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Shandong Kehui Pharmaceutical Co., Ltd

Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V

S-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality S-Benzyl Succinic Acid supplier in China

Cas:3972-36-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Butanedioicacid, 2-(phenylmethyl)-, (2S)-

Cas:3972-36-9

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(S)-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/619.html Product Name

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

FOB Price: $63.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--3972-36-9--(S)-2-Benzylsuccinic acid in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business r

TIANFUCHEM--3972-36-9--(S)-2-Benzylsuccinic acid in stock

Cas:3972-36-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

(S)-2-Benzylsuccinic acid In stock

Cas:3972-36-9

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 3972-36-9 with best quality

Cas:3972-36-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

(S)-2-Benzylsuccinic acid CAS NO 3972-36-9

Cas:3972-36-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Butanedioicacid, 2-(phenylmethyl)-, (2S)- 3972-36-9

Cas:3972-36-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(S)-2-Benzylsuccinic acid CAS:3972-36-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

(S)-2-Benzylsuccinic acid CAS:3972-36-9

Cas:3972-36-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3972-36-9

Cas:3972-36-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

(S)-2-Benzylsuccinic acid CAS: 3972-36-9 Specification product name (3ar,7as)-rel-octahydro-1h-isoindole hydrochloride cas no. 161829-92-1 appearance white powder assay ≥99% capa

Factory supply (S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Leader Biochemical Group

PRODUCT DETAILS

China Largest Factory Manufacturer sales (S)-2-Benzylsuccinic acid CAS 3972-36-9

Cas:3972-36-9

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

S-Benzyl Succinic Acid

Cas:3972-36-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:3972-36-9

S-Benzyl succinic acid

Cas:3972-36-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

(S)-2-Benzylsuccinic acid CAS NO.3972-36-9Appearance:Powder Storage:Store in Cool and dry .place, keep away from incompatible substances Package:according to customers' requirements Application:Used for pesticide and herbicide Transportation:By air(E

(S)-2-Benzylsuccinic acid CAS NO.3972-36-9

Cas:3972-36-9

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag,or as your request Application:For medicine , pesticide intermediates Tra

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Siwei Development Group Ltd.

Product name: (S)-2-Benzylsuccinic Acid CAS No.: 3972-36-9 Molecule Formula:C11H12O4 Molecule Weight:208.21 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTIN

Lower Price (S)-2-Benzylsuccinic Acid

Cas:3972-36-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

(S)-2-Benzylsuccinic acid 3972-36-9

Cas:3972-36-9

Min.Order:25 Kilogram

FOB Price: $450.0 / 480.0

Type:Other

inquiry

Shanghai Minstar Chemical Co., Ltd

(S)-2-Benzylsuccinic acid Chemical Properties Melting point 164.0 to 168.0 °C Boiling point 331.4±22.0 °C(Predicted) density 1.290±0.06 g/cm3(Predicted) pka 3.97±0.10(Predicted) CAS DataBase Reference 39

(S)-2-Benzylsuccinic acid

Cas:3972-36-9

Min.Order:1 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoic acid
1141895-98-8

(S)-3-benzyl-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-4-oxobutanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With dihydrogen peroxide; lithium hydroxide In tetrahydrofuran; water at 0℃;100%
bis[(S)-3-methyl-2-phenylbutylammonium] (S)-2-benzylsuccinate

bis[(S)-3-methyl-2-phenylbutylammonium] (S)-2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In water98.8%
phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate
140903-48-6

phenylmethyl 3-carboxy-2(S)-(phenylmethyl)-1-propanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol for 2h; Ambient temperature;97%
(Z)-2-benzylidenesuccinic acid
65756-81-2

(Z)-2-benzylidenesuccinic acid

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; triethylamine; Ru2Cl4((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2 In tetrahydrofuran; toluene at 35℃; under 2206.5 Torr; for 24h; op = 90percent, var. cat. RuHCl*2<(+)-BINAP>; Title compound not separated from byproducts;A 94%
B n/a
(3S)-4-[(3aS,6R,7aS)-tetrahydro-8,8-dimethyl-2,2-dioxido-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoic acid
787635-23-8

(3S)-4-[(3aS,6R,7aS)-tetrahydro-8,8-dimethyl-2,2-dioxido-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide at 0 - 20℃; for 13h;93%
2-benzylidenesuccinic acid
5653-88-3

2-benzylidenesuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen In methanol at 50℃; under 760.051 Torr; for 10h; Molecular sieve; Inert atmosphere; Large scale;81%
(Z)-2-benzylidenesuccinic acid
65756-81-2

(Z)-2-benzylidenesuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; acetic acid; palladium on activated charcoal at 75℃; for 3h;10%
2-benzylsuccinic acid
36092-42-9

