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Shanghai Yui Sifluo Co.. Ltd.

In fluorine chemical, Yuji Tech has been dedicated to R&D of production of ODS alternatives, fluoropolymers and fluorinated fine chemicals for years, and has become an international leading innovation enterprise in fluorine chemical research an

2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:5 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 2,2-difluoroethanamine CAS 430-67-1 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Factory supply 2,2-difluoroethanamine CAS 430-67-1 with fast delivery

Cas:430-67-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

2,2-DIFLUOROETHYLAMINE Basic information Product Name: 2,2-DIFLUOROETHYLAMINE Synonyms: CF2HCH2NH2;ART-CHEM-BB B028561;AKOS B028561;2,2-DIFLUOROETHYLAMINE;TIMTEC-BB

2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,2-Difluoroethanamine

Cas:430-67-1

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,2-difluoroethylamine

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2,2-DIFLUOROETHYLAMINE 430-67-1

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 430-67-1 with best quality

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 2,2-difluoroethanamine CAS No 430-67-1 Formula C2H5F2N Molecular Weight 8

2,2-Difluoroethylamine CAS: 430-67-1

Cas:430-67-1

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanamine,2,2-difluoro- (9CI) 430-67-1

Cas:430-67-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,2-DIFLUOROETHYLAMINE CAS:430-67-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

2,2-DIFLUOROETHYLAMINE CAS:430-67-1

Cas:430-67-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethanamine,2,2-difluoro- (9CI)

Cas:430-67-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:430-67-1

Cas:430-67-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 2,2-Difluoroethylamine CAS:430-67-1, Please contact us by email freely. We are leading exporter in China. If you really need this ca

2,2-Difluoroethylamine CAS:430-67-1 from FandaChem

Cas:430-67-1

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Ethanamine,2,2-difluoro- (9CI)

Cas:430-67-1

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale 2,2-Difluoroethanamine

Cas:430-67-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethanamine,2,2-difluoro- (9CI)

Cas:430-67-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship

TIANFU 430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2,2-Difluoroethylamine CAS No.:430-67-1 Molecule Formula:C2H5F2N Molecule Weight:81.06 Purity: 99.0% Package: 250kg/drum Description:Colorless transparent liquid Manufacture Standards:Enterprise Standard

High Quality 2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2,2-DIFLUOROETHYLAMINE Chemical Properties Boiling point 67.5-68.5 density 1,15 g/cm3 refractive index 1.3410-1.3450 pka 7.09±0.30(Predicted) InChIKey OVRWUZYZECPJOB-UHFFFAOYSA-N CAS DataBase Reference 430-67-1(CAS DataBas

2,2-Difluoroethylamine

Cas:430-67-1

Min.Order:1 Gram

FOB Price: $65.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

430-67-1 2,2-DIFLUOROETHYLAMINE

Cas:430-67-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

ProductName:2,2-difluoroethanamine Synonym:2,2-difluoroethaneamine;1-Amino-2,2-difluoroethane;2,2-difluoro-ethylamine;CF2HCH2NH2;Ethylamine,2,2-difluoro;2,2-Difluor-aethylamin;2,2-difluoroethan-1-amine;2,2-difluoroethanaminium; CAS No.:430-67-1

2,2-difluoroethanamine

Cas:430-67-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-chloro-2,2-difluoroethane
338-65-8

1-chloro-2,2-difluoroethane

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

Conditions
ConditionsYield
With ammonium hydroxide at 160℃; under 22502.3 Torr; for 2h; Temperature; Pressure; Large scale;90%
With ammonia; potassium iodide In 1-Methylpyrrolidine at 143 - 145℃; for 5.5h; Product distribution / selectivity; Autoclave;88%
With ammonium hydroxide; 18-crown-6 ether; potassium iodide In dimethyl sulfoxide Autoclave;79%
N-benzyl-2,2-difluoroethanamine
1184224-96-1

N-benzyl-2,2-difluoroethanamine

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In toluene at 80℃; under 4500.45 Torr; for 10h; Inert atmosphere;84%
2-bromo-1,1-difluoroethane
359-07-9

2-bromo-1,1-difluoroethane

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

Conditions
ConditionsYield
With ammonia; potassium iodide In dimethyl sulfoxide at 100℃; for 1h; Product distribution / selectivity; Autoclave;82%
With ammonia; water at 125℃;
With ammonia In neat (no solvent) at 160℃; Temperature;
N-(2,2-difluoroethyl)prop-2-en-1-amine
1178819-40-3

