Dayang Chem (Hangzhou) Co.,Ltd.

img _fcksaAppearance:Light Yellow powder Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochem

Oxindole

Cas:59-48-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Oxindole supplier in China

Cas:59-48-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Oxindole

Cas:59-48-3

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Oxindole

Cas:59-48-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

1. Direct manufacturer 2. Stock available 3. Stable and fine quality 4. Premium service Appearance:white to light yellow crystalline Storage:Refrigerator Package:bag/bottle/drum Application:pharmaceutical intermediate

Oxindole

Cas:59-48-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Oxindole Basic information Product Name: Oxindole Synonyms: OXINDOL;OXINDOLE;O-(AMINOPHENYL)ACETIC ACID LACTAM;TIMTEC-BB SBB004215;1,3-dihydro-2h-indol-2-on;1,3-Dihydro-indol-2-one;1,3-D

59-48-3

Cas:59-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

59-48-3 Oxindole

Cas:59-48-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Professional Factory CAS 59-48-3 with fast shipping

Cas:59-48-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

59-48-3 Oxindole/NSC 274863/TIMTEC-BB SBB004215

Cas:59-48-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Oxindole Synonyms: Diclofenac Sodium Impurity E;AKOS B028811;1,3-DIHYDRO-2H-INDOL-2-ONE;1,3-DIHYDRO-INDOLE-2-ONE;2-(AMINOPHENYL)ACETIC ACID LACTAM;2-HYDROXYINDOLE;2-INDOLINONE;2-KETOINDOLINE

Oxindole CAS: 59-48-3

Cas:59-48-3

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

2-Oxo-2,3-dihydroindoleCAS NO.:59-48-3

Cas:59-48-3

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla

Oxindole CAS 59-48-3 C8H7NO

Cas:59-48-3

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-Indol-2-one,1,3-dihydro- 59-48-3

Cas:59-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Oxindole CAS: 59-48-3 MF: C8H7NO MW: 133.15 EINECS: 200-429-5 Mol File: 59-48-3.mol Oxindole Structure Oxindole Chemical Properties Melting point 123-128 °C(lit.) Boiling point 227 °C73 mm Hg(lit.) d

Oxindole

Cas:59-48-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. A

2-Oxindole/CAS:59-48-3

Cas:59-48-3

Min.Order:5 Gram

FOB Price: $30.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Oxindole CAS:59-48-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, ste

Oxindole CAS:59-48-3

Cas:59-48-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-Indol-2-one,1,3-dihydro-

Cas:59-48-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2H-Indol-2-one,1,3-dihydro-/ LIDE PHARMA- Factory supply / Best price

Cas:59-48-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,3-Dihydroindol-2-One

Cas:59-48-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Oxindole

Cas:59-48-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Oxindole

Cas:59-48-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Oxindole

Cas:59-48-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Oxindole

Cas:59-48-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Manufacturer/High quality Oxindole 59-48-3

Cas:59-48-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-Oxindole

Cas:59-48-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

59-48-3 Oxindole

Cas:59-48-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Oxindole CAS No.:59-48-3 Molecule Formula:C8H7NO Molecule Weight:133.15 Purity: 98.0% Package: 25kg/drum Description:Light yellow crystalline powder Manufacture Standards:Enterprise Standard TESTING I

Best Quality Oxindole

Cas:59-48-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Oxindole

Cas:59-48-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

59-48-3 Oxindole

Cas:59-48-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Oxindole

Cas:59-48-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

indole-2,3-dione
91-56-5

indole-2,3-dione

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
Stage #1: indole-2,3-dione With hydrazine In methanol Heating;
Stage #2: With sodium ethanolate In ethanol Wolff-Kishner reduction; Heating; Further stages.;
98%
With hydrogen In ethanol at 70℃; under 1875.19 Torr; for 0.333333h;96.5%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.0833333h; Temperature; Reagent/catalyst; Inert atmosphere;94%
2-(2-nitrophenyl)acetic acid
3740-52-1

2-(2-nitrophenyl)acetic acid

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With iron; acetic acid at 100℃;95%
With palladium on activated charcoal; hydrogen; acetic acid at 20℃; for 4h;88%
With 5%-palladium/activated carbon; hydrogen In ethanol; water under 7500.75 Torr; for 24h; Autoclave;88%
methyl (2-nitrophenyl)acetate
30095-98-8

methyl (2-nitrophenyl)acetate

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
Stage #1: methyl (2-nitrophenyl)acetate With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 24h; Autoclave;
Stage #2: In ethyl acetate for 6h; Reflux; Molecular sieve;
99%
With iron; ammonium chloride; acetic acid at 100℃; for 24h;87.8%
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 25 °C
View Scheme
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / 2280.15 Torr / Sealed tube
2: ethyl acetate / 6 h / Reflux; Molecular sieve
View Scheme
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

