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China Synchem Technology Co.,Ltd

Benzonitrile, 3-ethoxy-4-methoxy- 60758-86-3 supplier in stock Apremilast commercial Customization Our Key Technology: 1. Low Temperature Reactions 2. Coupling Reactions 3. Fluorine Chemistry 4.

Benzonitrile, 3-ethoxy-4-methoxy-

Cas:60758-86-3

Min.Order:1 Kilogram

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

3-Ethoxy-4-methoxybenzonitrile CAS No.:60758-86-3 Name: 3-Ethoxy-4-methoxybenzonitrile Molecular Structure Molecular Formula: C10H11NO2 Molecular Weight: 177.20

High purity 3-Ethoxy-4-methoxybenzonitrile CAS No.:60758-86-3

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Benzonitrile, 3-ethoxy-4-Methoxy-

Cas:60758-86-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Benzonitrile, 3-ethoxy-4-Methoxy-

Cas:60758-86-3

Min.Order:1 Metric Ton

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

Benzonitrile, 3-ethoxy-4-Methoxy- 60758-86-3

Cas:60758-86-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Promotional 3-Ethoxy-4-Methoxy Benzonitrile CAS 60758-86-3

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 60758-86-3 with best quality

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzonitrile, 3-ethoxy-4-methoxy- 60758-86-3

Cas:60758-86-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Benzonitrile, 3-ethoxy-4-Methoxy-99%

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $68.0 / 75.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-Ethoxy-4-methoxy benzonitrile CAS: 60758-86-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

3-Ethoxy-4-methoxy benzonitrile CAS: 60758-86-3

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzonitrile, 3-ethoxy-4-methoxy-

Cas:60758-86-3

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Lonwin Chemical Group Limited

3-Ethoxy-4-methoxybenzonitrile CAS: 60758-86-3 Specification Name: 3-Ethoxy-4-methoxybenzonitrile Molecular Structure Molecular Formula: C10H11NO2 Molecular Weight: 177.20 CAS Registry Number: 60758-86-3 Solubility: Very slightly solub

Factory supply 3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzonitrile, 3-ethoxy-4-methoxy-

Cas:60758-86-3

Min.Order:0

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Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BENZONITRILE, 3-ETHOXY-4-METHOXY-

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzonitrile, 3-ethoxy-4-methoxy-

Cas:60758-86-3

Min.Order:0

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Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-ethoxy-4-Methoxybenzonitrile/High quality/Best price

Cas:60758-86-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Apremalist intermediates

Cas:60758-86-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

TIANFU-CHEM - Benzonitrile, 3-ethoxy-4-Methoxy-Appearance:Solid Storage:Room Temperature Package:according to customers' requirements Application:Organic synthesis Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF e

Benzonitrile, 3-ethoxy-4-Methoxy-

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Apremilast Impurity 2:3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Benzonitrile, 3-ethoxy-4-Methoxy- Chemical Properties Melting point 70℃ Boiling point 281.9±25.0℃ (760 Torr) density 1.09±0.1 g/cm3 (20 ºC 760 Torr) Fp 109.2±16.4℃ InChIKey XTIINWPNAMHVDG-UHFFFAOYSA-N

3-ethoxy-4-Methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

3-Ethoxy-4-methoxy benzonitrile

Cas:60758-86-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Benzonitrile, 3-ethoxy-4-methoxy-

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Gram

Negotiable

Type:Other

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Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Immune inflammatory

Apremilast APSB01 (60758-86-3)

Cas:60758-86-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/3-Ethoxy-4-Methoxy benzontrile

Cas:60758-86-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ZiBO KuoDing Trade company Ltd

ProName: Benzonitrile, 3-ethoxy-4-methoxy- CasNo: 60758-86-3 Appearance: off-white powder Application: organic synthesis Appearance:off white powder Storage:dry and cool place Package:25KG/DRUIM Application:intermediate of Apremilas

