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Kono Chem Co.,Ltd

Quick Details ProName: Healthy Injectable Livial Tibolone 563... CasNo: 5630-53-5 Molecular Formula: C25h34o3 Appearance: white crystalline powder Application: medical intermediate DeliveryTime: within a week

Tibolone 5630-53-5 Male Bodybuilding CAS NO.5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Tibolone CAS NO.5630-53-5

Cas:5630-53-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Tibolone Cas 5630-53-5 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Package:10g/bag, 1kg/foil bag or as you require Application:Hormone Transp

High quality BP Tibolone Cas 5630-53-5 supplied by reliable manufacturer

Cas:5630-53-5

Min.Order:10 Gram

FOB Price: $200.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Tibolone CAS No.:5630-53-5 Name: Tibolone Synonyms: 17-Hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one Molecular Structure Molecular Formula: C21H

High purity Tibolone CAS No.:5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tibolone

Cas:5630-53-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Tibolone 5630-53-5 Male Bodybuilding CAS NO.5630-53-5 5630-53-5 Producer

Cas:5630-53-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality tibolone

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tibolone

Cas:5630-53-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Tibolone 5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tibolone

Cas:5630-53-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tibolone/ LIDE PHARMA- Factory supply / Best price

Cas:5630-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:Hormone; Transportation:By sea or by air Port:Qingdao Port

Tibolone

Cas:5630-53-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 5630-53-5 Tibolone with best price

Cas:5630-53-5

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tibolone 5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every cl

Tibolone CAS No.5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Tibolone(Liviella)(Livial) CAS 5630-53-5 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Mad

High quality Tibolone(Liviella)(Livial) CAS 5630-53-5

Cas:5630-53-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tibolone Raw Powder

Cas:5630-53-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Tibolone

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

Tibolone 5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Tibolone

Cas:5630-53-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no signific

Tibolone

Cas:5630-53-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Tibolone CAS 5630-53-5 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,a

Tibolone CAS 5630-53-5

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tibolone

Cas:5630-53-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality BP Tibolone

Cas:5630-53-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Tibolone

Cas:5630-53-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Tibolone Manufacturer/High quality/Best price/In stock

Cas:5630-53-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

TiboloneCAS NO.: 5630-53-5

Cas:5630-53-5

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tibolone

Cas:5630-53-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Tibolone CAS No.:5630-53-5 Molecule Formula:C21H28O2 Molecule Weight:312.45 Purity: 99.0% Package: 25kg/drum Description:White or off-white crystalline powder Manufacture Standards:Enterprise Standard

Best Quality Tibolone

Cas:5630-53-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Tibolone

Cas:5630-53-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

C25H36O4

C25H36O4

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
With sulfuric acid In water; acetone at 0 - 5℃; for 1h; Industrial scale;90%
3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol
105186-33-2

3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol

A

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
1162-60-3

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

B

tibolone
5630-53-5

tibolone

C

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one
105186-34-3

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

Conditions
ConditionsYield
With oxalic acid In ethanol; water at 20℃; for 2h; Yields of byproduct given;A n/a
B 79%
C n/a
3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ2,5(10)-19-norandrastadien
15506-05-5

3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ2,5(10)-19-norandrastadien

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Stage #1: 3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ2,5(10)-19-norandrastadien With ascorbic acid In ethanol at 20 - 30℃; for 1h; Activated Carbon Darco G60;
Stage #2: With hydrogenchloride In ethanol; water at 20 - 25℃;
78%
With oxalic acid In methanol
7α-methylnorethynodrel ethylene ketal
677299-58-0

7α-methylnorethynodrel ethylene ketal

A

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
1162-60-3

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

B

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Stage #1: 7α-methylnorethynodrel ethylene ketal With formic acid In tetrahydrofuran; ethanol; water at 40 - 60℃; for 1h;
Stage #2: With formic acid In methanol for 6h;
A 19%
B 63.7%
Stage #1: 7α-methylnorethynodrel ethylene ketal With copper(II) sulfate In methanol; ethanol; water at 73 - 76℃; for 4.5h;
Stage #2: With copper(II) sulfate for 0.5h;
A 5.7%
B 49%
3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol
105186-33-2