B

indole-2,3-dione
91-56-5

indole-2,3-dione

Conditions
ConditionsYield
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 1h;A 44%
B 8%
With oxygen; titanium(IV) oxide In water for 4h; Irradiation;
With D-glucose; GDH; cytochrome P450 monooxygenase CYP116B4 from Labrenzia aggregata; nicotinamide adenine dinucleotide phosphate In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction;
With nicotinamide adenine dinucleotide phosphate; cytochrome P450 monooxygenase from Labrenzia aggregata In aq. buffer at 30℃; for 5h; pH=8.5; Enzymatic reaction; enantioselective reaction;
1-(toluene-4-sulfonyl)-1,3-dihydro-indol-2-one
1429481-71-9

1-(toluene-4-sulfonyl)-1,3-dihydro-indol-2-one

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With naphthalene radical anion sodium salt In 1,2-dimethoxyethane at -78 - 18℃; Reagent/catalyst;90%
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

B

2,2-di(3-indolyl)-3-indolone
17646-95-6

2,2-di(3-indolyl)-3-indolone

Conditions
ConditionsYield
With chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III); chloro[5,10,15,20-tetrakis(4-dimethy-lamino-2,3,5,6-tetrafluorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h;A 35%
B 7%
With ammonium persulfate; phosphoric acid In water pH=1.4; Oxidation;A 26%
B 32%
ethyl 2-nitrophenylacetate
31912-02-4

ethyl 2-nitrophenylacetate

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With acetic acid; zinc In ethanol at 70℃; for 4h; Inert atmosphere;93%
With acetic acid; zinc In ethanol at 70℃; for 4h;66%
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

B

indirubin
479-41-4

indirubin

C

indole-2,3-dione
91-56-5

indole-2,3-dione

Conditions
ConditionsYield
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 0.5h;A 64%
B 7%
C 6%
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

B

indole-2,3-dione
91-56-5

indole-2,3-dione

C

2,2-di(3-indolyl)-3-indolone
17646-95-6

2,2-di(3-indolyl)-3-indolone

Conditions
ConditionsYield
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); chloro[2-nitro-5,10,15,20-tetrakis(2,6-diclorophenyl)porphyrinate]manganese(III) In acetonitrile at 20℃; for 0.5h;A 50%
B 6%
C 6%
N'-(2-aminobenzylidene)-4-methylbenzenesulfonohydrazide
171359-95-8

N'-(2-aminobenzylidene)-4-methylbenzenesulfonohydrazide

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With tetraethylammonium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 20 - 110℃; for 1h; Solvent; Reagent/catalyst;83%
2-(2-nitrophenyl)acetic acid
3740-52-1

2-(2-nitrophenyl)acetic acid

A

2-oxoindole
59-48-3

2-oxoindole

B

1,3-dihydro-1-hydroxyindole-2-one
18108-55-9

1,3-dihydro-1-hydroxyindole-2-one

Conditions
ConditionsYield
Stage #1: 2-(2-nitrophenyl)acetic acid With 1,10-Phenanthroline; platinum on carbon; hydrogen In ethanol at 20℃; under 7500.75 Torr; Flow reactor; Green chemistry;
Stage #2: With acetic acid In ethanol at 20℃; Catalytic behavior; Reagent/catalyst; Solvent; Pressure; Green chemistry;
A n/a
B 83%
With sulfuric acid; zinc at 30℃;
With acetic acid; platinum Hydrogenation;
2-aminophenethyl alcohol
5339-85-5

2-aminophenethyl alcohol

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With potassium carbonate; [pentamethylcyclopentadienylRhCl2]2 In acetone at 100℃; for 8h;74%
Multi-step reaction with 3 steps
1: 1.) aq. HCl, NaNO2, 2.) NaN3
2: 50 percent / Pyridine, CF3COOH, Dicyclohexylcarbodiimide / dimethylsulfoxide; benzene / 0.5 h / 50 °C
3: 85 percent / decahydronaphthalene / 2 h / 190 - 200 °C
View Scheme
3-hydrazonoindolin-2-one
2365-44-8

