Items Standard Result Appearance White or off-white powder Off-white powder Identification HPLC
Cas:4498-67-3
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:4498-67-3
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inquiryUnique advantages of Indazole-3-carboxylic acid Cas 4498-67-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or pale yellow crystalline powder Storage:Cool dry place P
Cas:4498-67-3
Min.Order:1 Kilogram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:4498-67-3
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:4498-67-3
Min.Order:1 Kilogram
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:4498-67-3
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inquiryIndazole-3-carboxylic acid 4498-67-3 Indazole-3-carboxylic acid Basic information Product Name: Indazole-3-carboxylic acid Synonyms: 1H-INDAZOL-3-CARBONIC ACID;1H-INDAZOLE-3-CARBOXYLIC
Cas:4498-67-3
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inquiryProduct Description Product name Indazole-3-carboxylic acid CAS 4498-67-3 Assay 99% Appearance Yellow c
Cas:4498-67-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:4498-67-3
Min.Order:1 Kilogram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:4498-67-3
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Cas:4498-67-3
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:4498-67-3
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inquiryCAS No. 4498-67-3 Other Names 1h-indazole-3-carboxylic Acid MF C8H6N2O2 EINECS No. 224-794-5 Type Dyestuff Intermediates, Pharmaceutical Int
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & dr
Cas:4498-67-3
Min.Order:100 Gram
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inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
Cas:4498-67-3
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical inte
Cas:4498-67-3
Min.Order:100 Gram
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:4498-67-3
Min.Order:1 Kilogram
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inquiry7-Hydroxygranisetron CAS: 4498-67-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte
Cas:4498-67-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryPRODUCT DETAILS 7-Hydroxygranisetron Basic information Product Name: 7-Hydroxygranisetron Synonyms: 1H-INDAZOL-3
Cas:4498-67-3
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:4498-67-3
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inquiryHangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the business
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Cas:4498-67-3
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryAppearance:Yellow crystalline powder Storage:R.T Package:25kg/drum Application:Intermediate Transportation:Express/Sea/Air Port:Any port in China
Cas:4498-67-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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Cas:4498-67-3
Min.Order:100 Metric Ton
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:4498-67-3
Min.Order:0 Metric Ton
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Cas:4498-67-3
Min.Order:10 Kilogram
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inquiryName Indazole-3-carboxylic acid Synonyms 1H-Indazole-3-carboxylic acid Molecular Structure Molecular Formula
Conditions | Yield |
---|---|
Stage #1: indole-2,3-dione With sodium hydroxide In water at 20 - 50℃; for 1.5h; Stage #2: With sulfuric acid; sodium nitrite In water at 0℃; for 1h; Stage #3: With hydrogenchloride; tin(ll) chloride In water for 1.16667h; | 100% |
With sodium hydroxide; sulfuric acid; sulfur dioxide; sodium nitrite Reagens 4: Zinnchloruer; | |
With sulfuric acid; sodium nitrite danach SnCl2; |
methyl 1-acetylindazole-3-carboxylate
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In hydrogenchloride; water | 100% |
With sodium hydroxide; water for 1.5h; Heating; | 97% |
ethyl 1-acetyl-1H-indazole-3-carboxylate
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide; water for 1.5h; Heating; | 98% |
1-(3-(morpholine-4-carbonyl)-1H-indazol-1-yl)ethanone
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide; water for 3h; Heating; | 96% |
4-bromobenzylideneaminoisatine
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzylideneaminoisatine With hydrogenchloride In water; acetic acid at 90 - 100℃; for 1h; Stage #2: With acetic acid at 115℃; for 1h; | 85% |
1-(benzylideneamino)indoline-2,3-dione
