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Hangzhou Maytime Bio-Tech Co.,Ltd.

Product name :(1S,5R)-1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one CAS:63106-93-4 We are also manufacture and supply below milnacipran intermediates with high quality ,competitive price and best service. (1S,5R)-1-phenyl-3-oxa-bi

(1S,5R)-1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Think Chemical Co. Ltd

Name (1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one Molecular Structure Molecular Formula C11H10O2 Molec

Supply (1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one for Milnacipran

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one Manufacturer/High quality/Best price/In stock

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 63106-93-4 with competitive price

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: (1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one Molecular Formula:C11H10O2 Molecular Weight:174.2 CAS No.:63106-93-4 Appearance:Similar White To Slight Yellow Powder Appearance:Similar White To Slight Yellow Powder Storage:Store in cool and

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE 63106-93-4

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one 63106-93-4

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE CAS:63106-93-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE CAS:63106-93-4

Cas:63106-93-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE Synonyms: (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE;2-Oxo-1-phenyl-3-oxabicyclo[3.1.0]-hexane;1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one;(1R,2S)-rel-2-Oxo-1-phenyl-3-oxabicyclo[3

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE Manufactuered in China best quality

Cas:63106-93-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE

Cas:63106-93-4

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2-Oxo-1-Phenyl-3-Oxbicyclo[3.1.0]-Hexane CAS No.:63106-93-4 Molecule Formula:C11H10O2 Molecule Weight:174.20 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Best Quality 2-Oxo-1-Phenyl-3-Oxbicyclo[3.1.0]-Hexane

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

63106-93-4 (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE Chemical Properties Melting point 49-50 °C Boiling point 119 °C(Press: 0.1 Torr) density 1.300±0.06 g/cm3(Predicted)

(1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE

Cas:63106-93-4

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE Synonyms: (1S,5R)-1-PHENYL-3-OXA-BICYCLO[3.1.0]HEXAN-2-ONE;2-Oxo-1-phenyl-3-oxabicyclo…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:0

Negotiable

Type:Other

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(1S,5R)-1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Cas:63106-93-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

allyl α-phenyl-α-diazoacetate
145193-16-4

allyl α-phenyl-α-diazoacetate

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
With dirhodium(II) tetrakis[methyl2-oxaazetidine-4(S)carboxylate] In dichloromethane for 0.5h; Cyclization; Heating;80%
With dirhodium tetraacetate; trimethylsilylazide In dichloromethane at 40℃; for 1h; Reagent/catalyst;78%
phenylacetonitrile
140-29-4

phenylacetonitrile

epichlorohydrin
106-89-8

epichlorohydrin

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
Stage #1: phenylacetonitrile; epichlorohydrin With sodium hydride In N,N'-dimethylimidazolidinone; toluene at 10 - 20℃;
Stage #2: With potassium hydroxide; tetrabutylammonium sulfate In water; toluene Heating / reflux;
Stage #3: With hydrogenchloride In water; toluene at 60 - 70℃; for 2h;
68.1%
Stage #1: phenylacetonitrile With sodium hydride In 1,3-dimethyl-2-imidazolidinone; toluene at 10 - 20℃; for 2h;
Stage #2: epichlorohydrin In 1,3-dimethyl-2-imidazolidinone; toluene at 10 - 20℃;
Stage #3: With hydrogenchloride; potassium hydroxide; tetrabutylammonium sulfate more than 3 stages;
68.1%
Stage #1: phenylacetonitrile With sodium amide In benzene at 35℃; for 3h; Cooling with ice;
Stage #2: epichlorohydrin In benzene at 35℃; for 4h; Cooling with ice;
Stage #3: With potassium hydroxide In ethanol; water for 16.5h; Reflux;
Stage #1: phenylacetonitrile at 0 - 20℃; for 3h;
Stage #2: epichlorohydrin at 0 - 20℃; for 4h;
Stage #3: With potassium hydroxide In ethanol; water Reflux;
14.5 g
epichlorohydrin
106-89-8

