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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Chloro-Pyrazine-2-Carboxylic Acid supplier in China

Cas:36070-80-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

5-Chloropyrazine-2-carboxylic acid manufacturer/supplier manufacturer/supplier

Cas:36070-80-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 36070-80-1? 5-chloropyrazine-2-carboxylic acid? Manufacturer

Cas:36070-80-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Chloro-2-pyrazinecarboxylic acid

Cas:36070-80-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

5-Chlopopyrazine-2-carboxylic acid 36070-80-1

Cas:36070-80-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID

Cas:36070-80-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 36070-80-1 with fast shipping

Cas:36070-80-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

High quality 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID CAS 36070-80-1 with best price

Cas:36070-80-1

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5-Chloropyrazine-2-carboxylic acid 36070-80-1

Cas:36070-80-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID Chemical Properties Melting point 150-151℃ Boiling point 330.9±37.0 °C(Predicted) density 1.579±0.06 g/cm3(Predicted) storage temp. Keep in dark place,Sealed in dry,Room Temperatur

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID.

Cas:36070-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID CAS:36070-80-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID CAS:36070-80-1

Cas:36070-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:36070-80-1

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

5-Chloro-2-Pyrazine Carboxylic Acid

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

5-Chloropyrazine-2-carboxylic Acid

Cas:36070-80-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-Chloro-2-pyrazinecarboxylic acid

Cas:36070-80-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

5-chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Top quality 36070-80-1 low price 5-chloro-pyrazine-2-carboxylic acid factory in China Molecular Formula C5H3ClN2O2 Molar Mass 158.54 Density 1.579±0.06 g/cm3(Predicted) Melting Point 150-151℃

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-Chloro-Pyrazine-2-Carboxylic Acid

Cas:36070-80-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediate

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: 5-Chloro-2-Pyrazinecarboxylic Acid CAS No.:36070-80-1 Molecule Formula:C5H3ClN2O2 Molecule Weight:158.54 Purity: 98.0% Package: 25kg/drum Description:Light yellow powder Manufacture Standards:Enterprise Standard

High Quality 5-Chloro-2-Pyrazinecarboxylic Acid on hot selling

Cas:36070-80-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

5-Chloro-2-pyrazinecarboxylic acid

Cas:36070-80-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

5-Chloro-2-pyrazinecarboxylic acid

Cas:36070-80-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

5-Chloro-2-pyrazinecarboxylic acid

Cas:36070-80-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

5-Chloropyrazine-2-carboxylic acid

Cas:36070-80-1

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

methyl 5-chloropyrazine-2-carboxylate
33332-25-1

methyl 5-chloropyrazine-2-carboxylate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 25℃; for 42h;96%
Stage #1: methyl 5-chloropyrazine-2-carboxylate With methanol; sodium hydroxide; water In tetrahydrofuran at 0 - 20℃; for 5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; methanol; water
92%
With hydrogenchloride; potassium carbonate In tetrahydrofuran; water91%
5-hydroxypyrazinoic acid
34604-60-9

5-hydroxypyrazinoic acid

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 16h;93%
With thionyl chloride; N,N-dimethyl-formamide for 16h; Reflux;75%
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / 4 h / 75 °C
2: water
View Scheme
4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid
34604-60-9

4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
With phosphorus pentachloride In toluene at 80℃; for 2h; Large scale;85.6%
2-chloro-5-furan-2-yl-pyrazine
82619-63-4

2-chloro-5-furan-2-yl-pyrazine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
With potassium permanganate; Aliquat 336 In water; benzene at 0 - 40℃; for 4h;78%
With potassium permanganate; Aliquat 336 In water; benzene at 15 - 20℃; for 4.5h;76%
2-Hydroxy-5-(2'-furyl)pyrazine
82619-62-3

