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Hubei Langyou International Trading Co., Ltd

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powd

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

L-Tyrosine, 3-hydroxy-,methyl ester

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPANOIC ACID METHYL ESTERCASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPANOIC ACID METHYL ESTERCAS

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

L-Tyrosine,3-hydroxy-,methylester

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

7101-51-1

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoateAppearance:ask Storage:Keep in dry and cool condition Package:foil aluminium bag/vacuum packing Application:intermediates Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Jusheng Technology Co., Ltd.,

1,Best Quality: Our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other countries, and we have got very good feedback from our customers.so

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:10 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

(S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate7101-51-1

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Run-Biotech Co., Ltd.

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por

methyl 3-hydroxy-L-tyrosinate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

changchun tuocai technology co.,ltld

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoateAppearance:ask Storage:Keep in dry and cool condition Package:foil aluminium bag/vacuum packing Application:intermediates Transportation:by air or by sea

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Taizhou volsen chemical Co., Ltd

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ENAO Chemical Co, Limited

kodgyq8oAppearance:white powders Storage:Store at 2-8°C. Package:As per buyer requirement Application:Pharmaceuticals, Skincare, Medical Ingedients and others Transportation:By courier or By sea Port:As per buyer requirement

(S)-Methyl 2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Minshang Biotechnology Co., Ltd

Advanced and completed testing facilities Application:intermediates

7101-51-1

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai PengMo Biotechnology Co.,Ltd

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoateAppearance:ask Storage:Keep in dry and cool condition Package:foil aluminium bag/vacuum packing Application:intermediates Transportation:by air or by sea

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fenjun Chemical Co Ltd.

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Application:Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate

Cas:7101-51-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methanol
67-56-1

methanol

levodopa
59-92-7

levodopa

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃; Inert atmosphere;100%
With thionyl chloride Reflux;90%
With hydrogenchloride
L-Tyr-OMe
1080-06-4

L-Tyr-OMe

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
With 1,3,6,8-tetra-n-butylpyrimido<5,4-g>pteridine-2,4,5,7(1H,3H,6H,8H)-tetrone 10-oxide In acetonitrile for 0.666667h; Irradiation;25%
(+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine
7101-51-1, 41439-83-2, 71855-43-1

(+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine

A

levodopa
59-92-7

levodopa

B

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

C

(R)-(3,4-dihydroxyphenyl)alanine methyl ester
71855-43-1

(R)-(3,4-dihydroxyphenyl)alanine methyl ester

Conditions
ConditionsYield
With Alcalase; water In tert-butyl alcohol at 25℃; for 2.5h; pH=8.5; kinetic resolution; Title compound not separated from byproducts;
N-[(phenylmethoxy)carbonyl]-3-hydroxy-O-(phenylmethyl)-L-tyrosine methyl ester
105229-41-2

N-[(phenylmethoxy)carbonyl]-3-hydroxy-O-(phenylmethyl)-L-tyrosine methyl ester

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In dichloromethane
(S)-3-(3-Acetoxy-4-benzyloxy-phenyl)-2-benzyloxycarbonylamino-propionic acid methyl ester

(S)-3-(3-Acetoxy-4-benzyloxy-phenyl)-2-benzyloxycarbonylamino-propionic acid methyl ester

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 453 mg / NH3 / CH2Cl2; methanol / 1 h
2: H2 / Pd/C / CH2Cl2
View Scheme
L-tyrosine
60-18-4

L-tyrosine

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 67 percent / AlCl3 / nitrobenzene / 6 h / 100 °C
2: 74 percent / SOCl2 / Heating
3: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
4: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
5: mCPBA / CH2Cl2 / 40 °C
6: 453 mg / NH3 / CH2Cl2; methanol / 1 h
7: H2 / Pd/C / CH2Cl2
View Scheme
L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester
110774-03-3

L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
2: mCPBA / CH2Cl2 / 40 °C
3: 453 mg / NH3 / CH2Cl2; methanol / 1 h
4: H2 / Pd/C / CH2Cl2
View Scheme
(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride
32404-28-7

