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Jinan Finer Chemical Co., Ltd

Product description: Product name 5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine CAS number 733039-20-8 Assay ≥99% Appearance White powder Capacity 200mt/year Application Pa

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

Cas:733039-20-8

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine manufacturer/supplier

Cas:733039-20-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine CAS No.:733039-20-8 Name: 5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine Synonyms: N-(5-Bromo-2-chloropyrimidin-4-yl)(cyclopentyl)amine Molecular Structure Mole

High purity 5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine CAS No.:733039-20-8

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine

Cas:733039-20-8

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine

Cas:733039-20-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine(733039-20-8)

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

Cas:733039-20-8

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine

Cas:733039-20-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Leader Biochemical Group

About Product Technical Details 5-broMo-2-chloro-N-cyclopent

China Largest factory Manufacturer Supply 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine CAS 733039-20-8

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 733039-20-8 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 733039-20-8 with best quality

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine CAS:733039-20-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine CAS:733039-20-8

Cas:733039-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Pyrimidinamine, 5-bromo-2-chloro-N-cyclopentyl-/ LIDE PHARMA- Factory supply / Best price

Cas:733039-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine CAS: 733039-20-8 Specification Product name 5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine CAS number 733039-20-8 Assay ≥99% Appearance White po

Factory supply 5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

Cas:733039-20-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Pyrimidinamine, 5-bromo-2-chloro-N-cyclopentyl-

Cas:733039-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine CAS 733039-20-8

Cas:733039-20-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-BROMO-2-CHLORO-N-CYCLOPENTYLPYRIMIDIN-4-AMINE

Cas:733039-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine

Cas:733039-20-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

733039-20-8--5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Appearance:White Powder Storage:Room temperature Package:according to customers' requirements Application:Pharmaceutical intermediates,API Transportation:By air(EMS or EUB or FedEx or TNT

733039-20-8--5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Cas:733039-20-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 5-Bromo-2-Chloro-4-(Cyclopentylamino)pyrimidine CAS No.: 733039-20-8 Molecule Formula:C9H11BrClN3 Molecule Weight:276.56 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price 5-Bromo-2-Chloro-4-(Cyclopentylamino)pyrimidine on stock

Cas:733039-20-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

Cas:733039-20-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name:5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine CAS:733039-20-8 Molecular Formula:C9H11BrClN3 Molecular Weight:276.56074 Purity:99% Appearance:White powder Storage: Room Temperature Package: 25kg/drum or 20kg/bag Applica

5-Brom-2-chlor-N-cyclopentylpyrimidin-4-amin CAS: 733039-20-8

Cas:733039-20-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Synthetic route

Cyclopentamine

Cyclopentamine

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; for 6h;100%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 6h; Inert atmosphere;100%
With sodium hydrogencarbonate In dichloromethane at 20℃; for 13h; Reagent/catalyst; Solvent;97.5%
cyclopentyl chloride
930-28-9

cyclopentyl chloride

4-amino-5-bromo-2-chloropyrimidine
205672-25-9

4-amino-5-bromo-2-chloropyrimidine

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

Conditions
ConditionsYield
With triethylamine In methanol at 20℃;92.74%
With copper diacetate; sodium hydroxide In dichloromethane at 80℃; for 10h;77%
Cyclopentyl bromide
137-43-9

Cyclopentyl bromide

4-amino-5-bromo-2-chloropyrimidine
205672-25-9

4-amino-5-bromo-2-chloropyrimidine

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

Conditions
ConditionsYield
With copper(II) trifluoroacetate; sodium hydroxide In 1,4-dioxane at 80℃; for 6h; Reagent/catalyst; Solvent; Temperature;90%
2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

Cyclopentamine
1003-03-8

Cyclopentamine

A

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

B

5-bromo-4-chloro-N-cyclopentyl-2-pyrimidinamine

5-bromo-4-chloro-N-cyclopentyl-2-pyrimidinamine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 20℃; Reagent/catalyst;
2-butenoic acid
3724-65-0

