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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1'-Demethylnicotine

Cas:494-97-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

(S)-3-Pyrrolidin-2-yl-pyridine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

NORNICOTINE 494-97-3

Cas:494-97-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

NORNICOTINE, DL-(RG) CAS:494-97-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inter

NORNICOTINE, DL-(RG) CAS:494-97-3

Cas:494-97-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

NORNICOTINE

Cas:494-97-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

NORNICOTINE

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality Appearance:Pale Yellow to Reddish Brown Oil Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates

Nornicotine

Cas:494-97-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

NORNICOTINE

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Nornicotine

Cas:494-97-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

NORNICOTINE

Cas:494-97-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

NORNICOTINE

Cas:494-97-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (S)-3-(Pyrrolidin-2-yl)pyridine 1g

Cas:494-97-3

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

NORNICOTINE

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk productiongoods in stockswe have the best competitive price in the marketmeantime,we are committed to service to our every customer Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

NORNICOTINE, DL-(RG) CAS No.494-97-3

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

NornicotineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Nornicotine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

494-97-3

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NORNICOTINE, DL-(RG)

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

(S)-Nornicotine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

(S)-3-(Pyrrolidin-2-yl)pyridine

Cas:494-97-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

ENAO Chemical Co, Limited

For quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,

(S)-3-(Pyrrolidin-2-yl)pyridine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

(S)-3-(Pyrrolidin-2-yl)pyridine494-97-3

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

NORNICOTINE

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Capot Chemical Co., Ltd.

At Capot,We can synthesize and purify your complex molecules from 100 gram to 10 tons.Appearance:Clear colorless to light yellow liquid Storage:Dry,Seal and Cool place Package:1G,5G,10G,25G,100G,250G,500G,1KG,5KG,10KG,25KG,50KG,100KG,150KG,200KG. App

(S)-3-Pyrrolidin-2-yl-pyridine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Nicotine EP IMP F (nornicotine )

Cas:494-97-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (S)-Nornicotine, CAS:494-97-3 with the most competitive price and the best quality. W

(S)-Nornicotine

Cas:494-97-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(S)-1-(2,3,4,6-Tetra-O-pivaloyl-β-D-galactopyranosyl)-2-(3-pyridyl)pyrrolidine
252005-64-4

(S)-1-(2,3,4,6-Tetra-O-pivaloyl-β-D-galactopyranosyl)-2-(3-pyridyl)pyrrolidine

A

2,3,4,6-Tetra-O-pivaloyl-α/β-D-galactopyranose
135865-76-8, 135865-81-5, 144102-44-3, 148968-87-0, 150737-36-3

2,3,4,6-Tetra-O-pivaloyl-α/β-D-galactopyranose

B

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
In hydrogenchloride; methanol Hydrolysis;A n/a
B 95%
(S)-3-(1-azido-but-3-enyl)pyridine
314280-29-0

(S)-3-(1-azido-but-3-enyl)pyridine

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
With bis(cyclohexanyl)borane In tetrahydrofuran at -15 - 20℃; for 12h;85%
(S)-5-bromonornicotine (R)-(+)-α-methoxy-α-trifluoromethylphenyl acetic acid salt

(S)-5-bromonornicotine (R)-(+)-α-methoxy-α-trifluoromethylphenyl acetic acid salt

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Stage #1: (S)-5-bromonornicotine (R)-(+)-α-methoxy-α-trifluoromethylphenyl acetic acid salt With potassium hydroxide In water for 1h;
Stage #2: With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol at 20℃;
69%
rac-nornicotine
5746-86-1

rac-nornicotine

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
With borane-ammonia complex; 6-hydroxy-D-nicotine oxidase E350L/E352D mutant for 28h; Kinetics; Enzymatic reaction; enantioselective reaction;60%
With 6,6′-dinitro[1,1′-biphenyl]-2,2′-dicarboxylic acid
nicotin
54-11-5

nicotin

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
bioconversion, by cell suspension of Nicotiana plumbaginifolia;53.2%
With potassium permanganate
With water; silver(l) oxide
(S)-5-bromonornicotine (+)-MTPA