3-hydrazonoindolin-2-one

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With sodium In ethanol Reflux;69%
1,4-diaza-bicyclo[2.2.2]octane In 2-Ethylhexyl alcohol; water at 130 - 145℃; for 3.5 - 5h; Heating / reflux;66.5%
1,4-diaza-bicyclo[2.2.2]octane In 2-Ethylhexyl alcohol; hexan-1-ol at 130℃; for 2.5h;66.5%
at 255℃; under 90 Torr;
With potassium tert-butylate In ethanol for 2h; Reflux; Inert atmosphere;
Acetanilid
103-84-4

Acetanilid

ethyl iodoacetae
623-48-3

ethyl iodoacetae

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With silver(I) acetate; palladium diacetate; trifluoroacetic acid at 120℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;84%
1,4-Diiodobutane
628-21-7

1,4-Diiodobutane

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

N,N,N,N,-tetramethylethylenediamine
110-18-9

N,N,N,N,-tetramethylethylenediamine

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
Stage #1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine With diphosphorus pentasulfide In tetrahydrofuran; hexane at -25℃; for 0.5h; Nitrogen atmosphere;
Stage #2: 1,4-Diiodobutane In tetrahydrofuran; hexane at -25 - 20℃; for 14h;
50%
1-methoxyindolin-2-one
65816-14-0

1-methoxyindolin-2-one

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 1h;95%
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 80℃; for 8h;13%
2-aminophenylacetic acid methyl ester
35613-44-6

2-aminophenylacetic acid methyl ester

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; diphenylsilane; phenylboronic acid In m-xylene at 120℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;92%
for 0.333333h; Heating; under reduced pressure;
With water; trimethylamine at 30℃; Rate constant; dependency of rate constants on the nature of general base catalyst;
3-diazo-1,2,3,4-tetrahydro-2,4-dioxo-quinoline
7270-61-3

3-diazo-1,2,3,4-tetrahydro-2,4-dioxo-quinoline

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With rhodium(II) pivalate In water; chlorobenzene at 140℃; for 5h; Reagent/catalyst; Inert atmosphere;78%
dirhodium tetraacetate In acetonitrile Rearrangement; Wolff; Heating;40%
With water; acetic acid at 0℃; Irradiation.Mit der Licht einer Bogenlampe;
N-(2-chlorophenyl)acetamide
533-17-5

N-(2-chlorophenyl)acetamide

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran for 3h; Ambient temperature; Irradiation;74%
With lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 2.) 25 deg C, irradiation, 3 h; Yield given. Multistep reaction;
indole
120-72-9

indole

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With 1-fluoro-1,2-phenyliodohydrin-3-(1H)-one In 1,4-dioxane; water at 140℃; for 5h; Reagent/catalyst;81%
With silica-gel-supported sulfuric acid In dichloromethane at 25℃; for 10h; Reagent/catalyst; Solvent; regioselective reaction;78%
With dihydrogen peroxide; iron(II) bromide In water at 20℃; Catalytic behavior; Reagent/catalyst; Fenton Reaction; Green chemistry;66%
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

C16H12N2O4

C16H12N2O4

C

indole-2,3-dione
91-56-5

indole-2,3-dione

D

2,2-di(3-indolyl)-3-indolone
17646-95-6

2,2-di(3-indolyl)-3-indolone

E

dioxindol
61-71-2

dioxindol

Conditions
ConditionsYield
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 6h; Overall yield = 99 %;
1-(2-chloroacetyl)indolin-2-one
937606-68-3

1-(2-chloroacetyl)indolin-2-one

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With morpholine In ethanol at 20℃; Reagent/catalyst;
2-(2-chlorophenyl)acetamide
10268-06-1

2-(2-chlorophenyl)acetamide

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h;75%
1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate
382150-70-1

1,3-di-tert-butyl 2-(2-aminophenyl)propanedioate

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With acetic acid In methanol at 60℃; for 48h; Temperature;
indole
120-72-9

indole

A

2-oxoindole
59-48-3

2-oxoindole

B

indirubin
479-41-4

indirubin

C16H12N2O4

C16H12N2O4

D

indole-2,3-dione
91-56-5

indole-2,3-dione

E

2,2-di(3-indolyl)-3-indolone
17646-95-6

2,2-di(3-indolyl)-3-indolone

F

dioxindol
61-71-2

dioxindol

Conditions
ConditionsYield
With chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III); dihydrogen peroxide In acetonitrile at 20℃; for 3h; Overall yield = 91 %;
2'-chloro-benzeneacetic acid
2444-36-2

