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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance Almost white or light yellow powder Almost white powder Solubility

Jinan Finer Chemical Co., Ltd

Product description: Product name 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one CAS number 43200-81-3 Assay ≥98% Appearance Yellow crystalline powder Capacity

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:100 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-(5-Chloro-2-pyridyl)-6.7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one Basic information Product Name: 6-(5-Chlor

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 43200-81-3 with competitive price

Cas:43200-81-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one 43200-81-3

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Gram

FOB Price: $68.0 / 98.0

Type:Trading Company

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

Hot Selling CAS 43200-81-3 in Stock 100% Safe Delivery

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one CAS:43200-81-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one CAS:43200-81-3

Cas:43200-81-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

6-(5-Chloro-2-pyridyl)-6,7-dihydro-

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one CAS: 43200-81-3 Specificatio Product name 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one CAS number 43200-81-3

Factory supply 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

6-(5-CHLORO-2-PYRIDYL)-6,7-DIHYDRO-7-HYDROXY-5H-PYRROLO[3,4-B]PYRAZIN-5-ONE

Cas:43200-81-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one/High quality/Best price

Cas:43200-81-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

43200-81-3 CAS NO.43200-81-3

Cas:43200-81-3

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Yellow Crystalline Powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Eszopiclone intermediate Transportation:a

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one 99% min

Cas:43200-81-3

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-...

Cas:43200-81-3

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

Cas:43200-81-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3.4-b]pyrazin-5-yl acetate

6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3.4-b]pyrazin-5-yl acetate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With sulfuric acid In ethanol for 3h; Reflux;88.7%
6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine
43200-82-4

6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Stage #1: 6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine With potassium borohydride In 1,4-dioxane at 10 - 15℃; for 0.5h;
Stage #2: With water In 1,4-dioxane for 6h;
87.4%
With potassium borohydride; water In tetrahydrofuran at -10 - 5℃; for 3h; Large scale;70%
With potassium borohydride; potassium carbonate In 1,4-dioxane; water; N,N-dimethyl-formamide at 13℃; pH=11; Reagent/catalyst; Solvent; pH-value;95.5 g
With sodium hydroxide; sodium tetrahydroborate In water at 0 - 5℃; for 4 - 5h; Product distribution / selectivity;
(-)-Zopiclone
138680-08-7

(-)-Zopiclone

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Stage #1: (-)-Zopiclone With trifluoroacetic acid In dichloromethane for 18h; Heating / reflux;
Stage #2: With water; sodium hydrogencarbonate In dichloromethane at 0℃; pH=7.5 - 8; Product distribution / selectivity;
70%
Stage #1: (-)-Zopiclone With trifluoroacetic acid In dichloromethane for 18h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water at 0℃; pH=7.5 - 8; Product distribution / selectivity;
70%
Stage #1: (-)-Zopiclone With hydrogenchloride; water In methanol at 41℃; for 11h;
Stage #2: With sodium hydrogencarbonate In methanol; water at 10 - 15℃; Product distribution / selectivity;
41.24%
Stage #1: (-)-Zopiclone With hydrogenchloride; water In methanol at 41℃; for 11h;
Stage #2: With sodium hydrogencarbonate In methanol; water at 10 - 15℃; Product distribution / selectivity;
41.24%
With hydrogenchloride; water at 70℃; for 3h;
(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-18-4

(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

B

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-20-8

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With phosphate buffer; Candida antarctica lipase B Chirazyme-L2; triethylamine In water; toluene at 60℃; for 96h; pH=7;
(+/-)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-17-3

(+/-)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

B

(S)-(+)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-19-5

(S)-(+)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With phosphate buffer; Candida antarctica lipase B Novozym 435 In water; toluene at 60℃; for 96h; pH=7;
(R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt
144025-94-5

(R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Stage #1: (R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt With water; sodium hydrogencarbonate In dichloromethane; acetonitrile at 25 - 30℃; for 0.75h;
Stage #2: With hydrogenchloride; formic acid; water at 0 - 68℃; for 4h; Product distribution / selectivity;
(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-18-4

(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(R)-5-(chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine
1151528-25-4

(R)-5-(chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine

B

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

C

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-20-8

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With propan-1-ol; triethylamine; Novozyme 435 In toluene at 45℃; for 16 - 24h; Purification / work up; Enzymatic reaction; Resolution of racemate;A n/a
B n/a
C n/a
2,3-pyrazinedicarboxylic anhydride
4744-50-7