epichlorohydrin

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
Stage #1: phenylacetonitrile With sodium hydride In 1,3-dimethyl-2-imidazolidinone; toluene at 10 - 20℃; for 2h;
Stage #2: epichlorohydrin In 1,3-dimethyl-2-imidazolidinone; toluene at 10 - 20℃;
Stage #3: With hydrogenchloride; potassium hydroxide; tetrabutylammonium sulfate more than 3 stages;
68.1%
phenyl toluenesulfonamide
68-34-8

phenyl toluenesulfonamide

allyl α-phenyl-α-diazoacetate
145193-16-4

allyl α-phenyl-α-diazoacetate

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
With dirhodium tetraacetate In dichloromethane at 23℃;64%
6a-Phenyl-3a,6a-dihydro-3H-furo[3,4-c]pyrazole-4,6-dione
168475-91-0

6a-Phenyl-3a,6a-dihydro-3H-furo[3,4-c]pyrazole-4,6-dione

A

4-methyl-3-phenyl-2,5-dihydrofuran-2-one
33131-14-5

4-methyl-3-phenyl-2,5-dihydrofuran-2-one

B

3-methyl-4-phenylfuran-2(5H)-one
1575-48-0

3-methyl-4-phenylfuran-2(5H)-one

C

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

D

5-phenyl-3-oxabicyclo<3.1.0>hexan-2-one
96847-64-2, 121851-50-1

5-phenyl-3-oxabicyclo<3.1.0>hexan-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate 1.) benzene, 70 deg C, 2.) THF, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
allyl phenylacetate
1797-74-6

allyl phenylacetate

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / 1,8-diazobicyclo[5.4.0]undec-7-ene; p-acetamidobenzenesulfonyl azide / tetrahydrofuran / 11 h / 20 °C
2: 80 percent / dirhodium(II) tetrakis[methyl2-oxaazetidine-4(S)carboxylate] / CH2Cl2 / 0.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: 4-acetamidobenzenesulfonyl azide / acetonitrile / 0.25 h / Inert atmosphere; Cooling with ice
1.2: 16 h / 20 °C / Inert atmosphere
2.1: dirhodium tetraacetate; trimethylsilylazide / dichloromethane / 1 h / 40 °C
View Scheme
phenylacetyl chloride
103-80-0

phenylacetyl chloride

Ala ester

Ala ester

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N
2: 74 percent / 1,8-diazobicyclo[5.4.0]undec-7-ene; p-acetamidobenzenesulfonyl azide / tetrahydrofuran / 11 h / 20 °C
3: 80 percent / dirhodium(II) tetrakis[methyl2-oxaazetidine-4(S)carboxylate] / CH2Cl2 / 0.5 h / Heating
View Scheme
3-(2-bromophenyl)-3-methyldihydrofuran-2(3H)-one

3-(2-bromophenyl)-3-methyldihydrofuran-2(3H)-one

A

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

B

C11H10O2

C11H10O2

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium pivalate In dimethyl sulfoxide; toluene at 140℃; for 16h; Inert atmosphere;A 21 %Spectr.
B 48 %Spectr.
dimethyl 2-(2-bromophenyl)-2-methylsuccinate

dimethyl 2-(2-bromophenyl)-2-methylsuccinate

A

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

B

C11H10O2

C11H10O2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / tetrahydrofuran / 16 h / 0 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium pivalate / toluene; dimethyl sulfoxide / 16 h / 140 °C / Inert atmosphere
View Scheme
(±)-methyl 2-(2-bromophenyl)propanoate
115615-34-4

(±)-methyl 2-(2-bromophenyl)propanoate

A

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

B

C11H10O2

C11H10O2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
1.2: 16 h / -78 - 20 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran / 16 h / 0 °C
3.1: tetrakis(triphenylphosphine) palladium(0); potassium pivalate / toluene; dimethyl sulfoxide / 16 h / 140 °C / Inert atmosphere
View Scheme
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

Conditions
ConditionsYield
With hydrogen bromide at 80℃; for 2h;98%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid
69160-63-0

