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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 1-Bromo-3,5-Difluorobenzene supplier in China

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High quality 1-Bromo-3,5-Difluorobenzene CAS NO.461-96-1

Cas:461-96-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 1-Bromo-3,5-difluorobenzene CAS 461-96-1 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food

Factory supply 1-Bromo-3,5-difluorobenzene CAS 461-96-1 with fast delivery

Cas:461-96-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1

Negotiable

Type:Other

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Jinan Finer Chemical Co., Ltd

Product description: Product name 1-Bromo-3,5-difluorobenzene CAS number 461-96-1 Assay ≥99% Appearance Colorless transparent liquid Capacity 200mt/year Application Pharmaceu

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 461-96-1 1-Bromo-3,5-difluorobenzene Manufacturer

Cas:461-96-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

1-Bromo-3, 5-Difluorobenzene

Cas:461-96-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1-Bromo-3,5-difluorobenzene Manufacturer/High quality/Best price/In stock

Cas:461-96-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,5-Difluorobromobenzene

Cas:461-96-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

1-Bromo-3, 5-Difluorobenzene CAS:461-96-1

Cas:461-96-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 461-96-1 with fast shipping

Cas:461-96-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High quality 1-Bromo-3,5-Difluorobenzene CAS NO.461-96-1

Cas:461-96-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-Bromo-3,5-difluorobenzene/ LIDE PHARMA- Factory supply / Best price

Cas:461-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: 1-Bromo-3,5-difluorobenzene Molecular Formula:C6H3BrF2 Molecular Weight:192.99 CAS No.:461-96-1 Appearance:Colorless To Slight Yellow Clear Liquid Appearance:Colorless To Slight Yellow Clear Liquid Storage: Preserve in well-closed, light

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

1-Bromo-3,5-difluorobenzene 461-96-1

Cas:461-96-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Bromo-3,5-difluorobenzene 461-96-1

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

1-Bromo-3,5-difluorobenzene Basic information Product Name: 1-Bromo-3,5-difluorobenzene Synonyms: 1-Bromo-3,5-difluorobenzene,99%;1-BROMO-3,5-DIFLUOROBENZENE;3,5-DIFLUOROBROMOBENZENE;1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene];3,

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1-Bromo-3,5-difluorobenzene CAS:461-96-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

1-Bromo-3,5-difluorobenzene CAS:461-96-1

Cas:461-96-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High quality 1-Bromo-3,5-Difluorobenzene CAS NO.461-96-1

Cas:461-96-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

1-Bromo-3, 5-difluorobenzene 461-96-1

Cas:461-96-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 461-96-1 1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-BROMO-3,5-DIFLUOROBENZENE

Cas:461-96-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1-BROMO-3,5-DIFLUOROBENZENE

Cas:461-96-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1,3-Difluoro-5-bromobenzene

Cas:461-96-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

1-Bromo-3,5-difluorobenzene

Cas:461-96-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

(4-bromo-2,6-difluorophenyl)triethylsilane
184910-37-0

(4-bromo-2,6-difluorophenyl)triethylsilane

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
With potassium fluoride In tetrahydrofuran; water for 2h; Heating;93%
hypophosphorous acid
6303-21-5

hypophosphorous acid

2-bromo-4,6-difluoroaniline hydrobromide
101471-20-9

2-bromo-4,6-difluoroaniline hydrobromide

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
With sodium nitrite In hydrogenchloride75%
1,3-dibromo-5-fluorobenzene
1435-51-4

1,3-dibromo-5-fluorobenzene

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Stage #1: 1,3-dibromo-5-fluorobenzene With TurboGrignard In tetrahydrofuran; 1,4-dioxane at 0 - 25℃; Inert atmosphere;
Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 20℃; Inert atmosphere;
66%
Stage #1: 1,3-dibromo-5-fluorobenzene With TurboGrignard In tetrahydrofuran at 25℃; Inert atmosphere;
Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 25℃; Inert atmosphere;
66 %Chromat.
2-Brom-4,6-difluor-benzoldiazonium-chlorid

