2,4-Difluorobenzylamine supplier

Name
2,4-Difluorobenzylamine
EINECS 276-502-0
CAS No. 72235-52-0
Article Data7
CAS DataBase
Density 1.214 g/cm³
Solubility
Melting Point 255-256 °C(Solv: N,N-dimethylformamide (68-12-2))
Formula C₇H₇F₂N
Boiling Point 177.8 °C at 760 mmHg
Molecular Weight 143.136
Flash Point 68.3 °C
Transport Information UN 2735 8/PG 3
Appearance clear colorless to light yellow liquid
Safety 26-27-36/37/39-45-25
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms (2,4-Difluorophenyl)methanamine;2,4-Difluorobenzenemethanamine;[(2,4-Difluorophenyl)methyl]amine;
PSA 26.02000
LogP 2.12380

Synthetic route

: C13H17F2N4(1+)*Br(1-)

: 72235-52-0
2,4-Difluoro-benzylamine

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 6h; Reflux;	90.8%

: 3939-09-1
2,4-difluorobenzonitrile

: 72235-52-0
2,4-Difluoro-benzylamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In water; isopropyl alcohol at 60 - 80℃; under 7500.75 Torr; Temperature; Reagent/catalyst;	90%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 1,4-di(diphenylphosphino)-butane; iso-butanol; sodium hydroxide at 120℃; for 0.333333h; Inert atmosphere;	75 %Chromat.

: 372-18-9
1,3-Difluorobenzene

: 72235-52-0
2,4-Difluoro-benzylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen bromide; iron(III) chloride / 1,4-dioxane / 7 h / Reflux 2: 1,4-dioxane / 4 h / Reflux 3: hydrogenchloride / water; methanol / 6 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: hydrogenchloride; zinc(II) chloride / acetonitrile; water / 8 h / Reflux 2: toluene / 2 h / Reflux; Industrial scale 3: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: nitrobenzene / 2 h / 70 - 105 °C 2.1: ozone / chlorobenzene / 1.5 h / 0 °C 3.1: thionyl chloride / dichloromethane / 1 h / 50 °C 3.2: 1.5 h / 50 °C 4.1: sodium chloride; bromine / 2 h / 50 °C View Scheme

: 452-07-3
2,4-difluorobenzyl chloride

: 72235-52-0
2,4-Difluoro-benzylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene / 2 h / Reflux; Industrial scale 2: hydrogenchloride / water; isopropyl alcohol / 5 h / Reflux View Scheme

: (2,4-difluoro-benzyl)-hexamethylenetetraminium; chloride

: 72235-52-0
2,4-Difluoro-benzylamine

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol for 5h; Reflux;

: 937397-44-9
{1-benzyl-3-[(3-fluoro-4-nitro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

: 72235-52-0
2,4-Difluoro-benzylamine

: 937721-16-9
(1-benzyl-3-{[3-(2,4-difluoro-benzylamino)-4-nitro-benzenesulfonyl]-isobutyl-amino}-2-hydroxy-propyl)-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester

Conditions

Conditions	Yield
In tetrahydrofuran for 18h; Heating / reflux;	100%

: 72235-52-0
2,4-Difluoro-benzylamine

: 75-36-5
acetyl chloride

: 1030596-28-1
C9H9F2NO

Conditions

Conditions	Yield
With triethylamine at 20℃;	100%

: 72235-52-0
2,4-Difluoro-benzylamine

: 556-61-6
methyl thioisocyanate

: 1400799-52-1
1-(2,4-difluorobenzyl)-3-methylthiourea

Conditions

Conditions	Yield
at 20℃;	99%

: 1357289-08-7
2,5-dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate

: 72235-52-0
2,4-Difluoro-benzylamine

: 1229006-21-6
1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With acetic acid In toluene at 90℃; for 7h; Reagent/catalyst;	97%
With acetic acid In toluene at 90 - 95℃; Solvent; regioselective reaction;	210 g

: 5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: tert-butyl ((2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)methyl)carbamate

Conditions

Conditions	Yield
Stage #1: 5-(((tert-butoxycarbonyl)amino)methyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 0.5h; Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;	97%

: 124-07-2
Octanoic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: 816465-04-0
N-(2,4-difluorobenzyl)octanamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;	96%

: 201230-82-2
carbon monoxide

: 1206103-44-7
(3S,11 aR)-8-bromo-3-methyl-6-[(phenyl-methyl)oxy]-2,3,11,11a-tetrahydro[1,3]oxazolo[3,2-a] pyrido[1,2-d]pyrazine-5,7-dione

: 72235-52-0
2,4-Difluoro-benzylamine

: 1206103-45-8
(3S,11aR)-N-[(2,4-difluorophenyl)methyl]-3-methyl-5,7-dioxo-6-[(phenylmethyl)oxy]-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 9h;	96%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 9h;	96%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 7h;	96%

...Expand

: 1-(2,2-dimethoxy-ethyl)-3-methoxy-4-oxo-1,4-dihydro-pyridine-2,5-dicarboxylic acid dimethyl ester

