CAS No.449811-29-4,6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE Suppliers

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDEAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:An important raw material and intermediate used in Organic Synthesis, Pharmaceuticals Transp

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

laboratory Application:Synthetic building block

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

449811-29-4

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE CAS NO.449811-29-4

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ENAO Chemical Co, Limited

For quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,

6-Chloro-4-(methylamino)nicotinaldehyde

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

6-Chloro-4-(methylamino)nicotinaldehyde449811-29-4

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Run-Biotech Co., Ltd.

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por

6-CHLORO-4-(METHYLAMINO)NICOTINALDEHYDE

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Debye Scientific

Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

6-chloro-4-(methylamino)-3-Pyridinecarboxaldehyde

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Coupling Pharmaceutical R&D Co., Ltd.

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemical Co.Ltd

Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en

3-Pyridinecarboxaldehyde, 6-chloro-4-(methylamino)-

Cas:449811-29-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

: 449811-30-7
(6-chloro-4-(methylamino)pyridin-3-yl)methanol

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
With manganese(IV) oxide In dichloromethane at 20℃; Inert atmosphere;	93%
With manganese(IV) oxide In dichloromethane at 20℃; Inert atmosphere;	93%
With manganese(IV) oxide In dichloromethane at 30℃; for 6h;	87%

: 1060811-62-2
2,4-dichloro-5-pyridinecarboxaldehyde

: 74-89-5
methylamine

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
In tetrahydrofuran at 45℃; for 48h;	93%

: 449811-28-3
ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Stage #1: ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; for 3h; Stage #2: With manganese(IV) oxide In dichloromethane at 20℃; for 2h;	84%
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C 1.2: 20 °C 2.1: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme

: 6975-44-6
4,6-dihydroxynicotinic acid ethyl ester

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: trichlorophosphate / 3 h / 110 °C 2.1: acetonitrile; water / 3.5 h / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C 3.2: 20 °C 4.1: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
Multi-step reaction with 4 steps 1: trichlorophosphate / 2 h / Reflux 2: water; acetonitrile / 8 h / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 4: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme
Multi-step reaction with 4 steps 1: trichlorophosphate / 2 h / Reflux 2: water; acetonitrile / 8 h / 0 - 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 4: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: acetic anhydride / 1.5 h / 120 °C 1.2: 0 °C / Cooling 1.3: pH < 5 2.1: trichlorophosphate / 3 h / 110 °C 3.1: acetonitrile; water / 3.5 h / 0 - 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C 4.2: 20 °C 5.1: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
Multi-step reaction with 5 steps 1.1: orthoformic acid triethyl ester / 2 h / 120 °C 1.2: 0 - 20 °C 2.1: trichlorophosphate / 2 h / Reflux 3.1: water; acetonitrile / 8 h / 0 - 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 5.1: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme
Multi-step reaction with 5 steps 1: 2 h / 120 °C 2: trichlorophosphate / 2 h / Reflux 3: water; acetonitrile / 8 h / 0 - 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 5: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetonitrile; water / 3.5 h / 0 - 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C 2.2: 20 °C 3.1: manganese(IV) oxide / dichloromethane / 20 °C View Scheme
Multi-step reaction with 3 steps 1: water; acetonitrile / 8 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 3: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme
Multi-step reaction with 3 steps 1: water; acetonitrile / 8 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 3: manganese(IV) oxide / dichloromethane / 6 h / 30 °C View Scheme

: 73998-95-5
2,4-dichloro-5-hydroxymethylpyridine

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: manganese(IV) oxide / chloroform / 12 h / 75 °C 2: tetrahydrofuran / 48 h / 45 °C View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 446-18-4
4-fluoro-2-methyl-5-nitroaniline

: 1011464-19-9
2-chloro-5-((4-fluoro-2-methyl-5-nitrophenylamino)methyl)-N-methylpyridin-4-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In acetic acid at 20℃;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1609102-12-6
7-chloro-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridine-3-carboxylic acid

Conditions

Conditions	Yield
With piperidine; acetic acid In ethanol at 20℃; for 2.33333h; Reflux;	99%
With piperidine; acetic acid at 20℃; for 2.33333h; Reflux;	99%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 459-73-4
GlyOEt*HCl

: 3-amino-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 5h;	92%

: 409082-02-6
ethyl 2-(5-amino-2-chlorophenyl)acetate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012879-38-7
3-(5-amino-2-chlorophenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	83%
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	83%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 7-chloro-3-(2-chlorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere;	75%
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 2h; Inert atmosphere;	75%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012880-05-5
ethyl 2-(5-amino-4-fluoro-2-methylphenyl)acetate

: 1012878-63-5
3-(5-amino-4-fluoro-2-methylphenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 2h;	69%
With 40% potassium fluoride/alumina In N,N-dimethyl acetamide at 20℃; for 2h;	69%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012880-07-7
ethyl 2-(5-amino-2,4-difluorophenyl)acetate

: 1012878-86-2
3-(5-amino-2,4-difluorophenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide for 0.166667h;	68%
With 40% potassium fluoride/alumina In N,N-dimethyl acetamide for 0.166667h;	68%

: 651734-54-2
2,6-difluoro-3,5-dimethoxybenzeneamine

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 2-chloro-5-{[(2,6-difluoro-3,5-dimethoxyphenyl)amino]methyl}-N-methylpyridin-4-amine

Conditions

Conditions	Yield
Stage #1: 2,6-difluoro-3,5-dimethoxybenzeneamine With sodium tris(acetoxy)borohydride; trifluoroacetic acid at 0℃; for 0.0333333h; Stage #2: 6-chloro-4-(methylamino)pyridine-3-carbaldehyde In dichloromethane at 20℃;	68%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1442471-26-2
ethyl 2-(5-amino-2-bromo-4-fluorophenyl)acetate