2'-chloro-benzeneacetic acid

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
With ammonium hydroxide; copper In neat (no solvent) at 100℃; for 16h; Sealed tube;80%
With ammonia; water; copper diacetate; copper at 165℃; Unter Druck;
methyl (2-nitrophenyl)acetate
30095-98-8

methyl (2-nitrophenyl)acetate

A

2-oxoindole
59-48-3

2-oxoindole

B

2-aminophenylacetic acid methyl ester
35613-44-6

2-aminophenylacetic acid methyl ester

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate at 0℃; under 735.5 Torr; for 4h; Title compound not separated from byproducts;
With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 24h; Autoclave;
2-(2-nitrophenyl)acetic acid
3740-52-1

2-(2-nitrophenyl)acetic acid

A

2-oxoindole
59-48-3

2-oxoindole

B

isatide

isatide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / benzene / Heating
2: hydrogen / PtO2 / methanol / 2 h / 2585.7 Torr
3: H2O, trimethylamine / 30 °C / dependency of rate constants on the nature of general base catalyst
View Scheme
methyl (2-nitrophenyl)acetate
30095-98-8

methyl (2-nitrophenyl)acetate

A

2-oxoindole
59-48-3

2-oxoindole

B

isatide

isatide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / PtO2 / methanol / 2 h / 2585.7 Torr
2: H2O, trimethylamine / 30 °C / dependency of rate constants on the nature of general base catalyst
View Scheme
o'-(2,2-difluorovinyl)-p-toluenesulfonanilide

o'-(2,2-difluorovinyl)-p-toluenesulfonanilide

2-oxoindole
59-48-3

2-oxoindole

Conditions
ConditionsYield
Stage #1: o'-(2,2-difluorovinyl)-p-toluenesulfonanilide With trimethylsilyl trifluoromethanesulfonate; palladium dichloride In 1,1,1,3,3,3-hexafluoropropan-2-ol at 60℃; for 2h;
Stage #2: With water; sodium hydrogencarbonate In 1,1,1,3,3,3-hexafluoropropan-2-ol
90%
2-oxoindole
59-48-3

2-oxoindole

benzaldehyde
100-52-7

benzaldehyde

3-benzylideneoxindole
3359-49-7, 23772-61-4, 23782-37-8

3-benzylideneoxindole

Conditions
ConditionsYield
With UiO-66 metal organic framework nanoparticles In neat (no solvent) at 80℃; for 2h; Friedel-Crafts Alkylation; Sealed tube; Darkness;100%
With pyrrolidine In ethanol for 2h; Reflux;94%
With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate at 80℃; for 1h;93%
Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In acetic acid at 70℃; under 760.051 Torr; for 48h;100%
With C33H49ClNRh; hydrogen In 2,2,2-trifluoroethanol at 20℃; under 30003 Torr; for 24h; Autoclave; Molecular sieve;99%
With C31H47ClNRh; hydrogen In toluene at 25℃; under 37503.8 Torr; for 24h; Catalytic behavior; Solvent; Pressure; Concentration; Temperature; Molecular sieve; Autoclave; Schlenk technique; diastereoselective reaction;99%
2-oxoindole
59-48-3

2-oxoindole

indole-2,3-dione
91-56-5

indole-2,3-dione

isoindigo
476-34-6

isoindigo

Conditions
ConditionsYield
With hydrogenchloride In acetic acid Heating;100%
With zirconium(IV) chloride In ethanol Reagent/catalyst; Solvent; Temperature; Reflux;91%
With hydrogenchloride In water; acetic acid for 3h; Reflux;88%
2-oxoindole
59-48-3

2-oxoindole

4,6-dimethoxy-2,3-diphenyl-1H-indole
91107-10-7

4,6-dimethoxy-2,3-diphenyl-1H-indole

7-(indol-2'-yl)-4,6-dimethoxy-2,3-diphenylindole
91107-13-0

7-(indol-2'-yl)-4,6-dimethoxy-2,3-diphenylindole

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride In chloroform for 0.5h; Ambient temperature;100%
With trichlorophosphate In chloroform Heating;56%
With trichlorophosphate
2-oxoindole
59-48-3

2-oxoindole

1-iodo-1,2-hexadiene
2936-42-7

1-iodo-1,2-hexadiene

1-hexa-1,2-dienyl-1,3-dihydro-indol-2-one

1-hexa-1,2-dienyl-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With potassium phosphate; copper(I) thiophene-2-carboxylate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane In toluene at 85℃; for 6h;100%
2-oxoindole
59-48-3

