5-Fluoroisatin supplier | CasNO.443-69-6

Name
5-Fluoroisatin
EINECS -0
CAS No. 443-69-6
Article Data70
CAS DataBase
Density 1.446 g/cm³
Solubility
Melting Point 224-227 °C(lit.)
Formula C₈H₄FNO₂
Boiling Point 417.9oC at 760mmHg
Molecular Weight 165.124
Flash Point 206.5oC
Transport Information
Appearance red crystalline powder
Safety 26-37/39-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5-fluoro-1H-indole-2,3-dione;1H-Indole-2,3-dione, 5-fluoro-;
PSA 46.17000
LogP 1.09850

Synthetic route

: 351-09-7
N-(4-fluorophenyl)-2-(hydroxyimino) acetamide

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid In water at 80℃; for 0.333333h;	88.6%
With sulfuric acid In water at 50 - 75℃; Temperature;	88.2%
With sulfuric acid at 20℃;	85%

: N-(4-fluorophenyl)-2-(hydroxyimino)acetamide

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 50 - 75℃; for 0.333333h;	88.2%

: 2343-22-8
5-fluoroindoline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With iodine pentoxide In dimethyl sulfoxide at 80℃;	87%
With o-iodosobenzoic acid; oxygen In dimethyl sulfoxide at 80℃; for 12h; Green chemistry;	72%

: 1174558-44-1
3-(4-fluorophenylimino)-5-fluoro-N-(4-fluorophenyl)-3H-indole-2-amine

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water for 0.333333h; Reflux;	85%

: 56341-41-4
5-fluoroindol-2(3H)-one

A: 443-69-6
5-fluoro-1H-indole-2,3-dione

B: (E)-5-fluoro-5'-methoxy-[3,3'-biindolinylidene]-2,2'-dione

Conditions

Conditions	Yield
With oxygen; sodium iodide In tetrahydrofuran at 60℃; for 12h; Schlenk technique; chemoselective reaction;	A 80% B 8%

: 201230-82-2
carbon monoxide

: N'-(2-bromo-4-fluorophenyl)-N,N-dimethylurea

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Stage #1: N'-(2-bromo-4-fluorophenyl)-N,N-dimethylurea With methyllithium In tetrahydrofuran; diethyl ether at 0℃; Stage #2: With tert.-butyl lithium In tetrahydrofuran; diethyl ether; n-heptane at 0℃; for 1h; Stage #3: carbon monoxide In tetrahydrofuran; diethyl ether; n-heptane at 0℃; for 0.5h;	79%
Yield given; Multistep reaction;

: phenylglycine isopropyl ester

: 371-40-4
4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
In acetonitrile at 60℃; for 16h;	78.7%

: 399-52-0
5-fluoro-1H-indole

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; oxygen In acetonitrile at 20℃; for 18h;	68%

: 302-17-0
chloral hydrate

: 371-40-4
4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Stage #1: chloral hydrate; 4-fluoroaniline With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate In water Stage #2: With sulfuric acid at 60 - 80℃;	63%
Stage #1: chloral hydrate; 4-fluoroaniline With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate for 0.166667h; Heating; Stage #2: With sulfuric acid for 1h; Heating;
Stage #1: chloral hydrate; 4-fluoroaniline With hydroxylamine hydrochloride; sodium sulfate In water Sandmeyer reaction; Stage #2: With sulfuric acid In methanol Sandmeyer reaction;

: 4-Fluoroisonitrosoacetanilide

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid 1) 50 deg C, 30 min; 2) 80 deg C, 10 min;	62%

: 515-83-3
chloral ethyl hemiacetal

: 371-40-4
4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Stage #1: chloral ethyl hemiacetal; 4-fluoroaniline With hydrogenchloride; sodium sulfate In water for 1h; Stage #2: With hydroxylamine hydrochloride In water at 10 - 80℃; for 1.5h; Stage #3: With sulfuric acid at 60℃; for 6h;	61%

: 879274-72-3
(E)-N-(4-fluorophenyl)-2-(hydroxyimino)acetamide

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid In water at 50 - 90℃;	52%
With sulfuric acid In water at 50 - 90℃;	52%

: 56341-41-4
5-fluoroindol-2(3H)-one

A: 443-69-6
5-fluoro-1H-indole-2,3-dione

B: (E)-5,5'-difluoro-[3,3'-biindolinylidene]-2,2'-dione

Conditions

Conditions	Yield
With oxygen; sodium iodide In dimethyl sulfoxide at 100℃; for 12h; Schlenk technique; chemoselective reaction;	A 29% B 52%

: 79-37-8
oxalyl dichloride

: 371-40-4
4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With H-β zeolite In 1,2-dichloro-ethane at 80℃; for 36h; Inert atmosphere;	51%