3-Ethoxy-4-methoxybenzonitrile

Cas:60758-86-3

Min.Order:1 Gram

FOB Price: $100.0

Type:Trading Company

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Synthetic route

3-ethoxy-4-methoxybenzaldehyde
1131-52-8

3-ethoxy-4-methoxybenzaldehyde

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With hydroxylamine hydrochloride In acetonitrile at 5 - 84℃; Product distribution / selectivity;95.5%
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride, sodium hydroxide / aq. ethanol; H2O / Ambient temperature
2: acetic anhydride / Heating
View Scheme
With hydroxylamine hydrochloride In acetonitrile Reflux;
With hydroxylamine hydrochloride In formic acid at 85 - 90℃; Temperature;600 g
ethyl bromide
74-96-4

ethyl bromide

2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h;94%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 8h; Solvent; Concentration; Temperature; Industrial scale;94%
Stage #1: 2-methoxy-5-cyanophenol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.583333h;
Stage #2: ethyl bromide In N,N-dimethyl-formamide at 0 - 20℃;
With potassium carbonate In acetone Reflux;
3-ethoxy-4-hydroxybenzonitrile
60758-79-4

3-ethoxy-4-hydroxybenzonitrile

methyl iodide
74-88-4

methyl iodide

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Reflux;89.3%
1-methyl-4-nitrosobenzene
623-11-0

1-methyl-4-nitrosobenzene

(+/-)-3-ethoxy-2'-chloro-4-methoxy-benzoin-seqtrans-oxime

(+/-)-3-ethoxy-2'-chloro-4-methoxy-benzoin-seqtrans-oxime

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

A

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

B

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

3-ethoxy-4-methoxybenzaldoxime
1956-36-1

3-ethoxy-4-methoxybenzaldoxime

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With acetic anhydride Heating;
4-methoxy-3-ethoxy-benzaldehyde-oxime

4-methoxy-3-ethoxy-benzaldehyde-oxime

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With acetic anhydride
3-ethoxy-4-methoxy-benzoic acid amide
247569-89-7

3-ethoxy-4-methoxy-benzoic acid amide

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With trichlorophosphate In pyridine
4-ethoxy-3-methoxy-benzoic acid amide
247569-93-3

4-ethoxy-3-methoxy-benzoic acid amide

A

4-ethoxy-3-methoxybenzonitrile
81259-56-5

4-ethoxy-3-methoxybenzonitrile

B

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-methoxy-4-(2-methoxyethoxy)benzamide
247569-95-5

3-methoxy-4-(2-methoxyethoxy)benzamide

A

3-methoxy-4-(2-methoxyethoxy)benzonitrile
247569-96-6

3-methoxy-4-(2-methoxyethoxy)benzonitrile

B

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-benzyloxy-4-methoxybenzamide
247570-05-4

3-benzyloxy-4-methoxybenzamide

A

3-benzyloxy-4-methoxybenzonitrile
52805-37-5

3-benzyloxy-4-methoxybenzonitrile

B

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

isovanillin
621-59-0

isovanillin

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C
2: potassium carbonate / N,N-dimethyl-formamide
View Scheme
Multi-step reaction with 2 steps
1: sodium formate; hydroxylamine hydrochloride / formic acid / 5 h / 85 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: formic acid; sodium formate; hydroxylamine hydrochloride / 5 h / 85 °C / Industrial scale
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C / Industrial scale
View Scheme
2-methoxy-5-cyanophenol
52805-46-6

2-methoxy-5-cyanophenol

ethyl halide

ethyl halide

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide
4-hydroxy-3-ethoxybenzaldehyde
121-32-4

4-hydroxy-3-ethoxybenzaldehyde

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride / acetonitrile / 4 h / Reflux
2: potassium carbonate / acetone / 4 h / Reflux
View Scheme
ethyl 3-methoxy-4-(2-methoxyethoxy)benzoate
196194-41-9

ethyl 3-methoxy-4-(2-methoxyethoxy)benzoate

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

4-hydroxy-3-methoxybenzoic acid methyl ester
3943-74-6

4-hydroxy-3-methoxybenzoic acid methyl ester

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-methoxy-4-(2-methoxyethoxy)benzoic acid
247569-94-4