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid In dichloromethane; ISOPROPYLAMIDE; water at 15 - 90℃; Product distribution / selectivity; Reflux; Inert atmosphere; | 76% |
Stage #1: 1-(benzylideneamino)indoline-2,3-dione With hydrogenchloride; acetic acid In water at 90℃; for 1h; Stage #2: With acetic acid at 115℃; for 0.5h; | 71% |
3-(hydroxymethyl)-1H-indazole
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With chromium(VI) oxide; sulfuric acid In acetone at 20℃; for 24h; | 64% |
With chromium(VI) oxide; sulfuric acid In acetone at 20℃; for 24h; | 64% |
Conditions | Yield |
---|---|
With sodium hydroxide; sulfuric acid; sodium nitrite In hydrogenchloride; water | 31% |
1-dimethylamino-indolin-2-one
2,3-dimethyl-4-nitroso-aniline
sodium ethanolate
1H-Indazole-3-carboxylic acid
1-benzylideneamino-indole-2,3-dione
acetic acid
A
benzaldehyde
B
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
mit Wasserdampf; |
indazole-3-carbonitrile
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
N-acetylaminoisatin
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid for 2.5h; Heating; |
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid |
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
hydrogenchloride
1-benzylideneamino-indole-2,3-dione
A
benzaldehyde
B
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
mit Wasserdampf; |
oxalic acid-(benzylidene-phenyl-hydrazide)-chloride
A
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With carbon disulfide; aluminium trichloride |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / cc. H2SO4 / 4 h / Heating 2: 97 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 3: 87 percent / 90percent t-BuONO / acetic acid / 0.5 h / 90 - 95 °C 4: 97 percent / NaOH, water / 1.5 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 94 percent / cc. H2SO4 / 4 h / Heating 2: 97 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 3: 83 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 4: 98 percent / NaOH, water / 1.5 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 89 percent / SOCl2 / dimethylformamide; 1,2-dichloro-ethane / 35-40 deg C, 2 h then 20 deg C, 2 h 2: 95 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 3: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 4: 96 percent / NaOH, water / 3 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 89 percent / SOCl2 / dimethylformamide; 1,2-dichloro-ethane / 35-40 deg C, 2 h then 20 deg C, 2 h 2: 92 percent / Fe, aq. NH4Cl / propan-2-ol / 1 h / Heating 3: toluene / rt to 95 deg C 4: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 5: 96 percent / NaOH, water / 3 h / Heating View Scheme |
methyl (2-nitrophenyl)acetate
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 2: 87 percent / 90percent t-BuONO / acetic acid / 0.5 h / 90 - 95 °C 3: 97 percent / NaOH, water / 1.5 h / Heating View Scheme |
ethyl 2-nitrophenylacetate
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 2: 83 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 3: 98 percent / NaOH, water / 1.5 h / Heating View Scheme |
(2-acetylamino-phenyl)-acetic acid ethyl ester
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 83 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 2: 98 percent / NaOH, water / 1.5 h / Heating View Scheme |
methyl 3-(2-acetamidophenyl)propanoate
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / 90percent t-BuONO / acetic acid / 0.5 h / 90 - 95 °C 2: 97 percent / NaOH, water / 1.5 h / Heating View Scheme |
4-[(2-nitro-phenyl)-acetyl]-morpholine
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 95 percent / H2 / 5percent Pd/C / toluene / Ambient temperature 2: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 3: 96 percent / NaOH, water / 3 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 92 percent / Fe, aq. NH4Cl / propan-2-ol / 1 h / Heating 2: toluene / rt to 95 deg C 3: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 4: 96 percent / NaOH, water / 3 h / Heating View Scheme |
4-(2-aminophenylacetyl)morpholine
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / rt to 95 deg C 2: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 3: 96 percent / NaOH, water / 3 h / Heating View Scheme |
N-[2-(2-Morpholin-4-yl-2-oxo-ethyl)-phenyl]-acetamide
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 76 percent / 90percent t-BuONO / toluene / 0.5 h / 90 - 95 °C 2: 96 percent / NaOH, water / 3 h / Heating View Scheme |
N-Acetylaminoisonitrosoacetanilide
