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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

trans-4-Hydroxy-D-proline Manufacturer/High quality/Best price/In stock

Cas:3398-22-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 3398-22-9 H-D-Hyp-OH Manufacturer

Cas:3398-22-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3398-22-9 with competitive price

Cas:3398-22-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

trans-4-Hydroxy-D-proline CAS3398-22-9

Cas:3398-22-9

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 4-hydroxy-D-proline Synonyms: H-D-Hyp-OH CAS: 3398-22-9 MF: C5H9NO3 Appearance: White powder Storage:Store in cool and dry place, away from sun light. Package:25KG/Drum Application:Cosmetic grade Transportation:By sea or by air Port:Qingda

4-hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Trans-4-Hydroxy-D-Proline CAS. 3398-22-9

Cas:3398-22-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

D-Proline, 4-hydroxy-,(4S)- 3398-22-9

Cas:3398-22-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

trans-4-Hydroxy-D-proline CAS:3398-22-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

trans-4-Hydroxy-D-proline CAS:3398-22-9

Cas:3398-22-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

D-Proline, 4-hydroxy-,(4S)-

Cas:3398-22-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3398-22-9

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply H-D-Hyp-OH

Cas:3398-22-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

D-Proline, 4-hydroxy-,(4S)-

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

H-D-Hyp-OH

Cas:3398-22-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

trans-4-Hydroxy-D-proline Basic information Product Name: trans-4-Hydroxy-D-proline Synonyms: TRANS-D-HYDROXYPROLINE;TRANS-D-4-HYDROXYPROLINE;TRANS-4-HYDROXY-D-PROLINE;(2R,4S)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID;(2R,4S)-4-HYDROXYPYRROLIDI

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

D-trans-Hydroxyproli

Cas:3398-22-9

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

trans-D-4-Hydroxyproline cas no. 3398-22-9 98%

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

trans-4-Hydroxy-D-proline

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

trans-D-Hydroxyproline

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

H-D-Hyp-OH

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid

Cas:3398-22-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(2R,4S)-4-(benzyloxy)-1-N-tosylpyrrolidine-2-carboxylic acid

(2R,4S)-4-(benzyloxy)-1-N-tosylpyrrolidine-2-carboxylic acid

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
With ammonia; sodium at -70℃; for 3.5h; Inert atmosphere;79%
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline
77449-96-8

N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
With sodium hydroxide Erhitzen des Reaktionsprodukts mit wss. HCl;
trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-D-proline
114673-33-5

trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-D-proline

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
With hydrogenchloride
With hydrogenchloride
1-anilinoformyl-d-a-<4-oxy-proline >

1-anilinoformyl-d-a-<4-oxy-proline >

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
With ammonia at 95 - 100℃;
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline
77449-96-8

N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline

aqueous NaOH

aqueous NaOH

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
anschliessend Erhitzen mit wss. HCl;
trans-4-hydroxy-D,L-proline
618-28-0

trans-4-hydroxy-D,L-proline

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aqueous NaOH
2: (1S,2S)-2-amino-1-<4-nitro-phenyl>-propane-1,3-diol
3: aqueous HCl
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide
2: (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
3: hydrogenchloride
View Scheme
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline Methyl Ester
77449-95-7

N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline Methyl Ester

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous methanol. NaOH
2: aqueous NaOH / Erhitzen des Reaktionsprodukts mit wss. HCl
View Scheme
trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-DL-proline
103078-90-6, 114673-32-4, 114673-33-5

trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-DL-proline

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: brucine
2: aqueous HCl
View Scheme
Multi-step reaction with 2 steps
1: (1S,2S)-2-amino-1-<4-nitro-phenyl>-propane-1,3-diol
2: aqueous HCl
View Scheme
Multi-step reaction with 2 steps
1: (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
2: hydrogenchloride
View Scheme
trans-4-hydroxy-D,L-proline
618-28-0

trans-4-hydroxy-D,L-proline

A

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

B

4R-4-hydroxyproline
51-35-4

4R-4-hydroxyproline

Conditions
ConditionsYield
With shaking calcined L-Pro chiral ordered mesoporous silica Resolution of racemate;
(3S,5R)-3-(benzyloxy)-2-hydroxy-5-(hydroxymethyl)-1-N-tosylpyrrolidine

(3S,5R)-3-(benzyloxy)-2-hydroxy-5-(hydroxymethyl)-1-N-tosylpyrrolidine

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 30 °C / Inert atmosphere
2: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
3: ammonia; sodium / 3.5 h / -70 °C / Inert atmosphere
View Scheme
4-O-benzyl-2,3-dideoxy-2-(p-toluenesulfonamido)-D-glucitol

