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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 1-Chloro-2-Fluoro-4-Nitrobenzene supplier in China

Cas:350-31-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

4-Chloro-3-fluoronitrobenzene 446-09-3

Cas:350-31-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-Chloro-2-Fluoro-4-Nitrobenzene

Cas:350-31-2

Min.Order:1

Negotiable

Type:Other

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 350-31-2 with best quality

Cas:350-31-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,1-chloro-2-fluoro-4-nitro- 350-31-2

Cas:350-31-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At presen

1-Chloro-2-fluoro-4-nitrobenzene

Cas:350-31-2

Min.Order:1 Gram

FOB Price: $16.0 / 17.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzene,1-chloro-2-fluoro-4-nitro-

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloro-3-Fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Chloro-3-Fluoronitrobenzene CAS No.:350-31-2 Molecule Formula:C6H3ClFNO2 Molecule Weight:175.54 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TE

High Quality 4-Chloro-3-Fluoronitrobenzene on stock

Cas:350-31-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-Chloro-3-fluoronitrobenzene Synonyms: 350-31-2;4-Chloro-3-fluoronitrobenzenen;3-FLUORO-4-CHLORONITROBENZENE;4-CHLORO-3-FLUORONITROBENZENE;1-chloro-2-fluoro-4-nitrobenzene;3-FLUORO-4-CHLORONITROBENZENE,99%;1-Chloro-2-fluoro-4-nit

1-Chloro-2-fluoro-4-nitrobenzene 350-31-2 C6H3ClFNO2

Cas:350-31-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Chloro-3-fluoronitrobenzene cas no. 350-31-2 98%

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

1-chloro-2-fluoro-4-nitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price 1-Chloro-2-Fluoro-4-Nitrobenzene 350-31-2

Cas:350-31-2

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

1-Chloro-2-Fluoro-4-Nitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

1-chloro-2-fluoro-4-nitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

4-Chloro-3-fluoronitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

1-Chloro-2-fluoro-4-nitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-Chloro-2-fluoro-4-nitrobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

4-Chloro-3-Fluoroiodobenzene

Cas:350-31-2

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

2-fluoro-4-nitrophenol
403-19-0

2-fluoro-4-nitrophenol

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With para-tert-butylphenol; phosphorus pentachloride 1.) 130-140 deg C, 2 h, 2.) 230-240 deg C, 40 min;61%
4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination;44%
With sulfuric acid; fluorine
1-chloro-2-fluorobenzene
348-51-6

1-chloro-2-fluorobenzene

A

3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

B

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With nitric acid at 0℃;
With sulfuric acid; nitric acid at 0℃; for 0.5h; other reagent: nitric acid/acetic anhydride/zeolite H(1+)β; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
With molecular sieve; nitric acid; acetic anhydride at 0℃; for 3h; other reagent: nitric acid/sulfuric acid; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
4-chloro-3-fluoroaniline
367-22-6

4-chloro-3-fluoroaniline

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With sulfuric acid at -5℃; Diazotization.Behandeln der Diazoniumsalz-Loesung mit Natriumnitrit und Kupfer(I)-kupfer(II)-sulfit in Wasser;
1-chloro-2-fluorobenzene
348-51-6

1-chloro-2-fluorobenzene

nitric acid
7697-37-2

nitric acid

A

3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

B

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
at 0℃;
N-(3-fluorophenyl)acetamide
351-28-0

N-(3-fluorophenyl)acetamide

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium dicarbonate; hydrochloric acid; calcium chloride.
2: hydrochloric acid / Bei Kochen mit 20prozentiger Saeure
3: diluted sulfuric acid / -5 °C / Diazotization.Behandeln der Diazoniumsalz-Loesung mit Natriumnitrit und Kupfer(I)-kupfer(II)-sulfit in Wasser
View Scheme
N-(4-chloro-3-fluorophenyl)acetamide
351-31-5

N-(4-chloro-3-fluorophenyl)acetamide

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrochloric acid / Bei Kochen mit 20prozentiger Saeure
2: diluted sulfuric acid / -5 °C / Diazotization.Behandeln der Diazoniumsalz-Loesung mit Natriumnitrit und Kupfer(I)-kupfer(II)-sulfit in Wasser
View Scheme
morpholine
110-91-8

morpholine

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

3-fluoro-4-(4-morpholinyl)nitrobenzene
2689-39-6

3-fluoro-4-(4-morpholinyl)nitrobenzene

Conditions
ConditionsYield
Neat (no solvent);100%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

sodium thiophenolate
930-69-8

sodium thiophenolate

3-fluoro-4-(phenylthio)nitrobenzene
147696-80-8

3-fluoro-4-(phenylthio)nitrobenzene

Conditions
ConditionsYield
In methanol for 5h; Ambient temperature;78%
2-oxa-6-azaspiro[3.4]octane hemioxalate
220290-68-6

2-oxa-6-azaspiro[3.4]octane hemioxalate

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.4]octane

6-(2-fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.4]octane

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24.25h; Inert atmosphere;76%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

ethylene glycol
107-21-1

ethylene glycol

2-(2-fluoro-4-nitrophenoxy)ethan-1-ol
647858-19-3

2-(2-fluoro-4-nitrophenoxy)ethan-1-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;72.2%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

phenylmethanethiol
100-53-8

phenylmethanethiol

1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene
1242618-52-5

1-(benzylsulfanyl)-2-fluoro-4-nitrobenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 12h;62%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride
54745-74-3