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 96percent H2SO4 / 0.25 h / 85 °C 2: aq. H2SO4 / 2.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 79 percent / hydroxylamine hydrochloride, sodium sulphate, 1 N HCl / H2O / 0.17 h / 100 °C 2: 96percent H2SO4 / 0.25 h / 85 °C 3: aq. H2SO4 / 2.5 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tin; hydrochloric acid 2: acid; sodium nitrite 3: concentrated hydrochloric acid View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acid; sodium nitrite 2: concentrated hydrochloric acid View Scheme |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; | 100% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; for 10h; | 66% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; | 100% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; for 10h; | 10% |
4-chloro-aniline
1H-Indazole-3-carboxylic acid
N-(4-chlorophenyl)-1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; | 100% |
methanol
1H-Indazole-3-carboxylic acid
methyl 1H-indazole-3-carboxylate
Conditions | Yield |
---|---|
With sulfuric acid for 2h; Heating; | 98% |
With sulfuric acid for 2h; Reflux; | 95% |
With thionyl chloride for 3h; Reflux; | 95% |
5,6-diamino-1-ethyl-3,3-dimethylindol-2-one
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5,6-diamino-1-ethyl-3,3-dimethylindol-2-one; 1H-Indazole-3-carboxylic acid With PPA; phosphorus pentoxide at 150℃; for 6h; Stage #2: With ammonia In water pH=7 - 8; | 97% |
endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
1H-Indazole-3-carboxylic acid
endo-N-(9-methyl-9-azabicyclo<3.3.1>nonan-3-yl)-1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine In dichloromethane; N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 97% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; | 73% |
1H-Indazole-3-carboxylic acid
dimethyl sulfate
methyl 1H-indazole-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With potassium carbonate In acetone at 20℃; for 0.166667h; Stage #2: dimethyl sulfate In acetone for 4h; Reflux; | 95% |
Phenylpropargyl aldehyde
Benzyl isocyanide
1H-Indazole-3-carboxylic acid
4-bromo-aniline
Conditions | Yield |
---|---|
Stage #1: Phenylpropargyl aldehyde; 4-bromo-aniline In 2,2,2-trifluoroethanol at 20℃; for 0.166667h; Microwave irradiation; Stage #2: Benzyl isocyanide; 1H-Indazole-3-carboxylic acid In N,N-dimethyl-formamide at 20 - 110℃; Microwave irradiation; | 95% |
oxetan-3-yl-methylamine
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h; Reagent/catalyst; Temperature; Solvent; | 94% |
1H-Indazole-3-carboxylic acid
methylamine
1-methyl-3-indolecarboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With tin(ll) chloride In acetonitrile at 55℃; for 6h; Stage #2: methylamine In acetonitrile at 9℃; for 41h; Temperature; Reflux; | 93% |
tert-butyl [2-amino-2-(hydroxyimino)ethyl]carbamate
1H-Indazole-3-carboxylic acid
tert-butyl 2-(1H-indazole-3-carbonyloxyimino)-2-aminoethylcarbamate
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: tert-butyl 2-amino-2-(hydroxyimino)ethylcarbamate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere; | 92% |
Stage #1: 1H-Indazole-3-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: tert-butyl 2-amino-2-(hydroxyimino)ethylcarbamate In N,N-dimethyl-formamide at 20℃; | 92% |
1H-Indazole-3-carboxylic acid
1H-indazole-3-carbonyl chloride
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 2h; Inert atmosphere; | 91% |
With thionyl chloride for 1h; Reflux; | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 2h; | |
With thionyl chloride for 8h; Reflux; | |
With thionyl chloride at 80℃; for 4h; |
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With calcium methylate In methanol for 2h; Heating / reflux; Stage #2: dimethyl sulfate In methanol for 3h; Heating / reflux; Stage #3: With hydrogenchloride In water for 2h; pH=1; | 87.7% |
Conditions | Yield |
---|---|
With bromine; acetic acid at 90 - 120℃; for 16h; | 87.5% |
Stage #1: 1H-Indazole-3-carboxylic acid With acetic acid at 120℃; Stage #2: With bromine; acetic acid at 90℃; for 16h; | 87.5% |
With bromine; acetic acid at 90 - 120℃; for 16h; | 87.5% |
1H-Indazole-3-carboxylic acid
dimethyl sulfate
1-methyl-1H-indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With calcium oxide In methanol for 2h; Heating / reflux; Stage #2: dimethyl sulfate In methanol for 4h; Heating / reflux; | 85.6% |
Stage #1: 1H-Indazole-3-carboxylic acid With magnesium n-propylate In propan-1-ol for 2h; Heating / reflux; Stage #2: dimethyl sulfate In propan-1-ol at 20℃; for 5h; Heating / reflux; | 83.8% |
