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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,6-Difluoroaniline Manufacturer/High quality/Best price/In stock

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Name 2,6-Difluoroaniline Synonyms 2,6-Difluorobenzenamine Molecular Structure Molecular Formula

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:250 Kilogram

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,6-Difluorobenzeneamine

Cas:5509-65-9

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Medicine intermediate 2 6-Difluoroaniline CAS No.: 5509-65-9

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

2,6-Difluoroaniline Basic information Product Name: 2,6-Difluoroaniline Synonyms: Benzenamine, 2,6-difluoro-;2,6-DIFLUOROANILINE;2,6-DIFLUOROBENZENAMINE;2,6-DIFLUOROANILINE, 97+%;2,6-Dif

2,6-Difluoroaniline 5509-65-9

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 5509-65-9 with fast shipping

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name 2,6-Difluoroaniline Identification Synonyms 2,6-Difluorobenzenamine Molecular Formula C6H5F2N Molecular Weight 129.11 CAS Number 5509-65-9 EINECS/ELINCS 226-853-0 Appearance: Clear yellow liquid Storage:Preserve in well-closed, light-re

2,6-Difluoroaniline CAS:5509-65-9

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his products from many recent effective packing ways;

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white or off-white powder Storage:Store in sealed containers

Intermediate 2,6-Difluoroaniline 5509-65-9

Cas:5509-65-9

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,6-Difluoroaniline 5509-65-9

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2, 6-Difluoroaniline CAS :5509-65-9

Cas:5509-65-9

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Organic synthesis intermediate, 2,6-Difluoroaniline CAS:5509-65-9

Cas:5509-65-9

Min.Order:1 Kilogram

FOB Price: $48.2 / 51.6

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2,6-DifluoroanilineCAS:5509-65-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

2,6-DifluoroanilineCAS:5509-65-9

Cas:5509-65-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

High purity 2,6-Difluoroaniline with best quality CAS NO.5509-65-9 CAS NO.5509-65-9

Cas:5509-65-9

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

2,6-Difluoroaniline CAS:5509-65-9 Specification Item Standard Test Results Identification A.H-NMR:Comply with the structure Complies B.LC-MS:Comply with t

Factory Supply 2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,6-DIFLUOROANILINE

Cas:5509-65-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,6-Difluoroaniline/Manufacturer/High quality/Best price

Cas:5509-65-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2,6-Difluoroaniline CAS No.:5509-65-9 Molecule Formula:C6H5F2N Molecule Weight:129.11 Purity: 99.0% Package: 200kg/drum Description:Light yellow to brown liquid Manufacture Standards:Enterprise Standard

High Quality 2,6-Difluoroaniline

Cas:5509-65-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2,6-Difluoroaniline Manufacturer/High quality/Best price/In stock

Cas:5509-65-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

2,6-difluorobenzamide
18063-03-1

2,6-difluorobenzamide

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With sodium hypochlorite; sodium hydroxide In water at -5℃; for 2h; Reagent/catalyst; Hofmann Rearrangement; Large scale; Green chemistry;92%
With sodium hypochlorite; sodium hydroxide at -5℃; for 1.5h; Large scale;89.6%
1-chloro-2,6-difluorobenzene
38361-37-4

1-chloro-2,6-difluorobenzene

A

ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

B

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With ammonium hydroxide; copper(I) oxide at 160℃; for 24h; bomb; Further byproducts given;A 2%
B 71%
2-azido-1,3-difluorobenzene
102284-85-5

2-azido-1,3-difluorobenzene

toluene
108-88-3

toluene

A

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

B

N-benzyl-2,6-difluoroaniline

N-benzyl-2,6-difluoroaniline

C

cis-1,2-bis(2,6-difluorophenyl)diazene

cis-1,2-bis(2,6-difluorophenyl)diazene

Conditions
ConditionsYield
With naphtophenone at 25℃; for 4h; Product distribution; Irradiation; further tenmperatures;A 54%
B 13%
C 10%
2,6-difluorobenzoic acid
385-00-2

2,6-difluorobenzoic acid

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With sodium azide; sulfuric acid
1-chloro-3,5-difluorobenzene
1435-43-4

