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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Methylflavone-8-carboxylic acid Manufacturer/High quality/Best price/In stock

Cas:3468-01-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off white crystalline powder Off white crystalline powder Melt point

High purity Various Specifications 3-Methylflavone-8-carboxylic acid CAS:3468-01-7

Cas:3468-01-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

3-Methylflavone-8-carboxylic acid high purity

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Methylflavone-8-Carboxylic Acid supplier in China

Cas:3468-01-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Methylflavone-8-Carboxylic Acid

Cas:3468-01-7

Min.Order:1

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb

3-methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1028.html Product Name 3-Methylflavone-8-carboxylic acid CAS No. 3468-01-7

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Gram

FOB Price: $45.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 3468-01-7 with competitive price

Cas:3468-01-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

3-Methylflavone-8-carboxylic acid CAS NO 3468-01-7

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Maytime Bio-Tech Co.,Ltd.

Top Supplier. Appearance:white or off-white crystalline powder Storage:store in tight container. Package:25kgs/fiber drum Application:Flavoxate Hydrochloride intermediate Port:shanghai seaport

3-MethylFlavine -8-Carboxylic Acid CAS No 3468-01-7

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl- 3468-01-7

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time

High Quality 3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Kilogram

FOB Price: $180.0 / 200.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-Methylflavone-8-carboxylic acid CAS:3468-01-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

3-Methylflavone-8-carboxylic acid CAS:3468-01-7

Cas:3468-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl-

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl-

Cas:3468-01-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Methylflavone-8-Carboxylic Acid

Cas:3468-01-7

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-METHYLFLAVONE-8-CARBOXYLIC ACID 3468-01-7

Cas:3468-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl-

Cas:3468-01-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3-Methylflavone-8-Carboxylic Acid

Cas:3468-01-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

3468-1-7 C17H12O4 3-Methylflavone-8-carboxylic acidAppearance:white powder Storage:Normal temperature Package:according to customers' requirements Application:The main active metabolite of Flavoxate hydrochloride (FX) in human. T

3468-1-7 C17H12O4 3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Methylflavone-8-carboxylic acid Synonyms: LABOTEST-BB LT00454344;8-CARBOXY-3-METHYLFLAVONE;4H-1-BENZOPYRAN-8-CARBOXYLIC ACID, 3-METHYL-4-OXO-2-PHENYL-;3-METHYLFLAVONE-8-CARBOXYLIC ACID;3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxy

3-Methylflavone-8-carboxylic acid

Cas:3468-01-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 3-Methylflavone-8-Carboxylic Acid CAS No.:3468-01-7 Molecule Formula:C17H12O4 Molecule Weight:280.27 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

Best Quality 3-Methylflavone-8-Carboxylic Acid

Cas:3468-01-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

High Quality 3-Methylflavone-8-carboxylic acid 3468-01-7 in stock fast delivery good supplier

Cas:3468-01-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Synthetic route

methyl 2-benzoyloxy-3-propionylbenzoate

methyl 2-benzoyloxy-3-propionylbenzoate

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl 2-benzoyloxy-3-propionylbenzoate With aluminum oxide at 165℃; for 4h;
Stage #2: With sodium hydroxide In methanol; water at 75 - 80℃; for 1.5h; Temperature;
88%
8-formyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran
103085-54-7

8-formyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide In butanone at 90 - 95℃; for 44h;85%
With nitric acid In benzene Product distribution; Heating; various concentrations of HNO3.;85%
3-methyl-2-phenyl-8-(1-propenyl)-4H-1-benzopyran-4-one