3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
With oxalic acid In methanol; water at 25℃; Solvent; Reagent/catalyst; Temperature;60.6%
In water Product distribution / selectivity; Acidic conditions;
7α-methylestr-5(10)-ene-3,17-dione
105186-32-1

7α-methylestr-5(10)-ene-3,17-dione

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 86 percent / malonic acid / 24 h / 20 °C
2: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C
3: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C
View Scheme
3,3-dimethoxy-7α-methylestr-5(10)-en-17-one
88247-84-1

3,3-dimethoxy-7α-methylestr-5(10)-en-17-one

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C
2: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C
View Scheme
17β,19-dihydroxy-7-methylandrost-4-en-3-one

17β,19-dihydroxy-7-methylandrost-4-en-3-one

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 46 percent / CrO3, conc. H2SO4 / H2O; CH2Cl2 / 2.75 h / 30 - 40 °C
2: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C
3: 86 percent / malonic acid / 24 h / 20 °C
4: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C
5: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C
View Scheme
7α-methyl-3,17-dioxoandrost-4-en-19-al
63841-74-7

7α-methyl-3,17-dioxoandrost-4-en-19-al

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C
2: 86 percent / malonic acid / 24 h / 20 °C
3: 91 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 0 °C
4: 79 percent / oxalic acid dihydrate / H2O; ethanol / 2 h / 20 °C
View Scheme
7α-methylestrone 3-methyl ether
10449-00-0

7α-methylestrone 3-methyl ether

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: LiAlH4 / tetrahydrofuran
2: Na, tBuOH, liq. NH3 / tetrahydrofuran
3: Al(OiPr)3, cyclohexanone / toluene
4: ethane-1,2-diamine / dimethylsulfoxide; toluene
5: aq. oxalic acid / methanol
View Scheme
7α-methyloestradiol-3-methylether
15506-02-2

7α-methyloestradiol-3-methylether

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Al(OiPr)3, cyclohexanone / toluene
2: ethane-1,2-diamine / dimethylsulfoxide; toluene
3: aq. oxalic acid / methanol
View Scheme
3-Methoxy-7α-methyl-17-oxo-Δ2,5(10)-19-norandrostadien
5210-25-3

3-Methoxy-7α-methyl-17-oxo-Δ2,5(10)-19-norandrostadien

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethane-1,2-diamine / dimethylsulfoxide; toluene
2: aq. oxalic acid / methanol
View Scheme
3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol
15506-01-1

3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Na, tBuOH, liq. NH3 / tetrahydrofuran
2: Al(OiPr)3, cyclohexanone / toluene
3: ethane-1,2-diamine / dimethylsulfoxide; toluene
4: aq. oxalic acid / methanol
View Scheme
norethisterone
68-22-4

norethisterone

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: acetic anhydride; pyridine / 6 h / 20 °C / Industrial scale
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale
2.2: 3 h / 70 - 75 °C / Industrial scale
3.1: acetic acid / water / Industrial scale
4.1: 3 h / 0 - 5 °C / Industrial scale
5.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale
6.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale
View Scheme
3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne
2205-78-9

3,17-diacetoxy-19-nor-17βH-pregna-3,5-dien-20-yne

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale
1.2: 3 h / 70 - 75 °C / Industrial scale
2.1: acetic acid / water / Industrial scale
3.1: 3 h / 0 - 5 °C / Industrial scale
4.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale
5.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale
View Scheme
estra-4-ene-3,17-dione
734-32-7

estra-4-ene-3,17-dione

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium hydroxide / toluene; tert-butyl alcohol / 0.17 h / 760.05 Torr / Reflux; Industrial scale
1.2: 6 h / Industrial scale
2.1: acetic anhydride; pyridine / 6 h / 20 °C / Industrial scale
3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Industrial scale
3.2: 3 h / 70 - 75 °C / Industrial scale
4.1: acetic acid / water / Industrial scale
5.1: 3 h / 0 - 5 °C / Industrial scale
6.1: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale
7.1: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale
View Scheme
C22H27BrO3