2-Hydroxy-5-(2'-furyl)pyrazine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 52 percent / POCl3 / 3 h / Heating
2: 76 percent / KMnO4 / tricaprylmethylammonium chloride / benzene; H2O / 4.5 h / 15 - 20 °C
View Scheme
methyl 5-chloropyrazine-2-carboxylate
33332-25-1

methyl 5-chloropyrazine-2-carboxylate

hexan-1-ol
111-27-3

hexan-1-ol

A

5-(hexyloxy)pyrazine-2-carboxylic acid
668972-67-6

5-(hexyloxy)pyrazine-2-carboxylic acid

B

hexyl 5-hexyloxypyrazine-2-carboxylate
668972-68-7

hexyl 5-hexyloxypyrazine-2-carboxylate

C

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
Stage #1: hexan-1-ol With sodium at 60℃; for 0.75h;
Stage #2: methyl 5-chloropyrazine-2-carboxylate at 50℃; for 0.583333h;
5-chloropyrazine-2-carbonyl chloride
88625-23-4

5-chloropyrazine-2-carbonyl chloride

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
With water
1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile
57005-60-4

1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 6 h / 100 °C / Large scale
2.1: Aliquat 336 / sulfolane; toluene / 2.5 h / 150 °C / Dean-Stark; Large scale
2.2: Large scale
3.1: phosphorus pentachloride / toluene / 2 h / 80 °C / Large scale
View Scheme
sodium 3-carboxy-6-oxo-1H-pyrazine-2-carboxylate

sodium 3-carboxy-6-oxo-1H-pyrazine-2-carboxylate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Aliquat 336 / sulfolane; toluene / 2.5 h / 150 °C / Dean-Stark; Large scale
1.2: Large scale
2.1: phosphorus pentachloride / toluene / 2 h / 80 °C / Large scale
View Scheme
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-hydroxypyrazinoic acid
34604-60-9

5-hydroxypyrazinoic acid

Conditions
ConditionsYield
With sodium hydroxide for 1h; Heating;100%
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloropyrazine-2-carbonyl chloride
88625-23-4

5-chloropyrazine-2-carbonyl chloride

Conditions
ConditionsYield
With (COCl)2; N-methyl-acetamide In dichloromethane100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃;100%
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 5-chloropyrazine-2-carboxylate
33332-25-1

methyl 5-chloropyrazine-2-carboxylate

Conditions
ConditionsYield
In methanol; diethyl ether for 0.5h;100%
methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate
1245215-48-8

methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloropyrazine-2-carbonyl chloride
88625-23-4

5-chloropyrazine-2-carbonyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 23℃; for 18h;100%
oxetan-2-ylmethanol
61266-70-4

oxetan-2-ylmethanol

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-(oxetan-2-ylmethoxy)pyrazine-2-carboxylic acid

5-(oxetan-2-ylmethoxy)pyrazine-2-carboxylic acid

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 120℃; for 0.5h; Sealed tube; Microwave irradiation;99%
(R)-2-aminopentan-1-ol hydrochloric acid salt

(R)-2-aminopentan-1-ol hydrochloric acid salt

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

(R)-5-chloro-N-(1-hydroxypentan-2-yl)pyrazine-2-carboxamide

(R)-5-chloro-N-(1-hydroxypentan-2-yl)pyrazine-2-carboxamide

Conditions
ConditionsYield
With 2-chloro-1-methyl-pyridinium iodide In 1-methyl-pyrrolidin-2-one at 20℃; for 2h; Inert atmosphere;99%
trifluoroethylamine
753-90-2

trifluoroethylamine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide

5-chloro-N-(2,2,2-trifluoroethyl)pyrazine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;98.9%
With HATU In dichloromethane; N,N-dimethyl-formamide at 20℃; Inert atmosphere;72.8%
tert-Butyl 2,2,2-trichloroacetimidate
98946-18-0

tert-Butyl 2,2,2-trichloroacetimidate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloropyrazine-2-carboxylic acid tert-butyl ester
169335-50-6