: 113423-50-0
3,3-dibromo-5-fluoro-2-oxindole

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With water In methanol for 2h; Heating;

: 371-40-4
4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydroxylamine sulfate; sodium sulfate; HCl / ethanol; H2O 2: H2SO4 View Scheme
Multi-step reaction with 2 steps 1: 91 percent / NH2OH*HCl; sodium sulfate / H2O / 0.05 h / microwave irradiation 2: 61 percent / H2SO4 (86 percent) / 0.01 h / microwave irradiation View Scheme
Multi-step reaction with 2 steps 1: NH2OH 2: conc. H2SO4 / Heating View Scheme

: 1003-98-1
2-bromo-4-fluoroaniline

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: Et3N / tetrahydrofuran / 2 h / 0 °C 1.2: 71 percent / tetrahydrofuran / 1 h / 0 °C 2.1: MeLi / tetrahydrofuran; diethyl ether / 0 °C 2.2: t-BuLi / tetrahydrofuran; diethyl ether; heptane / 1 h / 0 °C 2.3: 79 percent / tetrahydrofuran; diethyl ether; heptane / 0.5 h / 0 °C View Scheme

: 56341-41-4
5-fluoroindol-2(3H)-one

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CuBr2 / ethyl acetate / 80 °C 2: water / methanol / 2 h / Heating View Scheme
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; oxygen In acetonitrile at 20℃; for 24h;

: 371-40-4
4-fluoroaniline

alkali thiocyanate: alkali thiocyanate

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH2OH*HCl, Na2SO4 2: H2SO4 View Scheme

: 20780-76-1
5-iodoisatin

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Stage #1: 5-iodoisatin With tetrakis(triphenylphosphine) palladium(0); bis(tri-n-butyltin); lithium chloride In 1,4-dioxane at 23 - 100℃; Inert atmosphere; Stage #2: With silver trifluoromethanesulfonate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(hexafluorophosphate) In acetone at 23℃; for 0.333333h; Inert atmosphere; regiospecific reaction;	11.9 mg

: 1261152-93-5
C8H5FN2O

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid; water

: 2146-07-8
p-fluoroaniline hydrochloride

: 443-69-6
5-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; sulfuric acid; sodium sulfate; hydroxylamine hydrochloride / water / 100 °C 2: sulfuric acid / 85 °C View Scheme

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 111-25-1
1-bromo-hexane

: 85511-62-2
5-fluoro-1-hexyl-isatin

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 140℃; Microwave irradiation;	100%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

-CH2CH2CH(CH3)2 halide: -CH2CH2CH(CH3)2 halide

: 1-isopentyl-5-methylindoline-2,3-dione

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃;	100%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

-CH2CH2CH(CH3)2 halide: -CH2CH2CH(CH3)2 halide

: C13H14FNO2

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃;	100%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

-CH2CH2CH3 halide: -CH2CH2CH3 halide

: 445218-47-3
5-fluoro-1-n-propylisatin

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃;	100%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

-CH3 halide: -CH3 halide

: 773-91-1
5-fluoro-1-methylisatin

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃;	100%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 56341-41-4
5-fluoroindol-2(3H)-one

Conditions

Conditions	Yield
With hydrazine hydrate In water at 140℃; for 6h; Temperature; Wolff-Kishner-Huang Minlon Reduction;	99.1%
With titanium tetrachloride; zinc In tetrahydrofuran at 20℃; for 0.1h; Inert atmosphere;	87%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide; hydrazine In ethylene glycol at 80℃; for 3h; Stage #2: With hydrogenchloride; water In ethylene glycol at 0 - 20℃; for 12h; pH=1 - 2;	81.9%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 19471-12-6
3,3'-methylenedianiline

: 3,3'-[methylenebis(3,1-phenylenenitrilo)]bis[1,3-dihydro-5-fluoro-2H-indol-2-one]

Conditions

Conditions	Yield
In water at 20℃; for 22h;	99%
With acetic acid In ethanol for 5h; Heating;	68%
In ethanol Heating;

: 120-72-9
indole

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 695168-61-7
5'-fluoro-1H,1''H-[3,3':3',3''-terindol]-2'(1'H)-one

