CAS No.468-68-8,(-)-Drimenol Suppliers

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)-

Cas:468-68-8

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)-

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Bakkenolide III CAS 24909-95-31-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-,

Cas:468-68-8

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

(-)-Drimenol

Cas:468-68-8

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)-

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Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)-

Cas:468-68-8

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Hangzhou Fandachem Co.,Ltd

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)- cas 468-68-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air,

1-Naphthalenemethanol,1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, (1S,4aS,8aS)- cas 468-68-8

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Zibo Hangyu Biotechnology Development Co., Ltd

home-produced Application:medicine

(-)-Drimenol

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(-)-Drimenol

Cas:468-68-8

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Synthetic route

: 50490-38-5, 125354-06-5, 40266-93-1
((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl acetate

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 0 - 20℃; for 0.416667h; Inert atmosphere;	100%
With potassium hydroxide In methanol at 18℃; for 1h;	86%
With potassium hydroxide In methanol	86%

: 52617-99-9
(+)-drimane-8,11-diol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In benzene at 20℃; for 1h;	92%
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 6h; regioselective reaction;	79%
With toluene-4-sulfonic acid In dichloromethane at 0 - 17℃; Reagent/catalyst; regioselective reaction;	58%

: 682744-24-7
(1S,4aS,8aS)-1-(tert-butyldimethylsilyloxymethyl)-1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetrmethylnaphthalene

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 25℃; for 36h;	92%

: 326795-18-0
(4aS,8aS)-2,5,5,8a-Tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalene-1-carbaldehyde

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at -8 - 20℃; for 2.25h; Reduction;	89%

: 155321-04-3
drim-7-en-11-yl (1R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo<2.2.1>heptane-1-carboxylate

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With barium dihydroxide In methanol at 20℃; for 2.5h;	88%

: 34437-62-2
drimendiol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In ethanol for 1.25h;	64%

: 53163-41-0
((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Stage #1: ((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate With sulfuric acid In ethanol for 0.00333333h; Stage #2: With potassium hydroxide In methanol for 0.005h;	57%
With sulfuric acid In ethanol	53%
Multi-step reaction with 2 steps 1: sulfuric acid / ethanol / 0.25 h / 0 - 20 °C / Inert atmosphere 2: potassium hydroxide / methanol / 0.42 h / 0 - 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / methanol / 1 h / 20 °C 2: toluene-4-sulfonic acid / dichloromethane / 0 - 17 °C View Scheme

: 53163-41-0
((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate

A: 468-68-8
(-)-drimenol

B: 50490-38-5, 125354-06-5, 40266-93-1
((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl acetate

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 0 - 20℃; for 0.25h; Inert atmosphere;	A 20% B 56%

: 53163-41-0
((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate

A: 54632-04-1
albicanol

B: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 20℃; for 18h;	A n/a B 52.8%

: 52617-99-9
(+)-drimane-8,11-diol

A: 54632-04-1
albicanol

B: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate at 60℃; Temperature; Inert atmosphere; regioselective reaction;	A 52% B 44%
With triphenylphosphine; diethylazodicarboxylate at 20℃; Reagent/catalyst; Inert atmosphere; regioselective reaction;	A 19% B 23%

: 89188-16-9
(4aS,8aS)-2,5,5,8a-Tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid 2,3-dihydroxy-propyl ester

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With diisobutylaluminium hydride In toluene for 8h; Ambient temperature;	50%

: 89188-16-9
sesquiterpenoic acid glyceride

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With diisobutylaluminium hydride

: (E)-3-(3,4-Dimethoxy-phenyl)-acrylic acid (1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl ester

A: 18523-76-7
(E)-3',4'-dimethoxycinnamyl alcohol

B: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 1h;	A n/a B 3 mg

: 197522-61-5
(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl ester

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With barium dihydroxide In methanol; dichloromethane for 2h; Ambient temperature;

: (+/-)-drim-7-en-11-ol acetate

A: 468-68-8
(-)-drimenol

B: 50490-38-5, 125354-06-5, 40266-93-1
((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl acetate

C: 186366-21-2
(5R,9R,10R)-(+)-drim-7-en-11-ol

D: (5R,9R,10R)-drim-7-en-11-ol acetate

Conditions

Conditions	Yield
With hog pancreas lipase In phosphate buffer at 20℃; for 22h; pH=6.5; Title compound not separated from byproducts;

...Expand

: 106-28-5
Farnesol

A: [(1S,2R,4aS,8aS)-2,5,5,8a-Tetramethyl-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-decahydro-naphthalen-1-yl]-methanol

