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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(R)-gamma-valerolactone

Cas:58917-25-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-τ-Valerolactone

Cas:58917-25-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Qingdao Beluga Import and Export Co., LTD

(R)-GAMMA-VALEROLACTONE CAS:58917-25-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

(R)-GAMMA-VALEROLACTONE CAS:58917-25-2

Cas:58917-25-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)- -Valerolactone

Cas:58917-25-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-gamma-valerolactone

Cas:58917-25-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

58917-25-2

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

D-AMINO ACID OXIDASE

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

(R)-5-Methyldihydrofuran-2(3H)-one

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

(R)-?-VALEROLACTONEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(R)-?-VALEROLACTONE

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-GAMMA-VALEROLACTONE

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

58917-25-2

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(R)-GAMMA-VALEROLACTONE

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

1. Subsidiary of Institute of Chemistry, Henan Academy of Sciences, national research platform;2. About 30 years’ experience in this field since 1983;3. An experienced R&D team consisting of Doctors and Masters;4. Various types of analytical instrume

National Research Platform ISO 9001 58917-25-2

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

(R)-gamma-valerolactone CAS NO.58917-25-2

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Capot Chemical Co., Ltd.

At Capot,We can synthesize and purify your complex molecules from 100 gram to 10 tons.Appearance:Clear colorless to light yellow liquid Storage:Dry,Seal and Cool place Package:1G,5G,10G,25G,100G,250G,500G,1KG,5KG,10KG,25KG,50KG,100KG,150KG,200KG. App

(R)-γ-Valerolactone

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (R)-GAMMA-VALEROLACTONE, CAS:58917-25-2 with the most competitive price and the best

(R)-GAMMA-VALEROLACTONE

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Nanjing Raymon Biotech Co., Ltd.

2(3H)-Furanone,dihydro-5-methyl-, (5R)- Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like DHL or Fedx. Port:Shanghai/She

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

58917-25-2

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemical Co.Ltd

Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NovaChemistry

high purity Application:Drug intermediates Materials intermediates and active molecules

(5R)-5-methyloxolan-2-one

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Julich Chiral Solutions

more information,please contact us

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chiracon GmbH

more information,please contact us

2(3H)-Furanone,dihydro-5-methyl-, (5R)-

Cas:58917-25-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

levulinic acid methyl ester
624-45-3

levulinic acid methyl ester

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; [RuCl2-((R)-binap)]*NEt3 In methanol at 40℃; under 2068.6 Torr; for 48h;99%
With hydrogenchloride; ruthenium trichloride; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In methanol at 60℃; under 45603.1 Torr; for 10h; Autoclave; optical yield given as %ee;88%
Stage #1: levulinic acid methyl ester With hydrogen In methanol at 65℃; under 68255.5 Torr; for 48h;
Stage #2: With sulfuric acid In methanol Heating;
72%
With Rhodococcus ruber alcohol dehydrogenase; isopropyl alcohol In aq. buffer at 30℃; for 24h; pH=9; Enzymatic reaction;n/a
(S)-2-[(R)-4-hydroxypentanamide]-3-phenyl-N-[(R)-1-phenylethyl]propanamide
1219498-05-1

(S)-2-[(R)-4-hydroxypentanamide]-3-phenyl-N-[(R)-1-phenylethyl]propanamide

A

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

B

(S)-2-amino-3-phenyl-N-[(R)-1-phenylethyl]propanamide
133287-30-6

(S)-2-amino-3-phenyl-N-[(R)-1-phenylethyl]propanamide

Conditions
ConditionsYield
With hydrogenchloride In methanol for 3h; Reflux;A 93%
B 96%
ethyl (S)-4-hydroxypentanoate
99631-16-0

ethyl (S)-4-hydroxypentanoate

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 20℃; for 20h; Inert atmosphere; enantioselective reaction;92%
γ-hydroxyvaleric acid
155847-13-5