2-benzylsuccinic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With (R)-1-phenyl-ethyl-amine
diethyl (S)-2-benzylsuccinate

diethyl (S)-2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In ethanol
trans-phenylitaconic acid
5653-88-3, 65756-81-2, 46427-07-0

trans-phenylitaconic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With formic acid; CF3SO3; triethylamine In dimethyl sulfoxide at 44.9℃; Rate constant;
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S,4S)-4-(Diphenylphosphino)-2-<(diphenylphosphino)-methyl>-N-phenoxycarbonylpyrrolidine In methanol; benzene at 20℃; under 760 Torr; for 4h;
trans-phenylitaconic acid
5653-88-3, 65756-81-2, 46427-07-0

trans-phenylitaconic acid

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogen; triethylamine; complex of Rh(COD)*BF4 and (4R,5R)-(+)-MOD-DIOP In methanol at 30℃; under 760 Torr; for 40h;A 79 % Spectr.
B n/a
With hydrogen; triethylamine; <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3 In tetrahydrofuran; ethanol at 35℃; under 1520 Torr; for 24h; RuHCl-bis<(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With <((R)-(1,1'-binaphthyl-2,2'-diyl)bis(diphenylphosphine))RuCl2>2NEt3; hydrogen; triethylamine In tetrahydrofuran; ethanol at 50℃; under 3800 Torr; for 24h; Title compound not separated from byproducts;
With hydrogen; triethylamine; hydridobis((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)ruthenium, PF6 salt In tetrahydrofuran; ethanol at 50℃; under 2280 Torr; for 24h; Yield given. Title compound not separated from byproducts;
With RuCl2(C6F5CN)2((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl); hydrogen; triethylamine In tetrahydrofuran; ethanol at 50℃; under 3800 Torr; for 24h; Title compound not separated from byproducts;
diethyl (2S)-2-benzyl-3-cyanosuccinate

diethyl (2S)-2-benzyl-3-cyanosuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With hydrogenchloride In acetic acid for 10h; Heating;
(S)-3-benzyl-4-methoxy-4-oxobutanoic acid
182247-45-6

(S)-3-benzyl-4-methoxy-4-oxobutanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol
methanol
67-56-1

methanol

(R)-3-Benzyl-pent-4-enenitrile
193147-43-2

(R)-3-Benzyl-pent-4-enenitrile

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

(R)-2-benzyl-5-methyl-4-hexenoic acid

(R)-2-benzyl-5-methyl-4-hexenoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With formic acid; dihydrogen peroxide; ozone 1.) MeOH; Yield given. Multistep reaction;
(S)-4-(tert-butoxy)-4-oxo-2-(1-phenylmethyl)butanoic acid
337518-87-3

(S)-4-(tert-butoxy)-4-oxo-2-(1-phenylmethyl)butanoic acid

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃;0.34 g
N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>
123191-44-6

N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>

benzylmagnesium chloride
6921-34-2

benzylmagnesium chloride

A

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

B

(R)-2-benzylsuccinic acid
21307-97-1

(R)-2-benzylsuccinic acid

Conditions
ConditionsYield
Stage #1: N,N'-fumaroyldi<(2R)-bornane-10,2-sultam>; benzylmagnesium chloride In tetrahydrofuran; diethyl ether at -78℃; for 3h;
Stage #2: With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran; water at 0℃; for 7h; Title compound not separated from byproducts;
1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one
127392-81-8

1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
2.1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
3.1: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
2.1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
3.1: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
hydrocinnamic acid chloride
645-45-4

hydrocinnamic acid chloride

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C
1.2: 91 percent / tetrahydrofuran; toluene / 16 h
2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
3.1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
4.1: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C
1.2: 91 percent / tetrahydrofuran; toluene / 16 h
2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C
2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C
3.1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
4.1: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 2 h / 0 °C
2: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 - 20 °C
3: trifluoroacetic acid / dichloromethane / 48 h
4: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
View Scheme
1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate
787635-22-7

1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / aq. LiOH; aq. H2O2 / tetrahydrofuran / 0 - 20 °C
2: 0.34 g / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 87 percent / trifluoroacetic acid / CH2Cl2 / 0 - 20 °C
2: 93 percent / aq. H2O2; LiOH*H2O / 13 h / 0 - 20 °C
View Scheme
Z-methyl 4-(phenyl)-3-methoxycarbonylbut-3-enoate
65756-82-3

Z-methyl 4-(phenyl)-3-methoxycarbonylbut-3-enoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / methanol / 12 h / Heating
2: 10 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

methylacetylene metal salt

methylacetylene metal salt

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: t-BuOK / 2-methyl-propan-2-ol / Heating
2: NaOH / methanol / 12 h / Heating
3: 10 percent / H2; acetic acid / 10 percent Pd/C / 3 h / 75 °C
View Scheme
Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate
131288-25-0

