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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

AF4

Cas:3345-29-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:Ac

3345-29-72,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,2,3,3,8,8,9,9-Octafluorotricyclo(8.2.2.24,7)hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane CAS 3345-29-7

Cas:3345-29-7

Min.Order:1 Kilogram

FOB Price: $70.0 / 90.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3345-29-7 with competitive price

Cas:3345-29-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

AF4

Cas:3345-29-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane 3345-29-7

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene CAS:3345-29-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene CAS:3345-29-7

Cas:3345-29-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Parylene HT/AF4 (CAS No. 3345-29-7) Parylene finds widespread use in various applications like aerospace, automotive, medical, semiconductor, and electric. It is a polymer that is best-suited for conformal coatings because of its inert nature. Paryl

Parylene HT/AF4 (CAS No. 3345-29-7)

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale 2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other producti

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene Basic information Product Name: 2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene Syno

TIANFU-CHEM CAS:3345-29-7 2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

supply 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane CAS NO.3345-29-7

Cas:3345-29-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

supply 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane CAS NO.3345-29-7

Cas:3345-29-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

supply 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane CAS NO.3345-29-7

Cas:3345-29-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

supply 1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane CAS NO.3345-29-7

Cas:3345-29-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

1,1,2,2,9,9,10,10-Octafluoro[2.2]paracyclophane

Cas:3345-29-7

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

2,2,3,3,8,8,9,9-Octafluorotricyclo[8.2.2.24,7]hexadeca-4,6,10,12,13,15-hexaene

Cas:3345-29-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

Synthetic route

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With phenylmagnesium bromide; palladium dichloride In tetrahydrofuran for 1h; Inert atmosphere; Reflux;98%
4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-41-5

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; zinc In N,N-dimethyl-formamide at 25℃; for 8h;96%
4-chloro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-42-6

4-chloro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; zinc In N,N-dimethyl-formamide at 80℃; for 8h;A 94%
B 3%
2,2-difluoro-2-(fluorosulfonyl)acetate
680-15-9

2,2-difluoro-2-(fluorosulfonyl)acetate

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-trifluoromethyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-trifluoromethyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With copper(I) bromide; palladium dichloride In N,N-dimethyl-formamide at 80℃; Reduction; trifluoromethylation;A 3%
B 84%
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With palladium dichloride In tetrahydrofuran Kumada Cross-Coupling; Inert atmosphere; Reflux;A 8%
B 83%
4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper In N,N-dimethyl-formamide at 80℃; for 8h;A 11%
B 74%
Stage #1: 4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane With palladium dichloride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: With <2.2>paracyclophan-4-ylmagnesium bromide In tetrahydrofuran at 20℃; for 8h; Inert atmosphere;
A 60%
B 30%
phenylmagnesium bromide

phenylmagnesium bromide

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
palladium dichloride In tetrahydrofuran for 16h; Phenylation; reduction; Heating;A 9%
B 72%
4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-37-9

4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-41-5

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Stage #1: 4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane With sulfuric acid; sodium nitrite In water; acetic acid at 0℃; for 2h; Diazotization;
Stage #2: With hydrogen bromide; copper(I) bromide In water; acetic acid at 70℃; for 1h; Substitution; Sandmeyer reaction; reduction;
A 6%
B 66%
methyllithium lithium bromide

methyllithium lithium bromide

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-methyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-methyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With palladium dichloride In tetrahydrofuran for 2h; Kumada Cross-Coupling; Inert atmosphere; Reflux;A 66%
B 31%
With palladium dichloride In tetrahydrofuran; diethyl ether at 0℃; for 5h; Kumada Cross-Coupling; Inert atmosphere;A 17 %Spectr.
B 81 %Spectr.
1,4-bis-(difluorochloromethyl)-benzene
2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

(Z)-2,3,8,8,9,9-Hexafluoro-tricyclo[8.2.2.24,7]hexadeca-1(13),2,4(16),5,7(15),10(14),11-heptaene

(Z)-2,3,8,8,9,9-Hexafluoro-tricyclo[8.2.2.24,7]hexadeca-1(13),2,4(16),5,7(15),10(14),11-heptaene

Conditions
ConditionsYield
With zinc In N,N-dimethyl acetamide at 100℃; for 4h; Substitution;A 60.5%
B 6%
4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-37-9

4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-chloro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-42-6

4-chloro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Stage #1: 4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane With sulfuric acid; sodium nitrite In water; acetic acid at 0℃; for 2h; Diazotization;
Stage #2: With hydrogenchloride; copper(l) chloride In water; acetic acid at 70℃; for 1h; Substitution; Sandmeyer reaction; reduction;
A 10%
B 60%
α-trimethylsilyl-α,α,α',α'-pentafluoroxylene
149194-32-1

