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Greenutra Resource Inc

Product Name: Lily Bulb Extract Botanical Name: Lilium brownii var. viridulum Part used: Bulbs and flowers of the White Lily plant Appearance: Yellow brown powder Specification: 5:1, 10:1, 20:1 Quality data

Lily Bulb Extract

Cas:315-22-0

Min.Order:1 Kilogram

FOB Price: $22.5

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Crotaline Manufacturer/High quality/Best price/In stock

Cas:315-22-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Crotaline supplier in China

Cas:315-22-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Crotaline CAS NO.315-22-0

Cas:315-22-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Crotaline

Cas:315-22-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% MONOCROTALINE 315-22-0 GMP Manufacturer

Cas:315-22-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Monocrotaline CAS 315-22-0

Cas:315-22-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 315-22-0 with competitive price

Cas:315-22-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

MONOCROTALINE

Cas:315-22-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

MONOCROTALINE

Cas:315-22-0

Min.Order:1 Gram

FOB Price: $150.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, steroids, pharmaceutical

MONOCROTALINE/315-22-0/Crotaline Manufacturer

Cas:315-22-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:315-22-0

Cas:315-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

MONOCROTALINE

Cas:315-22-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Crotaline

Cas:315-22-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

MONOCROTALINE

Cas:315-22-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Lily Bulb Extract CAS NO.315-22-0

Cas:315-22-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

MONOCROTALINE

Cas:315-22-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

MONOCROTALINCAS315-22-0

Cas:315-22-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Crotaline.99%

Cas:315-22-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Crotaline

Cas:315-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

MONOCROTALINE

Cas:315-22-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

315-22-0 CAS NO.315-22-0

Cas:315-22-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Crotaline

Cas:315-22-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

shanghai Tauto Biotech Co., Ltd

The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysis me

E-0932 Monocrotaline

Cas:315-22-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Monocrotaline

Cas:315-22-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

Hangzhou Dingyan Chem is a leading manufacturer and supplier of chemicals in China.We develop,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best qualit

Monocrotaline

Cas:315-22-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Monocrotaline

Cas:315-22-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

monocrotaline methylene acetal
110121-56-7, 121719-98-0, 121720-00-1

monocrotaline methylene acetal

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
With trityl tetrafluoroborate In dichloromethane for 48h; Heating;86%
With hydrogenchloride; trityl tetrafluoroborate 1.) CH2Cl2, reflux, 48 h, 2.) room temperature, 17.5 h; Yield given. Multistep reaction;
Conditions
ConditionsYield
With hydrogenchloride In ethylene glycol at 110℃; for 2h;75%
Monocrotaline N-oxide
35337-98-5

Monocrotaline N-oxide

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
With intestinal gut bacteria in a human fecal suspension at 37℃; for 5h; Enzymatic reaction;38%
grahamine
24583-56-0

grahamine

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
With hydrogenchloride
(2R,3R,4R)-2,3,4-trimethyl-2,3-methylenedioxypentanedioic anhydride
109391-24-4, 121787-06-2

(2R,3R,4R)-2,3,4-trimethyl-2,3-methylenedioxypentanedioic anhydride

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
2: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
3: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
2: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
3: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(2R,3R,4R)-2,3,4-Trimethyl-2,3-(methylenedioxy)pentanedioic acid
109494-78-2, 121787-04-0

(2R,3R,4R)-2,3,4-Trimethyl-2,3-(methylenedioxy)pentanedioic acid

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Ac2O / CH2Cl2 / 3.5 h / Heating
2: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
3: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
4: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: Ac2O / CH2Cl2 / 3.5 h / Heating
2: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
3: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
4: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentene
121719-94-6

(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentene

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1) BH3*THF, 2) 3 M NaOH, 30percent H2O2 / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h
2: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
3: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
4: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
5: Ac2O / CH2Cl2 / 3.5 h / Heating
6: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
7: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
8: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 8 steps
1: 1) BH3*THF, 2) 3 M NaOH, 30percent H2O2 / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h
2: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
3: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
4: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
5: Ac2O / CH2Cl2 / 3.5 h / Heating
6: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
7: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
8: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester
146070-68-0

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
2: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
3: Ac2O / CH2Cl2 / 3.5 h / Heating
4: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
5: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
6: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
2: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
3: Ac2O / CH2Cl2 / 3.5 h / Heating
4: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
5: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
6: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid
121719-96-8