: 72235-52-0
2,4-Difluoro-benzylamine

: 1616340-68-1
methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dirnethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

Conditions

Conditions	Yield
With acetic acid In toluene at 200℃; under 5171.62 Torr; Solvent; Reagent/catalyst; Temperature; Flow reactor; chemoselective reaction;	96%

: 32137-76-1
benzothiazole-2-carboxylic acid ethyl ester

: 72235-52-0
2,4-Difluoro-benzylamine

: N-(2,4-difluorobenzyl)benzo[d]thiazole-2-carboxamide

Conditions

Conditions	Yield
In acetonitrile at 100℃; for 0.25h; Sealed tube; Microwave irradiation;	95%

: C8H14O5

: 72235-52-0
2,4-Difluoro-benzylamine

: C15H19F2NO4

Conditions

Conditions	Yield
Stage #1: C8H14O5 With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 0 - 15℃; for 0.5h; Stage #2: 2,4-Difluoro-benzylamine In tetrahydrofuran at 0 - 20℃; for 1h; Reagent/catalyst; Solvent;	95%
Stage #1: C8H14O5 With 4-methyl-morpholine; chloroformic acid ethyl ester In tetrahydrofuran at 0 - 30℃; for 0.5h; Stage #2: 2,4-Difluoro-benzylamine In tetrahydrofuran at 10 - 15℃; for 1h;	94%

: 816465-13-1
N-(2,4-difluorobenzyl)-N-(4-ethylbenzyl)amine

: 72235-52-0
2,4-Difluoro-benzylamine

: N-(2,4-difluorobenzyl)-4-ethylbenzamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;	94%

: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-phenylethyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: (S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-phenylethyl)carbamate

Conditions

Conditions	Yield
Stage #1: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-phenylethyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;	94%

: 75-15-0
carbon disulfide

: 72235-52-0
2,4-Difluoro-benzylamine

: 106-93-4
ethylene dibromide

: 3-(2,4-difluorobenzyl)thiazolidine-2-thione

Conditions

Conditions	Yield
Stage #1: carbon disulfide; 2,4-Difluoro-benzylamine With N-benzyl-trimethylammonium hydroxide In dimethyl sulfoxide at 20℃; for 0.25h; Green chemistry; Stage #2: ethylene dibromide In dimethyl sulfoxide at 20℃; Inert atmosphere; Green chemistry;	93.95%

...Expand

: 1339879-91-2
(4R,12aS)-3,4,6,8,12,12a-hexahydro-4-methyl-6,8-dioxo-7-(phenylmethoxy)-2H-pyrido [1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: 1206102-11-5
(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole In dichloromethane for 36h;	93.3%
With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide at 20℃; for 32h;	73%

: 72235-52-0
2,4-Difluoro-benzylamine

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 157840-46-5
N2-(2,4-difluorobenzyl)-5-nitropyridine-2,6-diamine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol for 3h; Reflux; Inert atmosphere;	93%
With triethylamine In 1,4-dioxane

: 51-20-7
5-bromouracil

: 72235-52-0
2,4-Difluoro-benzylamine

: 867151-48-2
5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
at 160℃; for 6h;	93%
at 160℃; for 2h;	91%

: 112-05-0
nonanoic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: 816465-08-4
N-(2,4-difluorobenzyl)nonanamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 20℃;	93%

: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: (S)-tert-butyl (1-(2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)-4-((2,4-difluorobenzyl)carbamoyl)oxazol-5-yl)-2-methylpropyl)carbamate

Conditions

Conditions	Yield
Stage #1: (S)-5-(1-((tert-butoxycarbonyl)amino)-2-methylpropyl)-2-(3-(cyclopropylmethoxy)-4-methoxyphenyl)oxazole-4-carboxylic acid With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2,4-Difluoro-benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;	93%

: 18956-87-1
10H-phenothiazine-10-carbonyl chloride

: 72235-52-0
2,4-Difluoro-benzylamine

: N-(2,4-difluorobenzyl)-10H-phenothiazine-10-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	92.8%

: 3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxylic acid

: 72235-52-0
2,4-Difluoro-benzylamine

: N-(2,4-difluorobenzyl)-3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxamide

Conditions

Conditions	Yield
Stage #1: 3-isobutyl-1-(thiazol-2-yl)-1H-pyrazole-4-carboxylic acid With HATU In N,N-dimethyl-formamide for 0.166667h; Stage #2: 2,4-Difluoro-benzylamine With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	92%

: 122-60-1
Phenyl glycidyl ether

: 72235-52-0
2,4-Difluoro-benzylamine

: 1-[(2,4-difluorobenzyl)amino]-3-phenoxypropan-2-ol

Conditions

Conditions	Yield
Stage #1: Phenyl glycidyl ether; 2,4-Difluoro-benzylamine In N,N-dimethyl-formamide at 60℃; for 12h; Sealed tube; Stage #2: With water In N,N-dimethyl-formamide at 60℃; for 12h; Sealed tube; regioselective reaction;	92%