1-chloro-3,5-difluorobenzene

A

2,4-difluorophenylamine
367-25-9

2,4-difluorophenylamine

B

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
1,2,3-trichlorobenzene
87-61-6

1,2,3-trichlorobenzene

A

2,3-difluoroanilline
4519-40-8

2,3-difluoroanilline

B

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With ammonium hydroxide; cesium fluoride; copper(I) oxide 1.) N,N'-dimethylethyleneurea, 250 deg C (bomb), 12 h, 2.) 170 deg C (bomb), 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
With ammonium hydroxide; cesium fluoride; copper(I) oxide 1.) N,N'-dimethylethyleneurea, 250 deg C (bomb), 12 h, 2.) 160 deg C (bomb), 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
1,2,3-trichlorobenzene
87-61-6

1,2,3-trichlorobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) CsF, 2.) H2, N-ethyldiethanolamine / 2.) 10percent Pd/C / 1.) N,N'-dimethylethyleneurea, 250 deg C (bomb), 12 h, 2.) ethylene glycol, 100 deg C, 200 psi
2: 71 percent / conc. NH4OH / Cu2O / 24 h / 160 °C / bomb
View Scheme
Multi-step reaction with 2 steps
1: CsF / various solvent(s) / 12 h / 250 °C / reaction carried out in a bomb
2: 71 percent / conc. NH4OH / Cu2O / 24 h / 160 °C / bomb
View Scheme
1,3,5-trichlorobenzene
108-70-3

1,3,5-trichlorobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: KF / various solvent(s) / 12 h / 300 °C
View Scheme
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) nBuLi, (ii) /BRN= 1900390/
2: NaN3, H2SO4
View Scheme
2-Fluoroaniline
348-54-9

2-Fluoroaniline

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(I) bromide; pyridine / toluene / 20 h / 60 °C
2.1: potassium nitrate; bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 12 h / 90 °C / Sealed tube
2.2: 0.17 h / 20 °C
View Scheme
aniline
62-53-3

aniline

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: copper(I) bromide; pyridine / toluene / 20 h / 60 °C
2.1: potassium nitrate; bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethanol / 12 h / 55 °C / Sealed tube
2.2: 0.17 h / 20 °C
3.1: copper(I) bromide; pyridine / toluene / 20 h / 60 °C
4.1: potassium nitrate; bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 12 h / 90 °C / Sealed tube
4.2: 0.17 h / 20 °C
View Scheme
2,2'-difluoroazobenzene
401-44-5

2,2'-difluoroazobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Stage #1: 2,2'-difluoroazobenzene With N-fluorobis(benzenesulfon)imide; potassium nitrate; bis(dibenzylideneacetone)-palladium(0) In ethyl acetate at 90℃; for 12h; Sealed tube;
Stage #2: With sodium tetrahydroborate; copper(l) chloride In ethanol at 20℃; for 0.166667h;
41.3 mg
Multi-step reaction with 2 steps
1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
Azobenzene
1227476-15-4

Azobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium nitrate; bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethanol / 12 h / 55 °C / Sealed tube
1.2: 0.17 h / 20 °C
2.1: copper(I) bromide; pyridine / toluene / 20 h / 60 °C
3.1: potassium nitrate; bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 12 h / 90 °C / Sealed tube
3.2: 0.17 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C
2: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
3: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
C15H14F2N2

C15H14F2N2

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With sodium tetrahydroborate; copper(l) chloride In ethanol at 20℃;23.2 mg
Pd2(azobenzene)2Cl2

Pd2(azobenzene)2Cl2

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethyl acetate / 2 h / 20 °C / Sealed tube
2: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C
3: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
4: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-fluorobis(benzenesulfon)imide / ethyl acetate / 2 h / 20 °C / Sealed tube
2: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C
3: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
4: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: dichloromethane / 24 h / 20 °C
2: ethyl acetate / 2 h / 20 °C / Sealed tube
3: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C
4: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
5: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
C14H12N4O2Pd

C14H12N4O2Pd

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethyl acetate / 2 h / 20 °C / Sealed tube
2: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C
3: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 105 °C / Sealed tube
4: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
1-(2,4,6-trimethylphenyl)-2-phenyldiazene
20488-57-7, 20488-58-8, 29418-26-6

