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Benzene,1,3-difluoro-2-(trifluoromethyl)- cas 64248-60-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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3,5-dichloro-2,6-difluorobenzotrifluoride
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With sodium acetate In water; acetic acid |
2,6-difluoroaniline
trifluoromethylcopper(I)
A
1,3-Difluorobenzene
B
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 2,6-difluoroaniline With hydrogen fluoride; sodium nitrite In water; acetonitrile at 0℃; Inert atmosphere; Stage #2: trifluoromethylcopper(I) In water; N,N-dimethyl-formamide; acetonitrile at 0℃; for 0.25h; Inert atmosphere; Overall yield = 27 %Spectr.; |
piperazine
1,3-difluoro-2-(trifluoromethyl)benzene
1-(3-fluoro-2-(trifluoromethyl)phenyl)piperazine
Conditions | Yield |
---|---|
at 90℃; for 16h; | 73.4% |
carbon dioxide
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; diethyl ether at -70 - -65℃; for 1h; Stage #2: carbon dioxide In tetrahydrofuran; diethyl ether at -65 - 30℃; for 5h; Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether; water | 72% |
1,3-difluoro-2-(trifluoromethyl)benzene
(3-Fluoro-2-trifluoromethyl-phenyl)-hydrazine hydrochloride
Conditions | Yield |
---|---|
With hydrazine In dimethyl sulfoxide at 20℃; for 16h; | 67% |
1,3-difluoro-2-(trifluoromethyl)benzene
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; cyclohexane at -70℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; cyclohexane at -70℃; for 2h; | 65% |
Conditions | Yield |
---|---|
With potassium phosphate In N,N-dimethyl-formamide at 135℃; for 72h; | 40% |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: 2,3-dihydroimidazo[1,2-c]quinazolin-9-ol In N,N-dimethyl-formamide; mineral oil at 20℃; | 37% |
1,3-difluoro-2-(trifluoromethyl)benzene
1,3-difluoro-4-nitro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
With sulfuric acid; nitric acid | |
With sulfuric acid; nitric acid In dichloromethane |
5-(benzyloxy)-3H-imidazo[4,5-b]pyridine
1,3-difluoro-2-(trifluoromethyl)benzene
5-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; |
1,3-difluoro-2-(trifluoromethyl)benzene
4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C 1.2: 5 h / -65 - 30 °C 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C 3.1: triethylamine / dichloromethane / 1 h 3.2: 2 h 4.1: tetrahydrofuran / 2 h / 20 °C 5.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 5.2: 85 - 90 °C View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
2,4-difluoro-3-trifluoromethylbenzoyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C 1.2: 5 h / -65 - 30 °C 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C 1.2: 5 h / -65 - 30 °C 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C 3.1: triethylamine / dichloromethane / 1 h 3.2: 2 h View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale 4.2: 0.5 h / Large scale 4.3: 3 h / 0 - 5 °C / Large scale 5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 4.2: 24 h / Reflux 5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / toluene; mineral oil / 20 °C 4.2: 48 h / Reflux 5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With iron at 50 - 55℃; for 0.0833333h; Stage #2: With bromine at 50 - 70℃; for 2h; | 130 g |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / toluene; mineral oil / 0.5 h / 20 °C 4.2: 24 h / Reflux View Scheme | |
Multi-step reaction with 6 steps 1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C 1.2: 5 h / -65 - 30 °C 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C 3.1: triethylamine / dichloromethane / 1 h 3.2: 2 h 4.1: tetrahydrofuran / 2 h / 20 °C 5.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 5.2: 85 - 90 °C 6.1: sodium hydride / toluene; mineral oil / 0.5 h / 20 °C 6.2: 24 h / Reflux View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale 4.2: 0.5 h / Large scale 4.3: 3 h / 0 - 5 °C / Large scale View Scheme | |
Multi-step reaction with 4 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 4.2: 24 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / toluene; mineral oil / 20 °C 4.2: 48 h / Reflux View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale 4.2: 0.5 h / Large scale 4.3: 3 h / 0 - 5 °C / Large scale 5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / toluene; mineral oil / 20 °C 4.2: 48 h / Reflux 5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 4.2: 24 h / Reflux 5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale 4.2: 0.5 h / Large scale 4.3: 3 h / 0 - 5 °C / Large scale 5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / toluene; mineral oil / 20 °C 4.2: 48 h / Reflux 5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C 3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C 3.2: 85 - 90 °C 4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C 4.2: 24 h / Reflux 5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: iron / 0.08 h / 50 - 55 °C 1.2: 2 h / 50 - 70 °C 2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C 2.2: 0.5 h / 25 - 30 °C 2.3: 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C 1.2: 5 h / -65 - 30 °C 2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C 3.1: triethylamine / dichloromethane / 1 h 3.2: 2 h 4.1: tetrahydrofuran / 2 h / 20 °C View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere 1.2: 2 h / -70 °C 2.1: triethylamine / dichloromethane / -50 - 20 °C View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere 1.2: 2 h / -70 °C 2.1: triethylamine / dichloromethane / -50 - 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere 1.2: 2 h / -70 °C 2.1: triethylamine / dichloromethane / -50 - 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C 4.1: lithium hydroxide monohydrate; water / methanol / 5 h / 40 °C 4.2: pH 3 View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere 3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere 3.2: 2 h / 200 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere 3.1: potassium hydroxide / 72 h / Reflux; Inert atmosphere 4.1: N-ethylmorpholine; / ethanol / 16 h / Reflux View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere 3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere 3.2: 2 h / 200 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere 3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere 3.2: 2 h / 200 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere View Scheme |
1,3-difluoro-2-(trifluoromethyl)benzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere 1.2: 16 h / 20 °C / Inert atmosphere 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere 3.1: potassium hydroxide / 72 h / Reflux; Inert atmosphere View Scheme |
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