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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Amisulpride

Cas:71675-85-9

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Amisulpride Synonyms 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide Molecular Structure

Amisulpride/71675-85-9

Cas:71675-85-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Henan Sigma Biotechnology Co., Ltd.

1. We integrate research and development, production, and sales. A 1800 square meter research and development center,The company has conducted over 50 research and development and technical service projects annually, applied for more than 10 patents,

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

inquiry

Hangzhou Hysen Pharma co.,Ltd.

we are a is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a R&D center in

Amisulpride CAS:71675-85-9

Cas:71675-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Amisulpride

Cas:71675-85-9

Min.Order:1

Negotiable

Type:Other

inquiry

Henan Allgreen Chemical Co.,Ltd

Amisulpride Basic information Product Name: Amisulpride Synonyms: 4-AMINO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE;AMISULPRIDE;AMINOS

Amisulpride 71675-85-9

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Amisulpride 71675-85-9 GMP Manufacturer

Cas:71675-85-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

【Biological Activity] Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopam

amisulpride 71675-85-9

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Amisulpride

Cas:71675-85-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

AMISULPRIDE

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name Amisulpride CAS No. 71675-85-9

Amisulpride

Cas:71675-85-9

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 71675-85-9 with best quality

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Amisulpride CAS NO: 71675-85-9 Appearance: White Powder EINECS NO: 2

Amisulpride

Cas:71675-85-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai

CAS: 71675-85-9 Pharmaceutical Raw Materials Amisulpride

Cas:71675-85-9

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Amisulpride 71675-85-9

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $186.0 / 210.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Amisulpride CAS: 71675-85-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Amisulpride CAS: 71675-85-9

Cas:71675-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Kemi-Works Chemical Co., Ltd

ProductName:Amisulpride Synonyms:4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide CASNo.71675-85-9 1.We have been specializing in special fine chemical for long, with strong R&D strength. 2.ISO9001. 3.We

Amisulpride

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Factory supply Amisulpride in bulk with good price

Cas:71675-85-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Amisulpride CAS 71675-85-9

Cas:71675-85-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Amisulpride

Cas:71675-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Amisulpride

Cas:71675-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Amisulpride CAS 71675-85-9

Cas:71675-85-9

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

DAN-2163 Amisulpride 71675-85-9

Cas:71675-85-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Amisulpride

Cas:71675-85-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Amisulpride

Cas:71675-85-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Amisulpride

Cas:71675-85-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
In triethylamine; acetone100%
In triethylamine; acetone84%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

methyl 4-amino-5-(ethylsulfonyl)-2-methoxybenzoate

methyl 4-amino-5-(ethylsulfonyl)-2-methoxybenzoate

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 83℃; for 20h; Reagent/catalyst; Solvent; Temperature;96.5%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-4-amino-5-ethanesulfonylbenzoyl chloride

2-methoxy-4-amino-5-ethanesulfonylbenzoyl chloride

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
In dichloromethane at 20 - 40℃; for 6h; Temperature;89.4%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 10 - 20℃; for 1.5h;
Stage #2: 1-ethyl-2-pyrrolidinemethanamine With triethylamine In acetonitrile at 80℃; for 2h;
86.8%
With C36H24B4N2O3 In toluene for 14h; Molecular sieve; Reflux; chemoselective reaction;76%
With chloroformic acid ethyl ester; triethylamine In acetone at 0 - 30℃;70%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
With triethylamine In water; acetone61%
ethyl bromide
74-96-4

ethyl bromide

4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide
176849-91-5

4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: ethyl bromide; 4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere; Schlenk technique;
Stage #2: With potassium carbonate In methanol at 20℃; for 2h;
61%
ethyl bromide
74-96-4

ethyl bromide

C19H29N3O5S

C19H29N3O5S

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: ethyl bromide; C19H29N3O5S With 1,1'-bis-(diphenylphosphino)ferrocene; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tin; potassium hydrogenphosphate trihydrate; tetrabutylammomium bromide In dimethyl sulfoxide at 100℃; for 10h; Inert atmosphere;
Stage #2: With potassium carbonate In methanol at 20℃; for 2h;
61%
2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

1-ethyl-2-aminomethylpyrrolidine hydrochloride

1-ethyl-2-aminomethylpyrrolidine hydrochloride

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Stage #1: 2-methoxy-4-amino-5-ethylsulphonyl benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h;
Stage #2: 1-ethyl-2-aminomethylpyrrolidine hydrochloride With triethylamine In dichloromethane at 20℃;
29.7%
Methyl 4-amino-2-methoxybenzoate
27492-84-8

Methyl 4-amino-2-methoxybenzoate

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: bromine / methanol / 5 - 15 °C / Industry scale
2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
3.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
3.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
4.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
5.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: bromine / methanol / 5 - 15 °C / Industry scale
2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
3.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
3.2: 60 - 65 °C / Industry scale
3.3: pH 4 - 4.5 / Industry scale
4.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
4-Aminosalicylic acid
65-49-6