N-(2,2-difluoroethyl)prop-2-en-1-amine

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

Conditions
ConditionsYield
With ethanolamine; palladium 10% on activated carbon at 90℃;68%
2,2-difluoroacetamide
359-38-6

2,2-difluoroacetamide

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

Conditions
ConditionsYield
With sodium tetrahydroborate; boron trifluoride diethyl etherate60%
2-bromo-1,1-difluoroethane
359-07-9

2-bromo-1,1-difluoroethane

A

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

B

bis-(2,2-difluoro-ethyl)-amine
462-89-5

bis-(2,2-difluoro-ethyl)-amine

Conditions
ConditionsYield
With ethanol; ammonia at 125 - 145℃;
(1R,2S,3R,4S)-3-(2,2-Difluoro-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
93630-44-5

(1R,2S,3R,4S)-3-(2,2-Difluoro-ethylcarbamoyl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

A

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

B

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
129-64-6

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

Conditions
ConditionsYield
With water at 38℃; Rate constant;
(1R,7S)-5-(2,2-Difluoro-ethylamino)-5-hydroxy-4-oxa-tricyclo[5.2.1.02,6]dec-8-en-3-one

(1R,7S)-5-(2,2-Difluoro-ethylamino)-5-hydroxy-4-oxa-tricyclo[5.2.1.02,6]dec-8-en-3-one

A

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

B

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride
129-64-6

3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

Conditions
ConditionsYield
With water at 38℃; Rate constant;
methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester
946000-58-4

methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

C17H28ClF2NOSi

C17H28ClF2NOSi

Conditions
ConditionsYield
In ethanol at 60℃;100%
In ethanol at 60℃;
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2-methylchlorobenzene
95-49-8

2-methylchlorobenzene

N-(2,2-difluoro-ethyl)-o-toluidine
2366-95-2

N-(2,2-difluoro-ethyl)-o-toluidine

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;99%
With copper(I) oxide; copper
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

N-(2,2-difluoroethyl)-4-methoxyaniline

N-(2,2-difluoroethyl)-4-methoxyaniline

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;99%
With copper(I) oxide; C19H24N2O7; potassium carbonate In methanol at 100℃; for 24h; Ullmann Condensation;93%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-(vinylsulfonyl)-2-methylbenzene
5535-54-6

1-(vinylsulfonyl)-2-methylbenzene

5-(difluoromethyl)-3-(o-tolylsulfonyl)-4,5-dihydro-1H-pyrazole

5-(difluoromethyl)-3-(o-tolylsulfonyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; 1-(vinylsulfonyl)-2-methylbenzene With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
99%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

ethyl vinyl sulfone
1889-59-4

ethyl vinyl sulfone

3-(ethylsulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

3-(ethylsulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; ethyl vinyl sulfone With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
99%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-(vinylsulfonyl)-3-methylbenzene
5535-53-5

1-(vinylsulfonyl)-3-methylbenzene

3-((3-methylphenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

3-((3-methylphenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; 1-(vinylsulfonyl)-3-methylbenzene With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
99%
tert.-butylnitrite
540-80-7

tert.-butylnitrite

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-fluoro-2-(2-nitro-vinyl)-benzene
399-25-7

1-fluoro-2-(2-nitro-vinyl)-benzene

N-(2,2-difluoroethyl)-N-(1-(2-fluorophenyl)-2-nitroethyl)nitrous amide

N-(2,2-difluoroethyl)-N-(1-(2-fluorophenyl)-2-nitroethyl)nitrous amide

Conditions
ConditionsYield
With acetic acid at 20℃; for 6h;99%
tert.-butylnitrite
540-80-7

tert.-butylnitrite

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-chloro-2-(2-nitrovinyl)benzene
22568-07-6, 3156-34-1

1-chloro-2-(2-nitrovinyl)benzene

N-(1-(2-chlorophenyl)-2-nitroethyl)-N-(2,2-difluoroethyl)nitrous amide

N-(1-(2-chlorophenyl)-2-nitroethyl)-N-(2,2-difluoroethyl)nitrous amide

Conditions
ConditionsYield
With acetic acid at 20℃; for 6h;99%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-fluoro-2-(2-nitro-vinyl)-benzene
399-25-7

1-fluoro-2-(2-nitro-vinyl)-benzene

N-(2,2-difluoroethyl)-N-(1-(2-fluorophenyl)-2-nitroethyl)nitrous amide

N-(2,2-difluoroethyl)-N-(1-(2-fluorophenyl)-2-nitroethyl)nitrous amide

Conditions
ConditionsYield
With tert.-butylnitrite; acetic acid at 20℃; for 3h; Michael Addition;99%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-chloro-2-(2-nitrovinyl)benzene
22568-07-6, 3156-34-1