Conditions

Conditions	Yield
With titanium(IV) oxide In water at 20℃; Green chemistry;	99%
With bromine In acetonitrile at 20℃; for 7h;	92%
With C14H32N2O6S2(2+)*2ClO4(1-) In neat (no solvent) at 110℃; for 0.166667h; Catalytic behavior; Reagent/catalyst;	89%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1335116-93-2
6-fluoro-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 5-fluoro-1H-indole-2,3-dione; 3-(trifluoromethyl)propiophenone With potassium hydroxide In ethanol; water for 1h; Reflux; Stage #2: With hydrogenchloride In water pH=~ 3; Product distribution / selectivity;	99%
Stage #1: 5-fluoro-1H-indole-2,3-dione With potassium hydroxide In ethanol; water for 0.25h; Stage #2: 3-(trifluoromethyl)propiophenone In ethanol; water for 1h; Reflux; Stage #3: With hydrogenchloride In water pH=6;	34%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 6829-40-9
aminomalonic acid diethyl ester

: 762-42-5
dimethyl acetylenedicarboxylate

: 1459805-67-4
5',5'-diethyl 3',4'-dimethyl 5-fluoro-2-oxospiro[indoline-3,2'-pyrrole]-3',4',5',5'(1'H)-tetracarboxylate

Conditions

Conditions	Yield
With trifluoroacetic acid In 1,2-dichloro-ethane at 60℃; for 36h; Time; Molecular sieve;	99%

...Expand

: 2295-31-0
2,4-thiazolidinedion

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: C11H7FN2O4S

Conditions

Conditions	Yield
With water at 20℃; for 12h;	99%

: 141-84-4
2-thioxo-4-thiazolidinone

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 5-(5-Fluoro-3-hydroxy-2-oxoindolin-3- yl)-2-thioxothiazolidin-4-one

Conditions

Conditions	Yield
With water at 20℃; for 12h;	99%

: 59-48-3
2-oxoindole

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 5-fluoro-3-hydroxy-1,1',3,3'-tetrahydro-2H,2'H-3,3'-biindole-2,2'-dione

Conditions

Conditions	Yield
With water at 20℃; for 24h;	99%

: 17630-75-0
5-chloro-indolin-2-one

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: C16H10ClFN2O3

Conditions

Conditions	Yield
With water at 20℃; for 24h;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 23210-22-2
1-Phenyl-3-methylindolin-2-one

: C23H17FN2O3

Conditions

Conditions	Yield
With water at 20℃; for 24h;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 108-26-9
3-methyl-2-pyrazoline-5-one

: 5-fluoro-3-hydroxy-3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 29211-70-9
5-propyl-2,4-dihydro-3H-pyrazol-3-one

: 5-fluoro-3-hydroxy-3-(3-hydroxy-5-propyl-1H-pyrazol-4-yl)indolin-2-one

Conditions

Conditions	Yield
With water at 20℃; for 0.166667h; Green chemistry;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 3-phenyl-1-(1H-pyrazol-1-yl)but-3-en-1-one

: (S)-5-fluoro-4'-phenylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione

Conditions

Conditions	Yield
With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea In acetonitrile at 25℃; for 12h; enantioselective reaction;	99%

: 6303-73-7
1-(pyridin-2-yl)-butan-2-one

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1259522-46-7
2-ethyl-6-fluoro-3-(pyridin-2-yl)quinoline-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 90℃;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 2,2-difluoro-2-(3-methyl-4-nitro-1,2-oxazol-5-yl)-1-phenylethan-1-one

: 3-(difluoro(3-methyl-4-nitroisoxazol-5-yl)methyl)-5-fluoro-3-hydroxyindolin-2-one

Conditions

Conditions	Yield
With methanol; triethylamine at 20℃; for 24h;	99%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: (E)-5-fluoro-3-hydrazonoindolin-2-one

Conditions

Conditions	Yield
With hydrazine hydrate In methanol at 20℃; for 12.5h; Reflux;	98.3%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 127-17-3
2-oxo-propionic acid

: 220844-72-4
6-fluoroquinoline-2,4-dicarboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide at 110℃; for 6h;	98.15%
With sodium hydroxide at 110℃; for 4h;	70%
With potassium hydroxide In water at 40℃; for 16h; Pfitzinger Quinoline Synthesis;	65%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 372-09-8
cyanoacetic acid

: cyano(5-fluoro-2-oxo-2,3-dihydroindol-3-ylidene)acetic acid

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 20℃;	98%
With piperdinium acetate In water at 100℃; Knoevenagel Condensation;	90%

: 934273-32-2
2-amino-6-nonadecyl-benzoic acid

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: C34H47FN2O3

Conditions

Conditions	Yield
for 0.0333333h; microwave irradiation;	98%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 51-35-4
4R-4-hydroxyproline