: 1442470-77-0
3-(5-amino-2-bromo-4-fluoro-phenyl)-7-chloro-1-methyl-1H-[1,6]naphthyridin-2-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 0.166667h;	67%
With potassium fluoride on basic alumina In N,N-dimethyl acetamide at 20℃; for 0.166667h;	67%

: methyl 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzeneacetate

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 7-chloro-3-(3-hydroxyphenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 2h;	67%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012880-10-2
ethyl 2-(5-amino-2-chloro-4-fluorophenyl)acetate

: 1012878-83-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl acetamide at 20℃; for 1h;	60%
With 40% potassium fluoride/alumina In N,N-dimethyl acetamide at 20℃; for 1h;	60%

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 850449-93-3
methyl 2-(5-amino-2-methylphenyl)acetate

: 850451-77-3
3-(5-amino-2-methylphenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1021535-35-2
methyl 3-((methoxycarbonyl)methyl)-4-methylbenzoate

: 1021535-36-3
C18H15ClN2O3

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 850449-93-3
methyl 2-(5-amino-2-methylphenyl)acetate

: 3-(4-amino-2-methyl-phenyl)-7-chloro-1-methyl-1H-[1,6]naphthyridin-2-one

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1325215-16-4
(E)-ethyl-3-(6-chloro-4-(methylamino)pyridin-3-yl)acrylate

Conditions

Conditions	Yield
In tetrahydrofuran for 16h; Reflux;

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-17-5
7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-18-6
3-bromo-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation 3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-19-7
3-(tributylstannyl)-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation 3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C 4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-20-0
3-(2-(N,N-bis-(t-butoxycarbonyl)amino)-3,5-difluoropyridin-4-yl)-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation 3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C 4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube 5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube View Scheme

Yield

Multi-step reaction with 5 steps
1: tetrahydrofuran / 16 h / Reflux
2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation
3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C
4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube
5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube
View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-21-1
3-(2-amino-3,5-difluoropyridin-4-yl)-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation 3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C 4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube 5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube 6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: tetrahydrofuran / 16 h / Reflux
2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation
3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C
4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube
5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1325215-00-6
N-(4-(7-(ethylamino)-1-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-3,5-difluoropyridin-2-yl)propane-1-sulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: tetrahydrofuran / 16 h / Reflux 2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation 3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C 4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube 5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube 6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 7: triethylamine / dichloromethane / 16 h / 0 - 20 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: tetrahydrofuran / 16 h / Reflux
2: 1-methyl-pyrrolidin-2-one; water / 0.58 h / 150 °C / Microwave irradiation
3: pyridine; Phenylselenyl bromide / dichloromethane / 6 h / 39 °C
4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 48 h / 80 - 90 °C / Inert atmosphere; Sealed tube
5: copper(l) iodide; triphenyl-arsane / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 48 h / 60 °C / Inert atmosphere; Sealed tube
6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
7: triethylamine / dichloromethane / 16 h / 0 - 20 °C
View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012878-84-0
7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chloro-4-fluorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 1 h / 20 °C 2: 3 h / 180 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: 40% potassium fluoride/alumina / N,N-dimethyl acetamide / 1 h / 20 °C 2: 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one / 3 h / 180 °C / Inert atmosphere View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012878-85-1
3-(5-amino-2-chloro-4-fluorophenyl)-1-methyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 1 h / 20 °C 2: 3 h / 180 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / Reflux View Scheme
Multi-step reaction with 3 steps 1: 40% potassium fluoride/alumina / N,N-dimethyl acetamide / 1 h / 20 °C 2: 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(2-methoxyethylamino)-1,6-naphthyridin-2(1H)-one / 3 h / 180 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / Reflux View Scheme

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1012879-39-8
7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chlorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 4 h / 180 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 180 °C / Inert atmosphere View Scheme

Related products

44981-94-4

Glycine, N-(2-cyanoethyl)-, ethyl ester

44985-71-9

1-Propanaminium,3-carboxy-2-hydroxy-N,N,N-trimethyl-

4498-67-3

1H-Indazole-3-carboxylicacid

4498-68-4

1H-Indazole-3-carboxylicacid, ethyl ester

4498-72-0

Ethanone,1-(1H-indazol-3-yl)-

4498-74-2

1H-Indazole,3-(phenylmethyl)-

4498-99-1

Benzenemethanethiol,4-methyl-

44992-01-0

Ethanaminium,N,N,N-trimethyl-2-[(1-oxo-2-propen-1-yl)oxy]-, chloride (1:1)

4499-40-5

CHOLINE, with THEOPHYLLINE (1:1)

4499-86-9

Tetrapropylammonium hydroxide

Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

Henan Wentao Chemical Product Co., Ltd.

Hangzhou J&H Chemical Co., Ltd.

Antimex Chemical Limied

Henan Kanbei Chemical Co.,LTD

SAGECHEM LIMITED

Shanghai Chinqesen Biotechnology Co., Ltd.

ZHEJIANG JIUZHOU CHEM CO.,LTD

Jilin haofei import and export trade Co.,Ltd

ENAO Chemical Co, Limited

Shanghai Hanhong Scientific Co.,Ltd.

Chemical Technology Co.,LTD

Shanghai united Scientific Co.,Ltd.

Shanghai Run-Biotech Co., Ltd.

Debye Scientific

Shanghai Coupling Pharmaceutical R&D Co., Ltd.

Chemical Co.Ltd

Synthetic route

Related products

Hot Products