Benzyl (2S)-2-Benzyl-3-t-butoxycarbonyl Propionate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
2: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
(5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one
155956-29-9

(5R)-(-)-(1'-oxo-3'-phenylpropyl)-5,3,3-trimethylpyrrolidin-2-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 79 percent / LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C to r.t., overnight
2: 94 percent / BuLi / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 10 min, 2.) 0 deg C, 1 h
3: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
4: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
(S)-3-Benzyl-4-oxo-4-((R)-3,3,5-trimethyl-2-oxo-pyrrolidin-1-yl)-butyric acid tert-butyl ester
215373-19-6

(S)-3-Benzyl-4-oxo-4-((R)-3,3,5-trimethyl-2-oxo-pyrrolidin-1-yl)-butyric acid tert-butyl ester

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / BuLi / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 10 min, 2.) 0 deg C, 1 h
2: 82 percent / TFA / CH2Cl2 / 1 h / Ambient temperature
3: 97 percent / H2 / Pd/C / methanol / 2 h / Ambient temperature
View Scheme
dimethyl 2-benzylsuccinate
35262-43-2

dimethyl 2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) porcine pancrease lipase, 3) porcine pancrease lipase / 1) 0.1M KHPO4 buffer (pH = 7.2), 3) 0.1M KHPO4 buffer (pH = 7.2)
2: 1M NaOH / methanol
View Scheme
ethyl (R)-2-hydroxy-3-phenylpropanoate
15399-05-0, 15399-27-6, 20918-87-0, 20918-88-1

ethyl (R)-2-hydroxy-3-phenylpropanoate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8.7 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 2 h / Ambient temperature
2: conc. aq. HCl / acetic acid / 10 h / Heating
View Scheme
1,4-diethyl 2-benzylsuccinate
21654-18-2, 79909-18-5

1,4-diethyl 2-benzylsuccinate

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: α-chymotrypsin, aq. NaOH
2: aq. NaOH / ethanol
View Scheme
(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one
136159-65-4

(R)-4-benzyl-3-(3-phenyl-propionyl)-oxazolidin-2-one

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -70 - 20 °C
2: trifluoroacetic acid / dichloromethane / 48 h
3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.5 h / Large scale
1.2: Large scale
1.3: Large scale
2.1: Ru(OCOCH3)2{(S)-2,2'-bis(diphenylphosphino)-1,1'-dinaphthyl)}; hydrogen / methanol / 10 h / 50 °C / 760.05 Torr / Molecular sieve; Inert atmosphere; Large scale
View Scheme
cis-hexahydroisoindoline
1470-99-1, 1220913-24-5

cis-hexahydroisoindoline

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

mitiglinide
145375-43-5

mitiglinide

Conditions
ConditionsYield
Stage #1: (2S)-benzylsuccinic acid With 1H-imidazole; thionyl chloride; triethylamine In ethyl acetate at -10 - -5℃; for 6h;
Stage #2: cis-hexahydroisoindoline In ethyl acetate at 20℃; for 18h;
87%
2-(Trimethylsilyl)ethanol
2916-68-9

2-(Trimethylsilyl)ethanol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(2-trimethylsilanyl-ethyl) ester
182247-47-8

(S)-2-Benzyl-succinic acid bis-(2-trimethylsilanyl-ethyl) ester

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

(S)-2-Benzyl-succinic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
4-nitro-phenol
100-02-7

4-nitro-phenol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester
157060-06-5

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide
21715-90-2

endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester
204187-32-6

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

benzotriazol-1-ol
2592-95-2

benzotriazol-1-ol

(S)-2-Benzyl-succinic acid dibenzotriazol-1-yl ester

(S)-2-Benzyl-succinic acid dibenzotriazol-1-yl ester

Conditions
ConditionsYield
With thionyl chloride; triethylamine 1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, RT, overnight; Yield given. Multistep reaction;
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-2-benzyl-butan-1,4-diol
190185-60-5

(S)-2-benzyl-butan-1,4-diol

Conditions
ConditionsYield
With borane-THF
methanol
67-56-1

methanol

(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

dimethyl (S)-(-)-benzylsuccinate

dimethyl (S)-(-)-benzylsuccinate

Conditions
ConditionsYield
With toluene-4-sulfonic acid
(2S)-benzylsuccinic acid
3972-36-9

(2S)-benzylsuccinic acid

(S)-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
113867-24-6

(S)-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Conditions
ConditionsYield
With sulfuric acid at 20℃; for 8h;
With sulfuric acid In water at 60℃; for 0.333333h;

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