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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine dihydrochloride

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine 57061-71-9

Cas:57061-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE CAS:57061-71-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical int

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE CAS:57061-71-9

Cas:57061-71-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE,DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Piperazine,1-(2-chloroethyl)-4-[3-(trifluoromethyl)phenyl]- dihydrochloride

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE 2HCLAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE 2HCL

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

57061-71-9

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

Zhengzhou Kingorgchem Chemical Technology Co., Ltd. was founded on the basis of Organophosphorus Chemistry Lab of Institute of Chemistry Henan Academy of Sciences in 2015. The laboratory covers 600 m2 and the pilot plant covers 2000 m2. Kingorgchem i

National Research Platform ISO 9001 57061-71-9

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

shanghai Longyu biotechnology Co.,Ltd

We have strong R&D center which can support and provide custom synthesis accordingly such as fine chemicals,biotechnique , pharmaceuticals etc.We can provide free sample for our clients to test anf verify the quality of our goods.LongyuChem holds str

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HuBei Ipure Biotech CO.,ltd

HuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of p

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Hangzhou KieRay Chem Co.,Ltd.

Hangzhou KieRaychem Co.,Ltd.is located in Yuhang District of Hangzhou City and specialized in the chemical product customization, development, sales, import and export. Current business is focused on fine chemicals, pharmaceutical materials and int

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai AngewChem Co., Ltd.

Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale production. Complete

57061-71-9

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Raymon Biotech Co., Ltd.

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fedx.

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Jinan Great Chemical Co.,Ltd.

Application:Pharmaceutical intermediates

1-(2-CHLOROETHYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]PIPERAZINE DIHYDROCHLORIDE

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

57061-71-9

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.

1-(2-chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine dihydrochloride

1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Cas:57061-71-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

N-2-hydroxyethyl-N'-(3-trifluoromethylphenyl)-piperazine
40004-29-3

N-2-hydroxyethyl-N'-(3-trifluoromethylphenyl)-piperazine

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 2h; Reagent/catalyst; Solvent; Cooling with ice; Reflux;96%
With thionyl chloride In 1,2-dichloro-ethane at 20 - 80℃; for 4h; Temperature; Large scale;88%
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

1-(3-Trifluoromethylphenyl)piperazine
15532-75-9

1-(3-Trifluoromethylphenyl)piperazine

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With sodium hydroxide In acetone at 20℃; for 48h;79%
With sodium carbonate In N,N-dimethyl-formamide for 22h; Ambient temperature;
Stage #1: 1-(3-Trifluoromethylphenyl)piperazine With sodium hydroxide In dimethyl sulfoxide for 0.166667h;
Stage #2: 1-Bromo-2-chloroethane In dimethyl sulfoxide for 24h;
2-chloro-1-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethanone

2-chloro-1-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethanone

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 40℃; for 0.5h;60%
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

tris-(2-chloroethyl)amine hydrochloride
817-09-4

tris-(2-chloroethyl)amine hydrochloride

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol at 115 - 120℃; for 22h; Time;52.8%
tris-(2-chloro-ethyl)-amine
555-77-1

tris-(2-chloro-ethyl)-amine

3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol at 115 - 120℃; for 24h;45.9%
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

1-(3-Trifluoromethylphenyl)piperazine
15532-75-9

1-(3-Trifluoromethylphenyl)piperazine

A

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

B

4,4'-bis-(3-trifluoromethyl-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine
51299-16-2

4,4'-bis-(3-trifluoromethyl-phenyl)-1,1'-ethane-1,2-diyl-bis-piperazine

Conditions
ConditionsYield
In toluene for 6h; Alkylation; Heating;
1-Bromo-2-chloroethane
107-04-0

1-Bromo-2-chloroethane

1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
With triethylamine In hexane; dichloromethane
With triethylamine In hexane; dichloromethane
With triethylamine In dichloromethane for 9h; Heating / reflux;
With triethylamine In hexane; dichloromethane
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / acetone / 4 h / 20 - 60 °C / Large scale
2: thionyl chloride / 1,2-dichloro-ethane / 4 h / 20 - 80 °C / Large scale
View Scheme
4H-pyrido[3,2-b][1,4]oxazin-3-one
20348-09-8

4H-pyrido[3,2-b][1,4]oxazin-3-one

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

4-{2-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4H-pyrido[3,2-b][1,4]oxazin-3-one

4-{2-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4H-pyrido[3,2-b][1,4]oxazin-3-one

Conditions
ConditionsYield
With sodium ethanolate In N,N-dimethyl-formamide for 2h; Heating;92%
1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one
52099-72-6