(S)-5-bromonornicotine (+)-MTPA

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Stage #1: (S)-5-bromonornicotine (+)-MTPA With potassium hydroxide In diethyl ether
Stage #2: With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol for 1h;
53%
rac-nornicotine
5746-86-1

rac-nornicotine

A

nornicotine
494-97-3

nornicotine

B

(+)-nornicotine
7076-23-5

(+)-nornicotine

Conditions
ConditionsYield
With Chiralpak AD-H In methanol; N,N-dimethyl-ethanamine Resolution of racemate;A 30%
B 25%
nicotin
54-11-5

nicotin

A

nornicotine
494-97-3

nornicotine

B

S-(-)-Norcotinine
5980-06-3

S-(-)-Norcotinine

C

cotinine
486-56-6

cotinine

Conditions
ConditionsYield
With air; cofactor solution; phenobarbitone-induced rabbit hepatic homogenate In phosphate buffer at 37℃; for 1h; pH=7.4; Oxidation; demethylation; Further byproducts given;A 15.9%
B n/a
C 27.5%
D n/a
(S)-5-bromo-3-(1H-2-pyrrolidinyl)pyridine
83023-58-9

(S)-5-bromo-3-(1H-2-pyrrolidinyl)pyridine

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
With triethylamine; palladium on activated charcoal In ethanol under 760 Torr; for 1h; Yield given;
With hydrogen
With hydrogen; triethylamine; palladium on activated charcoal In ethanol under 760.051 Torr; for 1h;621 mg
nicotin
54-11-5

nicotin

A

N-methylmyosmine
525-74-6

N-methylmyosmine

B

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
In water at 28℃; for 120h; Product distribution; Cunninghamella echinulata IFO-4444; other times, other fungi;
nicotin
54-11-5

nicotin

A

N-formyl-2-(3-pyridyl)pyrrolidine
38840-03-8

N-formyl-2-(3-pyridyl)pyrrolidine

B

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
at 25℃; Nicotiana tabacum L. cv Wisconsin-38;
1-(N-methyl)-1,5-pentanediamine
32752-52-6

1-(N-methyl)-1,5-pentanediamine

A

N-methylanabasine
24380-92-5

N-methylanabasine

B

nornicotine
494-97-3

nornicotine

C

nicotin
54-11-5

nicotin

D

anatabine
581-49-7

anatabine

Conditions
ConditionsYield
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given;
N-ethylcadaverine
258818-11-0

N-ethylcadaverine

A

N-ethylanabasine
68245-76-1

N-ethylanabasine

B

nornicotine
494-97-3

nornicotine

C

nicotin
54-11-5

nicotin

D

anatabine
581-49-7

anatabine

Conditions
ConditionsYield
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given;
N-(4-aminobutyl)propylamine
70862-18-9

N-(4-aminobutyl)propylamine

A

nornicotine
494-97-3

nornicotine

B

nicotin
54-11-5

nicotin

C

anatabine
581-49-7

anatabine

D

N'-Propylnornicotine

N'-Propylnornicotine

Conditions
ConditionsYield
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given;
N-(4-aminobutyl)butylamine
70862-19-0

N-(4-aminobutyl)butylamine

A

nornicotine
494-97-3

nornicotine

B

nicotin
54-11-5

nicotin

C

anatabine
581-49-7

anatabine

D

N-n-butylnornicotine

N-n-butylnornicotine

Conditions
ConditionsYield
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given;
N-propylcadaverine

N-propylcadaverine

A

N-propylanabasine
68245-77-2

N-propylanabasine

B

nornicotine
494-97-3

nornicotine

C

nicotin
54-11-5

nicotin

D

anatabine
581-49-7

anatabine

Conditions
ConditionsYield
With Nicotiana rustica Condensation; Enzymatic reaction; Further byproducts given;
5-bromopyridine-3-carbaldehyde
113118-81-3