2-Brom-4,6-difluor-benzoldiazonium-chlorid

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
With hypophosphoric acid
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

A

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

B

1,4 - dibromo-2,6-difluorobenzene
128259-71-2

1,4 - dibromo-2,6-difluorobenzene

1,3-Difluoro-1,2,3,4,5,6-hexabromocyclohexane
128259-73-4

1,3-Difluoro-1,2,3,4,5,6-hexabromocyclohexane

D

2,4,5-Tribromo-1,3-difluorobenzene
128259-72-3

2,4,5-Tribromo-1,3-difluorobenzene

Conditions
ConditionsYield
With bromine In trichlorofluoromethane Irradiation; Further byproducts given. Yields of byproduct given;A n/a
B n/a
C 2.01 g
D n/a
2-bromo-4,6-difluoroaniline hydrobromide
101471-20-9

2-bromo-4,6-difluoroaniline hydrobromide

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
With sodium hypophosphite; hydrogen bromide; sodium nitrite Yield given. Multistep reaction;
With hydrogenchloride; hypophosphorous acid; sodium nitrite 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h; Yield given. Multistep reaction;
3,5-difluoroaniline
372-39-4

3,5-difluoroaniline

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Substitution; Sandmeyer reaction;
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C
2: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h
3: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C
4: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
5: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
6: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating
View Scheme
1-triethylsilyl-2,6-difluorobenzene
651027-02-0

1-triethylsilyl-2,6-difluorobenzene

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h
2: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C
3: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
4: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
5: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating
View Scheme
(3-bromo-2,6-difluorophenyl)triethylsilane
651027-03-1

(3-bromo-2,6-difluorophenyl)triethylsilane

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C
2: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
4: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating
View Scheme
(3,4-dibromo-2,6-difluorophenyl)triethylsilane
651027-05-3

(3,4-dibromo-2,6-difluorophenyl)triethylsilane

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
2: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating
View Scheme
(3,5-dibromo-2,6-difluorophenyl)triethylsilane
651027-04-2

(3,5-dibromo-2,6-difluorophenyl)triethylsilane

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
3: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating
View Scheme
2,4-difluorophenylamine
367-25-9

2,4-difluorophenylamine

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / Br2 / acetic acid / 0.25 h / Ambient temperature
2: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h
View Scheme
Multi-step reaction with 2 steps
1: 88 percent / Br2, acetic acid
2: 1.) NaNO2, HBr, 2.) NaH2PO2*xH2O
View Scheme
2-bromo-4,6-difluoroaniline
444-14-4

2-bromo-4,6-difluoroaniline

copper(I) oxide
1317-39-1, 146060-06-2

copper(I) oxide

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
With ammonium hydroxide
2-bromo-4,6-difluoroaniline hydrochloride

2-bromo-4,6-difluoroaniline hydrochloride

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

Conditions
ConditionsYield
Stage #1: 2-bromo-4,6-difluoroaniline hydrochloride With sodium nitrite In water at 0 - 5℃; for 1h; Green chemistry;
Stage #2: With sodium hypophosphite In water for 2h; Green chemistry;
190.9 g
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

(4-bromo-2,6-difluoro-phenyl)-trimethyl-silane
184910-20-1

(4-bromo-2,6-difluoro-phenyl)-trimethyl-silane

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -100 - -90℃; for 2h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at -85℃;
100%
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran at -100 - -90℃; for 2.33333h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran at -100 - 20℃;
100%
With n-butyllithium In tetrahydrofuran; hexane at -75℃;93%
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran at -100℃; for 2h;
Stage #2: chloro-trimethyl-silane In tetrahydrofuran at -100 - 20℃; for 16h;
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(3,5-difluorophenyl)piperazine-1-carboxylate
909418-94-6

tert-butyl 4-(3,5-difluorophenyl)piperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene; 1-t-Butoxycarbonylpiperazine With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In xylene at 50℃;
Stage #2: With macroporous polymer-supported isocyanate In xylene at 50℃; for 24h;
100%
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In toluene for 15h; Inert atmosphere; Reflux;100%
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In toluene for 15.5h; Time; Inert atmosphere; Reflux;100%
With Quinuclidine; nickel(II) bromide trihydrate In N,N-dimethyl acetamide at 20℃; for 3h; Sealed tube; Irradiation; Inert atmosphere;62%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