1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

BIMT 17 hydrochloride
147359-76-0

BIMT 17 hydrochloride

Conditions
ConditionsYield
Stage #1: 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one; 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane With potassium carbonate In dimethyl sulfoxide at 58℃; for 8h; Large scale;
Stage #2: With hydrogenchloride In ethanol; water at 65℃; for 2h; Temperature; Large scale;
77%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

C9H6NO3(1-)*Na(1+)

C9H6NO3(1-)*Na(1+)

6-Acetyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one
81522-22-7

6-Acetyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 1h; Heating;70%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

1-(2-azidoethyl)-4-(3-trifluoromethylphenyl)piperazine
670234-48-7

1-(2-azidoethyl)-4-(3-trifluoromethylphenyl)piperazine

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 60℃; for 16h;67.3%
With sodium azide In N,N-dimethyl-formamide at 50℃; for 10h;
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

C10H8NO3(1-)*Na(1+)

C10H8NO3(1-)*Na(1+)

6-Propionyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one
81514-00-3

6-Propionyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 1h; Heating;62%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

C14H7ClNO3(1-)*Na(1+)

C14H7ClNO3(1-)*Na(1+)

6-(2-Chloro-benzoyl)-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one
81533-87-1

6-(2-Chloro-benzoyl)-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 1h; Heating;61%
2-ethoxy-1H-benzo[d]imidazole
22219-23-4

2-ethoxy-1H-benzo[d]imidazole

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

flibanserin

flibanserin

Conditions
ConditionsYield
Stage #1: 2-ethoxy-1H-benzo[d]imidazole; 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane With sodium hydroxide In water; isopropyl alcohol at 75℃; for 2h;
Stage #2: With hydrogenchloride; isopropyl chloride at 4 - 70℃; for 2h; Temperature;
56.2%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

3-hydroxy-3,4-dihydrobenzotriazine-4-one
28230-32-2

3-hydroxy-3,4-dihydrobenzotriazine-4-one

3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-3H-benzo[d][1,2,3]triazin-4-one

3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethoxy}-3H-benzo[d][1,2,3]triazin-4-one

Conditions
ConditionsYield
With sodium hydroxide In ethanol for 24h; Substitution; Heating;40%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

3-<2-<4-<3-(trifluoromethyl)phenyl>-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

3-<2-<4-<3-(trifluoromethyl)phenyl>-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Conditions
ConditionsYield
40%
3H-benzooxazol-2-one; sodium salt
42142-71-2

3H-benzooxazol-2-one; sodium salt

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

3-{2-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one
81513-96-4

3-{2-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 1h; Heating;38%
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

C14H8NO3(1-)*Na(1+)

C14H8NO3(1-)*Na(1+)

6-Benzoyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one
81513-99-7

6-Benzoyl-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 1h; Heating;37%
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one
60832-72-6

2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

3-<2-<4-<3-(trifluoromethyl)phenyl>-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

3-<2-<4-<3-(trifluoromethyl)phenyl>-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Conditions
ConditionsYield
With sodium ethanolate 1.) EtOH, RT, 1 h, 2.) DMF, reflux, 1.5 h; Yield given. Multistep reaction;
(E)-5-Benzylidene-6-methyl-(4H)-pyridazin-3-on
26717-37-3

(E)-5-Benzylidene-6-methyl-(4H)-pyridazin-3-on

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

6-Methyl-5-[1-phenyl-meth-(E)-ylidene]-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

6-Methyl-5-[1-phenyl-meth-(E)-ylidene]-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
With sodium ethanolate 1.) ethanol, reflux, 1 h, 2.) DMF, reflux, 10 h; Yield given. Multistep reaction;
5-(4-Methylbenzylidene)-6-methyl-(4H)-pyridazin-3-on
132372-50-0

5-(4-Methylbenzylidene)-6-methyl-(4H)-pyridazin-3-on

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

6-Methyl-5-[1-p-tolyl-meth-(E)-ylidene]-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

6-Methyl-5-[1-p-tolyl-meth-(E)-ylidene]-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
With sodium ethanolate 1.) ethanol, reflux, 1 h, 2.) DMF, reflux, 10 h; Yield given. Multistep reaction;
5-(4-Fluorobenzylidene)-6-methyl-(4H)-pyridazin-3-on
132372-49-7

5-(4-Fluorobenzylidene)-6-methyl-(4H)-pyridazin-3-on

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-6-methyl-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

5-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-6-methyl-2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
With sodium ethanolate 1.) ethanol, reflux, 1 h, 2.) DMF, reflux, 10 h; Yield given. Multistep reaction;
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine
27144-85-0

2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

2-nitro-3-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethylamino}phenol
670234-43-2

