CAS No.51-43-4,L(-)-Epinephrine Suppliers,MSDS download

: (R)-4-(1-hydroxy-2-(methylamino)ethyl)benzen-1,2-diol L-tartrate

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 5 - 10℃; for 0.5h; pH=8.5;	100%

: 41787-64-8
(R)-1-(3,4-Dimethoxy-phenyl)-2-methylamino-ethanol

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With boron tribromide	97%

: epinephrine bitartrate

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 5 - 15℃; for 3h; pH=9; Inert atmosphere; Darkness;	93%

: C38H43NO9

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 40℃; for 4h;	89.7%

: (R)-1-(3,4-bis(benzyloxy)phenyl)-2-(methylamino)ethan-1-ol hydrochloride

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; ammonium formate In methanol at 50℃;	86%

: benzyl (R)-(2-(3,4-bis(benzyloxy)phenyl)-2-hydroxyethyl)(methyl)carbamate

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With formic acid; palladium 10% on activated carbon In methanol at 50℃; for 2h;	81%

: benzyl (R)-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)(methyl)carbamate

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With formic acid; palladium 10% on activated carbon In methanol at 50℃; for 1h;	74%

: 104819-58-1, 104873-32-7, 104873-33-8
R-(+)-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-hydroxy-2-methylamido-ethan

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol for 6h; Ambient temperature;	53.7%

: 99-45-6
adrenalone

A: C18H24N2O6

B: 51-43-4
L-epinephrine

C: 150-05-0
(S)-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide; isopropyl alcohol Electrochemical reaction; Title compound not separated from byproducts.;	A 5% B n/a C n/a

...Expand

dl-adrenaline: dl-adrenaline

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With D-tartaric acid

: 87-69-4
L-Tartaric acid

: 99-45-6
adrenalone

A: 51-43-4
L-epinephrine

B acid d-tartrate of d-adrenaline: acid d-tartrate of d-adrenaline

Conditions

Conditions	Yield
With water; hydrogen; platinum aus der methylalkoholischen Loesung des Reaktionsprodukts scheidet sich das saure d-Tartrat des l-Adrenalins zuerst aus;

...Expand

: 120-14-9
3,4-dimethoxy-benzaldehyde

hexadecyl magnesium iodide: hexadecyl magnesium iodide

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 1.) (-)-2-(2-HO-3-Br-5-t-Bu-C6H2-CH=N)-2'-HO-1,1'-binaphthyl, Ti(O-iPr)4, 2-HO-3,5-t-Bu2-C6H2-COOH, 2.) Me3SiCl, Et3N, 4.) TFA / 1.) toluene, 23 deg C, 1 h and 1 h, 23 deg C, 2.) toluene, -20 deg C, 15 min, 3.) toluene, -20 deg C to 23 deg C, 6 h, 4.) THF 2: imidazole / dimethylformamide 3: NaOH / H2O; methanol 4: SOCl2 5: NH4OH 6: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 7: 97 percent / BBr3 View Scheme

Yield

Multi-step reaction with 7 steps
1: 1.) (-)-2-(2-HO-3-Br-5-t-Bu-C6H2-CH=N)-2'-HO-1,1'-binaphthyl, Ti(O-iPr)4, 2-HO-3,5-t-Bu2-C6H2-COOH, 2.) Me3SiCl, Et3N, 4.) TFA / 1.) toluene, 23 deg C, 1 h and 1 h, 23 deg C, 2.) toluene, -20 deg C, 15 min, 3.) toluene, -20 deg C to 23 deg C, 6 h, 4.) THF
2: imidazole / dimethylformamide
3: NaOH / H2O; methanol
4: SOCl2
5: NH4OH
6: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating
7: 97 percent / BBr3
View Scheme

...Expand

: (S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(3,4-dimethoxy-phenyl)-propionamide

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 2: 97 percent / BBr3 View Scheme

: 188415-29-4
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(3,4-dimethoxy-phenyl)-propionic acid

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: SOCl2 2: NH4OH 3: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 4: 97 percent / BBr3 View Scheme

: (S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(3,4-dimethoxy-phenyl)-propionyl chloride

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NH4OH 2: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 3: 97 percent / BBr3 View Scheme

: 188415-28-3
(S)-3-(3,4-Dimethoxy-phenyl)-3-hydroxy-propionic acid benzyl ester

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: imidazole / dimethylformamide 2: NaOH / H2O; methanol 3: SOCl2 4: NH4OH 5: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 6: 97 percent / BBr3 View Scheme

: (S)-3-(tert-Butyl-dimethyl-silanyloxy)-3-(3,4-dimethoxy-phenyl)-propionic acid benzyl ester

A: 51-43-4
L-epinephrine

B potassium iodate: potassium iodate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: NaOH / H2O; methanol 2: SOCl2 3: NH4OH 4: 1.) PhI(OAc)2, KOH, 2.) LiAlH4 / 2.) THF, heating 5: 97 percent / BBr3 View Scheme