cyclohexylmagnesium bromide
931-50-0

cyclohexylmagnesium bromide

1-cyclohexyl-3,5-difluorobenzene

1-cyclohexyl-3,5-difluorobenzene

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II) In tetrahydrofuran for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;
Stage #2: cyclohexylmagnesium bromide With lithium bromide In tetrahydrofuran at 20℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;
100%
trifluoroethylamine
753-90-2

trifluoroethylamine

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3,5-difluoro-N-(2,2,2-trifluoroethyl)aniline

3,5-difluoro-N-(2,2,2-trifluoroethyl)aniline

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere;100%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(4-bromo-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-bromo-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1-(4,4'-di-tert-butyl-[2,2'-bipyridin]-6-yl)-2-(dimethyl(phenyl)silyl)-2,3-dihydro-1H-benzo[d][1,3,2]diazaborole at 140℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;99%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cyclopentyl methyl ether; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole at 100℃; for 16h; Schlenk technique; Inert atmosphere;87%
With (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;
sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate

sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate

bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)
225931-80-6

bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

C32H37BrF2O5PPdS(1-)*Na(1+)

C32H37BrF2O5PPdS(1-)*Na(1+)

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 1h;99%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

ethyl 6-benzyl-2,6-diazaspiro[3.4]octane-8-carboxylate

ethyl 6-benzyl-2,6-diazaspiro[3.4]octane-8-carboxylate

ethyl 7-benzyl-2-(3,5-difluorophenyl)-2,7-diazaspiro[3.4]octane-5-carboxylate

ethyl 7-benzyl-2-(3,5-difluorophenyl)-2,7-diazaspiro[3.4]octane-5-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In tert-butyl alcohol at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube;99%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

benzyl alcohol
100-51-6

benzyl alcohol

5-benzyloxy-3-fluorophenyl bromide
130722-44-0

5-benzyloxy-3-fluorophenyl bromide

Conditions
ConditionsYield
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran for 1h;
Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran at 20℃; for 49h;
98%
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran for 1h;
Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran at 20℃; for 49h;
98%
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran; mineral oil for 1h;
Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran; mineral oil at 20 - 40℃;
82%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

4-cyclobutenylbenzeneboronic acid

4-cyclobutenylbenzeneboronic acid

4'-cyclobutenyl-3,5-difluorobiphenyl

4'-cyclobutenyl-3,5-difluorobiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; for 4h; Inert atmosphere;98%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

4-cyclopentenylbenzeneboronic acid

4-cyclopentenylbenzeneboronic acid

4'-cyclopentenyl-3,5-difluorobiphenyl

4'-cyclopentenyl-3,5-difluorobiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; Inert atmosphere;98%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

[4-(cycloprop-1-en-1-yl)phenyl]boronic acid

[4-(cycloprop-1-en-1-yl)phenyl]boronic acid

4'-cyclopropenyl-3,5-difluorobiphenyl

4'-cyclopropenyl-3,5-difluorobiphenyl

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; for 4h; Inert atmosphere;98%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

Conditions
ConditionsYield
With potassium carbonate; butan-1-ol; palladium diacetate; triphenylphosphine at 100℃; for 1h;97%
With N,N,N,N,-tetramethylethylenediamine; C41H40IrN6 In acetonitrile at 45℃; for 48h; Sealed tube; Glovebox; Inert atmosphere;52%
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; C39H45IrN4 In N,N-dimethyl-formamide at 45℃; for 24h; Reagent/catalyst; Irradiation; Glovebox;97 %Spectr.
carbon dioxide
124-38-9

carbon dioxide

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

4-bromo-2,6-difluorobenzoic acid
183065-68-1

4-bromo-2,6-difluorobenzoic acid

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h;96%
Stage #1: 3,5-difluorobromobenzene With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78℃; under 150.012 Torr; for 0.5h;
86.8%
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.75h;
Stage #2: carbon dioxide at 20℃; for 16h;
84%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