2-nitro-3-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethylamino}phenol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2.1: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
3.1: K2CO3 / dimethylformamide / 2 h / 50 °C
3.2: 79 percent / 2-(methylsulfonyl)ethanol; NaH / dimethylformamide / 0.5 h / 20 °C
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

3,4,5-trihydroxy-6-(2-oxo-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2,3-dihydro-1H-benzoimidazol-4-yloxy)-tetrahydropyran-2-carboxylic acid

3,4,5-trihydroxy-6-(2-oxo-1-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2,3-dihydro-1H-benzoimidazol-4-yloxy)-tetrahydropyran-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2.1: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
3.1: K2CO3 / dimethylformamide / 2 h / 50 °C
3.2: 79 percent / 2-(methylsulfonyl)ethanol; NaH / dimethylformamide / 0.5 h / 20 °C
4.1: 80 percent / 1,1,4,7,10,10-Hexamethyltriethylenetetramine; Ag2CO3 / acetonitrile / 0.5 h / 20 °C
5.1: H2 / Pd/C / tetrahydrofuran / 30 h / 20 °C / 3375.27 Torr
6.1: 5.1 g / tetrahydrofuran / 48 h
7.1: 42 percent / aq. LiOH / tetrahydrofuran / 168 h / 20 °C
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

(2S,3S,4S,5R,6S)-6-(2-Amino-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethylamino}-phenoxy)-3,4,5-tris-(2,2-dimethyl-propionyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6S)-6-(2-Amino-3-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethylamino}-phenoxy)-3,4,5-tris-(2,2-dimethyl-propionyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2.1: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
3.1: K2CO3 / dimethylformamide / 2 h / 50 °C
3.2: 79 percent / 2-(methylsulfonyl)ethanol; NaH / dimethylformamide / 0.5 h / 20 °C
4.1: 80 percent / 1,1,4,7,10,10-Hexamethyltriethylenetetramine; Ag2CO3 / acetonitrile / 0.5 h / 20 °C
5.1: H2 / Pd/C / tetrahydrofuran / 30 h / 20 °C / 3375.27 Torr
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

methyl 3-[[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]amino]-2-nitrophenyl-2,3,4-tris-O-(2,2-dimethylpropanoyl)-β-D-glucopyranosiduronate
670234-44-3

methyl 3-[[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]amino]-2-nitrophenyl-2,3,4-tris-O-(2,2-dimethylpropanoyl)-β-D-glucopyranosiduronate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2.1: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
3.1: K2CO3 / dimethylformamide / 2 h / 50 °C
3.2: 79 percent / 2-(methylsulfonyl)ethanol; NaH / dimethylformamide / 0.5 h / 20 °C
4.1: 80 percent / 1,1,4,7,10,10-Hexamethyltriethylenetetramine; Ag2CO3 / acetonitrile / 0.5 h / 20 °C
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

(2S,3S,4S,5R,6S)-3,4,5-Tris-(2,2-dimethyl-propionyloxy)-6-(2-oxo-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-1H-benzoimidazol-4-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
670234-49-8

(2S,3S,4S,5R,6S)-3,4,5-Tris-(2,2-dimethyl-propionyloxy)-6-(2-oxo-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-1H-benzoimidazol-4-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 67.3 percent / NaN3 / dimethylformamide / 16 h / 60 °C
2.1: 83.6 percent / PPh3 / tetrahydrofuran; H2O / 2 h / 20 °C
3.1: K2CO3 / dimethylformamide / 2 h / 50 °C
3.2: 79 percent / 2-(methylsulfonyl)ethanol; NaH / dimethylformamide / 0.5 h / 20 °C
4.1: 80 percent / 1,1,4,7,10,10-Hexamethyltriethylenetetramine; Ag2CO3 / acetonitrile / 0.5 h / 20 °C
5.1: H2 / Pd/C / tetrahydrofuran / 30 h / 20 °C / 3375.27 Torr
6.1: 5.1 g / tetrahydrofuran / 48 h
View Scheme
1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

4-hydroxy-2-mercaptopyrimidine
141-90-2

4-hydroxy-2-mercaptopyrimidine

C17H19F3N4OS

C17H19F3N4OS

N,N-dimethylformamide(DMF)

N,N-dimethylformamide(DMF)

1,5,6,7-tetrahydro-indol-4-one
13754-86-4

1,5,6,7-tetrahydro-indol-4-one

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane
57061-71-9

1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane

1-{2-[4-(3-trifluoromethylphenyl)piperazine-1-yl]ethyl}-1,5,6,7-tetrahydroindol-4-one
496921-68-7

1-{2-[4-(3-trifluoromethylphenyl)piperazine-1-yl]ethyl}-1,5,6,7-tetrahydroindol-4-one

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide
With hydrogenchloride In 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide

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