4-O-benzyl-2,3-dideoxy-2-(p-toluenesulfonamido)-D-glucitol

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium periodate; sodium hydrogencarbonate / water; dichloromethane / 12 h / 0 - 30 °C / Inert atmosphere
2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 30 °C / Inert atmosphere
3: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
4: ammonia; sodium / 3.5 h / -70 °C / Inert atmosphere
View Scheme
1,6-di-O-acetyl-4-O-benzyl-2,3-dideoxy-2-(p-toluenesulfonamido)-D-glucopyranose

1,6-di-O-acetyl-4-O-benzyl-2,3-dideoxy-2-(p-toluenesulfonamido)-D-glucopyranose

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / Reflux; Inert atmosphere
2: sodium periodate; sodium hydrogencarbonate / water; dichloromethane / 12 h / 0 - 30 °C / Inert atmosphere
3: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 30 °C / Inert atmosphere
4: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
5: ammonia; sodium / 3.5 h / -70 °C / Inert atmosphere
View Scheme
benzyl chloroformate
501-53-1

benzyl chloroformate

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(4S)-1-[(benzyloxy)carbonyl]-4-hydroxy-D-proline
155153-78-9

(4S)-1-[(benzyloxy)carbonyl]-4-hydroxy-D-proline

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; for 1h;100%
Stage #1: benzyl chloroformate; trans-4-hydroxyproline With sodium hydrogencarbonate In water; toluene at 20℃; for 16.25h;
Stage #2: With hydrogenchloride In diethyl ether; water pH=2;
93%
Stage #1: benzyl chloroformate; trans-4-hydroxyproline With sodium hydrogencarbonate In water; toluene at 20℃; for 16h;
Stage #2: With hydrogenchloride In water pH=2; Cooling with ice;
93%
With sodium hydrogencarbonate
With sodium hydrogencarbonate In water
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S )-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
147266-92-0

(2R,4S )-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃;100%
With sodium hydroxide In 1,4-dioxane; water
With triethylamine In methanol for 2h; Reflux;11 g
C8H3ClF5N

C8H3ClF5N

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(2,4-difluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(2,4-difluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;93%
N-(2,5-difluorophenyl)-2,2,2-trifluoroacetimidoyl chloride

N-(2,5-difluorophenyl)-2,2,2-trifluoroacetimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(2,5-difluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(2,5-difluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;92%
With sodium hydrogencarbonate; titanium(IV) oxide
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

benzyl alcohol
100-51-6

benzyl alcohol

(2R,4S)-4-hydroxyproline benzyl ester

(2R,4S)-4-hydroxyproline benzyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene at 125℃; for 20h; Dean-Stark;91.1%
1,2-di(m-tolyl)disulfane
63930-17-6

1,2-di(m-tolyl)disulfane

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2S,4R)-2-carboxy-4-(3-fluorophenylthio)pyrrolidine

(2S,4R)-2-carboxy-4-(3-fluorophenylthio)pyrrolidine

Conditions
ConditionsYield
With tributylphosphine In tetrahydrofuran at 60 - 65℃; for 25h; Concentration;89.7%
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
481704-21-6

(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

Conditions
ConditionsYield
With acetyl chloride In methanol; diethyl ether at 20℃;87.6%
C8H3BrCl2F3N
1453185-82-4

C8H3BrCl2F3N

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(2-bromo-4-chlorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(2-bromo-4-chlorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;87%
N-(4-chlorophenyl)-2,2,2-trifluoroethanimidoyl chloride
143681-32-7

N-(4-chlorophenyl)-2,2,2-trifluoroethanimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(4-chlorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(4-chlorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;83%
maleic acid
110-16-7

maleic acid

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(S)-pyrrolidin-3-ol hydrogen maleate
1092655-33-8

(S)-pyrrolidin-3-ol hydrogen maleate

Conditions
ConditionsYield
Stage #1: trans-4-hydroxyproline With cyclohexenone In cyclohexanol for 3h; Reflux;
Stage #2: maleic acid at 35℃; for 0.5h;
80%
Stage #1: trans-4-hydroxyproline With cyclohexenone In cyclohexanol for 3h; Reflux;
Stage #2: maleic acid In cyclohexanol at 35℃; for 0.5h;
80%
2,2,2-trifluoro-N-[2-(trifluoromethyl)phenyl]ethanimidoyl chloride
61984-67-6

2,2,2-trifluoro-N-[2-(trifluoromethyl)phenyl]ethanimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-4-hydroxy-1-(2,2,2-trifluoroacetyl)-N-(2-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide

(2R,4S)-4-hydroxy-1-(2,2,2-trifluoroacetyl)-N-(2-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Reagent/catalyst; Solvent; Time; Inert atmosphere;78%
2,2,2-trifluoro-N-(3-(trifluoromethyl)phenyl)acetimidoyl chloride
69563-07-1

2,2,2-trifluoro-N-(3-(trifluoromethyl)phenyl)acetimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-4-hydroxy-1-(2,2,2-trifluoroacetyl)-N-(3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide

(2R,4S)-4-hydroxy-1-(2,2,2-trifluoroacetyl)-N-(3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;77%
C8H3ClF4N2O2

C8H3ClF4N2O2

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(4-fluoro-3-nitrophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(4-fluoro-3-nitrophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;77%
N-(4-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride
145372-31-2

N-(4-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-4-hydroxy-N-(4-nitrophenyl)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-4-hydroxy-N-(4-nitrophenyl)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;73%
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

3-hydroxypyrrolidine
100243-39-8

3-hydroxypyrrolidine

Conditions
ConditionsYield
With cyclohexenone; cyclohexanol for 2h; Heating;70%
N-(3,5-bis(trifluoromethyl)phenyl)-2,2,2-trifluoroacetimidoyl chloride

N-(3,5-bis(trifluoromethyl)phenyl)-2,2,2-trifluoroacetimidoyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(3,5-bis(trifluoromethyl)phenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;70%
C8H3Cl2F4N

C8H3Cl2F4N

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-N-(3-chloro-4-fluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

(2R,4S)-N-(3-chloro-4-fluorophenyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With titanium(IV) oxide; sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 8h; Inert atmosphere;70%
formaldehyd
50-00-0

formaldehyd

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

C12H21N2O8P
1451370-71-0

C12H21N2O8P

Conditions
ConditionsYield
Stage #1: trans-4-hydroxyproline With hydrogenchloride; hypophosphorous acid In water at 20℃; for 1h;
Stage #2: formaldehyd In water at 20℃; for 24h;
28%
2-bromo-4-methylvaleryl bromide
74204-03-8

2-bromo-4-methylvaleryl bromide

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

1-(DL-α-bromo-isocaproyl)-4-oxy-L-proline

1-(DL-α-bromo-isocaproyl)-4-oxy-L-proline

Conditions
ConditionsYield
With sodium hydroxide
potassium cyanate
590-28-3

potassium cyanate

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

6-hydroxy-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione
67943-20-8, 75281-55-9

6-hydroxy-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

Conditions
ConditionsYield
With water Eindampfen der Reaktionsloesung mit Salzsaeure;
chloroacetyl chloride
79-04-9

chloroacetyl chloride

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

1-chloroacetyl-4-oxy-L-proline

1-chloroacetyl-4-oxy-L-proline

Conditions
ConditionsYield
With sodium hydroxide
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

1-acetyl-4-acetoxy-L-prolin-ethyl ester
109492-71-9, 109525-34-0

1-acetyl-4-acetoxy-L-prolin-ethyl ester

Conditions
ConditionsYield
With hydrogenchloride Erwaermen des entstandenen Aethylesters mit Acetanhydrid und Natriumacetat;
dihydrogen peroxide
7722-84-1

dihydrogen peroxide

copper(II) sulfate
7758-99-8

copper(II) sulfate

trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

aqueous NaOH

aqueous NaOH

pyrrole-2-carboxyl acid
634-97-9

pyrrole-2-carboxyl acid

Conditions
ConditionsYield
Behandeln des Reaktionsgemisches mit Essigsaeure und wss. HCl;
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-2-hydroxymethyl-4-hydroxy-N-(carbobenzyloxy)pyrrolidine

(2R,4S)-2-hydroxymethyl-4-hydroxy-N-(carbobenzyloxy)pyrrolidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaHCO3 / H2O
2: SOCl2
3: NaBH4; LiCl
View Scheme
Multi-step reaction with 3 steps
1: NaHCO3
2: methanol
3: LiBH4 / tetrahydrofuran
View Scheme
trans-4-hydroxyproline
3398-22-9

trans-4-hydroxyproline

(2R,4S)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
79433-95-7

(2R,4S)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaHCO3 / H2O
2: SOCl2
View Scheme
Multi-step reaction with 2 steps
1: NaHCO3
2: methanol
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / toluene; water / 16.25 h / 20 °C
1.2: pH 2
2.1: thionyl chloride / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / toluene; water / 16 h / 20 °C
1.2: pH 2 / Cooling with ice
2.1: thionyl chloride / 12 h / 0 - 20 °C
View Scheme

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