[2-(3,5-difluorophenyl)ethynyl]trimethylsilane
445491-09-8

[2-(3,5-difluorophenyl)ethynyl]trimethylsilane

Conditions
ConditionsYield
96%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

ethyl 2-(dimethyl(oxo)-λ6-sulfaneylidene)acetate
19956-89-9

ethyl 2-(dimethyl(oxo)-λ6-sulfaneylidene)acetate

C12H14F2O3S

C12H14F2O3S

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In acetonitrile at 80℃; for 15h; Inert atmosphere; Schlenk technique; Sealed tube;96%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

2-(3-fluoro-4-trimethylsilylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane
574755-29-6

2-(3-fluoro-4-trimethylsilylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane

3,3',5'-trifluoro-4-trimethylsilylbiphenyl
574755-48-9

3,3',5'-trifluoro-4-trimethylsilylbiphenyl

Conditions
ConditionsYield
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane Suzuki coupling; Heating;95%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

para-methylphenylmagnesium bromide
4294-57-9

para-methylphenylmagnesium bromide

3,5-difluoro-4'-methyl-1,1'-biphenyl

3,5-difluoro-4'-methyl-1,1'-biphenyl

Conditions
ConditionsYield
With nickel(II) fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 0 - 40℃; for 18.5h; Inert atmosphere;95%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

2-[2-(trimethylsilyl)ethynyl]benzaldehyde
77123-58-1

2-[2-(trimethylsilyl)ethynyl]benzaldehyde

(3,5-difluorophenyl)(2-((trimethylsilyl)ethynyl)phenyl)methanol
1638754-71-8

(3,5-difluorophenyl)(2-((trimethylsilyl)ethynyl)phenyl)methanol

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene With iodine; magnesium
Stage #2: 2-[2-(trimethylsilyl)ethynyl]benzaldehyde In tetrahydrofuran at -78 - 20℃; for 1h;
95%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

2-hydroxy-2-methylpropanenitrile
75-86-5

2-hydroxy-2-methylpropanenitrile

3,5-difluorobenzonitrile
64248-63-1

3,5-difluorobenzonitrile

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene With copper(l) iodide; 1,10-Phenanthroline; potassium iodide In N,N-dimethyl-formamide at 110℃; for 6h;
Stage #2: 2-hydroxy-2-methylpropanenitrile With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 60h;
94%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3-bromo-5-fluorophenol
433939-27-6

3-bromo-5-fluorophenol

Conditions
ConditionsYield
Stage #1: 3,5-difluorobromobenzene With 2-(methylsulfonyl)ethyl alcohol; potassium tert-butylate In dimethyl sulfoxide at 0 - 20℃; for 3h;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide pH=1;
Stage #3: With sodium hydroxide In diethyl ether; water
94%
Stage #1: 3,5-difluorobromobenzene With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere;
Stage #2: With hydrogenchloride In diethylene glycol dimethyl ether; water at 20℃; Inert atmosphere;
92%
With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere;92%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3,5-difluoroaniline
372-39-4

3,5-difluoroaniline

Conditions
ConditionsYield
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; ammonia; sodium hydroxide In water at 100℃; for 12h;94%
With copper(I) oxide; ammonium hydroxide at 120℃; for 6h; Reagent/catalyst; Temperature; Autoclave; Green chemistry;85%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one
190966-43-9

2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one

2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one
228717-97-3

2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one

Conditions
ConditionsYield
Stage #1: With n-butyllithium In hexane at -78℃; for 0.5h; Metallation;
Stage #2: With Triisopropyl borate In hexane Substitution; Suzuki coupling;
Stage #3: 3,5-difluorobromobenzene; 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In water; toluene Substitution; Suzuki coupling; Heating;
93%
tetrahydrofuran
109-99-9

tetrahydrofuran

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

2-(3,5-difluorophenyl)tetrahydrofuran
1311230-64-4

2-(3,5-difluorophenyl)tetrahydrofuran

Conditions
ConditionsYield
Stage #1: tetrahydrofuran; 3,5-difluorobromobenzene With iodine; magnesium at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: With iron(III) oxide In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere;
93%
Stage #1: 3,5-difluorobromobenzene With iodine; magnesium In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: tetrahydrofuran With iron(III) oxide at 0 - 20℃; for 5h; Inert atmosphere;
92.84%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