3-methyl-2-phenyl-8-(1-propenyl)-4H-1-benzopyran-4-one

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / NaBr, H2SO4 / acetonitrile; H2O / 2.83 h / 45 °C / electrolysis
2: 1) H2SO4; 2) electrolysis / 1) MeOH, 60 deg C, 40 min; 2) 60 deg C, 48 h.
3: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
Multi-step reaction with 4 steps
1: 94 percent / NaBr, H2SO4 / acetonitrile; H2O / 2.83 h / 45 °C / electrolysis
2: 94 percent / 10percent H2SO4 / tetrahydrofuran / 11 h / Ambient temperature
3: 91 percent / H2SO4 / methanol / 6 h / Ambient temperature; electrolysis
4: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
Multi-step reaction with 4 steps
1: 94 percent / NaBr, H2SO4 / acetonitrile; H2O / 2.83 h / 45 °C / electrolysis
2: 94 percent / 10percent H2SO4 / tetrahydrofuran / 11 h / Ambient temperature
3: 74 percent / H2SO4, electrolysis / methanol / 50 °C / other temperatures, other reagent, other solvent.
4: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
8-(1,2-epoxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one
103085-50-3

8-(1,2-epoxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) H2SO4; 2) electrolysis / 1) MeOH, 60 deg C, 40 min; 2) 60 deg C, 48 h.
2: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
Multi-step reaction with 3 steps
1: 94 percent / 10percent H2SO4 / tetrahydrofuran / 11 h / Ambient temperature
2: 91 percent / H2SO4 / methanol / 6 h / Ambient temperature; electrolysis
3: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
Multi-step reaction with 3 steps
1: 94 percent / 10percent H2SO4 / tetrahydrofuran / 11 h / Ambient temperature
2: 74 percent / H2SO4, electrolysis / methanol / 50 °C / other temperatures, other reagent, other solvent.
3: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
8-(1,2-dihydroxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one
103085-53-6

8-(1,2-dihydroxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / H2SO4 / methanol / 6 h / Ambient temperature; electrolysis
2: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
Multi-step reaction with 2 steps
1: 74 percent / H2SO4, electrolysis / methanol / 50 °C / other temperatures, other reagent, other solvent.
2: 85 percent / HNO3 / benzene / Heating; various concentrations of HNO3.
View Scheme
0.5N-KOH

0.5N-KOH

Methyl 3-methylflavone-8-carboxylate
90101-87-4

Methyl 3-methylflavone-8-carboxylate

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
In methanol; water27.3 g (97.5%)
flavoxate hydrochloride

flavoxate hydrochloride

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Stage #1: flavoxate hydrochloride With sodium hydroxide for 3h; Reflux;
Stage #2: With hydrogenchloride; water
methyl salicylate
119-36-8

methyl salicylate

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bromine / dichloromethane / 4 h / 0 - 15 °C
1.2: 2.5 h / 60 - 65 °C
1.3: 1.5 h / 20 °C
2.1: sodium hydroxide / dichloromethane / 0 - 25 °C
3.1: aluminum oxide / 4 h / 165 °C
3.2: 1.5 h / 75 - 80 °C
View Scheme
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

N,N-Dimethylacrylamide
2680-03-7

N,N-Dimethylacrylamide

(E)-N,N-dimethyl-3-(3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)acrylamide

(E)-N,N-dimethyl-3-(3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)acrylamide

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; 2,2-dimethylpropanoic anhydride; bis[2-(diphenylphosphino)phenyl] ether; sodium chloride In 1,4-dioxane at 150℃; for 10h; Heck Reaction; Schlenk technique; Inert atmosphere;94%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

diethyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)phosphonate

diethyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)phosphonate

Conditions
ConditionsYield
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 130℃; for 18h; Schlenk technique; Inert atmosphere; Glovebox;93%
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane for 18h; Inert atmosphere; Schlenk technique; Heating;93%
dibutyl hydrogen phosphite
1809-19-4

dibutyl hydrogen phosphite

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

dibutyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)phosphonate

dibutyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)phosphonate

Conditions
ConditionsYield
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane for 18h; Inert atmosphere; Schlenk technique; Heating;93%
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 130℃; for 18h; Schlenk technique; Inert atmosphere; Glovebox;91%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

dicyclohexylphosphine oxide
14717-29-4

dicyclohexylphosphine oxide

8-(dicyclohexylphosphoryl)-3-methyl-2-phenyl-4H-chromen-4-one

8-(dicyclohexylphosphoryl)-3-methyl-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 130℃; for 18h; Schlenk technique; Inert atmosphere; Glovebox;83%
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane for 18h; Inert atmosphere; Schlenk technique; Heating;83%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