1-(2,4,6-trimethylphenyl)-2-phenyldiazene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 100 °C / Sealed tube
2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
View Scheme
2,2',6-trifluoroazobenzene

2,2',6-trifluoroazobenzene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Conditions
ConditionsYield
With sodium tetrahydroborate; copper(l) chloride In ethanol at 20℃;24.8 mg
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

1,3-difluoro-2-nitrosobenzene
29270-54-0

1,3-difluoro-2-nitrosobenzene

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 23℃; Inert atmosphere;100%
With Oxone In dichloromethane; water at 20℃; for 15h;99%
With potassium peroxymonosulfate sulfate In dichloromethane; water at 20℃; for 24h;86.49%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2,6-difluoro-4-iodoaniline
141743-49-9

2,6-difluoro-4-iodoaniline

Conditions
ConditionsYield
With N-iodo-succinimide; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 5 - 20℃; for 2.5h;100%
With Iodine monochloride In acetic acid at 20℃; for 0.25h;95%
Stage #1: 2,6-difluoroaniline With Iodine monochloride; acetic acid In water at 20℃; for 0.25h;
Stage #2: With sodium carbonate In water
95%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-((2,6-difluorophenyl)amino)-2-oxoacetate
648408-62-2

ethyl 2-((2,6-difluorophenyl)amino)-2-oxoacetate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 24h;100%
With triethylamine In tetrahydrofuran at 0℃; for 16h; Inert atmosphere;
thiophosgene
463-71-8

thiophosgene

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2,6-difluorophenylisothiocyanate
207974-17-2

2,6-difluorophenylisothiocyanate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;99%
With hydrogenchloride In dichloromethane for 3h; Ambient temperature;78%
In hydrogenchloride; dichloromethane
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

4-bromo-2,6-difluoroaniline
67567-26-4

4-bromo-2,6-difluoroaniline

Conditions
ConditionsYield
With N-Bromosuccinimide In acetonitrile at 20℃;99%
With N-Bromosuccinimide In chloroform at 20℃;93%
Stage #1: 2,6-difluoroaniline With bromine; acetic acid In water at 20℃; for 0.25h;
Stage #2: With sodium carbonate In water
92%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

acetic anhydride
108-24-7

acetic anhydride

N-(2,6-difluorophenyl)acetamide
3896-29-5

N-(2,6-difluorophenyl)acetamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h;98%
In toluene at 0 - 20℃; for 4h; Solvent; Temperature;94%
91%
3,5-diodosalicylaldehyde
2631-77-8

3,5-diodosalicylaldehyde

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

N-(3',5'-diiodo-salycilidene)-2,6-difluoroaniline

N-(3',5'-diiodo-salycilidene)-2,6-difluoroaniline

Conditions
ConditionsYield
With trifluoroacetic acid In toluene at 120℃; for 16h;98%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

potassium ethyl xanthogenate
140-89-6

potassium ethyl xanthogenate

2-mercapto-4-fluorobenzothiazole
154327-24-9

2-mercapto-4-fluorobenzothiazole

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 0.133333h; microwave irradiation;98%
In N,N-dimethyl-formamide at 120℃; for 3.5h; Inert atmosphere;98%
In N,N-dimethyl-formamide at 120℃; for 3.5h; Inert atmosphere;98%
In 1-methyl-pyrrolidin-2-one at 90℃; for 2h;56%
In N,N-dimethyl-formamide at 120℃; for 4h;
methyl 3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)amino]-4-pyrimidinyl}imidazo[1,2-a]pyridin-2-yl)benzoate
1089278-91-0

methyl 3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)amino]-4-pyrimidinyl}imidazo[1,2-a]pyridin-2-yl)benzoate

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

N-(2,6-difluorophenyl)-3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)amino]-4-pyrimidinyl}imidazo[1,2-a]pyridin-2-yl)benzamide
1089278-89-6

N-(2,6-difluorophenyl)-3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)amino]-4-pyrimidinyl}imidazo[1,2-a]pyridin-2-yl)benzamide

Conditions
ConditionsYield
Stage #1: methyl 3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}-2-methylphenyl)amino}-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl)benzoate; 2,6-difluoroaniline With sodium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.0833333h;
Stage #2: With sodium hydrogencarbonate In tetrahydrofuran; water
98%
4-iodoanisol
529-28-2

