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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 10Mt annually; Appearance:transparent liquid Storage:room temprature Package:1kg/bottle, 25kg/drum Application:Intermediate of Dolutegravir Port:Beijing/Shanghai/Shenzhen/Hangzhou

2,4-Difluorobenzylamine, Intermediate of Dolutegravir

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $100.0 / 110.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,4-Difluorobenzylamine supplier in China

Cas:72235-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 2,4-Difluorobenzylamine CAS 72235-52-0 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/F

Factory supply 2,4-Difluorobenzylamine CAS 72235-52-0 with fast delivery

Cas:72235-52-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of customer Port:shanghai

72235-52-0 2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 72235-52-0 2,4-Difluorobenzylamine Manufacturer

Cas:72235-52-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1102.html Product Name 2,4-Difluorobenzylamine CAS No. 72235-52-0

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Gram

FOB Price: $11.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

2,4-Difluorobenzylamine Basic information Product Name: 2,4-Difluorobenzylamine Synonyms: 2,4-DIFLUOROBENZYLAMINE;RARECHEM AL BW 0282;2,4-Difluorobenzylamine 97%;2,4-Difluorobenzylamine97%;2,4-DIFLUOROBEN

2,4-Difluorobenzylamine 72235-52-0

Cas:72235-52-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 72235-52-0 with best quality

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediat

2,4-DIFLUOROBENZYLAMINECAS NO.: 72235-52-0

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $4.0 / 5.0

Type:Lab/Research institutions

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenemethanamine,2,4-difluoro- 72235-52-0

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Benzenemethanamine,2,4-difluoro-/ LIDE PHARMA- Factory supply / Best price

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

We have two GMP facilities in Hubei Province and cooperative factories in Zhejiang Province We are concentrating on the R&D and technical service of APIs and pharmaceutical intermediates We strive to provide world-class service for every client

2,4-Difluorobenzylamine Organic Intermediates

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

FOB Price: $85.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2,4-Difluorobenzylamine CAS:72235-52-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

2,4-Difluorobenzylamine CAS:72235-52-0

Cas:72235-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenemethanamine,2,4-difluoro-

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2,4-DIFLOROBENZYLAMINE

Cas:72235-52-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzenemethanamine,2,4-difluoro-

Cas:72235-52-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,4-Difluorobenzylamine/High quality/Best price

Cas:72235-52-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

moderate price & quick delivery Appearance:clear colorless to light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Used for Pesticide interme

2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 2,4-Difluorobenzylamine CAS No.: 72235-52-0 Molecule Formula:C7H8F2N Molecule Weight:144.14 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

Lower Price 2,4-Difluorobenzylamine

Cas:72235-52-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

C13H17F2N4(1+)*Br(1-)

C13H17F2N4(1+)*Br(1-)

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 6h; Reflux;90.8%
2,4-difluorobenzonitrile
3939-09-1

2,4-difluorobenzonitrile

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With ammonium hydroxide; hydrogen In water; isopropyl alcohol at 60 - 80℃; under 7500.75 Torr; Temperature; Reagent/catalyst;90%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,4-di(diphenylphosphino)-butane; iso-butanol; sodium hydroxide at 120℃; for 0.333333h; Inert atmosphere;75 %Chromat.
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen bromide; iron(III) chloride / 1,4-dioxane / 7 h / Reflux
2: 1,4-dioxane / 4 h / Reflux
3: hydrogenchloride / water; methanol / 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride; zinc(II) chloride / acetonitrile; water / 8 h / Reflux
2: toluene / 2 h / Reflux; Industrial scale
3: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: nitrobenzene / 2 h / 70 - 105 °C
2.1: ozone / chlorobenzene / 1.5 h / 0 °C
3.1: thionyl chloride / dichloromethane / 1 h / 50 °C
3.2: 1.5 h / 50 °C
4.1: sodium chloride; bromine / 2 h / 50 °C
View Scheme
2,4-difluorobenzyl chloride
452-07-3

2,4-difluorobenzyl chloride

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 2 h / Reflux; Industrial scale
2: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux
View Scheme
(2,4-difluoro-benzyl)-hexamethylenetetraminium; chloride

(2,4-difluoro-benzyl)-hexamethylenetetraminium; chloride

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol for 5h; Reflux;
{1-benzyl-3-[(3-fluoro-4-nitro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester
937397-44-9

{1-benzyl-3-[(3-fluoro-4-nitro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(1-benzyl-3-{[3-(2,4-difluoro-benzylamino)-4-nitro-benzenesulfonyl]-isobutyl-amino}-2-hydroxy-propyl)-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester
937721-16-9

(1-benzyl-3-{[3-(2,4-difluoro-benzylamino)-4-nitro-benzenesulfonyl]-isobutyl-amino}-2-hydroxy-propyl)-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Conditions
ConditionsYield
In tetrahydrofuran for 18h; Heating / reflux;100%
2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

acetyl chloride
75-36-5

acetyl chloride

C9H9F2NO
1030596-28-1

C9H9F2NO

Conditions
ConditionsYield
With triethylamine at 20℃;100%
2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

methyl thioisocyanate
556-61-6

methyl thioisocyanate

1-(2,4-difluorobenzyl)-3-methylthiourea
1400799-52-1

1-(2,4-difluorobenzyl)-3-methylthiourea

Conditions
ConditionsYield
at 20℃;99%
2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
1357289-08-7