5-bromopyridine-3-carbaldehyde

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C
2: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C
3: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
4: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
5: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
6: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
7: H2
View Scheme
Multi-step reaction with 6 steps
1.1: DMP / CH2Cl2
1.2: tetrahydrofuran
2.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
3.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
4.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
5.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
6.1: H2
View Scheme
Multi-step reaction with 5 steps
1: diethyl ether / 1 h / -100 °C
2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
3: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
4: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
5: H2
View Scheme
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C
1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C
2.1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C
3.1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C
4.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
5.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
6.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
7.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
8.1: H2
View Scheme
Multi-step reaction with 7 steps
1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C
1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C
2.1: DMP / CH2Cl2
2.2: tetrahydrofuran
3.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
4.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
5.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
6.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
7.1: H2
View Scheme
Multi-step reaction with 6 steps
1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C
1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C
2.1: diethyl ether / 1 h / -100 °C
3.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
4.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
5.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
6.1: H2
View Scheme
1-(5-bromopyridin-3-yl)but-3-en-1-ol
360767-43-7

1-(5-bromopyridin-3-yl)but-3-en-1-ol

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C
2: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
3: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
4: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
5: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
6: H2
View Scheme
1-(5-bromopyridin-3-yl)but-3-en-1-one
360767-46-0

1-(5-bromopyridin-3-yl)but-3-en-1-one

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C
2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
3: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
4: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
5: H2
View Scheme
(R)-1-(5-bromopyridin-3-yl)but-3-en-1-ol
360767-40-4

(R)-1-(5-bromopyridin-3-yl)but-3-en-1-ol

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
2: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
3: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
4: H2
View Scheme
(S)-3-(1-azidobut-3-enyl)-5-bromopyridine
360767-36-8

(S)-3-(1-azidobut-3-enyl)-5-bromopyridine

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
2: H2
View Scheme
(R)-methanesulfonic acid 1-(5-bromopyridin-3-yl)but-3-enyl ester
360767-38-0

(R)-methanesulfonic acid 1-(5-bromopyridin-3-yl)but-3-enyl ester

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C
2: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C
3: H2
View Scheme
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrahydrofuran / 1 h / -100 °C
2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
3: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C
4: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrahydrofuran / 1 h / -100 °C
2: 88 percent / diphenylphosphorylazide; DBU / toluene / 72 h / 20 °C
3: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C
View Scheme
(R)-1-(pyridin-3-yl)but-3-en-1-ol
314280-28-9

(R)-1-(pyridin-3-yl)but-3-en-1-ol

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C
2: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C
3: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 88 percent / diphenylphosphorylazide; DBU / toluene / 72 h / 20 °C
2: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C
View Scheme
(R)-methanesulfonic acid 1-pyridin-3-yl-but-3-enyl ester
372519-16-9

(R)-methanesulfonic acid 1-pyridin-3-yl-but-3-enyl ester

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / NaN3 / dimethylformamide / 4 h / 60 °C
2: 85 percent / dicyclohexylborane / tetrahydrofuran / 12 h / -15 - 20 °C
View Scheme
4-(3-pyridyl)-4-oxobutanol
59578-62-0

4-(3-pyridyl)-4-oxobutanol

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 82 percent / (COCl)2; NEt3 / dimethylsulfoxide
2.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C
2.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C
3.1: 95 percent / aq. HCl; methanol
View Scheme
4-Oxo-1-(3-pyridyl)-1-butanone
76014-80-7

4-Oxo-1-(3-pyridyl)-1-butanone

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C
1.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C
2.1: 95 percent / aq. HCl; methanol
View Scheme
ethyl 5-bromo-3-pyridinecarboxylate
20986-40-7

ethyl 5-bromo-3-pyridinecarboxylate

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: 79 percent / NaBH4 / methanol; acetic acid / -40 - -20 °C
4: Et3N / 10percent Pd/C / ethanol / 1 h / 760 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran
2.1: sodium tetrahydroborate; acetic acid; methanol
2.2: Resolution of racemate
3.1: potassium hydroxide / diethyl ether
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / mineral oil; hexane; tetrahydrofuran / 1 h / Reflux; Inert atmosphere
1.2: Reflux
2.1: acetic acid; sodium tetrahydroborate / methanol; acetonitrile / 0.17 h / -40 - 20 °C
3.1: ethyl acetate / 0.25 h
4.1: potassium hydroxide / diethyl ether
4.2: 1 h
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / Reflux; Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: acetic acid; sodium tetrahydroborate / methanol / 0.5 h / -40 - 20 °C
3.1: ethyl acetate / 0.25 h / 20 °C
4.1: potassium hydroxide / water / 1 h
4.2: 20 °C
View Scheme
5-Bromo-3-(2-pyrrolidinyl)pyridine
71719-06-7