(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
2: Ac2O / CH2Cl2 / 3.5 h / Heating
3: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
4: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
5: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
2: Ac2O / CH2Cl2 / 3.5 h / Heating
3: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
4: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
5: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentanol
121719-93-5, 121787-08-4

(2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentanol

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 83 percent / POCl3, pyridine / 17 h / 85 °C
2: 1) BH3*THF, 2) 3 M NaOH, 30percent H2O2 / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h
3: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
4: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
5: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
6: Ac2O / CH2Cl2 / 3.5 h / Heating
7: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
8: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
9: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 9 steps
1: 83 percent / POCl3, pyridine / 17 h / 85 °C
2: 1) BH3*THF, 2) 3 M NaOH, 30percent H2O2 / 1) THF, 0 deg C, 20 h, 2) THF, r.t., 3 h
3: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
4: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
5: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
6: Ac2O / CH2Cl2 / 3.5 h / Heating
7: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
8: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
9: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-1-pentanol
121719-95-7, 121787-09-5

(2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-1-pentanol

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
2: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
3: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
4: Ac2O / CH2Cl2 / 3.5 h / Heating
5: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
6: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
7: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 7 steps
1: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -78 deg C, 2 min, 2) CH2Cl2, -78 deg C, 1 h
2: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.08 h / pH 7 phosphate buffer
3: 86 percent / 1 M NaOH, Na2RuO4 / 0.5 h / Ambient temperature
4: Ac2O / CH2Cl2 / 3.5 h / Heating
5: 1) Bu2SnO / 1) benzene, reflux, 24 h, 2) toluene, a) -40 deg C, 2 h, b) to r.t.
6: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
7: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(4R,5R)-5-((R)-1-Carboxy-ethyl)-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester
121719-97-9

(4R,5R)-5-((R)-1-Carboxy-ethyl)-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) Et3N, 2,4,6-trichlorobenzoyl chloride, 2) 4-(dimethylamino)pyridine / 1) THF, r.t., 3.5 h, 2) THF, toluene, reflux, 10 min
2: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 64 percent / 4-(dimethylamino)pyridine, 4-(dimethylamino)pyridine hydrochloride, dicyclohexylcarbodiimide / CHCl3 / 85 h
2: 86 percent / Ph3C*BF4 / CH2Cl2 / 48 h / Heating
View Scheme
(4R,5S)-5-[(R)-2-(Diethoxy-phosphoryloxy)-1-methyl-2-oxo-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

(4R,5S)-5-[(R)-2-(Diethoxy-phosphoryloxy)-1-methyl-2-oxo-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / Ambient temperature
2: 96 percent / 5percent aqueous HF / tetrahydrofuran
3: Et3N / CH2Cl2
4: 71 percent / Bu4N(1+)F(1-)*3H2O / acetonitrile / 34 °C
5: 75 percent / 38percent HCl / ethane-1,2-diol / 2 h / 110 °C
View Scheme
(4R,5S)-5-[(R)-1-((1R,7aR)-7-Hydroxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl)-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester
109391-29-9

(4R,5S)-5-[(R)-1-((1R,7aR)-7-Hydroxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl)-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2
2: 71 percent / Bu4N(1+)F(1-)*3H2O / acetonitrile / 34 °C
3: 75 percent / 38percent HCl / ethane-1,2-diol / 2 h / 110 °C
View Scheme
(4R,5S)-5-{(R)-1-[(1R,7aR)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl]-ethyl}-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester
109432-25-9

(4R,5S)-5-{(R)-1-[(1R,7aR)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl]-ethyl}-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 96 percent / 5percent aqueous HF / tetrahydrofuran
2: Et3N / CH2Cl2
3: 71 percent / Bu4N(1+)F(1-)*3H2O / acetonitrile / 34 °C
4: 75 percent / 38percent HCl / ethane-1,2-diol / 2 h / 110 °C
View Scheme
(4R,5S)-5-[(R)-1-((1R,7aR)-7-Methanesulfonyloxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl)-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

(4R,5S)-5-[(R)-1-((1R,7aR)-7-Methanesulfonyloxymethyl-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yloxycarbonyl)-ethyl]-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / Bu4N(1+)F(1-)*3H2O / acetonitrile / 34 °C
2: 75 percent / 38percent HCl / ethane-1,2-diol / 2 h / 110 °C
View Scheme
Lithium; (1R,7aR)-7-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-olate
89710-47-4

