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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/13.html Product Name 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS No.

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Cas:71675-87-1

Min.Order:1 Gram

FOB Price: $15.0

Type:Lab/Research institutions

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Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support ★.Shortest delivery time . Sales term: Has a strong chemical professional quality and strong sense of resp

4-Amino-5-(ethylsulfonyl)-2-methoxybenzoicacid

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $4.0 / 6.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Manufacturer/High quality/Best price/In stock

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Methoxy-4-Amino-5-Ethylsulphonyl Benzoic Acid supplier in China

Cas:71675-87-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS 71675-87-1 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical &

Manufacturer supply 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS 71675-87-1 with attractive price

Cas:71675-87-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

4-Amino-5-Ethylsulfonyl-2-Methoxybenzoic Acid[CAS:71675-87-1] Molecular Formula C10H13NO5S Molecular Weight 259.28 CAS Registry Number 71675-87-1

Supply 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Cas:71675-87-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Cas:71675-87-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-amino-5-(ethylsulphonyl)-o-anisic acid

Cas:71675-87-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Benzoic acid,4-amino-5-(ethylsulfonyl)-2-methoxy- 71675-87-1 ISO Producer

Cas:71675-87-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

best quality and lowest price

Cas:71675-87-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 99% CAS NO.71675-87-1

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic acid

Cas:71675-87-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

High purity CAS 71675-87-1 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3

High purity CAS 71675-87-1 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid in stock

Cas:71675-87-1

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Amino-5-(ethylsulfonyl)-2-methoxybenzoic acid CAS 71675-87-1

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 71675-87-1 with best quality

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name of product: 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Purity: 99.0%min CAS: 71675-87-1

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS: 71675-87-1

Cas:71675-87-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white to white powder Storage:R.T Package:25kg/drum Application:Amisulpride Intermediate Transportation:Express/Sea/Air Port:Any port in China

4-Amino-5-(ethylsulfonyl)-2-methoxybenzoicacid cas 71675-87-1

Cas:71675-87-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoic acid,4-amino-5-(ethylsulfonyl)-2-methoxy- 71675-87-1

Cas:71675-87-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We are Top supplier of Amisulpride intermediate 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS:71675-87-1 Storage:store in well closed container Package:25kgs/fiber drum Application:Amisulpride Intermediate Port:any chinese port

Shanghai Minstar Chemical Co., Ltd

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid Chemical Properties Melting point 82-85°C Boiling point 529.6±50.0 °C(Predicted) density 1.390±0.06 g/cm3(Predicted) storage temp. Keep in dark place,Inert atmosphere

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid。

Cas:71675-87-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Cas:71675-87-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail Quick Details ProName:4-Amino-5-

factory supply 99% misulpride Acid; AMINOSULTOPRIDE;CAS:71675-87-1

Cas:71675-87-1

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Factory price CAS 71675-87-1 Amisulpride Acid

Cas:71675-87-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoic acid,4-amino-5-(ethylsulfonyl)-2-methoxy-

Cas:71675-87-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Amisulpride Acid;4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS:71675-87-1 98%, Please contact us by email freely. We are leading expo

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Amino-5-(Ethylsulfonyl)-2-Methoxy Benzoic Acid

Cas:71675-87-1

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Amisulpride Intermediate

Cas:71675-87-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid CAS NO.71675-87-1 CAS NO.71675-87-1

Cas:71675-87-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1

Cas:71675-87-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate
1119455-01-4

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
ConditionsYield
Stage #1: methyl 4-amino-5-(ethylthio)-2-methoxybenzoate With dihydrogen peroxide; sodium tungstate In isopropyl alcohol at 40 - 45℃; Industry scale;
Stage #2: With water; sodium hydroxide In isopropyl alcohol at 60 - 65℃; Industry scale;
Stage #3: With hydrogenchloride In water; isopropyl alcohol pH=4 - 4.5; Industry scale;
82%
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
1.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
2.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
View Scheme
2-methoxy-4-amino-5-ethylthio benzoic acid

2-methoxy-4-amino-5-ethylthio benzoic acid

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide; sodium tungstate In methanol; water at 20 - 30℃; for 5h; Product distribution / selectivity;80%
Methyl 4-amino-2-methoxybenzoate
27492-84-8

Methyl 4-amino-2-methoxybenzoate

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: bromine / methanol / 5 - 15 °C / Industry scale
2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
3.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
3.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
4.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: bromine / methanol / 5 - 15 °C / Industry scale
2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
3.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
3.2: 60 - 65 °C / Industry scale
3.3: pH 4 - 4.5 / Industry scale
View Scheme
4-Aminosalicylic acid
65-49-6