2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester
1229006-21-6

1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Conditions
ConditionsYield
With acetic acid In toluene at 90℃; for 7h; Reagent/catalyst;97%
With acetic acid In toluene at 90 - 95℃; Solvent; regioselective reaction;210 g
5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

tert-butyl ((2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)methyl)carbamate

tert-butyl ((2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)methyl)carbamate

Conditions
ConditionsYield
Stage #1: 5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;
97%
Octanoic acid
124-07-2

Octanoic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)octanamide
816465-04-0

N-(2,4-difluorobenzyl)octanamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;96%
carbon monoxide
201230-82-2

carbon monoxide

(3S,11 aR)-8-bromo-3-methyl-6-[(phenyl-methyl)oxy]-2,3,11,11a-tetrahydro[1,3]oxazolo[3,2-a] pyrido[1,2-d]pyrazine-5,7-dione
1206103-44-7

(3S,11 aR)-8-bromo-3-methyl-6-[(phenyl-methyl)oxy]-2,3,11,11a-tetrahydro[1,3]oxazolo[3,2-a] pyrido[1,2-d]pyrazine-5,7-dione

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(3S,11aR)-N-[(2,4-difluorophenyl)methyl]-3-methyl-5,7-dioxo-6-[(phenylmethyl)oxy]-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
1206103-45-8

(3S,11aR)-N-[(2,4-difluorophenyl)methyl]-3-methyl-5,7-dioxo-6-[(phenylmethyl)oxy]-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 9h;96%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 9h;96%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 7h;96%
1-(2,2-dimethoxy-ethyl)-3-methoxy-4-oxo-1,4-dihydro-pyridine-2,5-dicarboxylic acid dimethyl ester

1-(2,2-dimethoxy-ethyl)-3-methoxy-4-oxo-1,4-dihydro-pyridine-2,5-dicarboxylic acid dimethyl ester

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dirnethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate
1616340-68-1

methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dirnethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Conditions
ConditionsYield
With acetic acid In toluene at 200℃; under 5171.62 Torr; Solvent; Reagent/catalyst; Temperature; Flow reactor; chemoselective reaction;96%
benzothiazole-2-carboxylic acid ethyl ester
32137-76-1

benzothiazole-2-carboxylic acid ethyl ester

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)benzo[d]thiazole-2-carboxamide

N-(2,4-difluorobenzyl)benzo[d]thiazole-2-carboxamide

Conditions
ConditionsYield
In acetonitrile at 100℃; for 0.25h; Sealed tube; Microwave irradiation;95%
C8H14O5

C8H14O5

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

C15H19F2NO4

C15H19F2NO4

Conditions
ConditionsYield
Stage #1: C8H14O5 With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 0 - 15℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine In tetrahydrofuran at 0 - 20℃; for 1h; Reagent/catalyst; Solvent;
95%
Stage #1: C8H14O5 With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 0 - 30℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine In tetrahydrofuran at 10 - 15℃; for 1h;
94%
N-(2,4-difluorobenzyl)-N-(4-ethylbenzyl)amine
816465-13-1

N-(2,4-difluorobenzyl)-N-(4-ethylbenzyl)amine

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)-4-ethylbenzamide

N-(2,4-difluorobenzyl)-4-ethylbenzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;94%
(S)-5-(1-((tert-butoxycarbonyl)amino)-2-phenylethyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

(S)-5-(1-((tert-butoxycarbonyl)amino)-2-phenylethyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-phenylethyl)carbamate

(S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-phenylethyl)carbamate

Conditions
ConditionsYield
Stage #1: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-phenylethyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;
94%
carbon disulfide
75-15-0

carbon disulfide

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

ethylene dibromide
106-93-4

ethylene dibromide

3-(2,4-difluorobenzyl)thiazolidine-2-thione

3-(2,4-difluorobenzyl)thiazolidine-2-thione

Conditions
ConditionsYield
Stage #1: carbon disulfide; 2,4-Difluoro-benzylamine With N-benzyl-trimethylammonium hydroxide In dimethyl sulfoxide at 20℃; for 0.25h; Green chemistry;
Stage #2: ethylene dibromide In dimethyl sulfoxide at 20℃; Inert atmosphere; Green chemistry;
93.95%
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
1339879-91-2

(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide
1206102-11-5

(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In dichloromethane for 36h;93.3%
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 20℃; for 32h;73%
2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

2-amino-6-chloro-3-nitropyridine
27048-04-0

2-amino-6-chloro-3-nitropyridine

N2-(2,4-difluorobenzyl)-5-nitropyridine-2,6-diamine
157840-46-5

N2-(2,4-difluorobenzyl)-5-nitropyridine-2,6-diamine

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol for 3h; Reflux; Inert atmosphere;93%
With triethylamine In 1,4-dioxane
5-bromouracil
51-20-7

