Quick Details ProName: Healthy Injectable Livial Tibolone 563... CasNo: 5630-53-5 Molecular Formula: C25h34o3 Appearance: white crystalline powder Application: medical intermediate DeliveryTime: within a week
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $800.0 / 1000.0
Type:Other
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:5630-53-5
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryUnique advantages for Tibolone Cas 5630-53-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Package:10g/bag, 1kg/foil bag or as you require Application:Hormone Transp
Cas:5630-53-5
Min.Order:10 Gram
FOB Price: $200.0
Type:Trading Company
inquiryTibolone CAS No.:5630-53-5 Name: Tibolone Synonyms: 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one Molecular Structure Molecular Formula: C21H
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:5630-53-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:5630-53-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Hormone; Transportation:By sea or by air Port:Qingdao Port
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:5630-53-5
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:5630-53-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every cl
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality Tibolone(Liviella)(Livial) CAS 5630-53-5 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Mad
Cas:5630-53-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:5630-53-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $16.0 / 20.0
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Factory direct sales, accept customization. Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no signific
Tibolone CAS 5630-53-5 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,a
Cas:5630-53-5
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:5630-53-5
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:5630-53-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:5630-53-5
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Product name: Tibolone CAS No.:5630-53-5 Molecule Formula:C21H28O2 Molecule Weight:312.45 Purity: 99.0% Package: 25kg/drum Description:White or off-white crystalline powder Manufacture Standards:Enterprise Standard
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
tibolone
Conditions | Yield |
---|---|
With sulfuric acid In water; acetone at 0 - 5℃; for 1h; Industrial scale; | 90% |
3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol
A
7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
B
tibolone
C
10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one
Conditions | Yield |
---|---|
With oxalic acid In ethanol; water at 20℃; for 2h; Yields of byproduct given; | A n/a B 79% C n/a |
3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ2,5(10)-19-norandrastadien
tibolone
Conditions | Yield |
---|---|
Stage #1: 3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ2,5(10)-19-norandrastadien With ascorbic acid In ethanol at 20 - 30℃; for 1h; Activated Carbon Darco G60; Stage #2: With hydrogenchloride In ethanol; water at 20 - 25℃; | 78% |
With oxalic acid In methanol |
7α-methylnorethynodrel ethylene ketal
A
7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
B
tibolone
Conditions | Yield |
---|---|
Stage #1: 7α-methylnorethynodrel ethylene ketal With formic acid In tetrahydrofuran; ethanol; water at 40 - 60℃; for 1h; Stage #2: With formic acid In methanol for 6h; | A 19% B 63.7% |
Stage #1: 7α-methylnorethynodrel ethylene ketal With copper(II) sulfate In methanol; ethanol; water at 73 - 76℃; for 4.5h; Stage #2: With copper(II) sulfate for 0.5h; | A 5.7% B 49% |
3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol
tibolone
Conditions | Yield |
---|---|
With oxalic acid In methanol; water at 25℃; Solvent; Reagent/catalyst; Temperature; | 60.6% |
In water Product distribution / selectivity; Acidic conditions; |
7α-methylestr-5(10)-ene-3,17-dione
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / malonic acid / 24 h / 20 °C 2: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C 3: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C View Scheme |
3,3-dimethoxy-7α-methylestr-5(10)-en-17-one
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C 2: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 46 percent / CrO3, conc. H2SO4 / H2O; CH2Cl2 / 2.75 h / 30 - 40 °C 2: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C 3: 86 percent / malonic acid / 24 h / 20 °C 4: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C 5: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C View Scheme |
7α-methyl-3,17-dioxoandrost-4-en-19-al
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C 2: 86 percent / malonic acid / 24 h / 20 °C 3: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C 4: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C View Scheme |
7α-methylestrone 3-methyl ether
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: LiAlH4 / tetrahydrofuran 2: Na, tBuOH, liq. NH3 / tetrahydrofuran 3: Al(OiPr)3, cyclohexanone / toluene 4: ethane-1,2-diamine / dimethylsulfoxide; toluene 5: aq. oxalic acid / methanol View Scheme |
7α-methyloestradiol-3-methylether
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Al(OiPr)3, cyclohexanone / toluene 2: ethane-1,2-diamine / dimethylsulfoxide; toluene 3: aq. oxalic acid / methanol View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethane-1,2-diamine / dimethylsulfoxide; toluene 2: aq. oxalic acid / methanol View Scheme |