2-butenoic acid

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one
1013916-37-4

2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one

Conditions
ConditionsYield
With triethylamine; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 75℃; for 6h; Temperature; Solvent; Reagent/catalyst; Inert atmosphere;94.8%
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With triethylamine; palladium dichloride In tetrahydrofuran at 60℃; for 5h;
Stage #2: 2-butenoic acid In tetrahydrofuran for 2h; Temperature; Reagent/catalyst; Solvent;
89.08%
Stage #1: 2-butenoic acid; 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With bis(benzonitrile)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine In tetrahydrofuran at 75℃; for 20h; Heck Reaction; Inert atmosphere;
Stage #2: In acetic anhydride at 75℃; for 2h; Temperature; Reagent/catalyst; Solvent;
80%
With triethylamine; palladium dichloride In 1-methyl-pyrrolidin-2-one at 75℃; for 6h; Temperature; Inert atmosphere;
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

tert-butyl 4-(6-{[5-bromo-4-(cyclopentylamino)pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate
733038-80-7

tert-butyl 4-(6-{[5-bromo-4-(cyclopentylamino)pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With potassium carbonate In dichloromethane at 60℃; for 0.5h;
Stage #2: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate In dichloromethane at 20 - 60℃; for 1h;
85%
Stage #1: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate; 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine In xylene; butan-1-ol at 100 - 140℃;
Stage #2: With sodium hydroxide In water; ethyl acetate; xylene; butan-1-ol
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

prop-1-yne
74-99-7

prop-1-yne

2-chloro-4-cyclopentylamino-5-(propynyl)pyrimidine

2-chloro-4-cyclopentylamino-5-(propynyl)pyrimidine

Conditions
ConditionsYield
With triphenylphosphine; palladium dichloride In N,N-dimethyl-formamide at 50℃; for 20h; Reagent/catalyst; Solvent; Temperature;85%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

methyl iodide
74-88-4

methyl iodide

(5-bromo-2-chloropyrimidin-4-yl)cyclopentylmethylamine

(5-bromo-2-chloropyrimidin-4-yl)cyclopentylmethylamine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 1.5h;84%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

(E)-but-2-enoic acid
107-93-7

(E)-but-2-enoic acid

2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one
1013916-37-4

2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; (E)-but-2-enoic acid With palladium diacetate; triethylamine In 1-methyl-pyrrolidin-2-one at 65℃; Inert atmosphere;
Stage #2: With acetic anhydride In 1-methyl-pyrrolidin-2-one at 65℃; Inert atmosphere;
81%
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; (E)-but-2-enoic acid With N-ethyl-N,N-diisopropylamine; palladium(II) chloride benzonitrile complex; tris-(o-tolyl)phosphine In tetrahydrofuran at 70℃; for 16h;
Stage #2: With acetic anhydride In tetrahydrofuran for 1.5h;
68%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

propargyl alcohol
107-19-7

propargyl alcohol

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
1374639-76-5

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With copper(l) iodide; palladium on activated charcoal; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: propargyl alcohol In tetrahydrofuran for 5.5h; Reflux;
Stage #3: With bis[2-(diphenylphosphino)phenyl] ether for 4h; Reflux;
74.5%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; N-butylamine In tetrahydrofuran at 29℃; for 20h; Sonogashira Cross-Coupling; Inert atmosphere; Reflux;62%
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; propargyl alcohol With tetrabutyl ammonium fluoride; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 25 - 67℃; for 2h; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In ethyl acetate
47.4%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-chloro-4-cyclopentylaminopyrimidine-5-aldehyde

2-chloro-4-cyclopentylaminopyrimidine-5-aldehyde

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine With isopropylmagnesium chloride In tetrahydrofuran at 0 - 5℃; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 20℃; Inert atmosphere;
74%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

acrylic acid
79-10-7

acrylic acid

C12H14ClN3O2

C12H14ClN3O2

Conditions
ConditionsYield
With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel dichloride In ethanol at 65℃; for 8h; Inert atmosphere;73.1%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

propynoic acid ethyl ester
623-47-2

propynoic acid ethyl ester

C14H16ClN3O2

C14H16ClN3O2

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In acetonitrile at 0 - 60℃; Inert atmosphere;73%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

N,N-dimethylpropynamide
2682-34-0

N,N-dimethylpropynamide

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
1211443-61-6

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Conditions
ConditionsYield
With N,N'-Diphenyloxamid; potassium carbonate; copper(l) chloride In dimethyl sulfoxide at 90 - 100℃; for 12h; Reagent/catalyst;73%
With N,N,N,N,-tetramethylethylenediamine; potassium carbonate; copper(l) chloride In dimethyl sulfoxide at 90 - 100℃; for 12h; Reagent/catalyst;71%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