(1S,2R)/(1R,2S)-2-(bromomethyl)-1-phenylcyclopropanecarboxylic acid

Conditions
ConditionsYield
With hydrogen bromide In acetic acid at 80℃; for 2h;96%
With hydrogen bromide In acetic acid at 80℃; for 2h;
methanol
67-56-1

methanol

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

C12H13ClO2

C12H13ClO2

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 10h; Temperature;94.5%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

diethylamine
109-89-7

diethylamine

1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane

1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane

Conditions
ConditionsYield
Stage #1: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one; diethylamine With sodium methylate In methanol; toluene at 20 - 30℃; for 8h;
Stage #2: With water; acetic acid In methanol; toluene
93.8%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

ethanol
64-17-5

ethanol

ethyl (+/-)-cis-2-(bromomethyl)-1-phenylcyclopropanecarboxylate
105310-49-4

ethyl (+/-)-cis-2-(bromomethyl)-1-phenylcyclopropanecarboxylate

Conditions
ConditionsYield
With dibromo sulfoxide at -15 - 20℃;90%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

diethylamine
109-89-7

diethylamine

(Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane

(Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane

Conditions
ConditionsYield
With sodium methylate In methanol; toluene at 20 - 30℃; for 15h; Product distribution / selectivity;87%
With sodium methylate In toluene at 60℃; for 15h; Product distribution / selectivity;
With sodium methylate In methanol at 20 - 60℃; for 15h; Product distribution / selectivity;
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1R,2S)-1-phenyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide
172016-06-7

(1R,2S)-1-phenyl-2-(hydroxymethyl)-N,N-diethylcyclopropanecarboxamide

Conditions
ConditionsYield
Stage #1: diethylamine With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 1h;
Stage #2: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one In tetrahydrofuran; hexane at -78 - -60℃;
Stage #3: With water; ammonium chloride In tetrahydrofuran; hexane
66.8%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

potassium phtalimide
1074-82-4

potassium phtalimide

(Z)-1-phenyl-2-(phthalimidomethyl)cyclopropanecarboxylic acid
69160-56-1

(Z)-1-phenyl-2-(phthalimidomethyl)cyclopropanecarboxylic acid

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 15h; Heating;57%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

potassium phtalimide
1074-82-4

potassium phtalimide

2-((1,3-dioxoisoindolin-2-yI)methyI)-1-phenylcyclopropane carboxylic acid

2-((1,3-dioxoisoindolin-2-yI)methyI)-1-phenylcyclopropane carboxylic acid

Conditions
ConditionsYield
Stage #1: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one; potassium phtalimide In dimethyl sulfoxide at 150℃; for 20h;
Stage #2: With acetic acid pH=5 - 6; Product distribution / selectivity;
51%
Stage #1: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one; potassium phtalimide With tetra-(n-butyl)ammonium iodide In 1-methyl-pyrrolidin-2-one at 150℃; for 20h;
Stage #2: With acetic acid pH=5 - 6; Product distribution / selectivity;
> 90 %Chromat.
Stage #1: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one; potassium phtalimide In 1-methyl-pyrrolidin-2-one at 150℃; for 20h;
Stage #2: With acetic acid pH=5 - 6; Product distribution / selectivity;
> 90 %Chromat.
Stage #1: 1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one; potassium phtalimide In DMF (N,N-dimethyl-formamide) at 50 - 150℃; for 20 - 24h;
Stage #2: With acetic acid pH=5 - 6; Product distribution / selectivity;
70 - > 90 %Chromat.
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

phenylmagnesium bromide

phenylmagnesium bromide

1,2-diphenyl-2-hydroxy-3-oxabicyclo <3,1,0> hexane
139048-20-7

1,2-diphenyl-2-hydroxy-3-oxabicyclo <3,1,0> hexane

Conditions
ConditionsYield
In diethyl ether for 1.5h; Heating;47%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(+)-2-Hydroxymethyl-1-phenylcyclopropanecarboxylic acid (1-phenylethyl)amide