3-methyl-2-phenyl-8-(2,2,2-trifluoroacetyl)-4H-chromen-4-one

3-methyl-2-phenyl-8-(2,2,2-trifluoroacetyl)-4H-chromen-4-one

Conditions
ConditionsYield
With dmap; cesium fluoride; trifluoroacetic anhydride at 120℃; for 15h; Schlenk technique; Inert atmosphere;80%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

triethylamine
121-44-8

triethylamine

N,N-diethyl-3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxamide
90101-88-5

N,N-diethyl-3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxamide

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; palladium diacetate; 2,2-dimethylpropanoic anhydride In toluene at 120℃; for 15h; Inert atmosphere;75%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N,N,3-trimethyl-4-oxo-2-phenyl-4H-chromene-8-carboxamide

N,N,3-trimethyl-4-oxo-2-phenyl-4H-chromene-8-carboxamide

Conditions
ConditionsYield
With trifuran-2-yl-phosphane; palladium diacetate; 2,2-dimethylpropanoic anhydride In toluene at 150℃; for 15h; Inert atmosphere;75%
8-amino quinoline
578-66-5

8-amino quinoline

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

C26H18N2O3

C26H18N2O3

Conditions
ConditionsYield
Stage #1: 3-methylflavone-8-carboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: 8-amino quinoline With triethylamine In dichloromethane at 0 - 45℃; for 12h;
73%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

8-((4-methoxyphenyl)ethynyl)-3-methyl-2-phenyl-4H-chromen-4-one

8-((4-methoxyphenyl)ethynyl)-3-methyl-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With 1,3-bis-(diphenylphosphino)propane; 2,2-dimethylpropanoic anhydride; palladium dichloride In 1,4-dioxane at 150℃; for 16h; Sonogashira Cross-Coupling; Inert atmosphere; Schlenk technique;70%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

Diphenylphosphine oxide
4559-70-0

Diphenylphosphine oxide

8-(diphenylphosphoryl)-3-methyl-2-phenyl-4H-chromen-4-one

8-(diphenylphosphoryl)-3-methyl-2-phenyl-4H-chromen-4-one

Conditions
ConditionsYield
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 115℃; for 18h; Schlenk technique; Inert atmosphere; Glovebox;68%
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 115℃; for 18h; Inert atmosphere; Schlenk technique;68%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

ethyl Phenylphosphinate
172487-18-2

ethyl Phenylphosphinate

ethyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)(phenyl)phosphinate

ethyl (3-methyl-4-oxo-2-phenyl-4H-chromen-8-yl)(phenyl)phosphinate

Conditions
ConditionsYield
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane at 130℃; for 18h; Schlenk technique; Inert atmosphere; Glovebox;67%
With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate In 1,4-dioxane for 18h; Inert atmosphere; Schlenk technique; Heating;67%
2,3,4-tri-O-acetyl-β-D-glucopyranosylamine uronic acid methyl ester
14365-73-2

2,3,4-tri-O-acetyl-β-D-glucopyranosylamine uronic acid methyl ester

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-[(3-methyl-4-oxo-2-phenyl-4H-chromene-8-carbonyl)-amino]-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6R)-3,4,5-Triacetoxy-6-[(3-methyl-4-oxo-2-phenyl-4H-chromene-8-carbonyl)-amino]-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 12h;49%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

1-(3-chloropropyl)piperidine hydrochloride
5472-49-1

1-(3-chloropropyl)piperidine hydrochloride

3-(1-piperidinyl)propyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate

3-(1-piperidinyl)propyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate

Conditions
ConditionsYield
With potassium hydroxide In methanol; isopropyl alcohol for 0.5h; Heating;32%
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

1-deoxy-1-{[(3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-yl)carbonyl]amino}-β-D-glucopyranuronic acid

1-deoxy-1-{[(3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-yl)carbonyl]amino}-β-D-glucopyranuronic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 49 percent / HOBT; DMAP; DCC / tetrahydrofuran / 12 h / 20 °C
2: 84 percent / LiOH / methanol; tetrahydrofuran; H2O / 0 °C
View Scheme
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