γ-hydroxyvaleric acid

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; enantioselective reaction;91%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 6h;83%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 6h;83%
With hydrogenchloride at 25℃; for 16h; Yield given;
ethyl (R)-4-((tert-butyldimethylsilyl)oxy)pentanoate

ethyl (R)-4-((tert-butyldimethylsilyl)oxy)pentanoate

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 20℃; for 24h;87%
3-(S)-oxiranyl-propionic acid methyl ester
85428-31-5

3-(S)-oxiranyl-propionic acid methyl ester

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium iodide In 1,2-dimethoxyethane for 2h; Heating;85%
(S)-5-tosyloxypentan-4-olide
58879-34-8

(S)-5-tosyloxypentan-4-olide

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With tri-n-butyl-tin hydride; sodium iodide; 2,2'-azobis(isobutyronitrile)79%
Multi-step reaction with 2 steps
1: 74 percent / LAH / tetrahydrofuran / 3 h / Heating
2: 40 percent / Ag2CO3/Celite / CHCl3 / 12 h / Heating
View Scheme
potassium cyanide

potassium cyanide

(R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane
75351-36-9

(R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
Stage #1: potassium cyanide; (R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane In ethanol; water for 16h; Reflux;
Stage #2: With hydrogenchloride In ethanol; water for 24h; Reflux;
75%
potassium cyanide
151-50-8

potassium cyanide

(R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane
75351-36-9

(R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water 1.) reflux, 16 h, 2.) reflux, 24 h;68%
levulinic acid
123-76-2

levulinic acid

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With yeast Pichia farinosa in a glucose medium at 30℃; for 48h;67%
Multi-step reaction with 2 steps
1: 83 percent / (-)-diisopinocampheylborane / tetrahydrofuran / 17 h / 20 °C
2: 83 percent / CF3CO2H / CH2Cl2 / 6 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: C67H80IrNOP(1+)*C32H12BF24(1-); hydrogen; triethylamine / methanol / 24 h / 65 °C
2: hydrogenchloride / water / 20 °C
View Scheme
(R)-ethyl-4-propionoxypentanoate
129549-69-5

(R)-ethyl-4-propionoxypentanoate

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 6h; Heating;65%
(S)-γ-Phenylselenomethyl-γ-butyrolactone
93752-75-1

(S)-γ-Phenylselenomethyl-γ-butyrolactone

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With triphenylstannane In toluene for 2.5h; Heating;64%
(-)-(S)-5-iodomethyloxol-3-en-2-one
85694-08-2

(-)-(S)-5-iodomethyloxol-3-en-2-one

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;63%
With calcium carbonate; Ni-Ra W-4 In ethanol for 2h;63%
(R)-1-(n-butyltellanyl)-3-butanol
943643-07-0

(R)-1-(n-butyltellanyl)-3-butanol

carbon dioxide
124-38-9

carbon dioxide

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
Stage #1: (R)-1-(n-butyltellanyl)-3-butanol With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.0833333h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78 - 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane at 20℃; for 0.5h; Further stages.;
52%
(4R)-pentane-1,4-diol
56718-04-8

(4R)-pentane-1,4-diol

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With Celite; silver carbonate In chloroform for 12h; Heating;40%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Trametes versicolor laccase In aq. buffer at 0℃; for 8h; pH=5; Enzymatic reaction;n/a
levulinic acid methyl ester
624-45-3

levulinic acid methyl ester

A

(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester
111043-99-3

(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester

B

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogen In methanol at 65℃; under 68255.5 Torr; for 48h;A 25%
B n/a
With hydrogenchloride; rhodium(III) chloride hydrate; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl In methanol at 65℃; under 45603.1 Torr; for 6h; Autoclave; optical yield given as %ee;
5-methylenedihydrofuran-2-one
10008-73-8