5‑bromo‑N‑cyclopentyl‑2‑(methylthio)pyrimidin‑4‑amine
733039-23-1

5‑bromo‑N‑cyclopentyl‑2‑(methylthio)pyrimidin‑4‑amine

Conditions
ConditionsYield
In dimethyl sulfoxide72%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

(2-tert-butoxy-2-oxoethyl)zinc(II) bromide
51656-70-3

(2-tert-butoxy-2-oxoethyl)zinc(II) bromide

tert-butyl 2-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)acetate

tert-butyl 2-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)acetate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene In tetrahydrofuran; 1,4-dioxane at 20℃; for 1h; Inert atmosphere;67%
With tris-(dibenzylideneacetone)dipalladium(0); monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene In tetrahydrofuran; 1,4-dioxane at 20℃; for 1h; Inert atmosphere;67%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

5-bromo-N4-cyclopentylpyrimidine-2,4-diamine
1169698-46-7

5-bromo-N4-cyclopentylpyrimidine-2,4-diamine

Conditions
ConditionsYield
With ammonia In water; isopropyl alcohol at 120℃; for 22h;66%
With ammonium hydroxide In isopropyl alcohol at 120℃; for 22h; Sealed tube; Inert atmosphere;66%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

hydroxy-1-propyne
6175-54-8

hydroxy-1-propyne

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
1374639-76-5

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride In tetrahydrofuran at 70℃; for 5h;65.9%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

4-amino-N-(1-methylpiperidin-4-yl)benzamide
50534-11-7

4-amino-N-(1-methylpiperidin-4-yl)benzamide

C22H29BrN6O

C22H29BrN6O

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 80℃; for 18h;63%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

Propiolaldehyde diethyl acetal
10160-87-9

Propiolaldehyde diethyl acetal

[2-chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-cyclopentyl amine
1211442-87-3

[2-chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-cyclopentyl amine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; Propiolaldehyde diethyl acetal With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: copper(l) iodide In tetrahydrofuran at 60℃; for 48h; Product distribution / selectivity; Inert atmosphere;
54%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Sonogashira coupling;41%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

2-chloro-N-cyclopentyl-5-((trimethylsilyl)ethynyl)pyrimidin -4-amine
1383481-56-8

2-chloro-N-cyclopentyl-5-((trimethylsilyl)ethynyl)pyrimidin -4-amine

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; for 8h; Inert atmosphere;53.1%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

4-(5-aminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
119285-07-3

4-(5-aminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

4-[5-(5-BROMO-4-CYCLOPENTYLAMINOPYRIMIDIN-2-YLAMINO)-PYNIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester
733039-28-6

4-[5-(5-BROMO-4-CYCLOPENTYLAMINOPYRIMIDIN-2-YLAMINO)-PYNIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC acid tert-butyl ester

Conditions
ConditionsYield
With sodium t-butanolate In toluene at 115℃; for 48h;45%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
876126-60-2

4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

C23H31BrN6O2

C23H31BrN6O2

Conditions
ConditionsYield
With hydrogenchloride In water; isopropyl alcohol at 80℃; for 18h;31%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

Methyl 2-butynoate
23326-27-4

Methyl 2-butynoate

2-chloro-7-cyclopentyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester
959799-27-0

2-chloro-7-cyclopentyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate; lithium chloride; palladium diacetate In N,N-dimethyl-formamide at 120℃; for 5h;25%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

1-(2-Chloro-7-cyclopentyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethanol
959799-21-4

1-(2-Chloro-7-cyclopentyl-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-ethanol

Conditions
ConditionsYield
With potassium acetate; lithium chloride; palladium diacetate In N,N-dimethyl-formamide at 120℃; for 5h;14.8%
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
1211443-61-6

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.67 h / 25 - 60 °C / Inert atmosphere
3: sodium cyanide / N,N-dimethyl-formamide; tetrahydrofuran / 4.25 h / 17 - 23 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0 - 60 °C / Inert atmosphere
2: copper(l) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 85 - 90 °C / Inert atmosphere
3: sodium hydroxide / methanol; water / 10 - 25 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 0 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 20 h / 50 °C
2.1: tetrabutyl ammonium fluoride / ethanol / 16 h / 60 °C
3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Sealed tube
3.2: 24 h / 100 °C / Sealed tube
View Scheme
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide)
1211441-98-3

