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Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

Clozapine

Cas:5786-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory supply 99% Hot Sale Original Clozapine Powder

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $25.0 / 150.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications clozapine CAS:5786-21-0

Cas:5786-21-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

APIs Appearance:Yellow crystalline powder Storage:Store at RT Package:25kg/drum or acc to customers' request Application:An antipsychotic; depigmentor Transportation:acc to customers' request Port:Shanghai Port

Good quality Clozapine 5786-21-0

Cas:5786-21-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Clozapine Bp/Usp

Cas:5786-21-0

Min.Order:1

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

CAS RN.: 5786-21-0 EINECS: 227-313-7 Molecular Weight: 326.8233

Clozapine 5786-21-0

Cas:5786-21-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Storage:Sealed, dry

Clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Clozapine 5786-21-0 GMP Manufacturer

Cas:5786-21-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Clozaril

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Clozapine

Cas:5786-21-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Clozapine CAS NO: 5786-21-0 Grade:Medical scientific research and export Molecular formula:C18H19ClN4 Molecular weight:326.84 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data s

Clozapine/cas:5786-21-0/Raw material spot

Cas:5786-21-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 5786-21-0 Clozapine Powder

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 5786-21-0 with best quality

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 5786-21-0 ,Clozapine

Cas:5786-21-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

[Product Name]: Clozapine [Apperance]: Light Yellow Crystalline Powder [Specification]: 99%min [Test Method]: HPLC [Cas No.]: 5786-21-0

Clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Best service Clozapin 5786-21-0 experienced leading industry 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearan

Best service Clozapin 5786-21-0 experienced leading industry

Cas:5786-21-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Pharmaceutical Antipsychotic Clozapine Powder CAS 5786-21-0 Clozapine Raw Material Powder Clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp

High-purity Clozapine,CAS:5786-21-0;BP2005,antipsychotic drug

Cas:5786-21-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

clozapine WITH BEST PRICE

Cas:5786-21-0

Min.Order:1 Gram

FOB Price: $7.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Clozapine CAS:5786-21-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Clozapine CAS:5786-21-0

Cas:5786-21-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

CAS 5786-21-0 Clozapine with Best Price

Cas:5786-21-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Clozapine CAS 5786-21-0

Cas:5786-21-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Hubei CuiRan Biotechnology Co., Ltd

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)

Clozapine

Cas:5786-21-0

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

clozapine CAS: 5786-21-0 Specification Items Specification Appearance Yellow crystalline powder Melting point 182 ~ 186 Related substances

Factory supply clozapine

Cas:5786-21-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Clozapine

Cas:5786-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Clozapine-Good quality and competitive price

Cas:5786-21-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Clozapine

Cas:5786-21-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Clozapine

Cas:5786-21-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

clozapine N-oxide

clozapine N-oxide

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With hydrogenchloride; titanium(III) chloride In water; acetonitrile at 20℃; for 1h;97%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
50892-62-1

8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With titanium tetrachloride In 1,4-dioxane; toluene for 2h; Heating;88%
With titanium tetrachloride53%
With hydrogenchloride; titanium tetrachloride In water; methoxybenzene; isopropyl alcohol; toluene
With titanium tetrachloride
clozapine N-oxide

clozapine N-oxide

(2E)-3-phenyl-2-propen-1-ol
4407-36-7

(2E)-3-phenyl-2-propen-1-ol

A

1-phenyl-propane-1,2,3-triol
63157-81-3

1-phenyl-propane-1,2,3-triol

B

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With osmium(VIII) oxide In water; tert-butyl alcohol at 20℃; for 19h; Inert atmosphere;A 73%
B 84%
N-(4-chloro-2-nitrophenyl)-N-{2-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amine
65514-72-9

N-(4-chloro-2-nitrophenyl)-N-{2-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amine

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With tributylphosphine at 150℃; for 48h; Temperature; Reagent/catalyst;80%
Multi-step reaction with 2 steps
1: 3 h / 150 °C
2: triphenylphosphine / 230 °C
View Scheme
N-{4-chloro-2-[(triphenylphosphoranylidene)amino]phenyl}-N-{2-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amine