2,3-pyrazinedicarboxylic anhydride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dmap; triethylamine / 5,5-dimethyl-1,3-cyclohexadiene / 13 h / 0 °C / Reflux
2.1: potassium borohydride / 1,4-dioxane / 0.5 h / 10 - 15 °C
2.2: 6 h
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 2.5 h / 20 - 52 °C
1.2: 1 h / 10 - 15 °C
2.1: dichloromethane / 1 h / Heating / reflux
2.2: 0.75 - 1 h / 25 - 30 °C / Heating / reflux
3.1: sodium hydroxide; sodium tetrahydroborate / water / 4 - 5 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1: propionic acid anhydride / 1 h / 60 - 105 °C
2: potassium borohydride; water / tetrahydrofuran / 3 h / -10 - 5 °C / Large scale
View Scheme
5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dmap; triethylamine / 5,5-dimethyl-1,3-cyclohexadiene / 13 h / 0 °C / Reflux
2.1: potassium borohydride / 1,4-dioxane / 0.5 h / 10 - 15 °C
2.2: 6 h
View Scheme
Multi-step reaction with 3 steps
1.1: toluene / 2.5 h / 20 - 52 °C
1.2: 1 h / 10 - 15 °C
2.1: dichloromethane / 1 h / Heating / reflux
2.2: 0.75 - 1 h / 25 - 30 °C / Heating / reflux
3.1: sodium hydroxide; sodium tetrahydroborate / water / 4 - 5 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: isopropyl alcohol / 5 h / Reflux; Large scale
2: 1 h / Reflux; Large scale
3: sulfuric acid / ethanol / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: propionic acid anhydride / 1 h / 60 - 105 °C
2: potassium borohydride; water / tetrahydrofuran / 3 h / -10 - 5 °C / Large scale
View Scheme
zopiclon
43200-80-2

zopiclon

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; acetonitrile / 3 - 4.5 h / 25 - 80 °C / Resolution of racemate
2.1: water; sodium hydrogencarbonate / dichloromethane; acetonitrile / 0.75 h / 25 - 30 °C
2.2: 4 h / 0 - 68 °C
View Scheme
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid
43200-83-5

3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 1 h / Heating / reflux
1.2: 0.75 - 1 h / 25 - 30 °C / Heating / reflux
2.1: sodium hydroxide; sodium tetrahydroborate / water / 4 - 5 h / 0 - 5 °C
View Scheme
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-17-3

(+/-)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 7h;98%
With pyridine In dichloromethane at 0 - 20℃; for 7h;98%
With pyridine In dichloromethane at 20℃; for 7h;
carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(1-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(1-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 4h;98%
With pyridine
2,2,2-trichloro-1,1-dimethylethoxychloroformate
66270-36-8

2,2,2-trichloro-1,1-dimethylethoxychloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(1,1-dimethyl-2,2,2-trichloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(1,1-dimethyl-2,2,2-trichloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 2h;98%
With pyridine
6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

2,2,2-Trichloroethyl chloroformate
17341-93-4

2,2,2-Trichloroethyl chloroformate

(+/-)-6-(5-chloropyridin-2-yl)-7-oxo-5-(2,2,2-trichloroethyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

(+/-)-6-(5-chloropyridin-2-yl)-7-oxo-5-(2,2,2-trichloroethyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 5h;98%
With pyridine In dichloromethane at 0 - 20℃; for 5h;98%
4-methylpiperazine-1-carbonyl chloride monohydrochloride
55112-42-0

4-methylpiperazine-1-carbonyl chloride monohydrochloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

zopiclon
43200-80-2

zopiclon

Conditions
ConditionsYield
Stage #1: 4-methylpiperazine-1-carbonyl chloride monohydrochloride With triethylamine In dichloromethane at 5℃; for 0.416667h;
Stage #2: dmap In dichloromethane for 0.0166667 - 0.0333333h;
Stage #3: 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one In dichloromethane at 20℃; for 7h; Product distribution / selectivity; Heating / reflux;
95%
With triethylamine; dmap In 2-methylpropyl acetate at 80℃; for 5.5h; Product distribution / selectivity;91.7%
Stage #1: 4-methylpiperazine-1-carbonyl chloride monohydrochloride With triethylamine In ethyl acetate for 0.166667h;
Stage #2: 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one; dmap In ethyl acetate at 60℃; for 7.5h; Product distribution / selectivity;
90%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloropyridin-2-yl)-7-oxo-5-(2-propenyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine
862210-86-4

6-(5-chloropyridin-2-yl)-7-oxo-5-(2-propenyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 6h;93%
6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
148891-53-6

6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene at -15℃; for 2h; Temperature;92.6%
benzoyl chloride
98-88-4

benzoyl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

benzoic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

benzoic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 4h;89%
butyryl chloride
141-75-3

butyryl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 5h;87%
carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-18-4

(+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 17h;86%
With pyridine In dichloromethane at 25℃; for 17h;86%
With pyridine In dichloromethane at 0 - 20℃; for 17h;86%
acetyl chloride
75-36-5

acetyl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3.4-b]pyrazin-5-yl acetate

6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3.4-b]pyrazin-5-yl acetate

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 5h;85%
4-methyl-piperazine-1-carbonyl chloride
39539-66-7

