1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryDiclofensine CAS:67165-56-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Superlist Name:Diclofensine Formula:17H17Cl2NO" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51);">C17H17Cl2NO Synonyms:… Appearance:white pwoder Storage:Kept in a cool, dry and ventilated place Package:Aluminum foi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediates Tr
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
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inquiryWhy is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t
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this cargo is produce by our lab that is good cargo for sold now Diclofensine(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。 Package:foil pack Application:Diclofensine(Ro-8-4650) is a highly effective monoamine reuptak
Cas:67165-56-4
Min.Order:100 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryDiclofensineAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol
A
4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
B
Diclofensine
Conditions | Yield |
---|---|
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane pH=9; | A 10% B 59% |
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane pH=~ 9; | |
Stage #1: 1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol With sulfuric acid In dichloromethane; water at 0℃; for 28h; Stage #2: With sodium hydroxide In dichloromethane; water pH=~ 9; |
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 2.2: pH ~ 9 View Scheme |
1-(3-methoxyphenyl)-N-methylmethanamine
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dichloromethane / 1 h / 0 °C 1.2: 1 h / 0 °C 2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 3.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 3.2: pH ~ 9 View Scheme |
3-methoxy-benzaldehyde
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C 2.1: dichloromethane / 1 h / 0 °C 2.2: 1 h / 0 °C 3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C 4.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C 4.2: pH ~ 9 View Scheme |
Diclofensine
Conditions | Yield |
---|---|
With CHIRALPAK AD Purification / work up; Resolution of racemate; | |
With Chiralpak AD column In diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate; |
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dichloro-ethane Reflux; |
Diclofensine
A
(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
B
(S)-diclofensine
Conditions | Yield |
---|---|
With Chiralpak AD column In n-heptane; diethylamine; isopropyl alcohol Purification / work up; Resolution of racemate; |
Diclofensine
4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C View Scheme |
Diclofensine
7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux View Scheme | |
Multi-step reaction with 9 steps 1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux 3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C 4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6.1: methanol / 1 h / Reflux 7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication 9.1: hydrogenchloride / ethanol; water / 1 h / 20 °C 9.2: pH 8 - 9 View Scheme |
Diclofensine
tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux 8: N,N-dimethyl-formamide / 1 h / 20 °C View Scheme | |
Multi-step reaction with 8 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux 7: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux 8: N,N-dimethyl-formamide / 1 h / 20 °C 9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate View Scheme | |
Multi-step reaction with 9 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux 7: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication 9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux 8: N,N-dimethyl-formamide / 1 h / 20 °C 9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate 10: hydrogenchloride / ethanol; dichloromethane / 2 h / 70 °C / Reflux View Scheme | |
Multi-step reaction with 10 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux 7: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication 9: Chiralpak AS-H column / methanol; carbon dioxide; triethylamine / Resolution of racemate 10: hydrogenchloride / ethanol; dichloromethane / 2 h / 70 °C / Reflux View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux 3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C 4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6.1: methanol / 1 h / Reflux 7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; Sonication 9.1: hydrogenchloride / ethanol; water / 1 h / 20 °C 9.2: pH 8 - 9 10.1: activated carbon / ethanol / 4 h / 20 - 70 °C View Scheme | |
Multi-step reaction with 8 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere 6: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 19.33 h / 0 - 20 °C 7: methanol / 1 h / Reflux 8: activated carbon / ethanol / 4 h / 20 - 70 °C View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / 2.25 h / 0 °C / Reflux 6: methanol / 1 h / Reflux View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h 4: boron tribromide / dichloromethane / -78 - 0 °C 5: pyridine / dichloromethane 6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere 7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere 8: potassium carbonate / ethanol; dichloromethane View Scheme |
Diclofensine
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 5: methanol / 1 h / Reflux View Scheme |
Diclofensine
4-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 5: methanol / 1 h / Reflux 6: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere 6: hydrazine hydrate / palladium 10% on activated carbon / ethanol / 5 h / 75 °C 7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h 4: boron tribromide / dichloromethane / -78 - 0 °C View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux 3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C 4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6.1: methanol / 1 h / Reflux 7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sonication 9.1: hydrogenchloride / ethanol; water / 20 °C 9.2: pH 8 - 9 View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2.1: hydrogen bromide / water; acetic acid / 8 h / Reflux 3.1: pyridine / dichloromethane / 1 h / -78 - 0 °C 4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6.1: methanol / 1 h / Reflux 7.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C 8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere; Sonication 9.1: hydrogenchloride / water / 2.5 h / 20 °C 10.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 10.2: pH ~ 9 View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h 4: boron tribromide / dichloromethane / -78 - 0 °C 5: pyridine / dichloromethane 6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h 4: boron tribromide / dichloromethane / -78 - 0 °C 5: pyridine / dichloromethane 6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere 7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dichloro-ethane / Reflux 2: methanol / 1 h / Reflux 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h 4: boron tribromide / dichloromethane / -78 - 0 °C 5: pyridine / dichloromethane View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 1 h / 80 °C / Inert atmosphere View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere View Scheme |
Diclofensine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux View Scheme |
Diclofensine
tert-butyl 4-(3,4-dichlorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate 2: hydrogen bromide / water; acetic acid / 8 h / Reflux 3: pyridine / dichloromethane / 1 h / -78 - 0 °C 4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere 5: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.92 h / 0 °C / Reflux 6: methanol / 1 h / Reflux 7: dmap; triethylamine / dichloromethane / 4 h / 20 °C View Scheme |
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