3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Na, tBuOH, liq. NH3 / tetrahydrofuran 2: Al(OiPr)3, cyclohexanone / toluene 3: ethane-1,2-diamine / dimethylsulfoxide; toluene 4: aq. oxalic acid / methanol View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetic anhydride; pyridine / 6 h / 20 °C / Industrial scale 2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale 2.2: 3 h / 70 - 75 °C / Industrial scale 3.1: acetic acid / water / Industrial scale 4.1: 3 h / 0 - 5 °C / Industrial scale 5.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale 6.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale 1.2: 3 h / 70 - 75 °C / Industrial scale 2.1: acetic acid / water / Industrial scale 3.1: 3 h / 0 - 5 °C / Industrial scale 4.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale 5.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium hydroxide / toluene; tert-butyl alcohol / 0.17 h / 760.05 Torr / Reflux; Industrial scale 1.2: 6 h / Industrial scale 2.1: acetic anhydride; pyridine / 6 h / 20 °C / Industrial scale 3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale 3.2: 3 h / 70 - 75 °C / Industrial scale 4.1: acetic acid / water / Industrial scale 5.1: 3 h / 0 - 5 °C / Industrial scale 6.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale 7.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetic acid / water / Industrial scale 2: 3 h / 0 - 5 °C / Industrial scale 3: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale 4: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 3 h / 0 - 5 °C / Industrial scale 2: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale 3: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: copper(l) chloride / tetrahydrofuran / -20 °C / Inert atmosphere 2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere 3: oxalic acid / methanol; water / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper dichloride / diethyl ether / -30 °C / Inert atmosphere 2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere 3: oxalic acid / methanol; water / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper diacetate / tetrahydrofuran; 2-methyltetrahydrofuran / -40 °C / Inert atmosphere 2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere 3: oxalic acid / methanol; water / 25 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere 2: oxalic acid / methanol; water / 25 °C View Scheme |
tibolone
17α-ethynyl-7α-methyl-5(10)-estren-3ξ,17β-diol
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In toluene at 0℃; for 3h; | 80% |
tibolone
A
3alpha-Hydroxytibolone
B
(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol
Conditions | Yield |
---|---|
With lithium tri(t-butoxy)aluminum hydride In tetrahydrofuran at -70℃; for 2h; | A 70% B n/a |
With ethanol; Sacharomyces cerevisiae CBS 3093 In phosphate buffer at 28℃; for 168h; pH=6.0; Title compound not separated from byproducts.; | |
Stage #1: tibolone With sodium tetrahydroborate In dichloromethane at 0 - 20℃; Stage #2: With acetic acid In dichloromethane at 20℃; | A 400 mg B 300 mg |
With sodium tetrahydroborate In dichloromethane at 0 - 20℃; for 5h; Microbiological reaction; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water for 48h; Reflux; | 70% |
With hydrogenchloride In methanol | |
With Fusarium lini NRRL 68751 In water; acetone at 22℃; for 144h; Microbiological reaction; Culture medium; Enzymatic reaction; | |
With Fusarium lini (ATCC 9593) In acetone for 144h; Microbiological reaction; |
tibolone
Conditions | Yield |
---|---|
With copper(II) bis(trifluoromethanesulfonate); triphenylphosphine; N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 20℃; for 20h; regioselective reaction; | 56% |
Multi-step reaction with 2 steps 1: 45 percent / hematoporphyrin, oxygen / pyridine / 1 h / 20 °C / Irradiation 2: 73 percent / triethyl phosphite / ethanol / 1 h / 20 °C View Scheme |
tibolone
10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one
Conditions | Yield |
---|---|
With oxygen; hematoporphyrin In pyridine at 20℃; for 1h; Irradiation; | 45% |
tibolone
3-Oxo-7α-methyl-17α-aethinyl-17β-hydroxy-Δ4.9-19-norandrostadien
Conditions | Yield |
---|---|
With pyridine; bromine In tetrachloromethane |
tibolone
3alpha-Hydroxytibolone
Conditions | Yield |
---|---|
With D-glucose; Kluyveromyces lactis CBS 2359 In phosphate buffer at 28℃; for 48h; pH=6.0; | |
Multi-step reaction with 3 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 0.85 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C 3: 95 percent / potassium carbonate / methanol; H2O / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 90 percent / pyridine / 3 h / 0 °C 3: 0.285 g / Candida antarctica lipase B Novozym 435; 1-octanol / toluene / 24 h / 30 °C View Scheme |
tibolone
(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 0.24 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: 70 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 2 h / -70 °C 2: 65 percent / Ph3P; diisopropyl azodicarboxylate / diethyl ether / 20 °C 3: 53 percent / Na2CO3 / methanol; H2O / 4 h / 50 °C View Scheme | |
With potassium phosphate; recombinant human aldo-keto reductase 1C2; NADPH In methanol at 37℃; pH=7; Kinetics; Reagent/catalyst; Concentration; aq. phosphate buffer; Enzymatic reaction; |
tibolone
17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-α3-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 0.85 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 90 percent / pyridine / 3 h / 0 °C 3: 0.135 g / Candida antarctica lipase B Novozym 435; 1-octanol / toluene / 24 h / 30 °C View Scheme |
tibolone
17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-ξ3-yl acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / DIBAL / toluene / 3 h / 0 °C 2: 90 percent / pyridine / 3 h / 0 °C View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 2 h / -70 °C 2: 65 percent / Ph3P; diisopropyl azodicarboxylate / diethyl ether / 20 °C View Scheme |
tibolone
7α-Methyl-3-oxo-17α-aethinyl-17β-hydroxy-Δ5.(10).9(11)-19-norandrostadien
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Br2, Py / CCl4 2: (i) pyrrolidine, MeOH, (ii) AcOH View Scheme |
tibolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Br2, Py / CCl4 2: (i) pyrrolidine, MeOH, (ii) AcOH 3: (i) MCPBA, CH2Cl2, (ii) Al2O3, (iii) BF3-Et2O View Scheme |
tibolone
Conditions | Yield |
---|---|
With hydrogenchloride In water | |
With hydrogenchloride In water; acetone for 4h; Reflux; |
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