1-chloro-2-(2-nitrovinyl)benzene

N-(1-(2-chlorophenyl)-2-nitroethyl)-N-(2,2-difluoroethyl)nitrous amide

N-(1-(2-chlorophenyl)-2-nitroethyl)-N-(2,2-difluoroethyl)nitrous amide

Conditions
ConditionsYield
With tert.-butylnitrite; acetic acid at 20℃; for 3h; Michael Addition;99%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

methyl N-cyanoacetimidate
5652-84-6

methyl N-cyanoacetimidate

N'-cyano-N-(2,2-difluoroethyl)ethanimidamide
1003859-01-5

N'-cyano-N-(2,2-difluoroethyl)ethanimidamide

Conditions
ConditionsYield
In methanol at 20℃; for 3h;98%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

5-(3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)phenyl)-6-chloro-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

5-(3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)phenyl)-6-chloro-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

5-(3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)phenyl)-6-((2,2-difluoroethyl)amino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

5-(3-(bicyclo[1.1.1]pentan-1-ylcarbamoyl)phenyl)-6-((2,2-difluoroethyl)amino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

Conditions
ConditionsYield
With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium tert-pentoxide In 1,4-dioxane at 90℃; for 0.25h;98%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

((vinylsulfonyl)methyl)benzene
15753-89-6

((vinylsulfonyl)methyl)benzene

3-(benzylsulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

3-(benzylsulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; ((vinylsulfonyl)methyl)benzene With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
98%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

(E)-(4-nitrobut-3-enyl)benzene
80922-14-1

(E)-(4-nitrobut-3-enyl)benzene

N-(2,2-difluoroethyl)-N-(1-nitro-4-phenylbutan-2-yl)nitrous amide

N-(2,2-difluoroethyl)-N-(1-nitro-4-phenylbutan-2-yl)nitrous amide

Conditions
ConditionsYield
With tert.-butylnitrite; acetic acid at 20℃; for 36h; Michael Addition;98%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2-methyl-1-(2,6,8-trichloropyrimido[5,4-d]pyrimidin-4-ylamino)propan-2-ol

2-methyl-1-(2,6,8-trichloropyrimido[5,4-d]pyrimidin-4-ylamino)propan-2-ol

1-[2,6-dichloro-8-(2,2-difluoroethylamino)pyrimido[5,4-d]pyrimidin-4-ylamino]-2-methylpropan-2-ol

1-[2,6-dichloro-8-(2,2-difluoroethylamino)pyrimido[5,4-d]pyrimidin-4-ylamino]-2-methylpropan-2-ol

Conditions
ConditionsYield
In tetrahydrofuran97%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

1-(vinylsulfonyl)-4-fluorobenzene
28122-14-7

1-(vinylsulfonyl)-4-fluorobenzene

3-((4-fluorophenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

3-((4-fluorophenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; 1-(vinylsulfonyl)-4-fluorobenzene With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
97%
1,4-dihydro-5,8-dimethoxy-1,4-epoxynaphthalene
26002-73-3

1,4-dihydro-5,8-dimethoxy-1,4-epoxynaphthalene

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

rac-(1R,2R)-5,8-dimethoxy-2-((2,2,2-trifluoroethyl)amino)-1,2-dihydronaphthalen-1-ol

rac-(1R,2R)-5,8-dimethoxy-2-((2,2,2-trifluoroethyl)amino)-1,2-dihydronaphthalen-1-ol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; tetra-(n-butyl)ammonium iodide In 1,4-dioxane; water at 80℃; for 0.333333h; Inert atmosphere; Green chemistry; regioselective reaction;97%
1,4-dihydronaphthalene-1,4-epoxide
573-57-9

1,4-dihydronaphthalene-1,4-epoxide

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

rac-(1R,2R)-2-((2,2-difluoroethyl)amino)-1,2-dihydronaphthalen-1-ol

rac-(1R,2R)-2-((2,2-difluoroethyl)amino)-1,2-dihydronaphthalen-1-ol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; tetra-(n-butyl)ammonium iodide In 1,4-dioxane; water at 80℃; for 0.333333h; Inert atmosphere; Green chemistry; regioselective reaction;96%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

para-chloroacetophenone
99-91-2

para-chloroacetophenone

1-(4-((2,2-difluoroethyl)amino)phenyl)ethan-1-one

1-(4-((2,2-difluoroethyl)amino)phenyl)ethan-1-one

Conditions
ConditionsYield
With C33H43ClNiO6P2; sodium triflate; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 100℃; for 18h; Inert atmosphere; Sealed tube;96%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