5-methylenedihydrofuran-2-one

A

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

B

(S)-γ-valerolactone
19041-15-7

(S)-γ-valerolactone

Conditions
ConditionsYield
With hydrogen; bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II) In dichloromethane at 50℃; under 76000 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogen; {RuCl(C6H6)((S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)}Cl In dichloromethane at 50℃; under 76000.1 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With tetrafluoroboric acid; hydrogen; ruthenium catalyst with atropoisomeric (R)-ligand In water; isopropyl alcohol at 60℃; under 45003.6 Torr; for 20h; Catalytic hydrogenation; Title compound not separated from byproducts;
4-hydroxyvaleric acid
13532-37-1, 103712-26-1

4-hydroxyvaleric acid

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogen cation
rac-5-Nitro-2-pentanol
54045-33-9

rac-5-Nitro-2-pentanol

A

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

B

(S)-γ-valerolactone
19041-15-7

(S)-γ-valerolactone

Conditions
ConditionsYield
With dihydrogen peroxide; potassium carbonate In methanol for 24h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
carbon dioxide
124-38-9

carbon dioxide

(R)-4-Chlor-2-butanol
90026-42-9

(R)-4-Chlor-2-butanol

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogenchloride; methylmagnesium chloride; lithium Yield given. Multistep reaction;
(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester
111043-99-3

(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester

A

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

B

(S)-γ-valerolactone
19041-15-7

(S)-γ-valerolactone

Conditions
ConditionsYield
acid Title compound not separated from byproducts;
(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester
111043-99-3

(R)-(-)-γ-hydroxy-γ-methylbutyric acid methylester

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
acid
(R)-(E)-Methyl 4-hydroxypent-2-enoate
124818-73-1

(R)-(E)-Methyl 4-hydroxypent-2-enoate

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal Yield given. Multistep reaction;
Acetic acid (2R,3R)-4-bromo-2-methyl-5-oxo-tetrahydro-furan-3-yl ester
96239-83-7

Acetic acid (2R,3R)-4-bromo-2-methyl-5-oxo-tetrahydro-furan-3-yl ester

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With hydrogen; triethylamine; palladium on activated charcoal
(R)-β-angelica lactone
62322-48-9

(R)-β-angelica lactone

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;
(R)-pent-4-en-2-ol
64584-92-5

(R)-pent-4-en-2-ol

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium dichromate; dimethylsulfide borane complex; sulfuric acid 1.) Et2O, a) -78 to 25 deg C, b) 25 deg C, 12 h, 2.) reflux, 1 h; Yield given. Multistep reaction;
Multi-step reaction with 4 steps
1: 90 percent / DMAP, Et3N / CH2Cl2 / 2 h
2: 1.) BH2Cl*SMe2, 2.) CrO3 / 1.) CH2Cl2, 25 deg C, 2 h, 2.) aq. AcOH, 25 deg C, 2 h
3: 1 N aq. NaOH / 1 h / 80 °C
4: aq. HCl / 16 h / 25 °C
View Scheme
(-)-(S)-5-n-propylthiomethyloxol-3-en-2-one
85694-15-1

(-)-(S)-5-n-propylthiomethyloxol-3-en-2-one

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;
(S)-(-)-γ-bromometil-α,β-butenolide
85694-09-3

(S)-(-)-γ-bromometil-α,β-butenolide

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;
(-)-(S)-5-phenylthiomethyloxol-3-en-2-one
85718-56-5

(-)-(S)-5-phenylthiomethyloxol-3-en-2-one

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;
(-)-(S)-5-methanesulfonyloxymethyloxol-3-en-2-one
85694-07-1

(-)-(S)-5-methanesulfonyloxymethyloxol-3-en-2-one

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With sodium hydrogencarbonate; Raney-Ni W-4 In ethanol for 2h;
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

(3S)-1,3-bis[(tert-butyldimethylsilyl)oxy]hex-5-ene
366454-99-1

(3S)-1,3-bis[(tert-butyldimethylsilyl)oxy]hex-5-ene

2-[4,6-bis(tert-butyl-dimethyl-silanyloxy)-hexyl]-1-(3-hydroxy-butyl)-cyclopropanol

2-[4,6-bis(tert-butyl-dimethyl-silanyloxy)-hexyl]-1-(3-hydroxy-butyl)-cyclopropanol