B: 52617-99-9
(+)-drimane-8,11-diol

C: 54632-04-1
albicanol

D: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
With Alicyclobacillus acidocaldarius squalene-hopene cyclase; Triton X-100 at 60℃; for 16h; pH=6.0;	A 8.7 mg B 6.3 mg C 4.7 mg D 2.0 mg

...Expand

: 53163-41-0
((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate

A: 54632-04-1
albicanol

B: 468-68-8
(-)-drimenol

C: 124377-31-7
(+)-[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methanol

Conditions

Conditions	Yield
Stage #1: ((1S,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl acetate With pyridine; trichlorophosphate at 20℃; for 2h; Stage #2: With potassium hydroxide In methanol at 20℃; for 0.333333h; Title compound not separated from byproducts;

...Expand

: 166406-74-2
(1S,3aR,5aS,9aS,9bR)-1-hydroxy-dodecahydro-3a,6,6,9a,-tetramethylnaphtho-[2,1-b]furan-2-one

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 30 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C 2: 91 percent / LiAlH4 / tetrahydrofuran / 3 h 3: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 4: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 5: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 6: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 7: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme
Multi-step reaction with 6 steps 1: 70 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C 2: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 3: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 4: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 5: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 6: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: 30 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C
2: 91 percent / LiAlH4 / tetrahydrofuran / 3 h
3: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C
4: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C
5: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C
6: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C
7: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C
View Scheme

Multi-step reaction with 6 steps
1: 70 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C
2: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C
3: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C
4: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C
5: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C
6: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C
View Scheme

: 765950-72-9
(3aR,5aS,9aS,9bR)-dodecahydro-3a,6,6,9a,-tetramethylnaphtho-[2,1-b]furan-1,2-diol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 91 percent / LiAlH4 / tetrahydrofuran / 3 h 2: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 3: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 4: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 5: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 6: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: 91 percent / LiAlH4 / tetrahydrofuran / 3 h
2: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C
3: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C
4: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C
5: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C
6: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C
View Scheme

: 52618-00-5
(1R,2R,4aS,8aS)-(+)-2-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydro-2,5,5,8a-tetramethyl-naphthalen-1-aldehyde

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 2: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 3: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 4: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: tin(IV) chloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere 2: sodium tetrahydroborate; methanol / 72 h / 0 - 20 °C / Inert atmosphere View Scheme

: 157722-55-9
(1S,2R,4aS,8aS)-1-(tert-butyldimethylsilyloxymethyl)-decahydro-2,5,5,8a-tetramethylnaphthalen-2-ol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 2: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme

: 1-[1,2-dihydroxyethyl]-(1R,2R,4aS,8aS)-decahydro-2,5,5,8a-tetramethylnaphthalen-2-ol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 2: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 3: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 4: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 5: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme

: 564-20-5, 1216-84-8, 30450-17-0, 58976-28-6, 64090-92-2, 67844-42-2, 79768-41-5, 79768-42-6, 86688-27-9, 86688-28-0, 95406-08-9, 98719-44-9, 98719-46-1, 131831-65-7, 140851-80-5
(3aR)-(+)-sclareolide

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: 65.6 percent / MoO5pyridineHMPA / tetrahydrofuran / 0.5 h / -78 °C 2.1: 30 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C 3.1: 91 percent / LiAlH4 / tetrahydrofuran / 3 h 4.1: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 5.1: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 6.1: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 7.1: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 8.1: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme
Multi-step reaction with 7 steps 1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: 65.6 percent / MoO5pyridineHMPA / tetrahydrofuran / 0.5 h / -78 °C 2.1: 70 percent / LiAlH4 / tetrahydrofuran / 4 h / 25 °C 3.1: 90 percent / lead tetraacetate / benzene / 4 h / 25 °C 4.1: 97 percent / LiALH4 / diethyl ether / 1 h / 20 °C 5.1: 98 percent / imidazole / dimethylformamide / 2 h / 25 °C 6.1: 45 percent / triethylamine; methanesulfonyl chloride / tetrahydrofuran / 4 h / 25 °C 7.1: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 36 h / 25 °C View Scheme
Multi-step reaction with 3 steps 1.1: diethyl ether / -78 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.24 h / Reflux 2.2: 20 °C 3.1: toluene-4-sulfonic acid / dichloromethane / 0 - 17 °C View Scheme

: 86546-84-1
(+)-drim-9(11)-en-8α-ol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: BH3*THF complex / tetrahydrofuran / 12 h / 20 °C 1.2: 94 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran; ethanol / 12 h / 20 °C 2.1: 92 percent / triphenylphosphine; diethyl azodicarboxylate / benzene / 1 h / 20 °C View Scheme