(1α,5α,6α)-3-N-benzyl-6-amino-3-aza-bicyclo[3.1.0]hexane
151860-17-2

(1α,5α,6α)-3-N-benzyl-6-amino-3-aza-bicyclo[3.1.0]hexane

(1α,5α,6α)-6N-[3-benzyl-3-azabicyclo [3.1.0]hexyl]-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxamide

(1α,5α,6α)-6N-[3-benzyl-3-azabicyclo [3.1.0]hexyl]-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 4-methyl-morpholine; DMF (N,N-dimethyl-formamide); 1-hydorxy benzotriazole at 0 - 20℃; for 3.5h;
1-aminomethyl-3-benzyl-3-azabicyclo [3.1.0] hexane
134574-95-1

1-aminomethyl-3-benzyl-3-azabicyclo [3.1.0] hexane

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

N-[3-benzyl-3-azabicyclo [3.1.0]hexyl-1-aminomethyl]-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxamide

N-[3-benzyl-3-azabicyclo [3.1.0]hexyl-1-aminomethyl]-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 4-methyl-morpholine; DMF (N,N-dimethyl-formamide); benzotriazol-1-ol at 0 - 20℃; for 3.5h;
N-(3-chloropropyl)-2-(3,4-dimethoxyphenyl)-N-methyl-ethylamine hydrochloride

N-(3-chloropropyl)-2-(3,4-dimethoxyphenyl)-N-methyl-ethylamine hydrochloride

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

8-{3-[2-(3,4-Dimethoxyphenyl)-N-methylethylamino]propoxycarbonyl}-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran hydrochloride
153240-51-8

8-{3-[2-(3,4-Dimethoxyphenyl)-N-methylethylamino]propoxycarbonyl}-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In N-methyl-acetamide; ethanol; water; isopropyl alcohol
3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine
21279-77-6

1-(2-methoxyphenyl)-4-(3-chloropropyl)piperazine

Rec 15/2667 dihydrochloride

Rec 15/2667 dihydrochloride

Conditions
ConditionsYield
With potassium carbonate In N-methyl-acetamide; ethanol
With potassium carbonate In N-methyl-acetamide; ethanol
Methyl 3-methylflavone-8-carboxylate
90101-87-4

Methyl 3-methylflavone-8-carboxylate

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

piperidinoethyl chloride
100859-97-0

piperidinoethyl chloride

flavoxate hydrochloride

flavoxate hydrochloride

Conditions
ConditionsYield
With sodium In N-hydroxyethylpiperidine; benzene
piperidine
110-89-4

piperidine

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

oxiranyl-methanol
556-52-5

oxiranyl-methanol

oxiranemethyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate
86433-56-9

oxiranemethyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate

2-hydroxy-3-(1-piperidinyl)propyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate

2-hydroxy-3-(1-piperidinyl)propyl 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylate

Conditions
ConditionsYield
With triethylamine In water; acetonitrile; benzene
1-(2-aminoisopropyl)-piperidine
54151-70-1

1-(2-aminoisopropyl)-piperidine

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-[2-(1-Piperidyl)propyl]-3-methylflavone-8-carboxamide
92606-55-8

N-[2-(1-Piperidyl)propyl]-3-methylflavone-8-carboxamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran
quinoline-S

quinoline-S

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride
51950-71-1

3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride

sodium hydrogensulfite

sodium hydrogensulfite

8-formyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran
103085-54-7

8-formyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran

Conditions
ConditionsYield
With thionyl chloride; palladium In 5,5-dimethyl-1,3-cyclohexadiene; water
1-(2-aminoethyl)pyrrolidine
7154-73-6

1-(2-aminoethyl)pyrrolidine

3-methylflavone-8-carboxylic acid
3468-01-7

3-methylflavone-8-carboxylic acid

3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride
51950-71-1

3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride

N-[2-(pyrrolidin-1-yl)ethyl]-3-methylflavone-8-carboxamide

N-[2-(pyrrolidin-1-yl)ethyl]-3-methylflavone-8-carboxamide

Conditions
ConditionsYield
With hydrogenchloride; thionyl chloride In benzene

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