(+)-2-Hydroxymethyl-1-phenylcyclopropanecarboxylic acid (1-phenylethyl)amide

(-)-2-Hydroxymethyl-1-phenylcyclopropanecarboxylic acid (1-phenylethyl)amide

(-)-2-Hydroxymethyl-1-phenylcyclopropanecarboxylic acid (1-phenylethyl)amide

Conditions
ConditionsYield
With 2-hydroxypyridin In toluene for 24h; Heating;A 33%
B 32%
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

A

2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid

B

(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one
63106-93-4, 96847-52-8, 96847-75-5, 96847-53-9

(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

Conditions
ConditionsYield
With Cunninghamella blakesleeana; water In N,N-dimethyl-formamide at 30℃; for 41h; biohydrolysis, pH 8;A n/a
B 32%
NH-pyrazole
288-13-1

NH-pyrazole

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1R,2S)-1-Phenyl-2-pyrazol-1-ylmethyl-cyclopropanecarboxylic acid
141402-58-6

(1R,2S)-1-Phenyl-2-pyrazol-1-ylmethyl-cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 60 deg C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
2-methyl-1H-pyrrole
636-41-9

2-methyl-1H-pyrrole

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1S,2R)-2-(2-Methyl-pyrrol-1-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid
141402-55-3

(1S,2R)-2-(2-Methyl-pyrrol-1-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 60 deg C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
indole
120-72-9

indole

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1R,2S)-2-Indol-1-ylmethyl-1-phenyl-cyclopropanecarboxylic acid
141402-56-4

(1R,2S)-2-Indol-1-ylmethyl-1-phenyl-cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 60 deg C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
methanol
67-56-1

methanol

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(+/-)-methyl cis-2-(bromomethyl)-1-phenylcyclopropanecarboxylate
105310-48-3

(+/-)-methyl cis-2-(bromomethyl)-1-phenylcyclopropanecarboxylate

Conditions
ConditionsYield
With dibromo sulfoxide at -15 - 20℃;
propan-1-ol
71-23-8

propan-1-ol

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

n-propyl (1R,2S/1S,2R)-2-(chloromethyl)-1-phenylcyclopropanecarboxylate
105310-50-7

n-propyl (1R,2S/1S,2R)-2-(chloromethyl)-1-phenylcyclopropanecarboxylate

Conditions
ConditionsYield
With thionyl chloride at -15 - 20℃;
3-Methylindole
83-34-1

3-Methylindole

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1S,2R)-2-(3-Methyl-indol-1-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid
141402-57-5

(1S,2R)-2-(3-Methyl-indol-1-ylmethyl)-1-phenyl-cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 60 deg C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
pyrrole
109-97-7

pyrrole

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1R,2S)-1-Phenyl-2-pyrrol-1-ylmethyl-cyclopropanecarboxylic acid
141402-53-1

(1R,2S)-1-Phenyl-2-pyrrol-1-ylmethyl-cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydride 1.) DMF, 60 deg C, 1 h, 2.) DMF, 60 deg C, 5 h; Yield given. Multistep reaction;
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

isopropyl alcohol
67-63-0

isopropyl alcohol

(Z)-isopropyl 1-phenyl-2-(phthalimidomethyl)cyclopropanecarboxylate
105310-51-8

(Z)-isopropyl 1-phenyl-2-(phthalimidomethyl)cyclopropanecarboxylate

Conditions
ConditionsYield
With thionyl chloride at -15 - 20℃;
1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

diethylamine
109-89-7

diethylamine

(1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide
172015-99-5

(1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide

Conditions
ConditionsYield
With n-butyllithium 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h; Yield given. Multistep reaction;
methanol
67-56-1

methanol

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one
63106-93-4

1-phenyl-3-oxa-bicyclo[3.1.0]hexan-2-one

(1R,2S)-2-Chloromethyl-1-phenyl-cyclopropanecarbonyl chloride

(1R,2S)-2-Chloromethyl-1-phenyl-cyclopropanecarbonyl chloride

Conditions
ConditionsYield
With thionyl chloride; zinc(II) chloride In benzene

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