Stage #1: 1H-Indazole-3-carboxylic acid With magnesium ethylate In propan-1-ol for 2h; Heating / reflux; Stage #2: dimethyl sulfate In propan-1-ol at 20℃; for 2h; Heating / reflux; | 79.2% |
Stage #1: 1H-Indazole-3-carboxylic acid With barium(II) oxide In propan-1-ol for 2h; Heating / reflux; Stage #2: dimethyl sulfate In propan-1-ol at 20℃; for 2h; Heating / reflux; | 65.4% |
4-amino-1-benzylpiperidine
1H-Indazole-3-carboxylic acid
N-(1-benzylpiperidin-4-yl)-1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With 1,1'-carbonyldiimidazole In DMF (N,N-dimethyl-formamide) at 60℃; for 2h; Stage #2: 4-amino-1-benzylpiperidine In DMF (N,N-dimethyl-formamide) at 60℃; for 2h; | 85.1% |
With 1,1'-carbonyldiimidazole 1.) DMF, 60 deg C, 2 h, 2.) DMF, 60 deg C, 2 h; Yield given. Multistep reaction; | |
In N-methyl-acetamide; dichloromethane; 1,1'-carbonyldiimidazole | 76%. |
N,O-dimethylhydroxylamine*hydrochloride
1H-Indazole-3-carboxylic acid
1H-indazole-3-carboxylic acid methoxy(methyl)amide
Conditions | Yield |
---|---|
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; 1H-Indazole-3-carboxylic acid With pyridine In tetrahydrofuran at 20℃; for 3h; Cooling with ice; Stage #2: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; | 85% |
With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran at 0 - 20℃; for 13.5h; | 84% |
Stage #1: N,O-dimethylhydroxylamine*hydrochloride; 1H-Indazole-3-carboxylic acid With pyridine In tetrahydrofuran at 0 - 20℃; for 2.5h; Stage #2: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; | 84% |
1H-Indazole-3-carboxylic acid
methyl 1H-indazole-3-carboxylate
Conditions | Yield |
---|---|
Stage #1: methanol With acetyl chloride at 0℃; for 0.166667h; Stage #2: 1H-Indazole-3-carboxylic acid at 0 - 20℃; | 85% |
With sodium bicarbonate; sulfuric acid In methanol | 61% |
In methanol |
oxotribromobis(triphenylphosphine)rhenium(V)
1H-Indazole-3-carboxylic acid
Conditions | Yield |
---|---|
With air In tetrahydrofuran byproducts: HBr, P(C6H5)3; addn. of Re complex to N compd. (1:1) in C4H8O, heating under reflux for4 h; concn., cooling to room temp., slow diffusion of diethyl ether, isolation of crystals, elem. anal.; | 85% |
1H-Indazole-3-carboxylic acid
1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20℃; for 2h; Inert atmosphere; Stage #2: With ammonia In tetrahydrofuran; water at 20℃; for 1h; | 85% |
Stage #1: 1H-Indazole-3-carboxylic acid With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20℃; for 2h; Inert atmosphere; Stage #2: With ammonia In tetrahydrofuran; water at 20℃; for 1h; Inert atmosphere; | 85% |
Stage #1: 1H-Indazole-3-carboxylic acid With thionyl chloride for 3h; Inert atmosphere; Reflux; Stage #2: With ammonia In tetrahydrofuran; water at 20℃; for 0.5h; Inert atmosphere; | 76% |
1H-Indazole-3-carboxylic acid
methyl iodide
1-methyl-1H-indazole-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With calcium oxide In methanol for 2h; Heating / reflux; Stage #2: methyl iodide In methanol at 20℃; for 26h; Heating / reflux; | 83.8% |
With hydrogenchloride; sodium chloride; sodium hydrogencarbonate In dimethyl sulfoxide; mineral oil |
2-methoxy-phenylamine
1H-Indazole-3-carboxylic acid
N-(2-methoxyphenyl)-1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; for 10h; | 82% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; | 70% |
1H-Indazole-3-carboxylic acid
4-amino-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol
Conditions | Yield |
---|---|
With trichlorophosphate at 90 - 95℃; | 82% |
aniline
1H-Indazole-3-carboxylic acid
1H-indazole-3-carboxylic acid phenylamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; | 81% |
Stage #1: 1H-Indazole-3-carboxylic acid With thionyl chloride for 3h; Inert atmosphere; Reflux; Stage #2: aniline In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; | 70% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 48h; | 64% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 100℃; for 10h; | 59% |
1H-Indazole-3-carboxylic acid
(±)-(1R,3r,5S)-9-benzyl-9-azabicyclo[3.3.1]nonan-3-yl acetate
N-[(3-endo)-9-(phenylmethyl)-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
Conditions | Yield |
---|---|
Stage #1: 1H-Indazole-3-carboxylic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: (±)-(1R,3r,5S)-9-benzyl-9-azabicyclo[3.3.1]nonan-3-yl acetate In dichloromethane; N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 81% |
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