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Changzhou Anchor Biological Technology Co., Ltd.

R & D and manufacturing enterprises have their own stock in stockAppearance:Off-white powder Storage:Shading, sealed, dry place. Package:According to the clients' requirement Application:pharmaceutical intermediates Transportation:by sea or by air Po

4-Pyrazolecarboxylic acid Manufacturer/High quality/Best price/In stock CAS NO.37718-11-9

Cas:37718-11-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changzhou Helios Biomedical Science and Technology Co.,LTD.

Changzhou Helios Biochemical Co., Ltd is a leading manufacturer and supplier for medical intermediates and pesticide intermediates . We specialize in custom synthesis of benzene ring, pyridine and pyrimidine derivatives to help customers to accelerat

4-Pyrazolecarboxylic Acid/Best supplier/High purity98%+/In stock/CAS No.37718-11-9

Cas:37718-11-9

Min.Order:0

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Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Pyrazolecarboxylic acid Manufacturer/High quality/Best price/In stock

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Pyrazole Carboxylic Acid supplier in China

Cas:37718-11-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 37718-11-9 1H-Pyrazole-4-carboxylic-acid

Cas:37718-11-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product Description Product Name 4-Pyrazolecarboxylic acid CAS No. 37718-11-9 Appearance White powder Assay ≥99% Capacity 100mt/year Min.packing 100gram

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

Pyrazole-4-carboxylic Acid

Cas:37718-11-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Pyrazole Carboxylic Acid

Cas:37718-11-9

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 4-Pyrazolecarboxylic acid 37718-11-9 ISO Manufacturer

Cas:37718-11-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

4-Pyrazolecarboxylic acid Manufacturer/High quality/Best price/In stock CAS NO.37718-11-9

Cas:37718-11-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 4-PYRAZOLECARBOXYLIC ACID

Cas:37718-11-9

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 37718-11-9 with best quality

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

1H-Pyrazole-4-carboxylic acid CAS37718-11-9

Cas:37718-11-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name: 1H-pyrazole-4-carboxylic acid Product category:Heterocyclic series CAS : 37718-11-9 Appearance: White solid Content: 99% Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Syn

1H-pyrazole-4-carboxylic acid

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Pyrazolecarboxylic acid 37718-11-9

Cas:37718-11-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 4-PYRAZOLECARBOXYLIC ACID CAS:37718-11-9

Cas:37718-11-9

Min.Order:1 Kilogram

FOB Price: $21.8 / 27.3

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Pyrazolecarboxylic acid CAS:37718-11-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

4-Pyrazolecarboxylic acid CAS:37718-11-9

Cas:37718-11-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:37718-11-9

Cas:37718-11-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

4-Pyrazolecarboxylic acid CAS: 37718-11-9 Specification product name 4-pyrazolecarboxylic acid cas no. 37718-11-9 appearance white powder assay ≥99% capacity 100mt/year

Factory supply 4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Pyrazole carboxylic Acid

Cas:37718-11-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Organic synthesis Transportation:Common products:Sea/Air/Courier Dangerous Che

4-pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-PYRAZOLECARBOXYLIC ACID

Cas:37718-11-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1H-PYRAZOLE-4-CARBOXYLIC ACID

Cas:37718-11-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Pyrazolecarboxylic acid

Cas:37718-11-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1H-pyrazole-4-carboxylic acid

Cas:37718-11-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Synthetic route

4-ethoxycarbonylpyrazole
37622-90-5

4-ethoxycarbonylpyrazole

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 2h; Reflux; Inert atmosphere;96%
1-phenyl-2-(4-pyrazolyl)ethanone
96780-98-2

1-phenyl-2-(4-pyrazolyl)ethanone

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With potassium permanganate In water for 0.5h; Heating;54%
With potassium permanganate In water for 0.5h; Product distribution; Heating;54%
4-methyl-1H-pyrazole
7554-65-6

4-methyl-1H-pyrazole

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 4-methyl-1H-pyrazole With sodium hydroxide In water at 60℃;
Stage #2: With potassium permanganate In water at 80 - 90℃; for 5h;
Stage #3: In water pH=< 2; Acidic conditions;
45%
With potassium permanganate; water
4-bromo-1H-pyrazole
2075-45-8

4-bromo-1H-pyrazole

phenyllithium
591-51-5

phenyllithium

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
anschliessend mit CO2;
4-phenyl-1H-pyrazole
10199-68-5

4-phenyl-1H-pyrazole

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
durch Nitrierung,Reduktion des Nitrierungsgemisches und nachfolgende Oxidation mit Permanganat;
1-benzyl-1H-pyrazole-4-carboxylic acid
401647-24-3