Lithium; (1R,7aR)-7-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-olate

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / Ambient temperature
2: 96 percent / 5percent aqueous HF / tetrahydrofuran
3: Et3N / CH2Cl2
4: 71 percent / Bu4N(1+)F(1-)*3H2O / acetonitrile / 34 °C
5: 75 percent / 38percent HCl / ethane-1,2-diol / 2 h / 110 °C
View Scheme
(4R,5R)-5-((R)-1-Carboxy-ethyl)-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid (7R,7aS)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl ester

(4R,5R)-5-((R)-1-Carboxy-ethyl)-4,5-dimethyl-[1,3]dioxolane-4-carboxylic acid (7R,7aS)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl ester

monocrotaline
315-22-0

monocrotaline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) 2,4,6-trichlorobenzoyl chloride, 2.) 4-dimethylaminopyridine / 1.) THF, room temperature, 3.5 h, 2.) toluene, reflux, 10 min
2: 1.) Ph3CBF4, 2.) 1M HCl / 1.) CH2Cl2, reflux, 48 h, 2.) room temperature, 17.5 h
View Scheme
monocrotaline
315-22-0

monocrotaline

retronecine
480-85-3

retronecine

Conditions
ConditionsYield
With methanol; potassium hydroxide at 100℃; for 0.0833333h; Microwave irradiation;99%
With barium dihydroxide In water 1.) from 40 deg C to 50 deg C, 2 h, 2.) reflux, 2 h;91%
With barium dihydroxide for 2h; heating;81%
monocrotaline
315-22-0

monocrotaline

retronecanol
567-39-5

retronecanol

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In water; isopropyl alcohol at 80℃; under 750.075 Torr; Solvent; Pressure; Temperature; Flow reactor;61%
monocrotaline
315-22-0

monocrotaline

Monocrotalic acid
26543-09-9

Monocrotalic acid

Conditions
ConditionsYield
With ethanol; acetic acid; platinum Hydrogenation;
With ethanol; nickel Hydrogenation;
monocrotaline
315-22-0

monocrotaline

1,2-didehydro-7β-hydroxy-1-methyl-8α-pyrrolizidine
6029-72-7

1,2-didehydro-7β-hydroxy-1-methyl-8α-pyrrolizidine

Conditions
ConditionsYield
With quinoline; Pd/SrCO3; ethanol Hydrogenation;
monocrotaline
315-22-0

monocrotaline

Monocrotaline N-oxide
35337-98-5

Monocrotaline N-oxide

Conditions
ConditionsYield
With ethanol; dihydrogen peroxide
With dihydrogen peroxide
monocrotaline
315-22-0

monocrotaline

A

spectabiline
520-55-8

spectabiline

B

12,13-diacetoxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanane-11,15-dione
25490-68-0

12,13-diacetoxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanane-11,15-dione

Conditions
ConditionsYield
With acetyl chloride
monocrotaline
315-22-0

monocrotaline

12,13-[(Ξ)-sulfinyldioxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanan-11,15-dione
77057-77-3

12,13-[(Ξ)-sulfinyldioxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanan-11,15-dione

Conditions
ConditionsYield
With thionyl chloride
monocrotaline
315-22-0

monocrotaline

(7aR)-7t-methyl-(7ar)-hexahydro-pyrrolizin-1t-ol; salt with monocrotalic acid

(7aR)-7t-methyl-(7ar)-hexahydro-pyrrolizin-1t-ol; salt with monocrotalic acid

Conditions
ConditionsYield
With ethanol; acetic acid; platinum under 2206.5 Torr; Hydration;
With ethanol; nickel under 2206.5 Torr; Hydration;
monocrotaline
315-22-0

monocrotaline

A

2,3-dimethyl-4-oxo-valeric acid
526-79-4

2,3-dimethyl-4-oxo-valeric acid

B

retronecine
480-85-3

retronecine

Conditions
ConditionsYield
With barium dihydroxide; water
acetic anhydride
108-24-7

acetic anhydride

monocrotaline
315-22-0

monocrotaline

12,13-diacetoxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanane-11,15-dione
25490-68-0

12,13-diacetoxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanane-11,15-dione