5-chloropyrazine-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With boron trifluoride dimethyl etherate In tetrahydrofuran; cyclohexane at 25℃; for 16h;94%
Stage #1: tert-Butyl 2,2,2-trichloroacetimidate; 5-chloropyrazinoic acid In tetrahydrofuran; cyclohexane at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With boron trifluoride dimethyl etherate In tetrahydrofuran; cyclohexane at 20℃; for 16h; Inert atmosphere;
94%
With boron trifluoride diethyl etherate In tetrahydrofuran; cyclohexane at 25℃; for 16h;92%
sodium methylate
124-41-4

sodium methylate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-methoxy-pyrazine-2-carboxylic acid
40155-42-8

5-methoxy-pyrazine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With sulfuric acid In methanol at 65℃; for 4h;
Stage #2: sodium methylate In methanol at 20℃; for 0.5h;
Stage #3: With sodium hydroxide In methanol; water at 40℃; for 1h;
94%
(R)-tert-butyl 2-methylpiperazine-1-carboxylate
170033-47-3

(R)-tert-butyl 2-methylpiperazine-1-carboxylate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

(R)-tert-butyl 4-(5-chloropyrazine-2-carbonyl)-2-methylpiperazine-1-carboxylate

(R)-tert-butyl 4-(5-chloropyrazine-2-carbonyl)-2-methylpiperazine-1-carboxylate

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h;92%
difluoroethanol
359-13-7

difluoroethanol

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-(2,2-difluoroethoxy)pyrazine-2-carboxylic acid
1174323-38-6

5-(2,2-difluoroethoxy)pyrazine-2-carboxylic acid

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 20 - 100℃; Inert atmosphere;91%
dimethyl amine
124-40-3

dimethyl amine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N,N-dimethylpyrazine-2-carboxamide
915949-00-7

5-chloro-N,N-dimethylpyrazine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20 - 25℃; for 2.16667h;
Stage #2: dimethyl amine In tetrahydrofuran; dichloromethane at 20 - 25℃; for 3.16667h;
91%
Stage #1: 5-chloropyrazinoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2.16667h;
Stage #2: dimethyl amine With triethylamine In dichloromethane at 20℃; for 2h;
91%
Stage #1: 5-chloropyrazinoic acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: dimethyl amine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h;
71.18%
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

2-chloro-5-(trifluoromethyl)-pyrazine
799557-87-2

2-chloro-5-(trifluoromethyl)-pyrazine

Conditions
ConditionsYield
With sulfur tetrafluoride; hydrogen fluoride at -40 - 80℃; for 6h; Temperature; Autoclave;90%
tert-butyl N-[(4aR,6S,11bR)-10-amino-3,3,6,11b-tetramethyl-4,4-dioxo-5,6-dihydro-4aH-[1]benzoxepino[4,5-b][1,4]thiazin-2-yl]-N-tert-butoxycarbonylcarbamate
1620980-96-2

tert-butyl N-[(4aR,6S,11bR)-10-amino-3,3,6,11b-tetramethyl-4,4-dioxo-5,6-dihydro-4aH-[1]benzoxepino[4,5-b][1,4]thiazin-2-yl]-N-tert-butoxycarbonylcarbamate

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

tert-butyl N-[(4aR,6S,11bR)-10-[(5-chloropyrazine-2-carbonyl)amino]-3,3,6,11b-tetramethyl-4,4-dioxo-5,6-dihydro-4aH-[1]benzoxepino[4,5-b][1,4]thiazin-2-yl]-N-tert-butoxycarbonylcarbamate
1620981-09-0

tert-butyl N-[(4aR,6S,11bR)-10-[(5-chloropyrazine-2-carbonyl)amino]-3,3,6,11b-tetramethyl-4,4-dioxo-5,6-dihydro-4aH-[1]benzoxepino[4,5-b][1,4]thiazin-2-yl]-N-tert-butoxycarbonylcarbamate