1-benzyl-1H-pyrazole-4-carboxylic acid

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With ammonia; sodium
4-bromo-1H-pyrazole
2075-45-8

4-bromo-1H-pyrazole

diethyl ether
60-29-7

diethyl ether

butyl lithium (2 mol)

butyl lithium (2 mol)

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
anschl. mit CO2 bei -70grad;
pyrazole-tricarboxylic acid-(3.4.5)

pyrazole-tricarboxylic acid-(3.4.5)

A

NH-pyrazole
288-13-1

NH-pyrazole

B

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
bei schnellem Erhitzen;
4-bromo-1H-pyrazole
2075-45-8

4-bromo-1H-pyrazole

diethyl ether
60-29-7

diethyl ether

butyl lithium (1 mol)

butyl lithium (1 mol)

A

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

B

4-bromo-1H-pyrazole-5-carboxylic acid

4-bromo-1H-pyrazole-5-carboxylic acid

Conditions
ConditionsYield
anschl. mit CO2 bei -70grad;
4-bromo-1H-pyrazole
2075-45-8

4-bromo-1H-pyrazole

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride; n-butyllithium In hexane; water
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

6-chloro-N4-methylpyridine-3,4-diamine
87034-76-2

6-chloro-N4-methylpyridine-3,4-diamine

6-chloro-1-methyl-2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]pyridine
1612171-92-2

6-chloro-1-methyl-2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-c]pyridine

Conditions
ConditionsYield
With polyphosphoric acid at 150℃; for 18h; Inert atmosphere; Sealed tube;100%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

6-bromopyridine-3,4-diamine
1033203-41-6

6-bromopyridine-3,4-diamine

6-bromo-2-(1H-pyrazol-4-yl)-3H-imidazo[4.5-c]pyridine
1612171-97-7

6-bromo-2-(1H-pyrazol-4-yl)-3H-imidazo[4.5-c]pyridine

Conditions
ConditionsYield
With polyphosphoric acid at 200℃; for 18h;100%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

6-bromopyridine-3,4-diamine
1033203-41-6

6-bromopyridine-3,4-diamine

6-bromo-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridine

6-bromo-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridine

Conditions
ConditionsYield
With polyphosphoric acid at 200℃; for 18h; Sealed tube;100%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

ethanol
64-17-5

ethanol

4-ethoxycarbonylpyrazole
37622-90-5

4-ethoxycarbonylpyrazole

Conditions
ConditionsYield
With sulfuric acid for 16h; Reflux;97%
With thionyl chloride at 0 - 20℃; for 3h;80%
With sulfuric acid
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

1H-pyrazole-4-carboxylic acid chloride
103286-53-9

1H-pyrazole-4-carboxylic acid chloride

Conditions
ConditionsYield
With thionyl chloride for 18h; Heating / reflux;97%
With thionyl chloride for 18h; Reflux;97%
With thionyl chloride at 85℃; Inert atmosphere;91%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

N-methoxy-1H-pyrazole-4-carboxamide

N-methoxy-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: N-methoxylamine hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;
94%
methanol
67-56-1

methanol

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

methyl pyrazole-4-carboxylate
51105-90-9

methyl pyrazole-4-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 0 - 80℃; for 16h;93.32%
With sulfuric acid at 70℃; for 20h;78%
With hydrogenchloride at 10 - 35℃;5 g
With sulfuric acid at 0℃; Reflux;4.5 g
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

6-bromo-N3-methylpyridine-3,4-diamine
1218997-22-8

6-bromo-N3-methylpyridine-3,4-diamine

6-bromo-3-methyl-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridine
1612172-01-6

6-bromo-3-methyl-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridine

Conditions
ConditionsYield
With polyphosphoric acid at 200℃; for 5h; Sealed tube;93%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

tert-butyl 4-(aminomethyl)benzylcarbamate
108468-00-4

tert-butyl 4-(aminomethyl)benzylcarbamate

(4-{[(1H-pyrazole-4-carbonyl)amino]methyl}benzyl)carbamic acid tert-butyl ester
1618648-11-5

(4-{[(1H-pyrazole-4-carbonyl)amino]methyl}benzyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 18h; Inert atmosphere;93%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid
848818-59-7

1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethyl acetate; N,N-dimethyl-formamide at 20℃; for 16h;91%
With toluene-4-sulfonic acid In DMF (N,N-dimethyl-formamide); ethyl acetate at 20℃; for 3h;90%
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 20h;70%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