: 62-13-5
1-(3,4-dihydroxyphenyl)-1-oxo-2-methylamino-ethan-hydrochlorid

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73 percent / NaHCO3 / benzene; H2O / 30 h 2: NaBH4 / methanol / 24 h 3: 53.7 percent / H2, conc HCl / Pd/C / ethanol / 6 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: hydrogen; palladium(II) hydroxide / water; methanol / 16 h / 10 - 40 °C / 150.01 Torr 2: methanol / 20 h / 20 °C / Large scale 3: ammonium hydroxide / water / 3 h / 5 - 15 °C / pH 9 / Inert atmosphere; Darkness View Scheme

: 104819-56-9, 104873-29-2, 104874-56-8
R-(+)-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-oxo-2-methylamido-ethan

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaBH4 / methanol / 24 h 2: 53.7 percent / H2, conc HCl / Pd/C / ethanol / 6 h / Ambient temperature View Scheme

: 87-69-4
L-Tartaric acid

: 329-65-7
Epinephrine

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Stage #1: L-Tartaric acid; Epinephrine at 20℃; for 1 - 3h; Stage #2: With ammonia; sodium hydrogensulfite In water at 5 - 10℃; for 0.25h; pH=8.5; Product distribution / selectivity;

: 99-45-6
adrenalone

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With (R)-epinephrine dehydrogenase; NADH In aq. phosphate buffer at 45℃; pH=6; Kinetics; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction; enantioselective reaction;	n/a

: 99-40-1
2-chloro-3',4'-dihydroxyacetophenone

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: acetonitrile; water / 3 h / 0 - 40 °C / Large scale 1.2: 1.5 h / 5 - 25 °C / Large scale 2.1: hydrogen; palladium(II) hydroxide / water; methanol / 16 h / 10 - 40 °C / 150.01 Torr 3.1: methanol / 20 h / 20 °C / Large scale 4.1: ammonium hydroxide / water / 3 h / 5 - 15 °C / pH 9 / Inert atmosphere; Darkness View Scheme

: 51-41-2
norepinephrine

: 14031-35-7, 17176-17-9, 29908-03-0, 75044-81-4, 78548-84-2, 79647-17-9, 91279-78-6
S-Adenosyl-L-methionine

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
With N-methyltransferase; 2-Amino-1-phenylethanol Enzymatic reaction;

: 60-18-4
L-tyrosine

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrobiopterin; oxygen; tyrosine hydroxylase / Enzymatic reaction 2: aromatic L-amino acid decarboxylase / Enzymatic reaction 3: oxygen; dopamine β-hydroxylase; ascorbic acid / Enzymatic reaction 4: 2-Amino-1-phenylethanol; N-methyltransferase / Enzymatic reaction View Scheme

: 59-92-7
levodopa

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aromatic L-amino acid decarboxylase / Enzymatic reaction 2: oxygen; dopamine β-hydroxylase; ascorbic acid / Enzymatic reaction 3: 2-Amino-1-phenylethanol; N-methyltransferase / Enzymatic reaction View Scheme

: 120-80-9
benzene-1,2-diol

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium carbonate / tetrahydrofuran; water / 5 h / 20 °C 2: trichlorophosphate / 3.5 h / 60 °C 3: water; ethanol / 2 h / 60 °C 4: sodium tetrahydroborate / ethanol / 5 h / 20 °C 5: hydrogenchloride / water; ethanol / 4 h / 40 °C View Scheme

: C35H36O8

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: trichlorophosphate / 3.5 h / 60 °C 2: water; ethanol / 2 h / 60 °C 3: sodium tetrahydroborate / ethanol / 5 h / 20 °C 4: hydrogenchloride / water; ethanol / 4 h / 40 °C View Scheme

: C37H37ClO9

: 51-43-4
L-epinephrine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water; ethanol / 2 h / 60 °C 2: sodium tetrahydroborate / ethanol / 5 h / 20 °C 3: hydrogenchloride / water; ethanol / 4 h / 40 °C View Scheme

: 329-65-7
Epinephrine

A: 51-43-4
L-epinephrine

B: 150-05-0
(S)-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol

Conditions

Conditions	Yield
With core-shell macrocyclic glycopeptide-based chiral stationary phase NicoShell In methanol; acetic acid; acetonitrile at 20℃; Reagent/catalyst; Resolution of racemate;
With phase-transitioned bovine serum albumin film-coated capillary column In methanol pH=8.5; Resolution of racemate;

: 51-43-4
L-epinephrine

: 57-06-7
N-allyl isothiocyanate

: 3-allyl-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3.5h;	85%

: 51-43-4
L-epinephrine

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 3-(4-chlorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3.5h;	84%

: 51-43-4
L-epinephrine

: 103-72-0
phenyl isothiocyanate

: 1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methyl-3-phenylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 4h;	82%

: 1235976-42-7
diethyl (α-acetoxymethyl)vinylphosphonate

: 51-43-4
L-epinephrine

: 1235976-71-2
(R)-diethyl 3-((2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)methylamino)prop-1-en-2-ylphosphonate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In tetrahydrofuran at 20℃; for 24h;	81%