α-trimethylsilyl-α,α,α',α'-pentafluoroxylene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4-tert-Butylcatechol; cesium fluoride In methoxybenzene at 160℃; for 24h;53%
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-41-5

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With palladium dichloride In tetrahydrofuran for 2h; Kumada Cross-Coupling; Inert atmosphere; Reflux;A 50%
B 19%
C16H7F8I

C16H7F8I

potassium tert-butylate
865-47-4

potassium tert-butylate

benzene
71-43-2

benzene

C20H16F8O

C20H16F8O

B

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

C

C22H12F8
498556-71-1

C22H12F8

Conditions
ConditionsYield
In dibutyl ether at 110℃; for 5h;A 35%
B 45.8%
C 3.5%
1,4-bis-(difluorochloromethyl)-benzene
2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With potassium iodide; zinc In N,N-dimethyl acetamide at 120 - 142℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;45.7%
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran Heating;22%
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-40-4

4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-phenyl-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

C

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

4,4'-bis(1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane)

Conditions
ConditionsYield
Stage #1: 4-iodo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane With palladium dichloride In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;
Stage #2: phenylmagnesium bromide In tetrahydrofuran at 20℃; for 11h; Inert atmosphere;
A 15%
B 38%
C 44%
α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene
651-12-7

α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With trimethylsilyltributyltin; cesium fluoride In tetrahydrofuran; dimethyl sulfoxide at 78℃; for 28h;40%
With trimethylsilyltributyltin; cesium fluoride In tetrahydrofuran; dimethyl sulfoxide at 75 - 80℃; Substitution;40%
With calcium chloride; zinc In N,N-dimethyl acetamide at 120 - 136℃; for 3h; Catalytic behavior; Reagent/catalyst;32.8%
With water; copper at 650℃;
Multi-step reaction with 2 steps
1: Cu / 640 °C
2: toluene / 110 °C
View Scheme
α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene
651-12-7

α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

dodecafluoro[2,2]paracyclophane

dodecafluoro[2,2]paracyclophane

Conditions
ConditionsYield
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran Heating;A 31.8%
B 2.1%
With lithium aluminium tetrahydride; titanium tetrachloride In tetrahydrofuran Mechanism; Heating;A 31.8%
B 2.1%
With lead(II) bromide; aluminium In N,N-dimethyl-formamide at 0 - 20℃; for 30h; Product distribution; Further Variations:; Reagents; Solvents; Temperatures;A 22%
B 19%
1,4-bis-(difluorochloromethyl)-benzene
2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene
651-12-7

α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With calcium chloride; zinc In N,N-dimethyl acetamide at 120 - 140℃; for 4h; Catalytic behavior; Reagent/catalyst;31.4%
1,4-bis-(difluorochloromethyl)-benzene
2629-68-7

1,4-bis-(difluorochloromethyl)-benzene

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

dodecafluoro[2,2]paracyclophane

dodecafluoro[2,2]paracyclophane

Conditions
ConditionsYield
With aluminium In N,N-dimethyl-formamide at 0 - 20℃; for 50h;A 22%
B 20%
α,α,α',α'-tetrafluoro-p-xylylene
2250-30-8

α,α,α',α'-tetrafluoro-p-xylylene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
In toluene at 110℃; Yield given;
1,4-bis(trifluoromethyl)benzene
433-19-2

1,4-bis(trifluoromethyl)benzene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / Mg / dimethylformamide / 0.5 h / 20 °C
2: 53 percent / CsF; Pd2(dba)3*CHCl3; 4-tert-butylcatechol / methoxybenzene / 24 h / 160 °C
View Scheme
Multi-step reaction with 2 steps
1: 58 percent Spectr. / Mg / dimethylformamide / 1 h / 20 °C
2: 53 percent / CsF; Pd2(dba)3*CHCl3; 4-tert-butylcatechol / methoxybenzene / 24 h / 160 °C
View Scheme
4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-35-7

4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 82 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 6 percent / copper(I) bromide; hydrobromic acid / H2O; acetic acid / 1 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 82 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 10 percent / copper(I) chloride; hydrochloric acid / H2O; acetic acid / 1 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 82 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 78 percent / potassium iodide / H2O; acetic acid / 1 h / 70 °C
3.1: 9 percent / palladium dichloride / tetrahydrofuran / 16 h / Heating
View Scheme
4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-37-9

4-amino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
1.2: 78 percent / potassium iodide / H2O; acetic acid / 1 h / 70 °C
2.1: 9 percent / palladium dichloride / tetrahydrofuran / 16 h / Heating
View Scheme
4-hydroxylamino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-36-8