Conditions
ConditionsYield
With titanium(IV) isopropylate; cyclohexylmagnesium bromide In diethyl ether; hexane; toluene at 25℃; for 2h; Kulinkovich cyclopropanation;92%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

R-(+)-γ-valerolactol
908850-87-3

R-(+)-γ-valerolactol

Conditions
ConditionsYield
With diisobutylaluminium hydride In dichloromethane at -78℃; for 0.5h; Inert atmosphere;91%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

C7H15O5P

C7H15O5P

(2E,6R)-6-hydroxyhept-2-enoic acid tert.-butyl ester
1073630-51-9

(2E,6R)-6-hydroxyhept-2-enoic acid tert.-butyl ester

Conditions
ConditionsYield
Stage #1: C7H15O5P With sodium hydride In tetrahydrofuran at 20℃; Cooling;
Stage #2: (R)-5-methyl-2-oxotetrahydrofuran With diisobutylaluminium hydride In tetrahydrofuran at -78 - 20℃;
90.1%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Sodium; [(R)-5-methyl-2-oxo-dihydro-furan-(3Z)-ylidene]-methanolate
82190-19-0

Sodium; [(R)-5-methyl-2-oxo-dihydro-furan-(3Z)-ylidene]-methanolate

Conditions
ConditionsYield
With sodium hydride In diethyl ether; ethanol Ambient temperature;84%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

(4R)-pentane-1,4-diol
56718-04-8

(4R)-pentane-1,4-diol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; Inert atmosphere;84%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

1-{[(S)-1-(Bbenzyloxy)hex-5-yn-3-yloxy]methyl}benzene
528598-36-9

1-{[(S)-1-(Bbenzyloxy)hex-5-yn-3-yloxy]methyl}benzene

(2R,9S)-9,11-bis(benzyloxy)-2-hydroxyundec-6-yn-5-one
1307273-50-2

(2R,9S)-9,11-bis(benzyloxy)-2-hydroxyundec-6-yn-5-one

Conditions
ConditionsYield
Stage #1: 1-{[(S)-1-(Bbenzyloxy)hex-5-yn-3-yloxy]methyl}benzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 0.166667h;
Stage #3: (R)-5-methyl-2-oxotetrahydrofuran In tetrahydrofuran at 78℃; for 1h;
82%
formaldehyd
50-00-0

formaldehyd

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

(R)-3-Hydroxymethyl-5-methyl-dihydro-furan-2-one

(R)-3-Hydroxymethyl-5-methyl-dihydro-furan-2-one

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -20 deg C, 15 min, 2.) 30 min;80.6%
allyl methyl carbonate
35466-83-2

allyl methyl carbonate

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

C10H16O2

C10H16O2

Conditions
ConditionsYield
Stage #1: (R)-5-methyl-2-oxotetrahydrofuran With lithium diisopropyl amide In tetrahydrofuran at -78 - -70℃; for 1h; Inert atmosphere;
Stage #2: allyl methyl carbonate With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); lithium chloride In tetrahydrofuran at -78℃; for 40h; Inert atmosphere; enantioselective reaction;
76%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

4,5-dihydro-5-methyl-2-(trimethylsiloxy)-3-(trimethylsilyl)furan
97549-87-6

4,5-dihydro-5-methyl-2-(trimethylsiloxy)-3-(trimethylsilyl)furan

Conditions
ConditionsYield
according to ref. 7.;75%
(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

(R)-5-Methyl-dihydro-furan-2-thione
489474-91-1

(R)-5-Methyl-dihydro-furan-2-thione

Conditions
ConditionsYield
With Lawessons reagent In toluene for 4h; Heating;65%
allyl iodid
556-56-9

allyl iodid

(R)-5-methyl-2-oxotetrahydrofuran
58917-25-2

(R)-5-methyl-2-oxotetrahydrofuran

Conditions
ConditionsYield
With lithium diisopropyl amide Yield given. Multistep reaction;

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