: 316803-64-2
Acetic acid (1R,2R,4aS,8aS)-1-iodomethyl-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-yl ester

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: t-BuOK; t-butyl methyl ether / dimethylsulfoxide / 1 h / 20 °C 1.2: 85 percent / H2O / dimethylsulfoxide / 5 h / 20 °C 2.1: BH3*THF complex / tetrahydrofuran / 12 h / 20 °C 2.2: 94 percent / aq. NaOH; aq. H2O2 / tetrahydrofuran; ethanol / 12 h / 20 °C 3.1: 92 percent / triphenylphosphine; diethyl azodicarboxylate / benzene / 1 h / 20 °C View Scheme

: 326795-16-8
(1S,3R,4R,4aS,8aS)-3-(Acetyloxy)-4-formyl-3,4a,8,8-tetramethyldecahydronaphthalen-1-yl acetate

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 77 percent / 2,4,6-collidine / 1.5 h / 200 °C 2: 89 percent / NaBH4 / ethanol / 2.25 h / -8 - 20 °C View Scheme

: (1S,3R,4R,8aS)-3-(Acetyloxy)-4-{(E/Z)-2-[[tert-butyl(dimethyl)silyl]oxy]ethenyl}-3,4a,8,8-tetramethyldecahydronaphthalen-1-yl acetate

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: O3; O2 / CH2Cl2; methanol / 0.17 h / -78 °C 1.2: 78 percent / Me2S / CH2Cl2; methanol / 20 °C 2.1: 77 percent / 2,4,6-collidine / 1.5 h / 200 °C 3.1: 89 percent / NaBH4 / ethanol / 2.25 h / -8 - 20 °C View Scheme

: 468-68-8, 19078-37-6, 54750-55-9, 84108-05-4, 84108-08-7, 90457-95-7, 90457-96-8
(+/-)-drim-7-en-11-ol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / CH2Cl2 / 1 h / Ambient temperature 2: Ba(OH)2 / methanol; CH2Cl2 / 2 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: 43 percent / pyridine / 3 h / 20 °C 2: 88 percent / barium hydroxide / methanol / 2.5 h / 20 °C View Scheme

: 64317-78-8
(E,E)-3,11-dimethylundeca-2,6,10-trien-1-ol

: 468-68-8
(-)-drimenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 56 percent / fluorosulfonic acid / various solvent(s) / 1 h / -78 °C 2: pyridine / CH2Cl2 / 1 h / Ambient temperature 3: Ba(OH)2 / methanol; CH2Cl2 / 2 h / Ambient temperature View Scheme

: 468-68-8
(-)-drimenol

: 105426-71-9
(1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,58a-tetramethylnaphtahelene-1-carboxaldehyde

Conditions

Conditions	Yield
Stage #1: (-)-drimenol With phosphorus pentoxide; dimethyl sulfoxide In dichloromethane at 20℃; for 0.666667h; Cooling with ice; Stage #2: With triethylamine In dichloromethane at 20℃; for 0.666667h;	99%
With Dess-Martin periodane In dichloromethane at 20℃; for 0.5h; Dess-Martin Oxidation;	98%
With phosphorus pentoxide; dimethyl sulfoxide at 20℃;	95%

: 468-68-8
(-)-drimenol

: 108-24-7
acetic anhydride

: 50490-38-5, 125354-06-5, 40266-93-1
((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl acetate

Conditions

Conditions	Yield
In pyridine	98%
With pyridine	97%
	95%
With dmap In dichloromethane at 20℃; for 2h;	95%

: 468-68-8
(-)-drimenol

AcX: AcX

: 50490-38-5, 125354-06-5, 40266-93-1
((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl acetate

Conditions

Conditions	Yield
	97%

: 468-68-8
(-)-drimenol

: 92464-53-4
(-)-7α,8α,11-trihydroxydrimane

Conditions

Conditions	Yield
With methanesulfonamide; AD-mix-β In water; tert-butyl alcohol at 20℃;	94%
Multi-step reaction with 3 steps 1: 97 percent / pyridine 2: 57.2 percent / N-methylmorpholine-N-oxide, OsO4 / H2O; acetone; 2-methyl-propan-2-ol / 192 h 3: 99 percent / KOH / methanol / Ambient temperature View Scheme

: 468-68-8
(-)-drimenol

: drimane-7β,8β,11-triol

Conditions

Conditions	Yield
With methanesulfonamide; AD-mix-α In water; tert-butyl alcohol at 20℃;	92%