: 2131-59-1
3-bromophenyl isothiocyanate

: 51-43-4
L-epinephrine

: 3-(3-bromophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3h;	81%

: 51-43-4
L-epinephrine

: 1840-19-3
1-isothiocyanato-3-trifluoromethyl-benzene

: 1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methyl-3-[3-(trifluoromethyl)phenyl]thiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3h;	80%

: 51-43-4
L-epinephrine

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-3-(4-fluorophenyl)-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3.5h;	79%

: 51-43-4
L-epinephrine

: 6590-94-9
3,4-dichlorophenyl isothiocyanate

: 3-(3,4-dichlorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 4h;	76%

: 51-43-4
L-epinephrine

: germanium dioxide

: C18H22GeN2O6

Conditions

Conditions	Yield
In water for 8h;	76%

: 51-43-4
L-epinephrine

: 2131-61-5
p-nitrophenyl isothiocyanate

: 1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methyl-3-(4-nitrophenyl)thiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3h;	75%

: 51-43-4
L-epinephrine

: 2392-68-9
3-chlorophenyl-isothiocyanate

: 3-(3-chlorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 2.5h;	74%

: 51-43-4
L-epinephrine

: 6590-96-1
2, 4-dichlorophenyl isothiocyanate

: 3-(2,4-dichlorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3h;	73%

: 51-43-4
L-epinephrine

: 137724-66-4
3-chloro-4-fluorophenyl isothiocyanate

: 3-(3-chloro-4-fluorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 2.5h;	72%

: 207974-17-2
2,6-difluorophenylisothiocyanate

: 51-43-4
L-epinephrine

: 3-(2,6-difluorophenyl)-1-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-1-methylthiourea

Conditions

Conditions	Yield
With pyridine; triethylamine In tetrahydrofuran at 40℃; for 3.5h;	71%

: 7086-79-5, 85031-77-2, 127288-10-2, 136521-14-7
(R)-4-methyl-3-(3'-oxobutyl)pent-4-enal

: 51-43-4
L-epinephrine

: (5R)-5-(2-{[(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)amino}ethyl)-6-methylhept-6-en-2-one

Conditions

Conditions	Yield
With trimethylamine-N-oxide; C27H28FeN3O3(1+)*BF4(1-); hydrogen In ethanol at 20℃; under 3750.38 Torr; for 16h; Autoclave; Inert atmosphere; chemoselective reaction;	65%

: 50-00-0
formaldehyd

: 51-43-4
L-epinephrine

: 79254-32-3
1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol hydrochloride

Conditions

Conditions	Yield
In hydrogenchloride; water for 18h; Ambient temperature;	57%
With hydrogenchloride; sodium hydrogencarbonate In water at 20℃; for 18h;	49%

: 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-propanoic acid,4-nitrophenyl ester

: 51-43-4
L-epinephrine

: 3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-N-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-N-methylpropanamide

Conditions

Conditions	Yield
In dimethyl sulfoxide; acetone	48%

: 51-43-4
L-epinephrine

: carbonic acid-p-(bis-2-chloroethylamino)phenyl ester-p-nitrophenyl ester

: 371754-23-3
(R)-[1'-amino-2'-hydroxy-2'-(4''-hydroxyphenyl)propionic acid methyl ester]-carbamic acid p-(bis-2-chloroethylamino)phenyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 72h;	44%

: 50-00-0
formaldehyd

: 51-43-4
L-epinephrine

A: 79254-32-3
1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol hydrochloride

B: 79201-22-2
1,2,3,4-tetrahydro-2-methyl-4,7,8-isoquinolinetriol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydrogencarbonate In water for 1h;	A n/a B 22%

...Expand

: 51146-89-5
(+/-)-9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid

: 51-43-4
L-epinephrine

A: 1100699-12-4
C27H41NO8

B: 1100699-16-8
C27H41NO8

Conditions

Conditions	Yield
With oxygen; tris hydrochloride In water; dimethyl sulfoxide at 25℃; for 15h; pH=8.0;	A 18% B 8%
With oxygen In water at 25℃; for 15h; pH=8;

...Expand

: copper(II) nitrate pentahydrate

: 51-43-4
L-epinephrine

: Cu(2+)*C6H3(OH)2CHOHCH2NHCH3*2NO3(1-)=[Cu(C6H3(OH)2CHOHCH2NHCH3)](NO3)2

Conditions

Conditions	Yield
In ethanol addn. of a soln. of metal salt in ethanol to a soln. of adrenaline in ethanol at 50°C with stirring; washing with ethanol, drying in vac.; elem. anal.;	15%

: 51-43-4
L-epinephrine

: 24997-19-1
1,13-bischloro-4,7,10-trioxatridecane

: 125558-93-2
C34H50N2O10

Conditions

Conditions	Yield
With sodium methylate In methanol; butan-1-ol for 20h; Heating;	5%

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