N-{4-chloro-2-[(triphenylphosphoranylidene)amino]phenyl}-N-{2-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amine

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With triphenylphosphine at 230℃;65%
styrene
292638-84-7

styrene

clozapine N-oxide

clozapine N-oxide

A

phenylethane 1,2-diol
93-56-1

phenylethane 1,2-diol

B

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With osmium(VIII) oxide In water; tert-butyl alcohol at 20℃; for 19h; Inert atmosphere;A 8%
B 53%
4-Chloro-2-nitroaniline
89-63-4

4-Chloro-2-nitroaniline

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: o-xylene / Dean-Stark
1.2: Reflux
2.1: iron; calcium chloride / water / 90 - 100 °C
3.1: triethylamine / dichloromethane / 0.33 h / 20 °C
3.2: 2.33 h / 20 °C
4.1: titanium tetrachloride / o-xylene / 10 - 15 °C / Reflux
5.1: titanium tetrachloride / 10 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1.2: 12 h / 20 °C / Reflux
2.1: iodine / 3 h / 50 - 55 °C
3.1: sodium dithionate / methanol / 2 h / 50 - 55 °C
4.1: toluene / 0 - 5 °C
5.1: trichlorophosphate / 3 h / Reflux
6.1: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
bromobenzene
108-86-1

bromobenzene

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.2: 12 h / 20 °C / Reflux
2.1: iodine / 3 h / 50 - 55 °C
3.1: sodium dithionate / methanol / 2 h / 50 - 55 °C
4.1: toluene / 0 - 5 °C
5.1: trichlorophosphate / 3 h / Reflux
6.1: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
N-(4-chloro-2-nitrophenyl)benzenamine
16611-15-7

N-(4-chloro-2-nitrophenyl)benzenamine

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: iodine / 3 h / 50 - 55 °C
2: sodium dithionate / methanol / 2 h / 50 - 55 °C
3: toluene / 0 - 5 °C
4: trichlorophosphate / 3 h / Reflux
5: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: o-xylene / Dean-Stark
1.2: Reflux
2.1: iron; calcium chloride / water / 90 - 100 °C
3.1: triethylamine / dichloromethane / 0.33 h / 20 °C
3.2: 2.33 h / 20 °C
4.1: titanium tetrachloride / o-xylene / 10 - 15 °C / Reflux
5.1: titanium tetrachloride / 10 °C / Reflux
View Scheme
N-(4-chloro-2-nitrophenyl)-N-phenylacetamide

N-(4-chloro-2-nitrophenyl)-N-phenylacetamide

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium dithionate / methanol / 2 h / 50 - 55 °C
2: toluene / 0 - 5 °C
3: trichlorophosphate / 3 h / Reflux
4: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
N-(4-chloro-2-aminophenyl)-N-phenylacetamide

N-(4-chloro-2-aminophenyl)-N-phenylacetamide

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene / 0 - 5 °C
2: trichlorophosphate / 3 h / Reflux
3: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
N-(2-(N-phenylacetamido)-5-chlorophenyl)-4-methylpiperazine-1-carboxamide

N-(2-(N-phenylacetamido)-5-chlorophenyl)-4-methylpiperazine-1-carboxamide

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate / 3 h / Reflux
2: potassium carbonate / ethanol / 3 h / Reflux
View Scheme
N-acetyl clozapine

N-acetyl clozapine

clozaril
5786-21-0

clozaril

Conditions
ConditionsYield
With potassium carbonate In ethanol for 3h; Reflux;5 g
2-(2-methylphenyl)pyridine
10273-89-9

