Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:494-97-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph
Cas:494-97-3
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:494-97-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryNORNICOTINE, DL-(RG) CAS:494-97-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter
Cas:494-97-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
superior quality Appearance:Pale Yellow to Reddish Brown Oil Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:494-97-3
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea
Cas:494-97-3
Min.Order:1 bottle
Negotiable
Type:Lab/Research institutions
inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
bulk productiongoods in stockswe have the best competitive price in the marketmeantime,we are committed to service to our every customer Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical
Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Cas:494-97-3
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Type:Trading Company
inquiryNornicotineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:494-97-3
Min.Order:10 Milligram
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Type:Lab/Research institutions
inquiryFor quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,
Cas:494-97-3
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inquiryfactory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S
Cas:494-97-3
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Type:Trading Company
inquiryJoyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom
At Capot,We can synthesize and purify your complex molecules from 100 gram to 10 tons.Appearance:Clear colorless to light yellow liquid Storage:Dry,Seal and Cool place Package:1G,5G,10G,25G,100G,250G,500G,1KG,5KG,10KG,25KG,50KG,100KG,150KG,200KG. App
Cas:494-97-3
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Type:Lab/Research institutions
inquiryThe system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin
FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (S)-Nornicotine, CAS:494-97-3 with the most competitive price and the best quality. W
(S)-1-(2,3,4,6-Tetra-O-pivaloyl-β-D-galactopyranosyl)-2-(3-pyridyl)pyrrolidine
A
2,3,4,6-Tetra-O-pivaloyl-α/β-D-galactopyranose
B
nornicotine
Conditions | Yield |
---|---|
In hydrogenchloride; methanol Hydrolysis; | A n/a B 95% |
(S)-3-(1-azido-but-3-enyl)pyridine
nornicotine
Conditions | Yield |
---|---|
With bis(cyclohexanyl)borane In tetrahydrofuran at -15 - 20℃; for 12h; | 85% |
nornicotine
Conditions | Yield |
---|---|
Stage #1: (S)-5-bromonornicotine (R)-(+)-α-methoxy-α-trifluoromethylphenyl acetic acid salt With potassium hydroxide In water for 1h; Stage #2: With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol at 20℃; | 69% |
Conditions | Yield |
---|---|
With borane-ammonia complex; 6-hydroxy-D-nicotine oxidase E350L/E352D mutant for 28h; Kinetics; Enzymatic reaction; enantioselective reaction; | 60% |
With 6,6′-dinitro[1,1′-biphenyl]-2,2′-dicarboxylic acid |
Conditions | Yield |
---|---|
bioconversion, by cell suspension of Nicotiana plumbaginifolia; | 53.2% |
With potassium permanganate | |
With water; silver(l) oxide |
nornicotine
Conditions | Yield |
---|---|
Stage #1: (S)-5-bromonornicotine (+)-MTPA With potassium hydroxide In diethyl ether Stage #2: With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol for 1h; | 53% |
Conditions | Yield |
---|---|
With Chiralpak AD-H In methanol; N,N-dimethyl-ethanamine Resolution of racemate; | A 30% B 25% |
nicotin
A
nornicotine
B
S-(-)-Norcotinine
C
cotinine
D
Nicotine-N-oxide
Conditions | Yield |
---|---|
With air; cofactor solution; phenobarbitone-induced rabbit hepatic homogenate In phosphate buffer at 37℃; for 1h; pH=7.4; Oxidation; demethylation; Further byproducts given; | A 15.9% B n/a C 27.5% D n/a |
(S)-5-bromo-3-(1H-2-pyrrolidinyl)pyridine
nornicotine
Conditions | Yield |
---|---|
With triethylamine; palladium on activated charcoal In ethanol under 760 Torr; for 1h; Yield given; | |
With hydrogen | |
With hydrogen; triethylamine; palladium on activated charcoal In ethanol under 760.051 Torr; for 1h; | 621 mg |
Conditions | Yield |
---|---|
In water at 28℃; for 120h; Product distribution; Cunninghamella echinulata IFO-4444; other times, other fungi; |
Conditions | Yield |
---|---|
at 25℃; Nicotiana tabacum L. cv Wisconsin-38; |
1-(N-methyl)-1,5-pentanediamine
A
N-methylanabasine
B
nornicotine
C
nicotin
D
anatabine
Conditions | Yield |
---|---|
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given; |
N-ethylcadaverine
A
N-ethylanabasine
B
nornicotine
C
nicotin
D
anatabine
Conditions | Yield |
---|---|
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given; |
N-(4-aminobutyl)propylamine
A
nornicotine
B
nicotin
C
anatabine
Conditions | Yield |
---|---|
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given; |
Conditions | Yield |
---|---|
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given; |
Conditions | Yield |
---|---|
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given; |
5-bromopyridine-3-carbaldehyde
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C 2: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 3: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 4: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 5: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 6: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 7: H2 View Scheme | |
Multi-step reaction with 6 steps 1.1: DMP / CH2Cl2 1.2: tetrahydrofuran 2.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 3.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 4.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 5.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 6.1: H2 View Scheme | |
Multi-step reaction with 5 steps 1: diethyl ether / 1 h / -100 °C 2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 3: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 4: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 5: H2 View Scheme |
5-bromo-3-pyridinecarboxylic acid