4-methyl-piperazine-1-carbonyl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

zopiclon
43200-80-2

zopiclon

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 3h; Reflux;80%
With dmap; triethylamine In acetonitrile at 60 - 65℃; for 1.5h; Large scale;80.9%
Stage #1: 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With sodium hydride In N,N-dimethyl-formamide; mineral oil at -10 - 35℃;
Stage #2: 4-methyl-piperazine-1-carbonyl chloride In N,N-dimethyl-formamide; mineral oil at -10 - 20℃; Product distribution / selectivity;
78.81%
Stage #1: 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With sodium hydride In N,N-dimethyl-formamide at -10℃;
Stage #2: 4-methyl-piperazine-1-carbonyl chloride In N,N-dimethyl-formamide at -10 - 20℃; for 3h; Product distribution / selectivity;
78.81%
With sodium hydride In N,N-dimethyl-formamide Product distribution / selectivity;
6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

3-hydroxymethyl-pyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide
1122549-43-2

3-hydroxymethyl-pyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide

Conditions
ConditionsYield
With sodium tetrahydroborate In 1,4-dioxane; water at 10 - 15℃; for 2h;75.2%
Vinyl chloroformate
5130-24-5

Vinyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-6-(5-chloropyridin-2-yl)-7-oxo-5-(vinyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine
190369-20-1

(+/-)-6-(5-chloropyridin-2-yl)-7-oxo-5-(vinyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
With pyridine In dichloromethane at 25℃; for 10h;75%
4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(p-nitrophenyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(p-nitrophenyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 21h;55%
With pyridine
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloropyridin-2-yl)-7-oxo-5-(N-succinimidyloxycarbonyloxi)-5,6-dihydropyrrolo[3,4b]pyrazine

6-(5-chloropyridin-2-yl)-7-oxo-5-(N-succinimidyloxycarbonyloxi)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
With pyridine; triethylamine In acetonitrile at 0 - 20℃; for 18h;40%
phenyl chloroformate
1885-14-9

phenyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

C18H11ClN4O4

C18H11ClN4O4

Conditions
ConditionsYield
With (R)-6-benzyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole; triethylamine In dichloromethane at 20℃; Catalytic behavior; enantioselective reaction;35%
2-nitrophenyl chloroformate
50353-00-9

2-nitrophenyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(o-nitrophenyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

(+/-)-7-(o-nitrophenyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

Conditions
ConditionsYield
With pyridine
carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-20-8

(S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

B

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
Stage #1: carbonochloridic acid, chloromethyl ester; 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With pyridine In dichloromethane at 25℃; for 17h;
Stage #2: With Candida antarctica lipase (fraction B) - octadecyl-Sepabeads; sodium phosphate In 1,4-dioxane; water at 25℃; pH=7;
2-Chloroethyl chloroformate
627-11-2

2-Chloroethyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(S)-(+)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
508169-19-5

(S)-(+)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

B

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
Stage #1: 2-Chloroethyl chloroformate; 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With pyridine In dichloromethane at 25℃; for 7h;
Stage #2: With Candida antarctica lipase (fraction B) - octadecyl-Sepabeads; sodium phosphate In 1,4-dioxane; water at 25℃; pH=7;
acetyl chloride
75-36-5

acetyl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

B

acetic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

acetic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

Conditions
ConditionsYield
Stage #1: acetyl chloride; 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With pyridine In dichloromethane at 25℃; for 5h;
Stage #2: With Candida antarctica lipase (fraction B) - octadecyl-Sepabeads; sodium phosphate In 1,4-dioxane; water at 37℃; pH=7;
butyryl chloride
141-75-3

butyryl chloride

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

B

(7S)-6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

(7S)-6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one

C

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

D

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

butyric acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester

Conditions
ConditionsYield
Stage #1: butyryl chloride; 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With pyridine In dichloromethane at 25℃; for 5h;
Stage #2: With Candida antarctica lipase (fraction B) - octadecyl-Sepabeads; sodium phosphate In 1,4-dioxane; water at 25℃; pH=7; Title compound not separated from byproducts;
Vinyl chloroformate
5130-24-5

Vinyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

A

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

(R)-6-(5-chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4b]pyrazine

B

(S)-6-(5-chloropyridin-2-yl)-7-oxo-5-(vinyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

(S)-6-(5-chloropyridin-2-yl)-7-oxo-5-(vinyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
Stage #1: Vinyl chloroformate; 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one With pyridine In dichloromethane at 25℃; for 10h;
Stage #2: With Candida antarctica lipase (fraction B) - octadecyl-Sepabeads; sodium phosphate In 1,4-dioxane; water at 25℃; pH=7;
6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

eszopiclone
138729-47-2

eszopiclone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / pyridine / CH2Cl2 / 17 h / 20 °C
2: Candida antarctica lipase B Chirazyme-L2; phosphate buffer; triethylamine / toluene; H2O / 96 h / 60 °C / pH 7
3: 90 percent / acetone / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: (R)-6-tert-butyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole; triethylamine / dichloromethane / 0 °C
2: acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: dmap; calcium oxide / dichloromethane; N,N-dimethyl-formamide / 10 - 30 °C
2: water; acetonitrile / 3 - 4.5 h / 25 - 80 °C / Resolution of racemate
3: water; sodium hydrogencarbonate / 3 - 4 h / 25 - 30 °C
View Scheme

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