: 181701-30-4
4-oxo-piperidine-1-carboxylic acid 2-(trimethylsilyl)ethyl ester

: 72235-52-0
2,4-Difluoro-benzylamine

: 2-(trimethylsilyl)ethyl 4-{[(2,4-difluorophenyl)methyl]amino}piperidine-1-carboxylate

Conditions

Conditions	Yield
With ethanol; sodium tris(acetoxy)borohydride for 22h;	92%
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 1h;	3.49 g

: 72235-52-0
2,4-Difluoro-benzylamine

: 13623-94-4
1,1-di(methylsulfanyl)-2-nitroethylene

: N,N'-bis(2,4-difluorobenzyl)-2-nitroethylene-1,1-diamine

Conditions

Conditions	Yield
In ethanol for 12h; Reflux;	91%

: 1445-73-4
1-Methyl-4-piperidone

: 72235-52-0
2,4-Difluoro-benzylamine

: N-[(2,4-difluorophenyl)methyl]-1-methylpiperidin-4-amine

Conditions

Conditions	Yield
With ethanol; sodium tris(acetoxy)borohydride at 20℃; for 2h;	91%
With ethanol; sodium tris(acetoxy)borohydride at 20℃; for 2h;	91%

: 201230-82-2
carbon monoxide

: 1206102-10-4
(4R,12aS)-7-(benzyloxy)-9-bromo-4-methyl-3,4,12,12atetrahydro-2H-pyrido [1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-6,8-dione

: 72235-52-0
2,4-Difluoro-benzylamine

: 1206102-11-5
(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2’:4,5]-pyrazino[2,1-b][1,3]oxazine-9-carboxamide

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 5h; Large scale;	90%
With N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0) In dimethyl sulfoxide at 90℃; for 5.5h; Product distribution / selectivity;	84%
With tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 90℃; for 5.5h; Solvent;	84%
With tetrakis(triphenylphosphine) palladium(0)

...Expand

: methyl 1-(benzyloxy)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxylate

: 72235-52-0
2,4-Difluoro-benzylamine

: 1-(benzyloxy)-N-(2,4-difluorobenzyl)-4-hydroxy-2-oxo-7-(piperidin-1-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 2h; Microwave irradiation;	90%

: N-[5-(4-fluoro-3-nitrophenyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethylpropionamide

: 72235-52-0
2,4-Difluoro-benzylamine

: N-{5-[4-(2,4-difluorobenzylamino)-3-nitrophenyl]-[1,3,4]thiadiazol-2-yl}-2,2-dimethylpropionamide

Conditions

Conditions	Yield
In ethanol at 100℃; for 1h; Microwave irradiation;	89%

: 2-(4-fluoro-3-nitrophenyl)-5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole

: 72235-52-0
2,4-Difluoro-benzylamine

: (2,4-difluorobenzyl)-{4-[5-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-2-nitrophenyl}amine

Conditions

Conditions	Yield
In ethanol at 100℃; for 1h; Microwave irradiation;	89%

2,4-Difluorobenzylamine Chemical Properties

Chemistry informtion about 2,4-Difluorobenzylamine (CAS NO.72235-52-0) is:
IUPAC Name: (2,4-Difluorophenyl)Methanamine
Synonyms: 2,4-Difluorobenzylamine ; Rarechem Al Bw 0282 ; 2,4-Difluorobenzylamine 97% ; 2,4-Difluorobenzylamine97% ; 2,4-Difluorobenzylamine Hydrochloride ; 2,4-Difluorobenzylamine, 98+% ; (2,4-Difluorophenyl)Methanamine ; Benzenemethanamine, 2,4-Difluoro-
MF: C₇H₇F₂N
MW: 143.13
EINECS: 276-502-0
Density: 1.214 g/cm³
Flash Point: 79.4 °C
Boiling Point: 183.8 °C at 760 mmHg
Vapour Pressure: 0.756 mmHg at 25°C
Enthalpy of Vaporization: 42.01 kJ/mol
Refractive Index: n20/D 1.49(lit.)
Sensitive: Air Sensitive
BRN: 3539259
Following is the molecular structure of 2,4-Difluorobenzylamine (CAS NO.72235-52-0) is:

2,4-Difluorobenzylamine Safety Profile

Safty information about 2,4-Difluorobenzylamine (CAS NO.72235-52-0) :
Hazard Codes:
C: Corrosive
Risk Statements:
R34:Causes burns.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S25:Avoid contact with eyes.
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III

2,4-Difluorobenzylamine Specification

2,4-Difluorobenzylamine (CAS NO.72235-52-0) is a clear colorless to light yellow liquid.
First Aid Measures:
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes: Get medical aid immediately. Do not allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).
Handling and Storage:
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
Handling: Wash thoroughly after handling. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Product Name

2,4-Difluorobenzylamine

Synthetic route

2,4-Difluorobenzylamine Chemical Properties

2,4-Difluorobenzylamine Safety Profile

2,4-Difluorobenzylamine Specification

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