3,4-dichlorobenzyl bromide
18880-04-1

3,4-dichlorobenzyl bromide

ethyl 1-(3,4-dichlorobenzyl)-1H-pyrazole-4-carboxylate
1035224-45-3

ethyl 1-(3,4-dichlorobenzyl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;91%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

aluminium(III) chloride hexahydrate

aluminium(III) chloride hexahydrate

[Al3(μ3-O)(OH)3][Cu3(μ3-O)(μ-1H-pyrazole-4-carboxylate)3(H2O)6]2

[Al3(μ3-O)(OH)3][Cu3(μ3-O)(μ-1H-pyrazole-4-carboxylate)3(H2O)6]2

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid; copper(II) nitrate trihydrate; aluminium(III) chloride hexahydrate With trifluoroacetic acid In N,N-dimethyl-formamide at 100℃; for 10h;
Stage #2: at 150℃; for 12h;
91%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

N,N-dimethyl-2-(2-neopentyl-5-(piperidin-4-ylmethylsulfonyl)-1H-benzoimidazol-1-yl)ethanamine
1236007-46-7

N,N-dimethyl-2-(2-neopentyl-5-(piperidin-4-ylmethylsulfonyl)-1H-benzoimidazol-1-yl)ethanamine

(4-((1-(2-(dimethylamino)ethyl)-2-neopentyl-1H-benzoimidazol-5-ylsulfonyl)methyl)piperidin-1-yl)(1H-pyrazol-4-yl)methanone
1236006-89-5

(4-((1-(2-(dimethylamino)ethyl)-2-neopentyl-1H-benzoimidazol-5-ylsulfonyl)methyl)piperidin-1-yl)(1H-pyrazol-4-yl)methanone

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane at 18 - 25℃; for 2h;90%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

(R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide
1360551-95-6

(R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

3-[(R)-1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole
1360552-35-7

3-[(R)-1-(4-bromo-phenyl)-1-cyclopropyl-ethyl]-5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazole

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Inert atmosphere;
Stage #2: (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In 1-methyl-pyrrolidin-2-one at 100℃; for 16h; Inert atmosphere;
90%
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In 1,4-dioxane at 55℃; for 0.5h;
Stage #2: (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In 1,4-dioxane at 120℃; for 18h;
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In 1,4-dioxane at 55℃; for 0.5h; Sealed tube;
Stage #2: (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In 1,4-dioxane at 120℃; for 18h; Sealed tube;
1.3 g
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

terephthalic acid
100-21-0

terephthalic acid

4C12H6Cu3N6O6(3-)*2H6O4Zn*12Zn(2+)*3O(2-)*3C8H4O4(2-)

4C12H6Cu3N6O6(3-)*2H6O4Zn*12Zn(2+)*3O(2-)*3C8H4O4(2-)

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one In N,N-dimethyl-formamide at 100℃; for 12h; Sealed tube;90%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

ammonium hydroxide
1336-21-6

ammonium hydroxide

zinc(II) nitrate
10196-18-6

zinc(II) nitrate

(ammonium)[Zn3(OH)(1H-pyrazole-4-carboxylic acid)3]

(ammonium)[Zn3(OH)(1H-pyrazole-4-carboxylic acid)3]

Conditions
ConditionsYield
In methanol; water; N,N-dimethyl-formamide for 6h; Reflux;90%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

6C12H6Cu3N6O6(3-)*6H6O4Zn*20Zn(2+)*5O(2-)*6C4H2N2O2(2-)

6C12H6Cu3N6O6(3-)*6H6O4Zn*20Zn(2+)*5O(2-)*6C4H2N2O2(2-)

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one In N,N-dimethyl-formamide at 85℃; for 72h; Sealed tube;88%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

2-chloro-4-[(1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile

2-chloro-4-[(1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile

C19H21ClN4O2

C19H21ClN4O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;88%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

water
7732-18-5

water

nickel(II) acetate tetrahydrate
6018-89-9

nickel(II) acetate tetrahydrate

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

8Ni(2+)*12H2O*4HO(1-)*6C4H2N2O2(2-)*4.5C3H7NO

8Ni(2+)*12H2O*4HO(1-)*6C4H2N2O2(2-)*4.5C3H7NO

Conditions
ConditionsYield
for 6h; Reflux;86%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N'-hydroxypropanimidamide

(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N'-hydroxypropanimidamide

5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine
1360549-37-6

5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran; N,N-dimethyl-formamide at 50 - 55℃; for 0.5h; Large scale;
Stage #2: (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N'-hydroxypropanimidamide In N,N-dimethyl-formamide at 105℃; Large scale;
86%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide
1360552-09-5