4-Aminosalicylic acid

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale
2.1: bromine / methanol / 5 - 15 °C / Industry scale
3.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
4.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
4.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
5.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale
2.1: bromine / methanol / 5 - 15 °C / Industry scale
3.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
4.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
4.2: 60 - 65 °C / Industry scale
4.3: pH 4 - 4.5 / Industry scale
View Scheme
methyl 4-amino-2-methoxy-5-thiocyanatobenzoate
59168-56-8

methyl 4-amino-2-methoxy-5-thiocyanatobenzoate

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
2.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
3.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
2.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
2.2: 60 - 65 °C / Industry scale
2.3: pH 4 - 4.5 / Industry scale
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine
168828-90-8

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

4-amino-5-(ethylsulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxybenzamide
1390617-35-2

4-amino-5-(ethylsulfonyl)-N-(S)-[[3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxooxazolidin-5-yl]methyl]-2-methoxybenzamide

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With chloroformic acid ethyl ester; triethylamine In dichloromethane at 0 - 20℃; for 0.5h;
Stage #2: (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine In dichloromethane at 0 - 20℃; for 4h;
93%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 10 - 20℃; for 1.5h;
Stage #2: 1-ethyl-2-pyrrolidinemethanamine With triethylamine In acetonitrile at 80℃; for 2h;
86.8%
With C36H24B4N2O3 In toluene for 14h; Molecular sieve; Reflux; chemoselective reaction;76%
With chloroformic acid ethyl ester; triethylamine In acetone at 0 - 30℃;70%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(S)-2-(Aminomethyl)-1-ethylpyrrolidine
22795-99-9

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(-)-Amisulpride

(-)-Amisulpride

Conditions
ConditionsYield
In acetone84%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

C20H24N2O9S2

C20H24N2O9S2

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25 - 40℃; for 12h; Reagent/catalyst; Solvent;72.52%
1-allyl 2-aminoethylpyrrolidine

1-allyl 2-aminoethylpyrrolidine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-[1-allyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-ethylsulphonyl benzamide
71675-89-3

N-[1-allyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-ethylsulphonyl benzamide

Conditions
ConditionsYield
With hydrogenchloride; triethylamine In water; acetone67%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(-)-(S)-2-Aminomethyl-1(cyclopropylmethyl)pyrrolidine
71820-57-0

(-)-(S)-2-Aminomethyl-1(cyclopropylmethyl)pyrrolidine

LUR 2366
72135-20-7

LUR 2366

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water66.5%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

4-amino-5-(ethylsulfonyl)-2-hydroxybenzoic acid
148516-65-8

4-amino-5-(ethylsulfonyl)-2-hydroxybenzoic acid

Conditions
ConditionsYield
With boron tribromide In dichloromethane at -50 - 20℃;65%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
With triethylamine In water; acetone61%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

1-ethyl-2-aminomethylpyrrolidine hydrochloride

1-ethyl-2-aminomethylpyrrolidine hydrochloride

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h;
Stage #2: 1-ethyl-2-aminomethylpyrrolidine hydrochloride With triethylamine In dichloromethane at 20℃;
29.7%
1-cyclohexylmethyl-pyrrolidin-3-R-ylamine

1-cyclohexylmethyl-pyrrolidin-3-R-ylamine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

isobutyl chloroformate
543-27-1

isobutyl chloroformate

A

benzamide
55-21-0

benzamide

B

N-(1-cyclohexylmethyl-3-pyrrolidinyl)-2-methoxy-4-amino-5-ethyl-sulphonyl-benzamide
72135-95-6

N-(1-cyclohexylmethyl-3-pyrrolidinyl)-2-methoxy-4-amino-5-ethyl-sulphonyl-benzamide

Conditions
ConditionsYield
With triethylamine In water; ethyl acetate; acetone
1-cyclopropylmethyl-3-aminopyrrolidine

1-cyclopropylmethyl-3-aminopyrrolidine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

isobutyl chloroformate
543-27-1

isobutyl chloroformate

N-(1-cyclopropylmethyl-3-pyrrolidinyl)-2-methoxy-4-amino-5-ethyl-sulphonyl-benzamide
72135-94-5

N-(1-cyclopropylmethyl-3-pyrrolidinyl)-2-methoxy-4-amino-5-ethyl-sulphonyl-benzamide

Conditions
ConditionsYield
With triethylamine In water; acetone; Diethyl carbonate
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

triethylamine hydrochloride
554-68-7

triethylamine hydrochloride

Conditions
ConditionsYield
With triethylamine In acetone
1-methyl-2-aminomethyl-pyrrolidine
26171-06-2

