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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the business

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Benzene,1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2,6-Difluorobenzotrifluoride / LIDE PHARMA- Factory supply / Best price

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM_2,6-Difluorobenzotrifluoride 64248-60-8

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 64248-60-8 with competitive price

Cas:64248-60-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzene,1,3-difluoro-2-(trifluoromethyl)- 64248-60-8

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,6-Difluorobenzotrifluoride CAS:64248-60-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

2,6-Difluorobenzotrifluoride CAS:64248-60-8

Cas:64248-60-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzene,1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzene,1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzene,1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,6-difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

1,3-Difluoro-2-(trifluoromethyl)benzene

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,6-Difluorobenzotrifluoride cas no. 64248-60-8 98%

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

1,3-Difluoro-2-(trifluoroMethyl)benzene

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzene,1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2,6-Difluorobenzotrifluoride CAS No.64248-60-8

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:White to beige crystals Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use a

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Benzene,1,3-difluoro-2-(trifluoromethyl)- cas 64248-60-8Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Benzene,1,3-difluoro-2-(trifluoromethyl)- cas 64248-60-8

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Other

inquiry

NANJING SUNNY PHARMATECH CO., LTD

We are professional supplier in China for this product, we are dedicated to providing customers with the best quality, price, and service. Please feel free to send us inquiries.Appearance:Please contact us for product details Package:As per shipment

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2,6-Difluorobenzotrifluoride

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

64248-60-8 Application:intermediate

Benzene, 1,3-difluoro-2-(trifluoromethyl)-

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

64248-60-8

Cas:64248-60-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

palladium on A-charcoal

palladium on A-charcoal

3,5-dichloro-2,6-difluorobenzotrifluoride
112860-78-3

3,5-dichloro-2,6-difluorobenzotrifluoride

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sodium acetate In water; acetic acid
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

trifluoromethylcopper(I)
77152-08-0

trifluoromethylcopper(I)

A

1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

B

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With hydrogen fluoride; sodium nitrite In water; acetonitrile at 0℃; Inert atmosphere;
Stage #2: trifluoromethylcopper(I) In water; N,N-dimethyl-formamide; acetonitrile at 0℃; for 0.25h; Inert atmosphere; Overall yield = 27 %Spectr.;
piperazine
110-85-0

piperazine

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

1-(3-fluoro-2-(trifluoromethyl)phenyl)piperazine
946399-80-0

1-(3-fluoro-2-(trifluoromethyl)phenyl)piperazine

Conditions
ConditionsYield
at 90℃; for 16h;73.4%
carbon dioxide
124-38-9

carbon dioxide

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

2,4-difluoro-3-(trifluoromethyl)benzoic acid

2,4-difluoro-3-(trifluoromethyl)benzoic acid

Conditions
ConditionsYield
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; diethyl ether at -70 - -65℃; for 1h;
Stage #2: carbon dioxide In tetrahydrofuran; diethyl ether at -65 - 30℃; for 5h;
Stage #3: With hydrogenchloride In tetrahydrofuran; diethyl ether; water
72%
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

(3-Fluoro-2-trifluoromethyl-phenyl)-hydrazine hydrochloride
952233-12-4

(3-Fluoro-2-trifluoromethyl-phenyl)-hydrazine hydrochloride

Conditions
ConditionsYield
With hydrazine In dimethyl sulfoxide at 20℃; for 16h;67%
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2,4-difluoro-3-(trifluoromethyl)benzaldehyde

2,4-difluoro-3-(trifluoromethyl)benzaldehyde

Conditions
ConditionsYield
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With n-butyllithium In tetrahydrofuran; cyclohexane at -70℃; for 0.5h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; cyclohexane at -70℃; for 2h;
65%
1H-imidazole
288-32-4

1H-imidazole

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

C13H9F3N4

C13H9F3N4

Conditions
ConditionsYield
With potassium phosphate In N,N-dimethyl-formamide at 135℃; for 72h;40%
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

2,3-dihydroimidazo[1,2-c]quinazolin-9-ol

2,3-dihydroimidazo[1,2-c]quinazolin-9-ol

9-(3-fluoro-2-(trifluoromethyl)phenoxy)-2,3-dihydroimidazo[1,2-c]quinazoline

9-(3-fluoro-2-(trifluoromethyl)phenoxy)-2,3-dihydroimidazo[1,2-c]quinazoline

Conditions
ConditionsYield
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h;
Stage #2: 2,3-dihydroimidazo[1,2-c]quinazolin-9-ol In N,N-dimethyl-formamide; mineral oil at 20℃;
37%
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

1,3-difluoro-4-nitro-2-(trifluoromethyl)benzene
123973-36-4

1,3-difluoro-4-nitro-2-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid In dichloromethane
5-(benzyloxy)-3H-imidazo[4,5-b]pyridine
1217349-81-9

5-(benzyloxy)-3H-imidazo[4,5-b]pyridine

1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

5-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine
1217350-42-9

5-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃;
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
957125-35-8

4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C
1.2: 5 h / -65 - 30 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dichloromethane / 1 h
3.2: 2 h
4.1: tetrahydrofuran / 2 h / 20 °C
5.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
5.2: 85 - 90 °C
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

2,4-difluoro-3-trifluoromethylbenzoyl chloride
157337-87-6

2,4-difluoro-3-trifluoromethylbenzoyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C
1.2: 5 h / -65 - 30 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