2-oxoindole

C19H15N5O
672318-77-3

C19H15N5O

C27H20N6O

C27H20N6O

Conditions
ConditionsYield
piperidine In ethanol for 14h; Heating / reflux;100%
2-oxoindole
59-48-3

2-oxoindole

5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid
280748-43-8

5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid

4-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid

4-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid

Conditions
ConditionsYield
In ethanol at 90 - 100℃;100%
268 mg (100%)
268 mg (100%)
268 mg (100%)
2-oxoindole
59-48-3

2-oxoindole

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

3-(4-bromobenzylidenyl)-2-indolinone

3-(4-bromobenzylidenyl)-2-indolinone

Conditions
ConditionsYield
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With piperidine In ethanol for 12h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 1h;
Stage #1: 2-oxoindole; 4-bromo-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h;
2-oxoindole
59-48-3

2-oxoindole

benzaldehyde
100-52-7

benzaldehyde

3-benzyl-2-oxindole
7511-08-2

3-benzyl-2-oxindole

Conditions
ConditionsYield
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
Stage #1: 2-oxoindole; benzaldehyde With piperidine In ethanol for 3h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃;
87%
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In methanol for 3h; Reflux;
Stage #2: With sodium tetrahydroborate In methanol
82%
2-oxoindole
59-48-3

2-oxoindole

3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde
1168720-53-3

3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

(E)-3-((3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)methylene)indolin-2-one
1247000-64-1

(E)-3-((3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)methylene)indolin-2-one

Conditions
ConditionsYield
With piperidine In ethanol at 20 - 70℃; for 2h;100%
With piperidine In ethanol at 20 - 70℃; for 2h;100%
2-oxoindole
59-48-3

2-oxoindole

Octanal
124-13-0

Octanal

C16H21NO

C16H21NO

Conditions
ConditionsYield
Reagent/catalyst; Aldol Condensation; Inert atmosphere;100%
2-oxoindole
59-48-3

2-oxoindole

benzaldehyde
100-52-7

benzaldehyde

3-phenyloxindole
3456-79-9, 123742-97-2

3-phenyloxindole

Conditions
ConditionsYield
Stage #1: 2-oxoindole; benzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
2-oxoindole
59-48-3

2-oxoindole

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

4-((2-oxoindolin-3-yl)methyl)benzonitrile

4-((2-oxoindolin-3-yl)methyl)benzonitrile

Conditions
ConditionsYield
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With piperidine In ethanol for 3h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 3h;
48%
Stage #1: 2-oxoindole; 4-cyanobenzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h;
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

2-oxoindole
59-48-3

2-oxoindole

3-(4-trifluoromethylbenzyl)-1,3-dihydroindol-2-one
931927-97-8

3-(4-trifluoromethylbenzyl)-1,3-dihydroindol-2-one

Conditions
ConditionsYield
Stage #1: 4-Trifluoromethylbenzaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
Stage #1: 4-Trifluoromethylbenzaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 2h;
2-oxoindole
59-48-3

2-oxoindole

3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

3-(3,4-dimethoxybenzyl)indolin-2-one

3-(3,4-dimethoxybenzyl)indolin-2-one

Conditions
ConditionsYield
Stage #1: 2-oxoindole; 3,4-dimethoxy-benzaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
2-oxoindole
59-48-3

2-oxoindole

β-naphthaldehyde
66-99-9

β-naphthaldehyde

3-(naphthalen-2-ylmethyl)indolin-2-one
1202521-48-9

3-(naphthalen-2-ylmethyl)indolin-2-one

Conditions
ConditionsYield
Stage #1: 2-oxoindole; β-naphthaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
2-oxoindole
59-48-3

2-oxoindole

4-methoxy-1-naphthaldehyde
15971-29-6

4-methoxy-1-naphthaldehyde

3-((4-methoxynaphthalen-1-yl)methyl)indolin-2-one

3-((4-methoxynaphthalen-1-yl)methyl)indolin-2-one

Conditions
ConditionsYield
Stage #1: 2-oxoindole; 4-methoxy-1-naphthaldehyde With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
2-oxoindole
59-48-3