5-bromouracil

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
867151-48-2

5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 160℃; for 6h;93%
at 160℃; for 2h;91%
nonanoic acid
112-05-0

nonanoic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)nonanamide
816465-08-4

N-(2,4-difluorobenzyl)nonanamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;93%
(S)-5-(1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

(S)-5-(1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-methylpropyl)carbamate

(S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-methylpropyl)carbamate

Conditions
ConditionsYield
Stage #1: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;
93%
10H-phenothiazine-10-carbonyl chloride
18956-87-1

10H-phenothiazine-10-carbonyl chloride

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)-10H-phenothiazine-10-carboxamide

N-(2,4-difluorobenzyl)-10H-phenothiazine-10-carboxamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h;92.8%
3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxylic acid

3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxylic acid

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-(2,4-difluorobenzyl)-3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxamide

N-(2,4-difluorobenzyl)-3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxamide

Conditions
ConditionsYield
Stage #1: 3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxylic acid With HATU In N,N-dimethyl-formamide for 0.166667h;
Stage #2: 2,4-Difluoro-benzylamine With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
92%
Phenyl glycidyl ether
122-60-1

Phenyl glycidyl ether

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

1-[(2,4-difluorobenzyl)amino]-3-phenoxypropan-2-ol

1-[(2,4-difluorobenzyl)amino]-3-phenoxypropan-2-ol

Conditions
ConditionsYield
Stage #1: Phenyl glycidyl ether; 2,4-Difluoro-benzylamine In N,N-dimethyl-formamide at 60℃; for 12h; Sealed tube;
Stage #2: With water In N,N-dimethyl-formamide at 60℃; for 12h; Sealed tube; regioselective reaction;
92%
4-oxo-piperidine-1-carboxylic acid 2-(trimethylsilyl)ethyl ester
181701-30-4

4-oxo-piperidine-1-carboxylic acid 2-(trimethylsilyl)ethyl ester

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

2-(trimethylsilyl)ethyl 4-{[(2,4-difluorophenyl)methyl]amino}piperidine-1-carboxylate

2-(trimethylsilyl)ethyl 4-{[(2,4-difluorophenyl)methyl]amino}piperidine-1-carboxylate

Conditions
ConditionsYield
With ethanol; sodium tris(acetoxy)borohydride for 22h;92%
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 1h;3.49 g
2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

1,1-di(methylsulfanyl)-2-nitroethylene
13623-94-4

1,1-di(methylsulfanyl)-2-nitroethylene

N,N'-bis(2,4-difluorobenzyl)-2-nitroethylene-1,1-diamine

N,N'-bis(2,4-difluorobenzyl)-2-nitroethylene-1,1-diamine

Conditions
ConditionsYield
In ethanol for 12h; Reflux;91%
1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-[(2,4-difluorophenyl)methyl]-1-methylpiperidin-4-amine

N-[(2,4-difluorophenyl)methyl]-1-methylpiperidin-4-amine

Conditions
ConditionsYield
With ethanol; sodium tris(acetoxy)borohydride at 20℃; for 2h;91%
With ethanol; sodium tris(acetoxy)borohydride at 20℃; for 2h;91%
carbon monoxide
201230-82-2

carbon monoxide

(4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4,12,12atetrahydro-2H-pyrido [1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione
1206102-10-4

(4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4,12,12atetrahydro-2H-pyrido [1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide
1206102-11-5

(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 5h; Large scale;90%
With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 5.5h; Product distribution / selectivity;84%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 5.5h; Solvent;84%
With tetrakis(triphenylphosphine) palladium(0)
methyl 1-(benzyloxy)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxylate

methyl 1-(benzyloxy)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxylate

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

1-(benzyloxy)-N-(2,4-difluorobenzyl)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide

1-(benzyloxy)-N-(2,4-difluorobenzyl)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 140℃; for 2h; Microwave irradiation;90%
N-[5-(4-fluoro-3-nitrophenyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethylpropionamide

N-[5-(4-fluoro-3-nitrophenyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethylpropionamide

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

N-{5-[4-(2,4-difluorobenzylamino)-3-nitrophenyl]-[1,3,4]thiadiazol-2-yl}-2,2-dimethylpropionamide

N-{5-[4-(2,4-difluorobenzylamino)-3-nitrophenyl]-[1,3,4]thiadiazol-2-yl}-2,2-dimethylpropionamide

Conditions
ConditionsYield
In ethanol at 100℃; for 1h; Microwave irradiation;89%
2-(4-fluoro-3-nitrophenyl)-5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

2-(4-fluoro-3-nitrophenyl)-5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

(2,4-difluorobenzyl)-{4-[5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-2-nitrophenyl}amine

(2,4-difluorobenzyl)-{4-[5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-2-nitrophenyl}amine

Conditions
ConditionsYield
In ethanol at 100℃; for 1h; Microwave irradiation;89%

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