: 1123858-19-4
5-fluoro-3-(1H-pyrrol-1-yl)-1,3-dihydroindol-2-one

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide In water at 80℃; for 0.5h; Green chemistry;	98%
With 1-butyl-3-methylimidazolium Tetrafluoroborate at 110℃; for 0.166667h; Microwave irradiation;	96%
With scandium tris(dodecyl sulfate) In water at 80℃; for 0.5h; Green chemistry;	96%
With β‐cyclodextrin In water at 60℃; for 1.5h;	94%
With iodine In water; acetonitrile at 20℃; for 4h; Irradiation;

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 126-81-8
dimedone

: 109-77-3
malononitrile

: 352329-70-5
2-amino-5'-fluoro-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile

Conditions

Conditions	Yield
With silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride In ethanol at 20℃; for 3.5h;	98%
With 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydroxide In water at 80℃; for 0.166667h; Green chemistry;	96%
In water at 80℃; for 0.133333h; Microwave irradiation; Green chemistry;	95%

...Expand

: 606-23-5
1H-indene-1,3(2H)-dione

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 121-69-7
N,N-dimethyl-aniline

: 1310937-72-4
2-(3-(4-(dimethylamino)phenyl)-5-fluoro-2-oxoindolin-3-yl)-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
With lithium perchlorate In ethanol for 4h; Friedel-Crafts type reaction; Reflux;	98%

...Expand

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 109-77-3
malononitrile

: 1429936-36-6
2'-amino-5-fluoro-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano[2,3-b]chromene]-3'-carbonitrile

Conditions

Conditions	Yield
With silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride In ethanol at 20℃; for 4.5h;	98%
With tetrabutylammonium acetate In melt at 100℃;	93%

...Expand

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 3949-36-8
3-acetylcoumarin

: 1610544-12-1
(R)-5-fluoro-3-hydroxy-3-[2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl]indolin-2-one

Conditions

Conditions	Yield
Stage #1: 3-acetylcoumarin With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R)-(6-methoxyquinolin-4-yl)(3-vinylquinuclidin-7-yl)methyl)urea In tetrahydrofuran at 5℃; for 0.333333h; Aldol Addition; Stage #2: 5-fluoro-1H-indole-2,3-dione In tetrahydrofuran at 5℃; for 24h; Aldol Addition; enantioselective reaction;	98%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 4-((1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)oxy)-N-phenylbutanethioamide

: 5-fluoro-3-hydroxy-3-(2-oxido-1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)indolin-2-one

Conditions

Conditions	Yield
In chloroform at 61℃; for 15h; Inert atmosphere;	98%

5-Fluoroisatin Specification

The 5-Fluoroindoline-2,3-dione is an organic compound with the formula C₈H₄FNO₂. The IUPAC name of this chemical is 5-fluoro-1H-indole-2,3-dione. With the CAS registry number 443-69-6, it is also named as 1H-Indole-2,3-dione, 5-fluoro-. The product's categories are Isatin Series; Blocks; Indoles Oxindoles; Indole/indoline/oxindole; Indole and Indoline; Indane/Indanone and Derivatives; Sunitinib; Heterocyclic Compounds; Indoles; Simple Indoles; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Boronic Acid; Building Blocks; Heterocyclic Building Blocks; Fluorinated Heterocyclic Series. Besides, it is a red crystalline powder, which is the intermediates of cardiovascular and anti-inflammatory drugs.

Physical properties about 5-Fluoroindoline-2,3-dione are: (1)ACD/LogP: 0.61 ; (2)ACD/LogD (pH 5.5): 0.61; (3)ACD/LogD (pH 7.4): 0.58; (4)ACD/BCF (pH 5.5): 1.71; (5)ACD/BCF (pH 7.4): 1.59; (6)ACD/KOC (pH 5.5): 51.14; (7)ACD/KOC (pH 7.4): 47.53; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)Polar Surface Area: 37.38 Å²; (11)Index of Refraction: 1.584; (12)Molar Refractivity: 37.41 cm³; (13)Molar Volume: 111.7 cm³; (14)Polarizability: 14.83×10^-24cm³; (15)Surface Tension: 50.8 dyne/cm; (16)Density: 1.477 g/cm³.

Preparation: this chemical can be prepared by hydroxyimino-acetic acid-(4-fluoro-anilide). This reaction will need reagent sulfuric acid.

Uses of 5-Fluoroindoline-2,3-dione: it can be used to produce 6-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione. It will need reagent CrO₃ and acetic acid.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1cc2c(cc1)NC(=O)C2=O
(2)InChI: InChI=1/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
(3)InChIKey: GKODDAXOSGGARJ-UHFFFAOYAY
(4)Std. InChI: InChI=1S/C8H4FNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
(5)Std. InChIKey: GKODDAXOSGGARJ-UHFFFAOYSA-N

Product Name

5-Fluoroisatin

Synthetic route

5-Fluoroisatin Specification

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