2-(2-methylphenyl)pyridine

clozaril
5786-21-0

clozaril

C30H29N5

C30H29N5

Conditions
ConditionsYield
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 48h; Inert atmosphere;96%
clozaril
5786-21-0

clozaril

clozapine N-oxide

clozapine N-oxide

Conditions
ConditionsYield
Stage #1: clozaril With 3-chloro-benzenecarboperoxoic acid In methanol at 23℃; for 0.166667h; Inert atmosphere;
Stage #2: With triethylamine In methanol for 0.166667h; Inert atmosphere;
94%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 0.166667h;
mesitylenesulfonylhydroxylamine
36016-40-7

mesitylenesulfonylhydroxylamine

clozaril
5786-21-0

clozaril

1-amino-4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylhexahydropyrazin-1-ium 2,4,6-trimethyl-1-benzenesulfonate

1-amino-4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylhexahydropyrazin-1-ium 2,4,6-trimethyl-1-benzenesulfonate

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.333333h;82%
ethyl 5-bromovalerate
14660-52-7

ethyl 5-bromovalerate

clozaril
5786-21-0

clozaril

C25H31ClN4O2

C25H31ClN4O2

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃;80%
carbon dioxide
124-38-9

carbon dioxide

clozaril
5786-21-0

clozaril

C19H19N5

C19H19N5

Conditions
ConditionsYield
With nickel(II) acetylacetonate; potassium fluoride; phenylsilane; ammonia; zinc; bis(2-diphenylphosphinoethyl)phenylphosphine In 1-methyl-pyrrolidin-2-one at 90 - 140℃; under 760.051 Torr; for 20h; Sealed tube;80%
N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
82626-48-0

N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide

clozaril
5786-21-0

clozaril

C37H39N7O

C37H39N7O

Conditions
ConditionsYield
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 144h; Reagent/catalyst; Inert atmosphere;76%
With C17H24N5Ru(1+)*F6P(1-); potassium acetate; potassium carbonate In 1-methyl-pyrrolidin-2-one at 35℃; for 144h; Inert atmosphere; Glovebox;76%
clozaril
5786-21-0

clozaril

N-desmethylclozapine
6104-71-8

N-desmethylclozapine

Conditions
ConditionsYield
Stage #1: clozaril With carbonochloridic acid 1-chloro-ethyl ester In 1,2-dicholoroethane at 0℃; for 22.5h; Inert atmosphere; Reflux;
Stage #2: With methanol at 50℃; for 2h; Inert atmosphere;
69%
Stage #1: clozaril With carbonochloridic acid 1-chloro-ethyl ester In 1,2-dichloro-ethane for 24h; Reflux;
Stage #2: With methanol at 50℃; for 2h;
With cytochrome P450 1A2; cytochrome P450 3A4
clozaril
5786-21-0

clozaril

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

11-(4-methylpiperazin-1-yl)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5H-dibenzo[b,e][1,4]diazepine

11-(4-methylpiperazin-1-yl)-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5H-dibenzo[b,e][1,4]diazepine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; XPhos In 1,4-dioxane at 110℃; for 12h; Inert atmosphere; Sealed tube;59%
clozaril
5786-21-0

clozaril

methyl iodide
74-88-4

methyl iodide

4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1,1-dimethylpiperazin-1-ium iodide

4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1,1-dimethylpiperazin-1-ium iodide

Conditions
ConditionsYield
In acetone at 20℃;55%
n-decanoyl chloride
112-13-0

n-decanoyl chloride

clozaril
5786-21-0

clozaril

1-[8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-5-yl]decan-1-one
1357146-74-7

1-[8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-5-yl]decan-1-one

Conditions
ConditionsYield
With pyridine; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;36%
clozaril
5786-21-0

clozaril

A

7-Hydroxyclozapine
355004-92-1

7-Hydroxyclozapine

B

C18H19ClN4O
1239601-19-4

C18H19ClN4O

Conditions
ConditionsYield
Stage #1: clozaril With ethylenediaminetetraacetic acid trisodium salt; oxygen; manganese (II) acetate tetrahydrate; ascorbic acid In water pH=4; Udenfriend reaction;
Stage #2: With ferrous(II) sulfate heptahydrate; ethylenediaminetetraacetic acid trisodium salt; oxygen In water at 45℃; for 2h; Udenfriend reaction;
A 4.93%
B 2.98%
GLUTATHIONE
70-18-8