(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide)

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.67 h / 25 - 60 °C / Inert atmosphere
3.1: sodium cyanide / N,N-dimethyl-formamide; tetrahydrofuran / 4.25 h / 17 - 23 °C / Inert atmosphere
4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 4-methyl-2-pentanone / 3.25 h / 37 - 103 °C / Inert atmosphere
5.1: hydrogenchloride; water / toluene / 1.08 h / 9 - 28 °C / Inert atmosphere
5.2: Si-thiol functionalized silica gel / 6 h / 30 - 53 °C / pH 2.9 - 3.5
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 20 h / 50 °C
2.1: tetrabutyl ammonium fluoride / ethanol / 16 h / 60 °C
3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Sealed tube
3.2: 24 h / 100 °C / Sealed tube
4.1: potassium carbonate / dichloromethane / 0.5 h / 60 °C
4.2: 1 h / 60 °C
5.1: phosphoric acid / dichloromethane
View Scheme
Multi-step reaction with 5 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: sodium t-butanolate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate / N,N-dimethyl acetamide / 0 - 110 °C / Inert atmosphere
5.1: hydrogenchloride / methanol; water / 10 - 25 °C
View Scheme
Multi-step reaction with 7 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: sodium hydroxide / methanol; water / 10 - 45 °C
5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 25 °C
6.1: sodium t-butanolate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate / N,N-dimethyl acetamide / 0 - 110 °C / Inert atmosphere
7.1: hydrogenchloride / methanol; water / 10 - 25 °C
View Scheme
Multi-step reaction with 7 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 0 - 110 °C / Inert atmosphere
5.1: lithium hydroxide monohydrate / methanol; water / 10 - 45 °C
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 30 °C
7.1: hydrogenchloride / methanol; water / 10 - 25 °C
View Scheme
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
1374639-77-6

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.67 h / 25 - 60 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: N-butylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran / 20 h / 29 °C / Inert atmosphere; Reflux
2: trifluoroacetic acid / tetrahydrofuran / 12 h / 29 - 60 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 70 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 70 °C
View Scheme
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide
1374639-78-7

N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.67 h / 25 - 60 °C / Inert atmosphere
3: sodium cyanide / N,N-dimethyl-formamide; tetrahydrofuran / 4.25 h / 17 - 23 °C / Inert atmosphere
4: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 4-methyl-2-pentanone / 3.25 h / 37 - 103 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 20 h / 50 °C
2.1: tetrabutyl ammonium fluoride / ethanol / 16 h / 60 °C
3.1: N-Bromosuccinimide / 1,2-dichloro-ethane / 3 h / 20 °C / Sealed tube
3.2: 24 h / 100 °C / Sealed tube
4.1: potassium carbonate / dichloromethane / 0.5 h / 60 °C
4.2: 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: sodium t-butanolate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate / N,N-dimethyl acetamide / 0 - 110 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 0 - 110 °C / Inert atmosphere
5.1: lithium hydroxide monohydrate / methanol; water / 10 - 45 °C
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 45 - 50 °C
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 30 °C
4.1: sodium hydroxide / methanol; water / 10 - 45 °C
5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 0 - 25 °C
6.1: sodium t-butanolate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate / N,N-dimethyl acetamide / 0 - 110 °C / Inert atmosphere
View Scheme
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine
733039-20-8

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.67 h / 25 - 60 °C / Inert atmosphere
3.1: sodium cyanide / N,N-dimethyl-formamide; tetrahydrofuran / 4.25 h / 17 - 23 °C / Inert atmosphere
4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 4-methyl-2-pentanone / 3.25 h / 37 - 103 °C / Inert atmosphere
5.1: hydrogenchloride; water / toluene / 1.08 h / 9 - 28 °C / Inert atmosphere
5.2: Si-thiol functionalized silica gel / 6 h / 30 - 53 °C / pH 2.9 - 3.5
6.1: isopropyl alcohol / 27 - 83 °C / Inert atmosphere
View Scheme
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