3-methoxy-4-(2-methoxyethoxy)benzoic acid

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

ethyl 4-cyclobutylmethoxy-3-methoxybenzoate
247569-98-8

ethyl 4-cyclobutylmethoxy-3-methoxybenzoate

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: N-methyl-acetamide; dichloromethane
3: trichlorophosphate / pyridine
View Scheme
3-hydroxy-4-methoxybenzoate
6702-50-7

3-hydroxy-4-methoxybenzoate

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N-methyl-acetamide
2: methanol
3: N-methyl-acetamide; dichloromethane
4: trichlorophosphate / pyridine
View Scheme
ethyl vanillate
617-05-0

ethyl vanillate

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
2: methanol
3: N-methyl-acetamide; dichloromethane
4: trichlorophosphate / pyridine
View Scheme
4-ethoxy-3-methoxybenzoic acid
3535-30-6

4-ethoxy-3-methoxybenzoic acid

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-methoxy-4-hydroxybenzoic acid
121-34-6

3-methoxy-4-hydroxybenzoic acid

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Isovanillic acid
645-08-9

Isovanillic acid

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sulfuric acid / methanol
2: potassium carbonate / N-methyl-acetamide
3: methanol
4: N-methyl-acetamide; dichloromethane
5: trichlorophosphate / pyridine
View Scheme
3-ethoxy-4-methoxybenzoic acid
2651-55-0

3-ethoxy-4-methoxybenzoic acid

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-methyl-acetamide; dichloromethane
2: trichlorophosphate / pyridine
View Scheme
methyl 3-(benzyloxy)-4-methoxy-benzoate
57535-57-6

methyl 3-(benzyloxy)-4-methoxy-benzoate

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: N-methyl-acetamide; dichloromethane
3: trichlorophosphate / pyridine
View Scheme
4-ethoxy-3-methoxybenzoic acid methyl ester
3535-24-8

4-ethoxy-3-methoxybenzoic acid methyl ester

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-ethoxy-4-methoxybenzoic acid methyl ester
97966-31-9

3-ethoxy-4-methoxybenzoic acid methyl ester

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol
2: N-methyl-acetamide; dichloromethane
3: trichlorophosphate / pyridine
View Scheme
dimethylsulfone
67-71-0

dimethylsulfone

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
1450657-31-4

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine

Conditions
ConditionsYield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at -5 - 0℃; for 2h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at -5 - 30℃;
96%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 5℃; for 1h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 30℃; for 2h;
83%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 5℃; for 1h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 30℃; for 2h;
83%
Stage #1: dimethylsulfone With sodium amide In tetrahydrofuran; dimethyl sulfoxide at 40℃;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 3.5h; Reagent/catalyst; Solvent; Temperature;
83%
dimethylsulfone
67-71-0

dimethylsulfone

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one
1450657-28-9

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

Conditions
ConditionsYield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane Large scale;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 5℃; Large scale;
Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane Large scale;
93%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 20℃; for 13h; Inert atmosphere;
85%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 10℃; for 3h; Inert atmosphere;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran at 0 - 20℃; for 6h;
81%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 10℃; for 3h; Inert atmosphere; Industrial scale;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran at 0 - 20℃; for 6h; Solvent; Concentration; Industrial scale;
81%
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfinyl)ethylamine

(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfinyl)ethylamine

Conditions
ConditionsYield
Stage #1: dimethyl sulfoxide With n-butyllithium In tetrahydrofuran; hexane at 0 - 5℃; for 1.5h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile With tri-n-butylstannyl chloride In tetrahydrofuran at 15 - 20℃; for 2.5h;
85.2%
Stage #1: dimethyl sulfoxide With n-butyllithium In tetrahydrofuran; hexane at 0 - 5℃; for 1.5h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile With tributyltin chloride In tetrahydrofuran; hexane; water at 15 - 20℃; for 14.5h; Time;
109.6 g
dimethylsulfone
67-71-0