C22H27BrO3

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / water / Industrial scale
2: 3 h / 0 - 5 °C / Industrial scale
3: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale
4: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale
View Scheme
Acetic acid (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Acetic acid (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3 h / 0 - 5 °C / Industrial scale
2: acetyl chloride / 3 h / -10 - 5 °C / Industrial scale
3: sulfuric acid / water; acetone / 1 h / 0 - 5 °C / Industrial scale
View Scheme
6,7-dehydro norethindrone

6,7-dehydro norethindrone

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) chloride / tetrahydrofuran / -20 °C / Inert atmosphere
2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere
3: oxalic acid / methanol; water / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: copper dichloride / diethyl ether / -30 °C / Inert atmosphere
2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere
3: oxalic acid / methanol; water / 25 °C
View Scheme
Multi-step reaction with 3 steps
1: copper diacetate / tetrahydrofuran; 2-methyltetrahydrofuran / -40 °C / Inert atmosphere
2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere
3: oxalic acid / methanol; water / 25 °C
View Scheme
7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
1162-60-3

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

tibolone
5630-53-5

tibolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere
2: oxalic acid / methanol; water / 25 °C
View Scheme
tibolone
5630-53-5

tibolone

17α-ethynyl-7α-methyl-5(10)-estren-3ξ,17β-diol
158932-37-7

17α-ethynyl-7α-methyl-5(10)-estren-3ξ,17β-diol

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene at 0℃; for 3h;80%
tibolone
5630-53-5

tibolone

A

3alpha-Hydroxytibolone
100239-44-9

3alpha-Hydroxytibolone

B

(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol
100239-45-0

(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol

Conditions
ConditionsYield
With lithium tri(t-butoxy)aluminum hydride In tetrahydrofuran at -70℃; for 2h;A 70%
B n/a
With ethanol; Sacharomyces cerevisiae CBS 3093 In phosphate buffer at 28℃; for 168h; pH=6.0; Title compound not separated from byproducts.;
Stage #1: tibolone With sodium tetrahydroborate In dichloromethane at 0 - 20℃;
Stage #2: With acetic acid In dichloromethane at 20℃;
A 400 mg
B 300 mg
With sodium tetrahydroborate In dichloromethane at 0 - 20℃; for 5h; Microbiological reaction;
tibolone
5630-53-5

tibolone

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one
1162-60-3

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water for 48h; Reflux;70%
With hydrogenchloride In methanol
With Fusarium lini NRRL 68751 In water; acetone at 22℃; for 144h; Microbiological reaction; Culture medium; Enzymatic reaction;
With Fusarium lini (ATCC 9593) In acetone for 144h; Microbiological reaction;
tibolone
5630-53-5

tibolone

7α-methyl-17α-ethynyl-10β,17β-dihydroxy-19-norandrost-4-en-3-one

7α-methyl-17α-ethynyl-10β,17β-dihydroxy-19-norandrost-4-en-3-one

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate); triphenylphosphine; N,N,N',N'-tetramethylguanidine In tetrahydrofuran at 20℃; for 20h; regioselective reaction;56%
Multi-step reaction with 2 steps
1: 45 percent / hematoporphyrin, oxygen / pyridine / 1 h / 20 °C / Irradiation
2: 73 percent / triethyl phosphite / ethanol / 1 h / 20 °C
View Scheme
tibolone
5630-53-5

tibolone

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one
105186-34-3

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

Conditions
ConditionsYield
With oxygen; hematoporphyrin In pyridine at 20℃; for 1h; Irradiation;45%
tibolone
5630-53-5

