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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Diclofensine 67165-56-4 GMP Manufacturer

Cas:67165-56-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Diclofensine in stock

Cas:67165-56-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Diclofensine

Cas:67165-56-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Diclofensine 67165-56-4

Cas:67165-56-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Diclofensine CAS:67165-56-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Diclofensine CAS:67165-56-4

Cas:67165-56-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Diclofensine

Cas:67165-56-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LUKE

Superlist Name:Diclofensine Formula:17H17Cl2NO" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51);">C17H17Cl2NO Synonyms:… Appearance:white pwoder Storage:Kept in a cool, dry and ventilated place Package:Aluminum foi

Diclofensine

Cas:67165-56-4

Min.Order:2 Gram

Negotiable

Type:Trading Company

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Diclofensine

Cas:67165-56-4

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-3,4-dihydro-1h-isoquinoline

Cas:67165-56-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr

Diclofensine

Cas:67165-56-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Diclofensine

Cas:67165-56-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Diclofensine in stock

Cas:67165-56-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

DiclofensineCAS NO.: 67165-56-4

Cas:67165-56-4

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

In Bulk SupplyDiclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

(+/-)-Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Diclofensine

Cas:67165-56-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-(3,4-Dichlorophenyl)-7-Methoxy-2-Methyl-1,2,3,4-tetrahydroisoquinoline

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC Diclofensine 67165-56-4

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DALIAN BAIJIA IMPORT AND EXPORT CO., LTD

this cargo is produce by our lab that is good cargo for sold now Diclofensine(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。 Package:foil pack Application:Diclofensine(Ro-8-4650) is a highly effective monoamine reuptak

Diclofensine

Cas:67165-56-4

Min.Order:100 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

DiclofensineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Diclofensine

Cas:67165-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol
802051-24-7

1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol

A

4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
692248-97-8

4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

B

Diclofensine
67165-56-4

Diclofensine

Conditions
ConditionsYield
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h;
Stage #2: With sodium hydroxide In dichloromethane pH=9;
A 10%
B 59%
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h;
Stage #2: With sodium hydroxide In dichloromethane pH=~ 9;
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane; water at 0℃; for 28h;
Stage #2: With sodium hydroxide In dichloromethane; water pH=~ 9;
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone
1254941-88-2

1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone

Diclofensine
67165-56-4

Diclofensine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C
2.2: pH ~ 9
View Scheme
1-(3-methoxyphenyl)-N-methylmethanamine
41789-95-1

1-(3-methoxyphenyl)-N-methylmethanamine

Diclofensine
67165-56-4

Diclofensine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane / 1 h / 0 °C
1.2: 1 h / 0 °C
2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
3.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C
3.2: pH ~ 9
View Scheme
3-methoxy-benzaldehyde
591-31-1

3-methoxy-benzaldehyde

Diclofensine
67165-56-4

Diclofensine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C
2.1: dichloromethane / 1 h / 0 °C
2.2: 1 h / 0 °C
3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
4.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C
4.2: pH ~ 9
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

(+)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With CHIRALPAK AD Purification / work up; Resolution of racemate;
With Chiralpak AD column In diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate;
carbonochloridic acid 1-chloro-ethyl ester
50893-53-3

carbonochloridic acid 1-chloro-ethyl ester

Diclofensine
67165-56-4

Diclofensine

C19H18Cl3NO3

C19H18Cl3NO3

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dichloro-ethane Reflux;
Diclofensine
67165-56-4

Diclofensine

A

(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
50560-45-7

(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

B

(S)-diclofensine
50560-38-8

(S)-diclofensine

Conditions
ConditionsYield
With Chiralpak AD column In n-heptane; diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate;
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
1255925-44-0

4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
View Scheme
Diclofensine
67165-56-4

Diclofensine

7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline
1254941-99-5

7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C
7: methanol / 1 h / Reflux
View Scheme
Multi-step reaction with 9 steps
1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6.1: methanol / 1 h / Reflux
7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication
9.1: hydrogenchloride / ethanol; water / 1 h / 20 °C
9.2: pH 8 - 9
View Scheme
Diclofensine
67165-56-4

Diclofensine

tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
1254942-01-2

tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C
7: methanol / 1 h / Reflux
8: N,N-dimethyl-formamide / 1 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
7: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

(+)-tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

(-)-tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

(-)-tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C
7: methanol / 1 h / Reflux
8: N,N-dimethyl-formamide / 1 h / 20 °C
9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate
View Scheme
Multi-step reaction with 9 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
7: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication
9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline monohydrochloride