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 74 percent / SOCl2 / Heating
2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
4: mCPBA / CH2Cl2 / 40 °C
5: 453 mg / NH3 / CH2Cl2; methanol / 1 h
6: H2 / Pd/C / CH2Cl2
View Scheme
methyl (S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoate monohydrochloride
57085-32-2

methyl (S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoate monohydrochloride

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
2: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
3: mCPBA / CH2Cl2 / 40 °C
4: 453 mg / NH3 / CH2Cl2; methanol / 1 h
5: H2 / Pd/C / CH2Cl2
View Scheme
L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)alanine methyl ester
105205-69-4

L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)alanine methyl ester

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: mCPBA / CH2Cl2 / 40 °C
2: 453 mg / NH3 / CH2Cl2; methanol / 1 h
3: H2 / Pd/C / CH2Cl2
View Scheme
levodopa
59-92-7

levodopa

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
With thionyl chloride In methanol for 18h;
methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate
37169-36-1

methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

Diethyl ketomalonate
609-09-6

Diethyl ketomalonate

6,7-dihydroxy-3,4-dihydro-2H-isoquinoline-1,1,3-tricarboxylic acid diethyl ester methyl ester

6,7-dihydroxy-3,4-dihydro-2H-isoquinoline-1,1,3-tricarboxylic acid diethyl ester methyl ester

Conditions
ConditionsYield
With trifluoroacetic acid In toluene at 85℃; for 2h; Pictet-Spegler condensation;98%
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

3,4,5-trimethoxy-benzaldehyde
86-81-7

3,4,5-trimethoxy-benzaldehyde

(1S,3S)-6,7-Dihydroxy-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
128049-96-7

(1S,3S)-6,7-Dihydroxy-1-(3,4,5-trimethoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With sodium acetate In acetic acid for 18h; Ambient temperature;95%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate
37169-36-1

methyl (S)-2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)propanoate

Conditions
ConditionsYield
With triethylamine In methanol at 20℃;95%
With sodium hydrogencarbonate In tetrahydrofuran at 0 - 20℃; for 2h; Product distribution / selectivity;90%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1h;13.4 g
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester
138908-56-2

(S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester

Conditions
ConditionsYield
Stage #1: L-DOPA methyl ester With thionyl chloride In methanol at 50℃; for 3h; Inert atmosphere; Cooling with ice;
Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 1h; Cooling with ice;
Stage #3: With potassium carbonate; dimethyl sulfate In acetone at 20℃; Reflux;
94.4%
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(3aR,6R,6aR)-2,2-dimethyl-6-(tosyloxymethyl)-tetrahydro-2H-furo[3,4-d]-1,3-dioxol-4-ol
950182-24-8

(3aR,6R,6aR)-2,2-dimethyl-6-(tosyloxymethyl)-tetrahydro-2H-furo[3,4-d]-1,3-dioxol-4-ol

C18H23NO7
1541171-38-3

C18H23NO7

Conditions
ConditionsYield
In dichloromethane at 20℃; for 10h; Pictet-Spengler Synthesis; Inert atmosphere; diastereoselective reaction;88%
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(S)-3-(3,4-Dihydroxy-phenyl)-2-ethoxycarbonylamino-propionic acid methyl ester
682801-34-9

(S)-3-(3,4-Dihydroxy-phenyl)-2-ethoxycarbonylamino-propionic acid methyl ester

Conditions
ConditionsYield
With iPrEtN In dichloromethane78%
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

D-lyxose tosylate

D-lyxose tosylate

C18H23NO7
1541171-41-8

C18H23NO7

Conditions
ConditionsYield
In dichloromethane at 20℃; for 47h; Pictet-Spengler Synthesis; Inert atmosphere; diastereoselective reaction;78%
C23H17N3O4
137130-06-4