4-Aminosalicylic acid

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale
2.1: bromine / methanol / 5 - 15 °C / Industry scale
3.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
4.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
4.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
5.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
6.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale
2.1: bromine / methanol / 5 - 15 °C / Industry scale
3.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
4.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
4.2: 60 - 65 °C / Industry scale
4.3: pH 4 - 4.5 / Industry scale
5.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
methyl 4-amino-2-methoxy-5-thiocyanatobenzoate
59168-56-8

methyl 4-amino-2-methoxy-5-thiocyanatobenzoate

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
2.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
2.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
3.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
4.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale
2.1: dihydrogen peroxide / sodium tungstate / isopropyl alcohol / 40 - 45 °C / Industry scale
2.2: 60 - 65 °C / Industry scale
2.3: pH 4 - 4.5 / Industry scale
3.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
2-methoxy-4-amino-5-ethylthio benzoic acid

2-methoxy-4-amino-5-ethylthio benzoic acid

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
2: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
methyl 4-amino-5-(ethylthio)-2-methoxybenzoate
1119455-01-4

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

amisulpride
71675-85-9

amisulpride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
1.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
2.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
3.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C
View Scheme
formic acid
64-18-6

formic acid

amisulpride
71675-85-9

amisulpride

4-formylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-formylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With acetic anhydride at 5 - 20℃;83%
Di-p-toluoyl-L-tartaric acid
32634-66-5

Di-p-toluoyl-L-tartaric acid

amisulpride
71675-85-9

amisulpride

(S)-4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide (2R,3R)-bis((4-methylbenzoyl)oxy)succinic acid salt

(S)-4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide (2R,3R)-bis((4-methylbenzoyl)oxy)succinic acid salt

Conditions
ConditionsYield
In water; acetonitrile at 70℃; for 0.25h;79.4%
amisulpride
71675-85-9

amisulpride

(-)-Amisulpride

(-)-Amisulpride

Conditions
ConditionsYield
With D-Malic acid In ethanol at 20℃; for 2h;64.7%
amisulpride
71675-85-9

amisulpride

cyclomaltooctaose
17465-86-0

cyclomaltooctaose

C48H80O40*C17H27N3O4S

C48H80O40*C17H27N3O4S

Conditions
ConditionsYield
In methanol; water for 24h;
acetic acid
64-19-7

acetic acid

amisulpride
71675-85-9

amisulpride

4-ethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-ethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;309 mg
acetone
67-64-1

acetone

amisulpride
71675-85-9

amisulpride

4-isopropylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-isopropylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In N,N-dimethyl-formamide; acetone at 40℃; Cooling with ice;550 mg
propionaldehyde
123-38-6

propionaldehyde

amisulpride
71675-85-9

amisulpride

4-n-propylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-n-propylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane518 mg
benzaldehyde
100-52-7

benzaldehyde

amisulpride
71675-85-9

amisulpride

4-benzylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-benzylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In N,N-dimethyl-formamide at 40℃;366 mg
amisulpride
71675-85-9

amisulpride

4-dimethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-dimethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 5 - 20 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 5 - 60 °C
3: 21 h / 30 °C
View Scheme
amisulpride
71675-85-9

amisulpride

4-ethylmethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-ethylmethylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic anhydride / 5 - 20 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 5 - 60 °C
3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 17 h / 20 °C
View Scheme
amisulpride
71675-85-9

amisulpride

4-methylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

4-methylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic anhydride / 5 - 20 °C
2: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 5 - 60 °C
View Scheme
amisulpride
71675-85-9

amisulpride

C17H27N3O4S*C20H8Br4O5

C17H27N3O4S*C20H8Br4O5

Conditions
ConditionsYield
pH=3.3;
(2S,3S)-di-4-toluoyltartaric acid
32634-68-7

(2S,3S)-di-4-toluoyltartaric acid

amisulpride
71675-85-9

amisulpride

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide di-p-toluoyl tartrate

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide di-p-toluoyl tartrate

Conditions
ConditionsYield
In acetonitrile at 75℃; for 0.5h; Temperature; Inert atmosphere; Large scale;26.73 kg
amisulpride
71675-85-9

amisulpride

A

(-)-Amisulpride

(-)-Amisulpride

B

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
With diethylamine In acetonitrile at 30℃; under 26252.6 Torr; Resolution of racemate; Large scale;A 3752.2 g
B 2346 g
amisulpride
71675-85-9

amisulpride

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

(R)-(+)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile / 0.5 h / 75 °C / Inert atmosphere; Large scale
2: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / Inert atmosphere; Large scale
View Scheme
amisulpride
71675-85-9

amisulpride

(S)-(-)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide D-tartrate

(S)-(-)-4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide D-tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diethylamine / acetonitrile / 30 °C / 26252.6 Torr / Resolution of racemate; Large scale
2: methanol / 0.75 h / 22 °C
View Scheme
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