: 468-68-8
(-)-drimenol

: 124-63-0
methanesulfonyl chloride

: 112853-87-9
((1S,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)methyl methanesulfonate

Conditions

Conditions	Yield
With pyridine for 40h; Ambient temperature;	90%
With N,N,N,N,-tetramethylethylenediamine In dichloromethane at 0℃; for 0.0833333h; Inert atmosphere;

: 468-68-8
(-)-drimenol

A: 33762-81-1
(+)-[(1S,2S,8aS)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]methanol

B: 510-98-5
[(1S,2R,4aS,8aS)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]methanol

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In ethyl acetate at 0℃; for 0.5h;	A 90% B 8%
With Crabtree's catalyst; hydrogen In dichloromethane at 0 - 20℃; under 760.051 Torr; for 2h; stereoselective reaction;	A 9% B 89%
With Crabtree's catalyst; hydrogen In dichloromethane at 0℃; under 760.051 Torr; for 2h;	A 9% B 89%
With palladium on activated charcoal; hydrogen Overall yield = 85 %;	A n/a B n/a

: 468-68-8
(-)-drimenol

: 33762-81-1
(+)-[(1S,2S,8aS)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]methanol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In dichloromethane for 4h;	75%
With palladium on activated charcoal; hydrogen at 20℃; for 12h; Inert atmosphere;	75%

: 468-68-8
(-)-drimenol

: 51020-10-1
(-)-(8aS)-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydro-1H-naphthalen-2-one

Conditions

Conditions	Yield
With pyridinium chlorochromate In dichloromethane	60%
With potassium dichromate; sulfuric acid
Multi-step reaction with 2 steps 1: (i) H2, PtO2, AcOEt, (ii) CrO3, aq. AcOH, KHSO4, (iii) Pb(OAc)4, Cu(OAc)2, Py, benzene 2: CrO3, AcOH View Scheme
Multi-step reaction with 2 steps 1: hydrogen; palladium on activated charcoal / 12 h / 20 °C / Inert atmosphere 2: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere View Scheme

: 468-68-8
(-)-drimenol

: 124987-04-8
3β,11-dihydroxydrimene

Conditions

Conditions	Yield
for 29h; Rhizopus arrhizus;	60%
With Rhizopus arrhizus for 29h;	60%

: 468-68-8
(-)-drimenol

A: drimane-7β,8β,11-triol

B: 92464-53-4
(-)-7α,8α,11-trihydroxydrimane

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III) In water; tert-butyl alcohol at 0 - 20℃;	A 24% B 58%

: 468-68-8
(-)-drimenol

: (4aS,5S,8aS)-5-(azidomethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine In toluene at 0 - 20℃; for 3h; Mitsunobu Displacement; Inert atmosphere;	58%

: 468-68-8
(-)-drimenol

: 25487-94-9
(-)-(4aS,8aS)-2,5,5,8a-tetramethyl-4a,5,6,7,8,8a-hexahydro-4H-naphthalen-1-one

Conditions

Conditions	Yield
With Jones reagent at 0℃; for 1h;	55%

: 468-68-8
(-)-drimenol

A: 124987-04-8
3β,11-dihydroxydrimene

B: 55732-96-2
[(1aS,2S,2aS,6aS,7aR)-1a,2a,6,6-tetramethyldecahydronaphtho[2,3-b]oxiren-2-yl]methanol

C: 6α-hydroxy drimenol

Conditions

Conditions	Yield
for 28h; Mucor plumbeus;	A 7% B 3% C 50%

...Expand

: 468-68-8
(-)-drimenol

A: 31197-54-3
1,1,5,6-tetramethyl-1,2,3,4-tetrahydronaphthalene

B: 1,1,5,6,8-pentamethyl-1,2,3,4-tetrahydronaphthalene

C: 1-(2',3',6'-trimethylphenyl)-4-methylpent-3-ene

Conditions

Conditions	Yield
With iodine In toluene for 5h; Concentration; Solvent; Reagent/catalyst; Reflux;	A 25% B 46% C 24%
With iodine In 5,5-dimethyl-1,3-cyclohexadiene for 0.7h; Reagent/catalyst; Concentration; Solvent; Reflux;	A 43% B 28% C 29%

...Expand

: 64-17-5
ethanol

: 468-68-8
(-)-drimenol

A: 7α-ethoxydrim-8-en-11-ol

B: 34437-62-2
drimendiol

C: 149286-42-0
drim-7-ene-9α,11-diol

Conditions

Conditions	Yield
With selenium(IV) oxide for 5h; Heating;	A 8% B 35% C 44%

...Expand

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