(4-((2,2-difluoroethyl)amino)phenyl)(phenyl)methanone

(4-((2,2-difluoroethyl)amino)phenyl)(phenyl)methanone

Conditions
ConditionsYield
With C33H43ClNiO6P2; sodium triflate; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 100℃; for 18h; Inert atmosphere; Sealed tube;96%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

N-(2,2-difluoroethyl)-2-nitroaniline
1186528-20-0

N-(2,2-difluoroethyl)-2-nitroaniline

Conditions
ConditionsYield
In acetonitrile for 24h; Reflux;95%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2,3-dichloro-7-methylpyrido[3,4-b]pyrazine

2,3-dichloro-7-methylpyrido[3,4-b]pyrazine

3-chloro-N-(2,2-difluoroethyl)-7-methylpyrido[3,4-b]pyrazin-2-amine

3-chloro-N-(2,2-difluoroethyl)-7-methylpyrido[3,4-b]pyrazin-2-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 48h;95%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

N-(2,2-difluoro-ethyl)-o-toluidine
2366-95-2

N-(2,2-difluoro-ethyl)-o-toluidine

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;95%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

tolyl vinyl sulfone
5535-52-4

tolyl vinyl sulfone

3-((4-methylphenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

3-((4-methylphenyl)sulfonyl)-5-(difluoromethyl)-4,5-dihydro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,2-difluorethylamine; tolyl vinyl sulfone With tert.-butylnitrite; acetic acid In chloroform at 55℃; under 1034.32 Torr; for 0.166667h; Flow reactor;
Stage #2: In chloroform at 20℃;
Stage #3: With silica gel In hexane; ethyl acetate
95%
4-n-chlorophenylacetylene
873-73-4

4-n-chlorophenylacetylene

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

5-(4-chlorophenyl)-3-(difluoromethyl)isoxazole

5-(4-chlorophenyl)-3-(difluoromethyl)isoxazole

Conditions
ConditionsYield
With copper(l) iodide; tert.-butylnitrite; acetic acid; zinc dibromide In chloroform at 20℃; for 24h; Schlenk technique; Inert atmosphere;95%
tert.-butylnitrite
540-80-7

tert.-butylnitrite

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

N-(2,2-difluoroethyl)-N-(2-nitro-1-phenylethyl)nitrous amide

N-(2,2-difluoroethyl)-N-(2-nitro-1-phenylethyl)nitrous amide

Conditions
ConditionsYield
With acetic acid at 20℃; for 6h;95%
nitrostyrene
5153-67-3

nitrostyrene

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

N-(2,2-difluoroethyl)-N-(2-nitro-1-phenylethyl)nitrous amide

N-(2,2-difluoroethyl)-N-(2-nitro-1-phenylethyl)nitrous amide

Conditions
ConditionsYield
With tert.-butylnitrite; acetic acid at 20℃; for 3h; Reagent/catalyst; Temperature; Michael Addition;95%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

2-bromonaphthalene
580-13-2

2-bromonaphthalene

N-(2,2-difluoroethyl)naphthalen-2-amine

N-(2,2-difluoroethyl)naphthalen-2-amine

Conditions
ConditionsYield
With copper(I) oxide; C19H24N2O7; potassium carbonate In methanol at 100℃; for 24h; Ullmann Condensation;95%
6-chloronicotinylaldehyde
23100-12-1

6-chloronicotinylaldehyde

2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

N-[(6-chloropyridin-3-yl)methylidene]-2,2-difluoroethylamine
1135038-51-5

N-[(6-chloropyridin-3-yl)methylidene]-2,2-difluoroethylamine

Conditions
ConditionsYield
Stage #1: 6-chloronicotinylaldehyde; 2,2-difluorethylamine In toluene at 20℃; for 2h;
Stage #2: With magnesium sulfate In toluene at 50℃; for 5h;
94%
2,2-difluorethylamine
430-67-1

2,2-difluorethylamine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl N-(2,2-difluoroethyl)carbamate

tert-butyl N-(2,2-difluoroethyl)carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 1.5h;94%
With triethylamine In dichloromethane at 25℃; for 16h;80.08%
With triethylamine In dichloromethane at 20℃;

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