5-Bromo-3-(2-pyrrolidinyl)pyridine

nornicotine
494-97-3

nornicotine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: Et3N / 10percent Pd/C / ethanol / 1 h / 760 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: ethyl acetate / 0.25 h
2.1: potassium hydroxide / diethyl ether
2.2: 1 h
View Scheme
Multi-step reaction with 2 steps
1.1: ethyl acetate / 0.25 h / 20 °C
2.1: potassium hydroxide / water / 1 h
2.2: 20 °C
View Scheme
methyl 4-iodobutanoate
14273-85-9

methyl 4-iodobutanoate

nornicotine
494-97-3

nornicotine

(S)-methyl 4-(2-(pyridin-3-yl)pyrrolidin-1-yl)butanoate

(S)-methyl 4-(2-(pyridin-3-yl)pyrrolidin-1-yl)butanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;78%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;78%
methyl 6-iodohexanoate
14273-91-7

methyl 6-iodohexanoate

nornicotine
494-97-3

nornicotine

(S)-methyl 6-(2-(pyridin-3-yl)pyrrolidin-1-yl)hexanoate

(S)-methyl 6-(2-(pyridin-3-yl)pyrrolidin-1-yl)hexanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;75%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;75%
4-(4-bromo-2-chloro-phenoxy)-benzaldehyde
1040051-31-7

4-(4-bromo-2-chloro-phenoxy)-benzaldehyde

nornicotine
494-97-3

nornicotine

C22H20BrClN2O

C22H20BrClN2O

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 15h; Inert atmosphere;74%
methyl trans-γ-iodocrotonate
65495-78-5

methyl trans-γ-iodocrotonate

nornicotine
494-97-3

nornicotine

methyl (E)-4-((S)-2-(pyridin-3-yl)pyrrolidin-1-yl)but-2-enoate

methyl (E)-4-((S)-2-(pyridin-3-yl)pyrrolidin-1-yl)but-2-enoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;73%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;73%
3-chloro-4-(4-formylphenoxy)benzamide
676494-59-0

3-chloro-4-(4-formylphenoxy)benzamide

nornicotine
494-97-3

nornicotine

(S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
1346133-08-1

(S)-3-chloro-4-(4-((2-(pyridin-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;68%
(6-iodohexyl)-carbamic acid 1,1-dimethylethyl ester
172846-36-5

(6-iodohexyl)-carbamic acid 1,1-dimethylethyl ester

nornicotine
494-97-3

nornicotine

[6-[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]hexyl]-carbamic acid 1,1-dimethylethyl ester
350820-82-5

[6-[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]hexyl]-carbamic acid 1,1-dimethylethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 15h;59%
benzyl 4-iodobutanoate
118058-69-8

benzyl 4-iodobutanoate

nornicotine
494-97-3

nornicotine

(2S)-2-(3-pyridinyl)-1-pyrrolidinebutanoic acid phenylmethyl ester
350820-86-9

(2S)-2-(3-pyridinyl)-1-pyrrolidinebutanoic acid phenylmethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;58%
N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid N-(4-iodobutyl)amide

N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid N-(4-iodobutyl)amide

nornicotine
494-97-3

nornicotine

N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid N-(4-((S)-2-(pyridin-3-yl)pyrrolidin-1-yl)butyl)amide

N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid N-(4-((S)-2-(pyridin-3-yl)pyrrolidin-1-yl)butyl)amide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;51%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;51%
tert-butyl 4-((5-iodopentyl)carbamoyl)piperidine-1-carboxylate

tert-butyl 4-((5-iodopentyl)carbamoyl)piperidine-1-carboxylate

nornicotine
494-97-3

nornicotine

(S)-tert-butyl 4-((5-(2-(pyridin-3-yl)pyrrolidin-1-yl)pentyl)carbamoyl)piperidine-1-carboxylate

(S)-tert-butyl 4-((5-(2-(pyridin-3-yl)pyrrolidin-1-yl)pentyl)carbamoyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;49%

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