GLUTATHIONE

clozaril
5786-21-0

clozaril

A

C-6 glutathionyl clozapine

C-6 glutathionyl clozapine

B

C-9 glutathionyl clozapine

C-9 glutathionyl clozapine

Conditions
ConditionsYield
With horseradish peroxidase type VI; dihydrogen peroxide In phosphoric acid at 25℃; for 4h; pH=7.4; Oxidation; Enzymatic reaction;
With sodium hypochlorite In ethanol; water Oxidation;
clozaril
5786-21-0

clozaril

clozapine nitrenium ion

clozapine nitrenium ion

Conditions
ConditionsYield
With hypochloric acid In water at 25℃; pH=6; Kinetics; Oxidation;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-acetylcystein
616-91-1

N-acetylcystein

clozaril
5786-21-0

clozaril

keyhole limpet hemocyanin

keyhole limpet hemocyanin

clozapine-N-acetylcystein-modified keyhole limpet hemocyanin

clozapine-N-acetylcystein-modified keyhole limpet hemocyanin

Conditions
ConditionsYield
Stage #1: N-acetylcystein; clozaril With sodium hypochlorite In ethanol for 0.166667h; pH=4.0;
Stage #2: 1-hydroxy-pyrrolidine-2,5-dione With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide; acetonitrile
Stage #3: keyhole limpet hemocyanin In phosphate buffer; acetonitrile at 20℃; for 1h; pH=8.0;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-acetylcystein
616-91-1

N-acetylcystein

clozaril
5786-21-0

clozaril

rabbit serum albumin

rabbit serum albumin

clozapine-N-acetylcystein-modified rabbit serum albumin

clozapine-N-acetylcystein-modified rabbit serum albumin

Conditions
ConditionsYield
Stage #1: N-acetylcystein; clozaril With sodium hypochlorite In ethanol for 0.166667h; pH=4.0;
Stage #2: 1-hydroxy-pyrrolidine-2,5-dione With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide; acetonitrile
Stage #3: rabbit serum albumin In phosphate buffer; acetonitrile at 20℃; for 1h; pH=8.0;
clozaril
5786-21-0

clozaril

8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine
156632-03-0

8-chloro-11-(4-methylpiperazin-1-yl)-5-nitroso-5H-dibenzo[b,e][1,4]diazepine

Conditions
ConditionsYield
With isopentyl nitrite In dichloromethane
With isopentyl nitrite In dichloromethane at 20℃; for 3h;
clozaril
5786-21-0

clozaril

8-chloro-11-(4-methyl-piperazin-1-yl)-5-nitro-5H-dibenzo[b,e][1,4]diazepine

8-chloro-11-(4-methyl-piperazin-1-yl)-5-nitro-5H-dibenzo[b,e][1,4]diazepine

Conditions
ConditionsYield
With isopentyl nitrite In dichloromethane at 20℃; for 3h;
clozaril
5786-21-0

clozaril

8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-5-amine
136772-01-5

8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepin-5-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isoamyl nitrite / CH2Cl2
2: AcOH; Zn
View Scheme
Multi-step reaction with 2 steps
1: isoamyl nitrite / CH2Cl2 / 3 h / 20 °C
2: 0.84 g / Zn; AcOH / 3 h
View Scheme
Multi-step reaction with 2 steps
1: isopentyl nitrite / dichloromethane / 3 h / 20 °C
2: acetic acid; zinc / 4 h / 10 - 15 °C
View Scheme
Stage #1: clozaril With isopentyl nitrite In dichloromethane at 27℃; for 3h;
Stage #2: With acetic acid; zinc at 10 - 15℃; for 1h;
clozaril
5786-21-0

clozaril

N-[8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e][1,4]diazepin-5-yl]-nicotinamide

N-[8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e][1,4]diazepin-5-yl]-nicotinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isoamyl nitrite / CH2Cl2 / 3 h / 20 °C
2.1: 0.84 g / Zn; AcOH / 3 h
3.1: Argopore-CHO resin; NaBH3CN; AcOH
3.2: Et3N
3.3: TFA
View Scheme
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