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C 1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C 2.1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C 3.1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 4.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 5.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 6.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 7.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 8.1: H2 View Scheme | |
Multi-step reaction with 7 steps 1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C 1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C 2.1: DMP / CH2Cl2 2.2: tetrahydrofuran 3.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 4.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 5.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 6.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 7.1: H2 View Scheme | |
Multi-step reaction with 6 steps 1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C 1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C 2.1: diethyl ether / 1 h / -100 °C 3.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 4.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 5.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 6.1: H2 View Scheme |
1-(5-bromopyridin-3-yl)but-3-en-1-ol
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 2: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 3: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 4: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 5: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 6: H2 View Scheme |
1-(5-bromopyridin-3-yl)but-3-en-1-one
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 3: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 4: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 5: H2 View Scheme |
(R)-1-(5-bromopyridin-3-yl)but-3-en-1-ol
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 2: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 3: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 4: H2 View Scheme |
(S)-3-(1-azidobut-3-enyl)-5-bromopyridine
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 2: H2 View Scheme |
(R)-methanesulfonic acid 1-(5-bromopyridin-3-yl)but-3-enyl ester
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 2: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C 3: H2 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 1 h / -100 °C 2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 3: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C 4: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: tetrahydrofuran / 1 h / -100 °C 2: 88 percent / diphenylphosphorylazide; DBU / toluene / 72 h / 20 °C 3: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme |
(R)-1-(pyridin-3-yl)but-3-en-1-ol
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 2: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C 3: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 88 percent / diphenylphosphorylazide; DBU / toluene / 72 h / 20 °C 2: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme |
(R)-methanesulfonic acid 1-pyridin-3-yl-but-3-enyl ester
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C 2: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme |
4-(3-pyridyl)-4-oxobutanol
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 82 percent / (COCl)2; NEt3 / dimethylsulfoxide 2.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C 2.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C 3.1: 95 percent / aq. HCl; methanol View Scheme |
4-Oxo-1-(3-pyridyl)-1-butanone
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C 1.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C 2.1: 95 percent / aq. HCl; methanol View Scheme |
ethyl 5-bromo-3-pyridinecarboxylate
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 2: 79 percent / NaBH4 / methanol; acetic acid / -40 - -20 °C 4: Et3N / 10percent Pd/C / ethanol / 1 h / 760 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran 2.1: sodium tetrahydroborate; acetic acid; methanol 2.2: Resolution of racemate 3.1: potassium hydroxide / diethyl ether View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydride / mineral oil; hexane; tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: Reflux 2.1: acetic acid; sodium tetrahydroborate / methanol; acetonitrile / 0.17 h / -40 - 20 °C 3.1: ethyl acetate / 0.25 h 4.1: potassium hydroxide / diethyl ether 4.2: 1 h View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: Reflux; Inert atmosphere 2.1: acetic acid; sodium tetrahydroborate / methanol / 0.5 h / -40 - 20 °C 3.1: ethyl acetate / 0.25 h / 20 °C 4.1: potassium hydroxide / water / 1 h 4.2: 20 °C View Scheme |
5-Bromo-3-(2-pyrrolidinyl)pyridine
nornicotine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: Et3N / 10percent Pd/C / ethanol / 1 h / 760 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: ethyl acetate / 0.25 h 2.1: potassium hydroxide / diethyl ether 2.2: 1 h View Scheme | |
Multi-step reaction with 2 steps 1.1: ethyl acetate / 0.25 h / 20 °C 2.1: potassium hydroxide / water / 1 h 2.2: 20 °C View Scheme |
methyl 4-iodobutanoate
nornicotine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 78% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 78% |
methyl 6-iodohexanoate
nornicotine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 75% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 75% |
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 15h; Inert atmosphere; | 74% |
methyl trans-γ-iodocrotonate
nornicotine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 73% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 73% |
3-chloro-4-(4-formylphenoxy)benzamide
nornicotine
(S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; | 68% |
(6-iodohexyl)-carbamic acid 1,1-dimethylethyl ester
nornicotine
[6-[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]hexyl]-carbamic acid 1,1-dimethylethyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 15h; | 59% |
benzyl 4-iodobutanoate
nornicotine
(2S)-2-(3-pyridinyl)-1-pyrrolidinebutanoic acid phenylmethyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; | 58% |
nornicotine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 51% |
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 51% |
nornicotine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h; | 49% |
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