tibolone

3-Oxo-7α-methyl-17α-aethinyl-17β-hydroxy-Δ4.9-19-norandrostadien
15506-11-3

3-Oxo-7α-methyl-17α-aethinyl-17β-hydroxy-Δ4.9-19-norandrostadien

Conditions
ConditionsYield
With pyridine; bromine In tetrachloromethane
tibolone
5630-53-5

tibolone

3alpha-Hydroxytibolone
100239-44-9

3alpha-Hydroxytibolone

Conditions
ConditionsYield
With D-glucose; Kluyveromyces lactis CBS 2359 In phosphate buffer at 28℃; for 48h; pH=6.0;
Multi-step reaction with 3 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 0.85 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C
3: 95 percent / potassium carbonate / methanol; H2O / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 90 percent / pyridine / 3 h / 0 °C
3: 0.285 g / Candida antarctica lipase B Novozym 435; 1-octanol / toluene / 24 h / 30 °C
View Scheme
tibolone
5630-53-5

tibolone

(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol
100239-45-0

(3β,7α,17α)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3,17-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 0.24 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C
View Scheme
Multi-step reaction with 3 steps
1: 70 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 2 h / -70 °C
2: 65 percent / Ph3P; diisopropyl azodicarboxylate / diethyl ether / 20 °C
3: 53 percent / Na2CO3 / methanol; H2O / 4 h / 50 °C
View Scheme
With potassium phosphate; recombinant human aldo-keto reductase 1C2; NADPH In methanol at 37℃; pH=7; Kinetics; Reagent/catalyst; Concentration; aq. phosphate buffer; Enzymatic reaction;
tibolone
5630-53-5

tibolone

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-α3-yl acetate
500019-09-0

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-α3-yl acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 0.85 g / Candida antarctica lipase Novozym 435 / toluene / 1 h / 30 °C
View Scheme
tibolone
5630-53-5

tibolone

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-β3-yl acetate

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-β3-yl acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 90 percent / pyridine / 3 h / 0 °C
3: 0.135 g / Candida antarctica lipase B Novozym 435; 1-octanol / toluene / 24 h / 30 °C
View Scheme
tibolone
5630-53-5

tibolone

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-ξ3-yl acetate
500019-11-4

17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-ξ3-yl acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / DIBAL / toluene / 3 h / 0 °C
2: 90 percent / pyridine / 3 h / 0 °C
View Scheme
tibolone
5630-53-5

tibolone

Benzoic acid (3S,7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-2,3,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Benzoic acid (3S,7R,8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-2,3,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 2 h / -70 °C
2: 65 percent / Ph3P; diisopropyl azodicarboxylate / diethyl ether / 20 °C
View Scheme
tibolone
5630-53-5

tibolone

7α-Methyl-3-oxo-17α-aethinyl-17β-hydroxy-Δ5.(10).9(11)-19-norandrostadien
15505-74-5

7α-Methyl-3-oxo-17α-aethinyl-17β-hydroxy-Δ5.(10).9(11)-19-norandrostadien

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Br2, Py / CCl4
2: (i) pyrrolidine, MeOH, (ii) AcOH
View Scheme
tibolone
5630-53-5

tibolone

3-Oxo-7α-methyl-17α-ethinyl-17β-hydroxy-Δ4.9.11-19-norandrostatrien

3-Oxo-7α-methyl-17α-ethinyl-17β-hydroxy-Δ4.9.11-19-norandrostatrien

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Br2, Py / CCl4
2: (i) pyrrolidine, MeOH, (ii) AcOH
3: (i) MCPBA, CH2Cl2, (ii) Al2O3, (iii) BF3-Et2O
View Scheme
tibolone
5630-53-5

tibolone

[7α,17α]-17-hydroxy-7-methyl-19-norpregn-4(5)-en-20-yn-3-one

[7α,17α]-17-hydroxy-7-methyl-19-norpregn-4(5)-en-20-yn-3-one

Conditions
ConditionsYield
With hydrogenchloride In water
With hydrogenchloride In water; acetone for 4h; Reflux;

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