dimethylsulfone

3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine
253168-94-4

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

Conditions
ConditionsYield
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran; hexane at 0 - 5℃;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; hexane at 0 - 20℃; Product distribution / selectivity; Inert atmosphere;
76.1%
Stage #1: dimethylsulfone With potassium hexamethylsilazane In tetrahydrofuran at 0 - 10℃; for 1h; Large scale;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran for 0.5h; Large scale;
Stage #3: With sodium tetrahydroborate; acetic acid In tetrahydrofuran at 0 - 62℃; Temperature; Large scale;
65%
Stage #1: dimethylsulfone With potassium tert-butylate In dimethyl sulfoxide at 30℃; for 3h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran; dimethyl sulfoxide for 3.5h;
Stage #3: With sodium tetrahydroborate In tetrahydrofuran; dimethyl sulfoxide at 30℃; for 1h;
50%
Stage #1: dimethylsulfone With n-butyllithium In tetrahydrofuran at 0 - 5℃; for 1.5h;
Stage #2: 3-ethoxy-4-methoxybenzenecarbonitrile In tetrahydrofuran at 0 - 30℃; for 1.5h; Further stages;
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-ethoxy-4-methoxythiobenzamide
60758-99-8

3-ethoxy-4-methoxythiobenzamide

Conditions
ConditionsYield
With pyridine; hydrogen sulfide; triethylamine Ambient temperature;
With hydrogenchloride; thioacetamide In N,N-dimethyl-formamide at 100℃; for 2h;
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

6-[2-(3-Ethoxy-4-methoxy-phenyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one

6-[2-(3-Ethoxy-4-methoxy-phenyl)-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl, thioacetamide / dimethylformamide / 2 h / 100 °C
2: ethanol / 2 h / Heating
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

2-(3-ethoxy-4-methoxyphenyl)-4-(2'-pyrazinyl)thiazole
115540-95-9

2-(3-ethoxy-4-methoxyphenyl)-4-(2'-pyrazinyl)thiazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen sulphide gas, triethylamine, pyridine / Ambient temperature
2: ethanol / Heating
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

2-(3-ethoxy-4-methoxyphenyl)-4-(5'-nitro-2'-furyl)thiazole
115541-17-8

2-(3-ethoxy-4-methoxyphenyl)-4-(5'-nitro-2'-furyl)thiazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen sulphide gas, triethylamine, pyridine / Ambient temperature
2: ethanol / Heating
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-ethoxy-4-methoxybenzylamine
108439-67-4

3-ethoxy-4-methoxybenzylamine

Conditions
ConditionsYield
In tetrahydrofuran; ethyl acetate
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
1312793-92-2

3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 18 h / 0 °C / Reflux
2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere
2.2: 3.5 h / 0 - 30 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 10 h / 110 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux
2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere
2.2: 13.5 h / 0 - 110 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

C10H14N2O3
885957-47-1

C10H14N2O3

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 0℃; for 18h; Reflux;
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 0℃; for 18h; Reflux;
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

tert-butyl 4-(3-(3-ethoxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate
1312793-85-3

tert-butyl 4-(3-(3-ethoxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 18 h / 0 °C / Reflux
2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere
2.2: 3.5 h / 0 - 30 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide / 10 h / 110 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux
2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere
2.2: 13.5 h / 0 - 110 °C / Inert atmosphere
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

C21H31N3O6

C21H31N3O6

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 18 h / 0 °C / Reflux
2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere
2.2: 3.5 h / 0 - 30 °C / Inert atmosphere
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine
608142-27-4

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 5 °C
1.2: 2 h / 0 - 30 °C
2.1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / 2,2,2-trifluoroethanol / 18 h / 50 °C / 5414.51 Torr / Inert atmosphere
View Scheme
3-ethoxy-4-methoxybenzenecarbonitrile
60758-86-3

3-ethoxy-4-methoxybenzenecarbonitrile

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine
608141-42-0

(S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / Large scale
1.2: 0 - 5 °C / Large scale
1.3: Large scale
2.1: toluene-4-sulfonic acid / toluene / Dean-Stark; Large scale
2.2: Large scale
2.3: Large scale
3.1: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 5 °C
1.2: 2 h / 0 - 30 °C
2.1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; hydrogen / 2,2,2-trifluoroethanol / 18 h / 50 °C / 13689.1 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 - 5 °C
1.2: 2 h / 0 - 30 °C
2.1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 2,2,2-trifluoroethanol / 18 h / 50 °C / 4654.46 Torr / Inert atmosphere
View Scheme

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