Conditions
ConditionsYield
With acetyl chloride
monocrotaline
315-22-0

monocrotaline

2,3,4-trimethyl-L-2-deoxy-arabinitol

2,3,4-trimethyl-L-2-deoxy-arabinitol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran
monocrotaline
315-22-0

monocrotaline

(2R,3R,4R)-2,3,4-Trimethyl-2,3-(methylenedioxy)pentanedioic acid
109494-78-2, 121787-04-0

(2R,3R,4R)-2,3,4-Trimethyl-2,3-(methylenedioxy)pentanedioic acid

Conditions
ConditionsYield
Multistep reaction;
monocrotaline
315-22-0

monocrotaline

A

spectabiline
520-55-8

spectabiline

B

O,O'-diacetyl-monocrotaline

O,O'-diacetyl-monocrotaline

Conditions
ConditionsYield
With acetyl chloride
Ketene
463-51-4

Ketene

monocrotaline
315-22-0

monocrotaline

A

12,13-carbonyldioxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanan-11,15-dione
76971-16-9

12,13-carbonyldioxy-(13βH,14βH)-14,19-dihydro-20-nor-crotalanan-11,15-dione

B

spectabiline

spectabiline

Conditions
ConditionsYield
With chloroform
monocrotaline
315-22-0

monocrotaline

Dehydroretronecine
23107-12-2

Dehydroretronecine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: 40 percent / o-bromanil / CHCl3 / 0.03 h
View Scheme
monocrotaline
315-22-0

monocrotaline

5'-monophosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine
103958-13-0

5'-monophosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: 40 percent / o-bromanil / CHCl3 / 0.03 h
3: 0.9 percent / aq. K2CO3 / 6 h / 60 °C / pH 7.4
View Scheme
monocrotaline
315-22-0

monocrotaline

hydroquinone

hydroquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: o-bromanil / CHCl3 / 0.03 h
View Scheme
monocrotaline
315-22-0

monocrotaline

3'-monophosphate of 7-(deoxyadenosine-N6-yl)dehydrosupinidine

3'-monophosphate of 7-(deoxyadenosine-N6-yl)dehydrosupinidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: 40 percent / o-bromanil / CHCl3 / 0.03 h
3: aq. K2CO3 / 40 h / 60 °C / pH 8.0
View Scheme
monocrotaline
315-22-0

monocrotaline

3'-monophosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine
612490-81-0

3'-monophosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: 40 percent / o-bromanil / CHCl3 / 0.03 h
3: 2.5 percent / aq. K2CO3 / 6 h / 60 °C / pH 8.0 / stirred anaerobically
View Scheme
monocrotaline
315-22-0

monocrotaline

3',5'-bisphosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine

3',5'-bisphosphate of 7-(deoxyguanosin-N2-yl)dehydrosupinidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 81 percent / Ba(OH)2*8H2O / 2 h / heating
2: 40 percent / o-bromanil / CHCl3 / 0.03 h
3: 2.5 percent / aq. K2CO3 / 6 h / 60 °C / pH 8.0 / stirred anaerobically
4: dithiotreitol; ATP; MgCl2 / cloned T4 polynucleotide kinase / H2O / 0.67 h / 37 °C / pH 9.5
View Scheme
monocrotaline
315-22-0

monocrotaline

platynecine
520-62-7

platynecine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Ba(OH)2 / H2O / 1 h / Heating
2: 20 mg / hydrogen / Pd/C / ethanol / 2 h
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide; methanol / 0.08 h / 100 °C / Microwave irradiation
2: hydrogen / ethanol / 50 °C / 750.08 Torr / Flow reactor
View Scheme
monocrotaline
315-22-0

monocrotaline

(7R,7aR)-7-Hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizine-1-carbaldehyde
154922-76-6

(7R,7aR)-7-Hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizine-1-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / Ba(OH)2*8H2O / H2O / 1.) from 40 deg C to 50 deg C, 2 h, 2.) reflux, 2 h
2: Dess-Martin periodinane, CF3COOH / CH2Cl2 / 1 h
View Scheme
monocrotaline
315-22-0

monocrotaline

<9-2H>-retronecine

<9-2H>-retronecine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / Ba(OH)2*8H2O / H2O / 1.) from 40 deg C to 50 deg C, 2 h, 2.) reflux, 2 h
2: Dess-Martin periodinane, CF3COOH / CH2Cl2 / 1 h
3: NaB(2)H4 / methanol / 0.5 h / 0 °C
View Scheme

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