C23H17N3O4

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

methyl (2S)-3-(3,4-dihydroxyphenyl)-2-[(2-{3-[4-(1H-3-indolyl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-3-pyrrolyl]-1H-1-indolyl}acetyl)amino]propanoate
1246473-68-6

methyl (2S)-3-(3,4-dihydroxyphenyl)-2-[(2-{3-[4-(1H-3-indolyl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-3-pyrrolyl]-1H-1-indolyl}acetyl)amino]propanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;73%
1-pyrenemethanol
24463-15-8

1-pyrenemethanol

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-[(pyren-1-yl)methoxycarbonyl]-L-3,4-dihydroxyphenylalanine methyl ester
1251958-98-1

N-[(pyren-1-yl)methoxycarbonyl]-L-3,4-dihydroxyphenylalanine methyl ester

Conditions
ConditionsYield
Stage #1: 1-pyrenemethanol; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 0 - 20℃; for 1h;
Stage #2: L-DOPA methyl ester In N,N-dimethyl-formamide for 12h;
40%
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

4'-O-demethyl-4β-(4''-carboxyanilino)-4-desoxypodophyllotoxin
152833-18-6

4'-O-demethyl-4β-(4''-carboxyanilino)-4-desoxypodophyllotoxin

(S)-3-(3,4-Dihydroxy-phenyl)-2-{4-[(5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-ylamino]-benzoylamino}-propionic acid methyl ester

(S)-3-(3,4-Dihydroxy-phenyl)-2-{4-[(5S,5aS,8aR,9R)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-ylamino]-benzoylamino}-propionic acid methyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;33%
Fmoc-Gly-H

Fmoc-Gly-H

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

A

(1R,3S)-1-[(N-fluorenyl)methoxycarbonyl]aminomethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1R,3S)-1-[(N-fluorenyl)methoxycarbonyl]aminomethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

B

(1S,3S)-1-[(N-fluorenyl)methoxycarbonyl]aminomethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1S,3S)-1-[(N-fluorenyl)methoxycarbonyl]aminomethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

C

(1R,3S)-1-[(9H-Fluoren-1-ylmethoxycarbonylamino)-methyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

(1R,3S)-1-[(9H-Fluoren-1-ylmethoxycarbonylamino)-methyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

D

(1S,3S)-1-[(9H-Fluoren-1-ylmethoxycarbonylamino)-methyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

(1S,3S)-1-[(9H-Fluoren-1-ylmethoxycarbonylamino)-methyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 6h; Pictet-Spengler condensation;A 29%
B 19%
C n/a
D n/a
Fmoc-Ala-H

Fmoc-Ala-H

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

A

(1R,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}ethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1R,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}ethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

B

(1S,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}ethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1S,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}ethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

C

(1S,3S)-1-[(S)-1-(9H-Fluoren-1-ylmethoxycarbonylamino)-ethyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

(1S,3S)-1-[(S)-1-(9H-Fluoren-1-ylmethoxycarbonylamino)-ethyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

D

(1R,3S)-1-[(S)-1-(9H-Fluoren-1-ylmethoxycarbonylamino)-ethyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

(1R,3S)-1-[(S)-1-(9H-Fluoren-1-ylmethoxycarbonylamino)-ethyl]-7,8-dihydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 6h; Pictet-Spengler condensation;A 28%
B 23%
C n/a
D n/a
Fmoc-Phe-H

Fmoc-Phe-H

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

A

(1S,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}phenylethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1S,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}phenylethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

B

(1R,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}phenylethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

(1R,3S,1'S)-1-{[1'-(N-fluorenyl)methoxycarbonyl]amino}phenylethyl-3-methoxycarbonyl-1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 6h; Pictet-Spengler condensation;A 25%
B 26%
3-(benzyloxycarbonylamino)propanoic acid
2304-94-1

3-(benzyloxycarbonylamino)propanoic acid

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

β-alanyl-L-dopa
21612-39-5

β-alanyl-L-dopa

Conditions
ConditionsYield
(i) Et3N, POCl3, (ii) aq. NaOH, (iii) H2, Pd-C; Multistep reaction;
3-(4-iodophenyl)propionic acid
1643-29-4