4-iodoanisol

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2,6-difluoro-N-(2-methoxyphenyl)aniline

2,6-difluoro-N-(2-methoxyphenyl)aniline

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 100℃; Buchwald-Hartwig Coupling; Inert atmosphere;98%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;96%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine In toluene at 100℃; Inert atmosphere;
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

acetylacetone
123-54-6

acetylacetone

3-(2-(2,6-difluorophenyl)hydrazono)pentane-2,4-dione

3-(2-(2,6-difluorophenyl)hydrazono)pentane-2,4-dione

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h;
Stage #2: acetylacetone With sodium acetate In methanol; water at 20℃;
98%
Stage #1: 2,6-difluoroaniline With hydrogenchloride; acetic acid; sodium nitrite In water at 0℃; for 0.75h;
Stage #2: acetylacetone With sodium acetate In ethanol; water for 1h;
94%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

acetylacetone
123-54-6

acetylacetone

C11H10F2N2O2

C11H10F2N2O2

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h;
Stage #2: acetylacetone With sodium acetate In ethanol; water at 0 - 20℃; for 10h;
98%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2-nitrobenzyl chloride
610-14-0

2-nitrobenzyl chloride

N-(2,6-difluorophenyl)-2-nitrobenzamide
936025-10-4

N-(2,6-difluorophenyl)-2-nitrobenzamide

Conditions
ConditionsYield
In 1,4-dioxane at 20℃;97%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

C12H16BF2NO2

C12H16BF2NO2

Conditions
ConditionsYield
In [D3]acetonitrile at 20℃; for 6h; Inert atmosphere;97%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

acetaldehyde
75-07-0

acetaldehyde

N-ethyl-2,6-difluoroaniline
13800-03-8

N-ethyl-2,6-difluoroaniline

Conditions
ConditionsYield
Stage #1: acetaldehyde With sodium tetrahydroborate; acetic acid In 1,2-dichloro-ethane at 0 - 20℃; for 1h;
Stage #2: 2,6-difluoroaniline In 1,2-dichloro-ethane at 20℃;
97%
2-bromothiazole-4-carboxylic Acid
5198-88-9

2-bromothiazole-4-carboxylic Acid

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2-bromo-N-(2,6-difluorophenyl)thiazole-4-carboxamide

2-bromo-N-(2,6-difluorophenyl)thiazole-4-carboxamide

Conditions
ConditionsYield
Stage #1: 2-bromothiazole-4-carboxylic Acid With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2,6-difluoroaniline In N,N-dimethyl-formamide at 20℃; for 16h;
96%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

4-bromo-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzoyl chloride

4-bromo-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzoyl chloride

4-bromo-N-(2,6-difluorophenyl)-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide

4-bromo-N-(2,6-difluorophenyl)-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;96%
With triethylamine In dichloromethane at 20℃; for 1h;96%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2-(4-bromophenyl)benzothiazole
19654-19-4

2-(4-bromophenyl)benzothiazole

N-(4-(benzo[d]thiazol-2-yl)phenyl)-2,6-difluoroaniline

N-(4-(benzo[d]thiazol-2-yl)phenyl)-2,6-difluoroaniline

Conditions
ConditionsYield
With C47H70BrO4PPdSi; sodium t-butanolate In tetrahydrofuran at 20℃; for 1h; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere; Sealed tube;96%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2-(bromomethyl)benzonitrile
22115-41-9

2-(bromomethyl)benzonitrile

2-(2,6-difluorophenyl)-2,3-dihydro-isoindol-1-ylideneamine hydrobromide

2-(2,6-difluorophenyl)-2,3-dihydro-isoindol-1-ylideneamine hydrobromide

Conditions
ConditionsYield
at 150℃; for 16h; Schlenk technique; Inert atmosphere;95.3%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

pivaloyl chloride
3282-30-2

pivaloyl chloride

N-(2,6-difluorophenyl)trimethylacetamide
1240020-41-0

N-(2,6-difluorophenyl)trimethylacetamide

Conditions
ConditionsYield
With triethylamine In toluene at 0 - 50℃;95%
In toluene at 20℃; Reflux;
2-chlorosulfonyl-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine
147150-78-5