(R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine
1360549-37-6

5-(4-{(R)-1-cyclopropyl-1-[5-(1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]ethyl}phenyl)pyrimidin-2-ylamine

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid With Carbonyldiimidazole In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 1h; Inert atmosphere;
Stage #2: (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In tetrahydrofuran; N,N-dimethyl-formamide at 105℃; for 17h; Inert atmosphere;
85.9%
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Inert atmosphere;
Stage #2: (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In 1-methyl-pyrrolidin-2-one at 100℃; for 16h; Inert atmosphere;
82%
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20 - 50℃; for 0.5h;
Stage #2: (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In tetrahydrofuran for 24h; Reflux;
Stage #3: With acetic acid at 90℃; for 2h;
Stage #1: 1H-pyrazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20 - 50℃; for 0.5h;
Stage #2: (R,Z)-2-(4-(2-aminopyrimidin-5-yl)phenyl)-2-cyclopropyl-N′-hydroxypropanimidamide In tetrahydrofuran for 24h; Reflux;
Stage #3: With acetic acid at 20 - 90℃; for 2h;
14.7 g
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

diethyl cyanophosphonate
2942-58-7

diethyl cyanophosphonate

3-[4-(piperidinomethyl)pyrid-2-yloxy]prop-1-ylamine
88443-62-3

3-[4-(piperidinomethyl)pyrid-2-yloxy]prop-1-ylamine

N-[3-(4-Piperidinomethyl-2-pyridyloxy)propyl]-pyrazole-4-carboxamide

N-[3-(4-Piperidinomethyl-2-pyridyloxy)propyl]-pyrazole-4-carboxamide

Conditions
ConditionsYield
With sodium chloride; sodium hydrogencarbonate; triethylamine In N-methyl-acetamide85%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one

N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)-1H-pyrazole-4-carboxamide

N-((1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolin-4-yl)methyl)-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
Stage #1: 1H-pyrazole-4-carboxylic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: 4-(aminomethyl)-1-methyl-5,6,7,8-tetrahydroisoquinolin-3(2H)-one In dichloromethane at 20℃; for 7h;
84%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

2,6-Naphthalenedicarboxylic acid
1141-38-4

2,6-Naphthalenedicarboxylic acid

4C12H6Cu3N6O6(3-)*4H6O4Zn*12Zn(2+)*3O(2-)*C4H2N2O2(2-)*2C12H6O4(2-)

4C12H6Cu3N6O6(3-)*4H6O4Zn*12Zn(2+)*3O(2-)*C4H2N2O2(2-)*2C12H6O4(2-)

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 100℃; for 16h; Sealed tube;83%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

3C12H6Cu3N6O6(3-)*H5O4Zn(1-)*6Zn(2+)*C4H2N2O2(2-)

3C12H6Cu3N6O6(3-)*H5O4Zn(1-)*6Zn(2+)*C4H2N2O2(2-)

Conditions
ConditionsYield
In N,N-dimethyl acetamide at 85℃; for 72h; Sealed tube;82%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

ethyl vinyl ether
109-92-2

ethyl vinyl ether

C8H12N2O3

C8H12N2O3

Conditions
ConditionsYield
With hydrogenchloride In water; N,N-dimethyl-formamide at 40℃; for 2h;82%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

2-(1H-pyrazol-4-yl)benzo[d]thiazole
40142-85-6

2-(1H-pyrazol-4-yl)benzo[d]thiazole

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 100℃; for 0.166667h; Microwave irradiation; Sealed tube;81%
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

methyl pyrazole-4-carboxylate
51105-90-9

methyl pyrazole-4-carboxylate

Conditions
ConditionsYield
With hydrogenchloride In methanol; water79.6%
With sulfuric acid; sodium methylate In methanol; chloroform
1H-pyrazole-4-carboxylic acid
37718-11-9

1H-pyrazole-4-carboxylic acid

copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

zinc(II) nitrate hexahydrate

zinc(II) nitrate hexahydrate

terephthalic acid
100-21-0

terephthalic acid

2,6-Naphthalenedicarboxylic acid
1141-38-4

2,6-Naphthalenedicarboxylic acid

12C4H2N2O2(2-)*2C8H4O4(2-)*C12H6O4(2-)*12Cu(1+)*12Zn(2+)*3O(2-)

12C4H2N2O2(2-)*2C8H4O4(2-)*C12H6O4(2-)*12Cu(1+)*12Zn(2+)*3O(2-)

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 100℃; for 16h;79%

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