3-(4-iodophenyl)propionic acid

L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(S)-3-(3,4-Dihydroxy-phenyl)-2-[3-(4-iodo-phenyl)-propionylamino]-propionic acid methyl ester
132513-20-3

(S)-3-(3,4-Dihydroxy-phenyl)-2-[3-(4-iodo-phenyl)-propionylamino]-propionic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

sodium 3-(4-methoxyphenyl)oxiran-2-carboxylate
84382-48-9

sodium 3-(4-methoxyphenyl)oxiran-2-carboxylate

(1S,3S)-6,7-Dihydroxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
133761-45-2, 133761-46-3

(1S,3S)-6,7-Dihydroxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

(1S,3R)-6,7-Dihydroxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester
133761-45-2, 133761-46-3

(1S,3R)-6,7-Dihydroxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
With acetic acid In water at 35℃; for 36h;A 145 mg
B 45 mg
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

levodopa
59-92-7

levodopa

Conditions
ConditionsYield
With water; sodium chloride In dimethyl sulfoxide at 37℃; Rate constant; also human plasma as reagent;
With sodium carbonate In acetonitrile for 15h;
With potassium hydroxide In methanol
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

3-(4-fluoro-3-nitrophenyl)propanoic acid
160877-40-7

3-(4-fluoro-3-nitrophenyl)propanoic acid

(2S)-methyl 3-(3,4-dihydroxyphenyl)-2-[3-(4-fluoro-3-nitrophenyl)propionylamino]propionate
203310-99-0

(2S)-methyl 3-(3,4-dihydroxyphenyl)-2-[3-(4-fluoro-3-nitrophenyl)propionylamino]propionate

Conditions
ConditionsYield
With 1.) TMS-X Yield given. Multistep reaction;
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine
173775-54-7

(R)-N-(tert-butoxycarbonyl)-4-fluoro-3-nitrophenylalanine

methyl N-[N-(tert-butyloxycarbonyl)-L-(3,4-dihydroxyphenylalanyl)]-D-4-fluoro-3-nitrophenylalaninate
203311-03-9

methyl N-[N-(tert-butyloxycarbonyl)-L-(3,4-dihydroxyphenylalanyl)]-D-4-fluoro-3-nitrophenylalaninate

Conditions
ConditionsYield
With 1.) TMS-X Yield given. Multistep reaction;
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(S)-N-(tert-butyloxycarbonyl)-4-fluoro-3-nitrophenylalanine

(S)-N-(tert-butyloxycarbonyl)-4-fluoro-3-nitrophenylalanine

methyl N-[N-(tert-butyloxycarbonyl)-L-(3,4-dihydroxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalanine
203311-01-7

methyl N-[N-(tert-butyloxycarbonyl)-L-(3,4-dihydroxyphenylalanyl)]-L-4-fluoro-3-nitrophenylalanine

Conditions
ConditionsYield
With 1.) TMS-X Yield given. Multistep reaction;
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

L-dopachrome methyl ester

L-dopachrome methyl ester

Conditions
ConditionsYield
With sodium periodate In phosphate buffer for 0.166667h; pH=6.0; Oxidation; cyclization;
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

acetyl chloride
75-36-5

acetyl chloride

2-amino-3-(3,4-diacetoxyphenyl)-propionic acid
39101-99-0

2-amino-3-(3,4-diacetoxyphenyl)-propionic acid

Conditions
ConditionsYield
With trifluoroacetic acid at 20℃;
L-DOPA methyl ester
7101-51-1

L-DOPA methyl ester

(S)-2-Amino-3-(3,4-dioxo-cyclohexa-1,5-dienyl)-propionic acid methyl ester

(S)-2-Amino-3-(3,4-dioxo-cyclohexa-1,5-dienyl)-propionic acid methyl ester

Conditions
ConditionsYield
With 3-methyl-2-benzothiazolinone hydrazone; (S)-(-)-1,1'-binapthyl-2,2-diamine copper(II) In methanol; phosphate buffer at 20℃; pH=8.6; Kinetics; Further Variations:; Catalysts;

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