(+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline monohydrochloride

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C
7: methanol / 1 h / Reflux
8: N,N-dimethyl-formamide / 1 h / 20 °C
9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate
10: hydrogenchloride / ethanol; dichloromethane / 2 h / 70 °C / Reflux
View Scheme
Multi-step reaction with 10 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
7: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication
9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate
10: hydrogenchloride / ethanol; dichloromethane / 2 h / 70 °C / Reflux
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-7-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline L-tartrate

(+)-7-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline L-tartrate

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6.1: methanol / 1 h / Reflux
7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication
9.1: hydrogenchloride / ethanol; water / 1 h / 20 °C
9.2: pH 8 - 9
10.1: activated carbon / ethanol / 4 h / 20 - 70 °C
View Scheme
Multi-step reaction with 8 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C
7: methanol / 1 h / Reflux
8: activated carbon / ethanol / 4 h / 20 - 70 °C
View Scheme
Diclofensine
67165-56-4

Diclofensine

2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)benzonitrile

2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)benzonitrile

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 2.25 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
View Scheme
Diclofensine
67165-56-4

Diclofensine

5-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazin-2-amine

5-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
4: boron tribromide / dichloromethane / -78 - 0 °C
5: pyridine / dichloromethane
6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere
7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere
8: potassium carbonate / ethanol; dichloromethane
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
1255925-09-7

4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
5: methanol / 1 h / Reflux
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
1255924-39-0

4-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
5: methanol / 1 h / Reflux
6: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-4-(3,4-dichlorophenyl)-7-(pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

(+)-4-(3,4-dichlorophenyl)-7-(pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere
6: hydrazine hydrate / palladium 10% on activated carbon / ethanol / 5 h / 75 °C
7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-7-methoxy-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

4-(3,4-dichlorophenyl)-7-methoxy-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-ol

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
4: boron tribromide / dichloromethane / -78 - 0 °C
View Scheme
Diclofensine
67165-56-4

Diclofensine

C19H15Cl3F3NO5S

C19H15Cl3F3NO5S

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-4-(3,4-dichlorophenyl)-7-(6-(difluoromethoxy)pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

(+)-4-(3,4-dichlorophenyl)-7-(6-(difluoromethoxy)pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6.1: methanol / 1 h / Reflux
7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sonication
9.1: hydrogenchloride / ethanol; water / 20 °C
9.2: pH 8 - 9
View Scheme
Diclofensine
67165-56-4

Diclofensine

(+)-4-(3,4-dichlorophenyl)-7-(6-(trifluoromethyl)pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

(+)-4-(3,4-dichlorophenyl)-7-(6-(trifluoromethyl)pyridazin-3-yl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6.1: methanol / 1 h / Reflux
7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C
8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sonication
9.1: hydrogenchloride / water / 2.5 h / 20 °C
10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
10.2: pH ~ 9
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
4: boron tribromide / dichloromethane / -78 - 0 °C
5: pyridine / dichloromethane
6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere
View Scheme
Diclofensine
67165-56-4

Diclofensine

5-(4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazin-2-amine

5-(4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrazin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
4: boron tribromide / dichloromethane / -78 - 0 °C
5: pyridine / dichloromethane
6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere
7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

4-(3,4-dichlorophenyl)-2-(2-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux
2: methanol / 1 h / Reflux
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h
4: boron tribromide / dichloromethane / -78 - 0 °C
5: pyridine / dichloromethane
View Scheme
Diclofensine
67165-56-4

Diclofensine

7-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

7-([1,2,4]triazolo[1,5-α]pyridin-6-yl)-4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere
View Scheme
Diclofensine
67165-56-4

Diclofensine

C22H26BCl2NO2

C22H26BCl2NO2

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
View Scheme
Diclofensine
67165-56-4

Diclofensine

4-(3,4-dichlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline

4-(3,4-dichlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
View Scheme
Diclofensine
67165-56-4

Diclofensine

tert-butyl 4-(3,4-dichlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
1255925-45-1

tert-butyl 4-(3,4-dichlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
2: hydrogen bromide / water; acetic acid / 8 h / Reflux
3: pyridine / dichloromethane / 1 h / -78 - 0 °C
4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere
5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux
6: methanol / 1 h / Reflux
7: dmap; triethylamine / dichloromethane / 4 h / 20 °C
View Scheme
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