Conditions
ConditionsYield
With pyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h; Sealed tube;87%
(1S,5S,6S)-5-(5-amino-2,3-difluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine

(1S,5S,6S)-5-(5-amino-2,3-difluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-chloro-2-pyrazinecarboxamide

N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-chloro-2-pyrazinecarboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃;83%
azetidine
503-29-7

azetidine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

azetidin-1-yl(5-chloropyrazin-2-yl)methanone
915948-98-0

azetidin-1-yl(5-chloropyrazin-2-yl)methanone

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: azetidine With triethylamine In dichloromethane at 20℃; for 72h;
82%
methanol
67-56-1

methanol

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

methyl 5-chloropyrazine-2-carboxylate
33332-25-1

methyl 5-chloropyrazine-2-carboxylate

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With thionyl chloride at 80℃; for 2h;
Stage #2: methanol at 50℃; for 2h;
81%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Time;65%
With thionyl chloride at 0 - 70℃; for 2h;4.5 g
2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

C9H12ClN3O2

C9H12ClN3O2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine In dichloromethane at 20℃; for 0.5h;80%
2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]benzenamine

2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]benzenamine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl}pyrazine-2-carboxamide

5-chloro-N-{2-fluoro-6-[(4,6-dimethoxy-1,3,5-triazin-2-yl)methyl]phenyl}pyrazine-2-carboxamide

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 20℃; for 2h; Alkaline conditions;77%
(1R)-2,2,2-trifluoro-1-methylethylamine hydrochloride

(1R)-2,2,2-trifluoro-1-methylethylamine hydrochloride

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide
1416785-17-5

5-chloro-N-[(1R)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;76%
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

(5-chloro-2-pyrazinyl)methanol
72788-94-4

(5-chloro-2-pyrazinyl)methanol

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With oxalyl dichloride In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #2: With sodium hydroxide In 1,4-dioxane; water at 5℃; Inert atmosphere;
75%
Multi-step reaction with 2 steps
1: diethyl ether; methanol / 0.5 h
2: diisobutylaluminium hydride / tetrahydrofuran / 2 h / 0 °C
View Scheme
ethanolamine
141-43-5

ethanolamine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide

5-chloro-N-(2-hydroxyethyl)pyrazine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 5-chloropyrazinoic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 0.333333h;
Stage #2: ethanolamine In dichloromethane at 0 - 20℃; for 1h;
75%
(S)-1,1,1-trifluoropropan-2-amine
125278-10-6

(S)-1,1,1-trifluoropropan-2-amine

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide
1416785-19-7

5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;73%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃;73%
(S)-1-cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride
1338377-73-3

(S)-1-cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-chloro-N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]pyrazine-2-carboxamide
1416785-21-1

5-chloro-N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]pyrazine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃;72%
5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

2-amino-3,5-bis(4-trifluoromethylphenyl)pyrazine

2-amino-3,5-bis(4-trifluoromethylphenyl)pyrazine

N-(3,5-bis(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-5-chloropyrazine-2-carboxamide

N-(3,5-bis(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-5-chloropyrazine-2-carboxamide

Conditions
ConditionsYield
Stage #1: 2-amino-3,5-bis(4-trifluoromethylphenyl)pyrazine With 1-methyl-1H-imidazole; methanesulfonyl chloride In dichloromethane at 0 - 20℃; for 0.75h;
Stage #2: 5-chloropyrazinoic acid In dichloromethane at 0 - 45℃; for 4h; Reflux;
72%
carbostyril 124
19840-99-4

carbostyril 124

5-chloropyrazinoic acid
36070-80-1

5-chloropyrazinoic acid

5-((4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)amino)pyrazine-2 carboxylic acid

5-((4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)amino)pyrazine-2 carboxylic acid

Conditions
ConditionsYield
With tin; copper; potassium carbonate Reflux;71%

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