1-methyl-2-aminomethyl-pyrrolidine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-(1-methyl-2-pyrrolidylmethyl)-2-methoxy-4-amino-5-ethylsulphonylbenzamid
71675-88-2, 71675-93-9

N-(1-methyl-2-pyrrolidylmethyl)-2-methoxy-4-amino-5-ethylsulphonylbenzamid

Conditions
ConditionsYield
With triethylamine In water; acetone
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(R)-2-aminomethyl-1-ethylpyrrolidine
22795-97-7

(R)-2-aminomethyl-1-ethylpyrrolidine

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid; isopropyl chloroformate With triethylamine In acetone at 5℃; for 0.5h;
Stage #2: (R)-2-aminomethyl-1-ethylpyrrolidine In acetone at 0 - 20℃; for 1.5h;
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

R-amisulpride maleic acid

R-amisulpride maleic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / acetone / 0.5 h / 5 °C
1.2: 1.5 h / 0 - 20 °C
2.1: methanol / 5 h / 45 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide L-tartrate

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide L-tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / acetone / 0.5 h / 5 °C
1.2: 1.5 h / 0 - 20 °C
2.1: methanol / 2 h / 40 - 45 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

R-amisulpride hydrochloride

R-amisulpride hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / acetone / 0.5 h / 5 °C
1.2: 1.5 h / 0 - 20 °C
2.1: hydrogenchloride / water; methanol; diethyl ether / 2 h / 20 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(S)-N-(2,4-dimethoxybenzyl)-4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

(S)-N-(2,4-dimethoxybenzyl)-4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / acetone / 0.25 h / 0 - 10 °C / Inert atmosphere
1.2: 1.5 h / -5 - 5 °C
2.1: acetone / 4 h / 0 - 20 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(-)-Amisulpride

(-)-Amisulpride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / acetone / 0.25 h / 0 - 10 °C / Inert atmosphere
1.2: 1.5 h / -5 - 5 °C
2.1: acetone / 4 h / 0 - 20 °C
3.1: hydrogenchloride / methanol; water / 2 h / 20 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

pivaloyl chloride
3282-30-2

pivaloyl chloride

4-amino-2-methoxy-5-ethylsulfonyl benzoate pivalic anhydride

4-amino-2-methoxy-5-ethylsulfonyl benzoate pivalic anhydride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With triethylamine In acetone at 0 - 10℃; for 0.25h; Inert atmosphere;
Stage #2: pivaloyl chloride In acetone at -5 - 5℃; for 1.5h;
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(S)-2-(Aminomethyl)-1-ethylpyrrolidine
22795-99-9

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

(-)-Amisulpride

(-)-Amisulpride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -10℃; for 1h; Inert atmosphere;
Stage #2: (S)-2-(Aminomethyl)-1-ethylpyrrolidine In acetone at -10 - 20℃; Temperature; Reagent/catalyst; Inert atmosphere;
49 g
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -8 - 0℃;
Stage #2: (S)-2-(Aminomethyl)-1-ethylpyrrolidine In acetone at 0 - 20℃; Temperature;
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -10℃; for 1h;
Stage #2: (S)-2-(Aminomethyl)-1-ethylpyrrolidine In tert-butyl methyl ether; ethyl acetate; acetone for 2h;
With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -8 - 20℃; Inert atmosphere;
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(S)-2-(Aminomethyl)-1-ethylpyrrolidine
22795-99-9

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

(S)-(-)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide D-tartrate

(S)-(-)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide D-tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / acetone / 1 h / -10 °C / Inert atmosphere
1.2: -10 - 20 °C / Inert atmosphere
2.1: methanol / 0.75 h / 22 °C
View Scheme
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

(R)-2-aminomethyl-1-ethylpyrrolidine
22795-97-7

(R)-2-aminomethyl-1-ethylpyrrolidine

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -10 - 20℃; Temperature; Reagent/catalyst; Inert atmosphere;7 g
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -9℃; for 1h;
Stage #2: (R)-2-aminomethyl-1-ethylpyrrolidine In acetone for 16h; Temperature;
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -10℃; for 1h;
Stage #2: (R)-2-aminomethyl-1-ethylpyrrolidine In tert-butyl methyl ether; ethyl acetate; acetone for 2h;
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With 4-methyl-morpholine; chloroformic acid ethyl ester In acetone at -9℃; for 1h;
Stage #2: (R)-2-aminomethyl-1-ethylpyrrolidine In acetone for 16h;

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