4-hydroxylamino-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 77 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 6 percent / copper(I) bromide; hydrobromic acid / H2O; acetic acid / 1 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 77 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 10 percent / copper(I) chloride; hydrochloric acid / H2O; acetic acid / 1 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 77 percent / iron; hydrochloric acid / ethanol; H2O / 4 h / Heating
2.1: H2SO4; NaNO2 / acetic acid; H2O / 2 h / 0 °C
2.2: 78 percent / potassium iodide / H2O; acetic acid / 1 h / 70 °C
3.1: 9 percent / palladium dichloride / tetrahydrofuran / 16 h / Heating
View Scheme
para-xylene
106-42-3

para-xylene

3-methyl-phthalic acid-dichloride

3-methyl-phthalic acid-dichloride

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / Br2 / 5 h / 130 - 160 °C
2: 85 percent / SbF3 / 120 °C / 40 Torr
3: 55 percent / N-bromosuccinimide / CCl4 / Heating; Irradiation
4: Cu / 640 °C
5: toluene / 110 °C
View Scheme
1,4-bis(dibromomethyl)benzene
1592-31-0

1,4-bis(dibromomethyl)benzene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / SbF3 / 120 °C / 40 Torr
2: 55 percent / N-bromosuccinimide / CCl4 / Heating; Irradiation
3: Cu / 640 °C
4: toluene / 110 °C
View Scheme
p-bis(difluoromethyl)benzene
369-54-0

p-bis(difluoromethyl)benzene

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 55 percent / N-bromosuccinimide / CCl4 / Heating; Irradiation
2: Cu / 640 °C
3: toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: 78 percent / N-bromosuccinimide / CCl4 / Heating; Irradiation
2: 31.8 percent / TiCl4, LiAlH4 / tetrahydrofuran / Heating
View Scheme
Multi-step reaction with 2 steps
1: NBS / CCl4 / Irradiation
2: Cu, H2O / 650 °C
View Scheme
terephthalaldehyde,
623-27-8

terephthalaldehyde,

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / SF4 / 150 °C
2: 78 percent / N-bromosuccinimide / CCl4 / Heating; Irradiation
3: 31.8 percent / TiCl4, LiAlH4 / tetrahydrofuran / Heating
View Scheme
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

α,α,α',α'-tetrafluoro-p-xylylene
2250-30-8

α,α,α',α'-tetrafluoro-p-xylylene

Conditions
ConditionsYield
at 450 - 600℃; under 0 Torr; Decomposition; flash vacuum pyrolysis;100%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-35-7

4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With nitric acid90%
With nitronium tetrafluoborate In sulfolane at 25℃; for 16h; Nitration;86%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane-4,7-dione
1173111-79-9

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane-4,7-dione

B

C16H6F8O3
1173111-81-3

C16H6F8O3

Conditions
ConditionsYield
With sulfuric acid; iodic acid In trifluoroacetic acid at 20℃; Reflux;A 56%
B 20%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-41-5

4-bromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

p-dibromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
299975-30-7

p-dibromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With N-Bromosuccinimide; sulfuric acid In trifluoroacetic acid at 20 - 80℃; for 28h; Bromination;A n/a
B 55%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

p-dibromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
299975-30-7

p-dibromo-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With N-Bromosuccinimide; sulfuric acid In trifluoroacetic acid at 20 - 80℃; for 28h;55%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
257863-35-7

4-nitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

pseudo-o-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
300700-86-1, 300766-00-1

pseudo-o-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

C

pseudo-m-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

pseudo-m-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With nitronium tetrafluoborate In sulfolane at 80℃; Nitration;A 36%
B 16%
C 16%
With nitronium tetrafluoborateA 36%
B n/a
C 16%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

A

pseudo-o-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
300700-86-1, 300766-00-1

pseudo-o-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

B

pseudo-m-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

pseudo-m-dinitro-1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

Conditions
ConditionsYield
With nitronium tetrafluoborate In sulfolane at 80℃; for 16h; Nitration;A 27%
B n/a
With nitronium tetrafluoborate In sulfolane at 20 - 80℃;A n/a
B 27%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

2,9,9,10,10-pentafluoro-1-trimethylsilyl[2.2]paracyclophan-1-ene

2,9,9,10,10-pentafluoro-1-trimethylsilyl[2.2]paracyclophan-1-ene

Conditions
ConditionsYield
With magnesium In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere;23%
1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane
3345-29-7

1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane

1,1,2,2,9,9,10,10-octafluoro<2.2>paracyclophane radical anion

1,1,2,2,9,9,10,10-octafluoro<2.2>paracyclophane radical anion

Conditions
ConditionsYield
With tetrabutylammonium perchlorate In 1,2-dimethoxyethane at -85.1℃; Product distribution; study of the radical anion formation by continous electrolysis;

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