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride

3-(2-fluoro-4-nitrophenyl)-8-oxa-3-azabicyclo[3.2.1]octane

3-(2-fluoro-4-nitrophenyl)-8-oxa-3-azabicyclo[3.2.1]octane

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24.25h; Inert atmosphere; Sealed tube;39%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

sodium methylate
124-41-4

sodium methylate

A

2-fluoro-1-methoxy-4-nitrobenzene
455-93-6

2-fluoro-1-methoxy-4-nitrobenzene

B

2-chloro-5-nitroanisole
1009-36-5

2-chloro-5-nitroanisole

Conditions
ConditionsYield
In methanol for 12h; Heating;A 37%
B 22%
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

sodium methylate
124-41-4

sodium methylate

3,4-dimethoxynitrobenzene
709-09-1

3,4-dimethoxynitrobenzene

Conditions
ConditionsYield
at 80℃;
at 80℃;
o-hydroxymethyl thiophenol
4521-31-7

o-hydroxymethyl thiophenol

1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

[2-(2-Fluoro-4-nitro-phenylsulfanyl)-phenyl]-methanol
73129-14-3

[2-(2-Fluoro-4-nitro-phenylsulfanyl)-phenyl]-methanol

Conditions
ConditionsYield
With copper; potassium carbonate at 160 - 170℃;
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

[2-(4-Chloro-2-fluoro-phenylsulfanyl)-phenyl]-methanol
73129-18-7

[2-(4-Chloro-2-fluoro-phenylsulfanyl)-phenyl]-methanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Cu, K2CO3 / 160 - 170 °C
2: aq. HCl, Fe / ethanol
3: (i) NaNO2, aq. HCl, (ii) CuCl
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

[2-(4-Amino-2-fluoro-phenylsulfanyl)-phenyl]-methanol
73129-16-5

[2-(4-Amino-2-fluoro-phenylsulfanyl)-phenyl]-methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cu, K2CO3 / 160 - 170 °C
2: aq. HCl, Fe / ethanol
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

linezolid

linezolid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / o-xylene / Reflux
4.2: 15 h / 90 °C / Inert atmosphere
5.1: 15 h / 20 °C
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

linezolid
165800-03-3

linezolid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / o-xylene / 1 h / Reflux
5.1: hydrogenchloride; water / 0.25 h / 20 °C
5.2: pH 8 - 9
6.1: dichloromethane; water / 1 h / 20 °C
6.2: pH 9 / cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: sodium hydrogencarbonate / water
4: n-butyllithium
View Scheme
Multi-step reaction with 4 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
4: Tributylphosphine oxide; lithium bromide / o-xylene
View Scheme
Multi-step reaction with 6 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / toluene / 1 h / Inert atmosphere; Reflux
5.1: hydrogenchloride / dichloromethane; water / 1 h / 20 °C
5.2: pH 7 / cooling with ice
6.1: dichloromethane; water / 1 h / 20 °C
6.2: pH 9 / cooling with ice
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / o-xylene / 1 h / Reflux
5.1: hydrogenchloride; water / 0.25 h / 20 °C
5.2: pH 8 - 9
View Scheme
Multi-step reaction with 5 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / toluene / 1 h / Inert atmosphere; Reflux
5.1: hydrogenchloride / dichloromethane; water / 1 h / 20 °C
5.2: pH 7 / cooling with ice
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate
168828-81-7, 1027135-00-7

benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: sodium hydrogencarbonate / water
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate
224323-51-7

3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

(5S)-(N)-[[(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine hydrochloride

(5S)-(N)-[[(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
4: Tributylphosphine oxide; lithium bromide / o-xylene / 1 h / Reflux
5: hydrogenchloride; ethanol / ethyl acetate / 45 °C
View Scheme
Multi-step reaction with 5 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / toluene / 1 h / Inert atmosphere; Reflux
5.1: hydrogenchloride; water / dichloromethane / 0.5 h / 20 °C
5.2: pH 8 - 9
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

(S)-(E,Z)-5-((benzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
1330034-71-3

(S)-(E,Z)-5-((benzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
4: Tributylphosphine oxide; lithium bromide / o-xylene / 1 h / Reflux
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

(S)-(E,Z)-5-((4-chlorobenzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
1345879-82-4

(S)-(E,Z)-5-((4-chlorobenzylideneamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
4: Tributylphosphine oxide; lithium bromide / toluene / 1 h / Inert atmosphere; Reflux
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

A

C14H16BrFN2O3

C14H16BrFN2O3

B

(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one
1345879-89-1

(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Neat (no solvent)
2: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3: toluene / -20 °C / Inert atmosphere; Reflux
4: Tributylphosphine oxide; lithium bromide / o-xylene / Reflux
View Scheme
1-chloro-2-fluoro-4-nitrobenzene
350-31-2

1-chloro-2-fluoro-4-nitrobenzene

(S)-5-(azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolin-2-one
1345879-91-5

(S)-5-(azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Neat (no solvent)
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice
3.1: toluene / -20 °C / Inert atmosphere; Reflux
4.1: Tributylphosphine oxide; lithium bromide / o-xylene / Reflux
4.2: 15 h / 90 °C / Inert atmosphere
View Scheme

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