2-chlorosulfonyl-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

florasulam
145701-23-1

florasulam

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With N-chloro-succinimide; dimethylsulfide In acetonitrile at -20℃; Inert atmosphere;
Stage #2: 2-chlorosulfonyl-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine With 3-Methylpyridine In acetonitrile at 20 - 40℃; Temperature; Inert atmosphere;
94.2%
In propylene glycol at 40℃; for 1.5h; Product distribution / selectivity;88%
In propylene glycol; dichloromethane at 25 - 45℃; for 5.5 - 8h; Product distribution / selectivity;84.6%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

N-sulfinyl-2,6-diflouroaniline
80829-40-9

N-sulfinyl-2,6-diflouroaniline

Conditions
ConditionsYield
With N-(chlorosulfinyl)imidazole In dichloromethane at -40 - 20℃; for 1.5h; Inert atmosphere;94%
With thionyl chloride
4-methoxypyridine
620-08-6

4-methoxypyridine

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

N-(2,6-difluorophenyl)pyridin-4-amine

N-(2,6-difluorophenyl)pyridin-4-amine

Conditions
ConditionsYield
With potassium hexamethylsilazane In tetrahydrofuran at 100℃; for 16h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;94%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

4-acetophenyl triflate
109613-00-5

4-acetophenyl triflate

1-(4-((2,6-difluorophenyl)amino)phenyl)ethan-1-one

1-(4-((2,6-difluorophenyl)amino)phenyl)ethan-1-one

Conditions
ConditionsYield
With C46H27F24FeNiP2(1+)*CF3O3S(1-); triethylamine In 2-methyltetrahydrofuran at 100℃; for 16h; Concentration; Schlenk technique; Inert atmosphere; Glovebox; Sealed tube;94%
o-benzenedisulfonimide
4482-01-3

o-benzenedisulfonimide

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

2,6-difluorobenzenediazonium o-benzenedisulfonimide

2,6-difluorobenzenediazonium o-benzenedisulfonimide

Conditions
ConditionsYield
With acetic acid; isopentyl nitrite at 0 - 5℃; Diazotization;93%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

2,6-difluoro-N-(2-nitrophenyl)aniline
1033225-43-2

2,6-difluoro-N-(2-nitrophenyl)aniline

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With sodium tert-amylate In tetrahydrofuran at 0 - 10℃; for 1.11667h; Large scale reaction;
Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran at 9 - 15℃; for 3h; Thermodynamic data; Concentration; Time; Large scale reaction;
93%
Stage #1: 2,6-difluoroaniline With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 0.166667h;
Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran; pentane at 0 - 20℃; for 0.5h;
68%
Stage #1: 2,6-difluoroaniline With sodium hydride In N,N-dimethyl-formamide for 0.5h;
Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide for 16h;
2-chloro-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine
1422126-58-6

2-chloro-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine

2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

C18H13F2N5
1431985-43-1

C18H13F2N5

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline With lithium hexamethyldisilazane In tetrahydrofuran at 0℃; for 1h;
Stage #2: 2-chloro-7-(1-methyl-1H-pyrazol-4-yl)-1,5-naphthyridine In tetrahydrofuran at 0 - 20℃;
93%
Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 70℃; for 3h; regioselective reaction;93%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

4-bromo-2,6-difluoroaniline
67567-26-4

4-bromo-2,6-difluoroaniline

(E)-1-(4-bromo-2,6-difluorophenyl)-2-(2,6-difluorophenyl)diazene

(E)-1-(4-bromo-2,6-difluorophenyl)-2-(2,6-difluorophenyl)diazene

Conditions
ConditionsYield
Stage #1: 2,6-difluoroaniline; 4-bromo-2,6-difluoroaniline With Oxone In dichloromethane; water at 20℃; for 17h; Inert atmosphere;
Stage #2: In acetic acid; toluene; trifluoroacetic acid at 20℃;
93%
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

acetyl chloride
75-36-5

acetyl chloride

N-(2,6-difluorophenyl)acetamide
3896-29-5

N-(2,6-difluorophenyl)acetamide

Conditions
ConditionsYield
In toluene at 0 - 20℃; for 4h;93%

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