9H-carbazole
86-74-8

9H-carbazole

9,9’-(5-bromo-1,3-phenylene)bis(9H-carbazole)
750573-24-1

9,9’-(5-bromo-1,3-phenylene)bis(9H-carbazole)

Conditions
ConditionsYield
Stage #1: 9H-carbazole With potassium tert-butylate at 120 - 140℃;
Stage #2: 3,5-difluorobromobenzene for 2h;
93%
Stage #1: 9H-carbazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: 3,5-difluorobromobenzene In N,N-dimethyl-formamide; mineral oil at 130℃; for 12h; Cooling with ice;
92%
With caesium carbonate In N,N-dimethyl-formamide at 170℃; for 15h;91%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
147081-29-6

(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

(S)-4-(3,5-difluoro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

(S)-4-(3,5-difluoro-phenyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃; for 3.5h; Inert atmosphere; Reflux;93%
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 2.5h; Inert atmosphere;
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3,6-di(tert-butyl)-9H-carbazole
37500-95-1

3,6-di(tert-butyl)-9H-carbazole

9,9’-(5-bromo-1,3-phenylene)bis(3,6-di-tert-butyl-9H-carbazole)

9,9’-(5-bromo-1,3-phenylene)bis(3,6-di-tert-butyl-9H-carbazole)

Conditions
ConditionsYield
Stage #1: 3,6-di(tert-butyl)-9H-carbazole With 1,3-dimethyl-2-imidazolidinone; potassium tert-butylate at 120℃;
Stage #2: 3,5-difluorobromobenzene at 150℃; for 1h; Inert atmosphere;
93%
Stage #1: 3,6-di(tert-butyl)-9H-carbazole With sodium hydride In N,N-dimethyl-formamide for 0.5h;
Stage #2: 3,5-difluorobromobenzene In N,N-dimethyl-formamide for 16h; Reflux;
80.4%
With sodium hydride In N,N-dimethyl-formamide Reflux;79.1%
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 24h;
With caesium carbonate In N,N-dimethyl-formamide at 120℃; Inert atmosphere;59.9 g
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

[2-(3,5-difluorophenyl)ethynyl]trimethylsilane
445491-09-8

[2-(3,5-difluorophenyl)ethynyl]trimethylsilane

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 120℃; for 0.0833333h; Sonogashira Cross-Coupling; Microwave irradiation; Sealed tube; Inert atmosphere;92%
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 120℃; for 0.25h; Inert atmosphere;90%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 100℃; for 16h; Inert atmosphere; Sealed tube;80%
With copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride
With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) Heating;
(2RS,4SR)-4-[5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-4-hydroxy-2-methyltetrahydropyran

(2RS,4SR)-4-[5-fluoro-3-(naphth-2-ylmethoxy)phenyl]-4-hydroxy-2-methyltetrahydropyran

2-Naphthalenemethanol
1592-38-7

2-Naphthalenemethanol

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

5-fluoro-3-(naphth-2-ylmethoxy)bromobenzene

5-fluoro-3-(naphth-2-ylmethoxy)bromobenzene

Conditions
ConditionsYield
92%
3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

phenol
108-95-2

phenol

((5-bromo-1,3-phenylene)bis(oxy))dibenzene
41318-73-4

((5-bromo-1,3-phenylene)bis(oxy))dibenzene

Conditions
ConditionsYield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 18h; Inert atmosphere;92%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 170℃; for 10h; Inert atmosphere;35.9 g
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 170℃; for 10h; Inert atmosphere;35.9 g
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 48h; Inert atmosphere;119 g
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 48h; Inert atmosphere;119 g

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