2-oxoindole

2-ethenyl-1-benzothiophene
78646-50-1

2-ethenyl-1-benzothiophene

3-(benzo[b]thiophen-2-ylmethyl)indolin-2-one

3-(benzo[b]thiophen-2-ylmethyl)indolin-2-one

Conditions
ConditionsYield
Stage #1: 2-oxoindole; 2-ethenyl-1-benzothiophene With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
5-bromo-2-furancarboxaldehyde
1899-24-7

5-bromo-2-furancarboxaldehyde

2-oxoindole
59-48-3

2-oxoindole

C13H10BrNO2

C13H10BrNO2

Conditions
ConditionsYield
Stage #1: 5-bromo-2-furancarboxaldehyde; 2-oxoindole With pyrrolidine In ethanol for 2h; Reflux;
Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;
100%
2-oxoindole
59-48-3

2-oxoindole

5-methoxy-7-methoxyindole-2-carboxylic acid methyl ester
27508-96-9

5-methoxy-7-methoxyindole-2-carboxylic acid methyl ester

methyl 4-(indol-2'-yl)-5,7-dimethoxyindole-2-carboxylate

methyl 4-(indol-2'-yl)-5,7-dimethoxyindole-2-carboxylate

Conditions
ConditionsYield
With trichlorophosphate at 60℃; for 2.5h;100%
2-oxoindole
59-48-3

2-oxoindole

indole-2,3-dione
91-56-5

indole-2,3-dione

3-hydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione
6011-63-8

3-hydroxy-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

Conditions
ConditionsYield
With water at 20℃; for 24h;99%
In ethanol for 9h; Reflux;96%
With Sulfonic-acid-functionalized nanoporous silica In water at 140℃; for 0.5h; Mechanism; Time; Solvent;95%
2-oxoindole
59-48-3

2-oxoindole

acetone
67-64-1

acetone

3-Isopropylidene-1,3-dihydro-indol-2-one
5085-04-1

3-Isopropylidene-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With morpholine for 16h; Knoevenagel Condensation; Reflux;99%
With pyridine; titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 1h; Temperature; Knoevenagel Condensation;96%
With piperidine In ethanol for 3h; Knoevenagel condensation; Reflux;92%
2-oxoindole
59-48-3

2-oxoindole

3-(4-bromophenyl)-4,6-dimethoxy-1H-indole
74794-91-5

3-(4-bromophenyl)-4,6-dimethoxy-1H-indole

3-(4"-bromophenyl)-7-(indol-2'-yl)-4,6-dimethoxyindole

3-(4"-bromophenyl)-7-(indol-2'-yl)-4,6-dimethoxyindole

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride In chloroform for 0.5h; Ambient temperature;99%
2-oxoindole
59-48-3

2-oxoindole

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

1-(methoxymethyl)indolin-2-one
240798-84-9

1-(methoxymethyl)indolin-2-one

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;99%
Stage #1: 2-oxoindole With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: chloromethyl methyl ether In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil at 0 - 23℃; for 24h; Inert atmosphere;
79%
Stage #1: 2-oxoindole With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;
Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide at 20℃; for 3h;
63%
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.5h;52%
2-oxoindole
59-48-3

2-oxoindole

5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester
26018-26-8

5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

(Z)-4-methyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid ethyl ester

(Z)-4-methyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
piperidine In ethanol Heating / reflux;99%
With piperidine In ethanol Heating;1.98 g
2-oxoindole
59-48-3

2-oxoindole

piperonol
495-76-1

piperonol

3-benzo[1,3]dioxol-5-ylmethyl-1,3-dihydroindol-2-one

3-benzo[1,3]dioxol-5-ylmethyl-1,3-dihydroindol-2-one

Conditions
ConditionsYield
With potassium hydroxide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] at 110℃; for 15h; Inert atmosphere; Neat (no solvent);99%
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110℃; for 20h; Inert atmosphere;79%
With rhodium(III) chloride hydrate; triphenylphosphine; sodium hydroxide at 110 - 115℃; Sealed tube; Inert atmosphere;74%
2-oxoindole
59-48-3

2-oxoindole

(E)-1-(1,3-diphenylallyl)indolin-2-one
1383192-54-8

(E)-1-(1,3-diphenylallyl)indolin-2-one

Conditions
ConditionsYield
With perrhenic acid anhydride In dichloromethane at 20℃; for 0.166667h;99%
2-oxoindole
59-48-3

2-oxoindole

C14H9NO4
942264-47-3

C14H9NO4

C22H14N2O4
1415650-37-1

C22H14N2O4

Conditions
ConditionsYield
With piperidine In ethanol at 20℃; for 3h;99%

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