2,4-difluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide

2,4-difluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C
1.2: 5 h / -65 - 30 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dichloromethane / 1 h
3.2: 2 h
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

potassium N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

potassium N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale
4.2: 0.5 h / Large scale
4.3: 3 h / 0 - 5 °C / Large scale
5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
4.2: 24 h / Reflux
5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / toluene; mineral oil / 20 °C
4.2: 48 h / Reflux
5.1: potassium tert-butylate / tert-butyl alcohol; pentane / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene

1-bromo-2,4-difluoro-3-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: 1,3-difluoro-2-(trifluoromethyl)benzene With iron at 50 - 55℃; for 0.0833333h;
Stage #2: With bromine at 50 - 70℃; for 2h;
130 g
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-4-[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)thio]-3-oxobutanamide

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-4-[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)thio]-3-oxobutanamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / toluene; mineral oil / 0.5 h / 20 °C
4.2: 24 h / Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C
1.2: 5 h / -65 - 30 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dichloromethane / 1 h
3.2: 2 h
4.1: tetrahydrofuran / 2 h / 20 °C
5.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
5.2: 85 - 90 °C
6.1: sodium hydride / toluene; mineral oil / 0.5 h / 20 °C
6.2: 24 h / Reflux
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide
1246761-03-4

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale
4.2: 0.5 h / Large scale
4.3: 3 h / 0 - 5 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
4.2: 24 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / toluene; mineral oil / 20 °C
4.2: 48 h / Reflux
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide sodium

N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide sodium

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale
4.2: 0.5 h / Large scale
4.3: 3 h / 0 - 5 °C / Large scale
5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / toluene; mineral oil / 20 °C
4.2: 48 h / Reflux
5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
4.2: 24 h / Reflux
5.1: sodium t-butanolate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

lithium N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

lithium N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)acetamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: dichloromethane / 0.08 h / 0 - 5 °C / Large scale
4.2: 0.5 h / Large scale
4.3: 3 h / 0 - 5 °C / Large scale
5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / toluene; mineral oil / 20 °C
4.2: 48 h / Reflux
5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
3.1: bromine; acetic acid / 0.5 h / 55 - 60 °C
3.2: 85 - 90 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
4.2: 24 h / Reflux
5.1: lithium hydroxide monohydrate / ethanol / 1 h / -5 - 0 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

1-[2,4-difluoro-3-(trifluoromethyl)phenyl]ethanone

1-[2,4-difluoro-3-(trifluoromethyl)phenyl]ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iron / 0.08 h / 50 - 55 °C
1.2: 2 h / 50 - 70 °C
2.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C
2.2: 0.5 h / 25 - 30 °C
2.3: 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; diethyl ether / 1 h / -70 - -65 °C
1.2: 5 h / -65 - 30 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C
3.1: triethylamine / dichloromethane / 1 h
3.2: 2 h
4.1: tetrahydrofuran / 2 h / 20 °C
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

methyl 2-((3-fluoro-6-formyl-2-(trifluoromethyl)phenyl)thio)acetate

methyl 2-((3-fluoro-6-formyl-2-(trifluoromethyl)phenyl)thio)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere
1.2: 2 h / -70 °C
2.1: triethylamine / dichloromethane / -50 - 20 °C
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

methyl 6-fluoro-7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

methyl 6-fluoro-7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere
1.2: 2 h / -70 °C
2.1: triethylamine / dichloromethane / -50 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

6-fluoro-7-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid

6-fluoro-7-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -70 °C / Inert atmosphere
1.2: 2 h / -70 °C
2.1: triethylamine / dichloromethane / -50 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
4.1: lithium hydroxide monohydrate; water / methanol / 5 h / 40 °C
4.2: pH 3
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

ethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4-(trifluoromethyl)-2-2’-bipyridine-4’-carboxylate

ethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4-(trifluoromethyl)-2-2’-bipyridine-4’-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

ruthenium(II) bis(diethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2,2'-bipyridine-4,4'-dicarboxylate)

ruthenium(II) bis(diethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2,2'-bipyridine-4,4'-dicarboxylate)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere
3.2: 2 h / 200 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
3.1: potassium hydroxide / 72 h / Reflux; Inert atmosphere
4.1: N-ethylmorpholine; / ethanol / 16 h / Reflux
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

ruthenium(II) bis(ethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4-(trifluoromethyl)-2-2’-bipyridine-4’-carboxylate)

ruthenium(II) bis(ethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4-(trifluoromethyl)-2-2’-bipyridine-4’-carboxylate)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere
3.2: 2 h / 200 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

ruthenium(II) bis(6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4,4’-bis(trifluoromethyl)-2,2’-bipyridine)

ruthenium(II) bis(6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-4,4’-bis(trifluoromethyl)-2,2’-bipyridine)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
3.1: propyl cyanide; N-ethylmorpholine; / 16 h / 120 °C / Inert atmosphere
3.2: 2 h / 200 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

diethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2,2'-bipyridine-4,4'-dicarboxylate

diethyl 6-(2,4-difluoro-3-(trifluoromethyl)phenyl)-2,2'-bipyridine-4,4'-dicarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
View Scheme
1,3-difluoro-2-(trifluoromethyl)benzene
64248-60-8

1,3-difluoro-2-(trifluoromethyl)benzene

C29H25F5N5O4Ru(1+)*F6P(1-)

C29H25F5N5O4Ru(1+)*F6P(1-)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere
3.1: potassium hydroxide / 72 h / Reflux; Inert atmosphere
View Scheme

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