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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

High quality Methyl-4-aza-5a-androsten-3- one-17b-carboxylic acid

Cas:73671-92-8

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 73671-92-8 with best price

Cas:73671-92-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Methyl-4-aza-5a-androsten-3-one-17b-carboxylic acid

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Methyl-4-aza-5alpfa-androst a-3-one -17beta-carboxylate 73671-92-8

Cas:73671-92-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE CAS:73671-92-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE CAS:73671-92-8

Cas:73671-92-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Methyl-4-aza-5alpfa-androst a-3-one -17beta-carboxylate

Cas:73671-92-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

METHYL?4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DUTASTERIDE INTERMEDIATE M3

Cas:73671-92-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Methyl-4-aza-5a-androsten-3- one-17b-carboxylic acid

Cas:73671-92-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Methyl 4-aza-5alpha-androsta-3-one-17beta-carboxylate

Cas:73671-92-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Methyl 4-Aza-5Alpha-Androsta-3-One-17Beta-Carboxylate

Cas:73671-92-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Methyl-4-aza-5alpfa-androst a-3-one -17beta-carboxylate

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Methyl-4-aza-5alpfa-androst a-3-one -17beta-carboxylate

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Methyl 4-aza-5alpha-Androsta-3-one-17beta-CarboxylateAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Methyl 4-aza-5alpha-Androsta-3-one-17beta-Carboxylate

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Other

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

factory?direct?saleAppearance:powder Storage:In cool ,dry place Package:G/bottle; Kg/bag; 258kg/barrel Application:for pharma use Transportation:Air or sea freight Port:Any main ports of China

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

73671-92-8

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE(M3)

Cas:73671-92-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

3-carbonyl-4-aza-5-androstene-17β-carboxylic acid methyl ester

3-carbonyl-4-aza-5-androstene-17β-carboxylic acid methyl ester

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid at 20 - 80℃; under 3750.38 - 4500.45 Torr; for 12h; Inert atmosphere; Industrial scale;94.7723%
3-oxo-4-aza-5α-androstane-17β-carboxylic acid
103335-55-3

3-oxo-4-aza-5α-androstane-17β-carboxylic acid

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating;
With hydrogenchloride In methanol at 20℃; for 3h; Reflux;
methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate
103335-41-7

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In dichloromethane
3,20-dioxo-4-aza-pregnan-5-ene
20283-95-8

3,20-dioxo-4-aza-pregnan-5-ene

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
2: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
3: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
C20H31NO3
1416955-23-1

C20H31NO3

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / methanol / 0.58 h
2: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
3: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
4: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
3,20-dioxo-4-aza-5α-pregnane
73711-89-4

3,20-dioxo-4-aza-5α-pregnane

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
2: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
Progesterone
57-83-0

Progesterone

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: potassium carbonate; sodium periodate; potassium permanganate / tert-butyl alcohol; water / 1 h / 50 °C
2: triethylamine / tetrahydrofuran / 2 h / -5 - -2 °C / Inert atmosphere
3: ammonium acetate / tetrahydrofuran / 1 h / Reflux; Inert atmosphere
4: hydrogenchloride / water; tetrahydrofuran / 1 h / -15 - 0 °C
5: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
6: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
7: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate; sodium periodate; potassium permanganate / tert-butyl alcohol; water / 1 h / 50 °C
2: triethylamine / tetrahydrofuran / 2 h / -5 - -2 °C / Inert atmosphere
3: ammonia / methanol / 0.5 h / 0 - 25 °C
4: toluene-4-sulfonic acid / methanol / 0.58 h
5: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
6: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
7: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
3,5-seco-4-norpregn-5,20-dion-3-carboxylic acid
3510-20-1

3,5-seco-4-norpregn-5,20-dion-3-carboxylic acid

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine / tetrahydrofuran / 2 h / -5 - -2 °C / Inert atmosphere
2: ammonium acetate / tetrahydrofuran / 1 h / Reflux; Inert atmosphere
3: hydrogenchloride / water; tetrahydrofuran / 1 h / -15 - 0 °C
4: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
5: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
6: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / tetrahydrofuran / 2 h / -5 - -2 °C / Inert atmosphere
2: ammonia / methanol / 0.5 h / 0 - 25 °C
3: toluene-4-sulfonic acid / methanol / 0.58 h
4: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
5: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
6: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
3,5-seco-4-norpregn-5,20-dioxo-3-(ethoxycarbonyl)carboxylate
1416955-18-4

3,5-seco-4-norpregn-5,20-dioxo-3-(ethoxycarbonyl)carboxylate

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ammonium acetate / tetrahydrofuran / 1 h / Reflux; Inert atmosphere
2: hydrogenchloride / water; tetrahydrofuran / 1 h / -15 - 0 °C
3: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
4: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
5: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1: ammonia / methanol / 0.5 h / 0 - 25 °C
2: toluene-4-sulfonic acid / methanol / 0.58 h
3: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
4: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
5: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
3,20-dioxo-4-aza-pregnan-5α-ol

3,20-dioxo-4-aza-pregnan-5α-ol

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / water; tetrahydrofuran / 1 h / -15 - 0 °C
2: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
3: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
4: hydrogenchloride / methanol / 3 h / 20 °C / Reflux
View Scheme
2,5-bis(trifluoromethyl)aniline
328-93-8

2,5-bis(trifluoromethyl)aniline

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide
164656-22-8

(5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide

Conditions
ConditionsYield
Stage #1: 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester With boron tribromide In dichloromethane at 25℃; for 0.333333h;
Stage #2: 2,5-bis(trifluoromethyl)aniline In dichloromethane at 50℃;
93%
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

Methyl-2-iodo-3-oxo-4-aza-5-α-androstane-17β-carboxylate

Methyl-2-iodo-3-oxo-4-aza-5-α-androstane-17β-carboxylate

Conditions
ConditionsYield
With I2; N-ethyl-N,N-diisopropylamine In dichloromethane; acetonitrile88%
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

methyl (2α,5α,17β)-2-iodo-3-oxo-4-aza-5-androstane-17-carboxylate
149198-45-8

methyl (2α,5α,17β)-2-iodo-3-oxo-4-aza-5-androstane-17-carboxylate

Conditions
ConditionsYield
Stage #1: 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine In dichloromethane at -14 - 20℃; for 0.0833333h; Cooling with acetone-dry ice;
Stage #2: With iodine In dichloromethane for 2h; Cooling with acetone-dry ice;
87%
With trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; iodine 1) CH2Cl2, -15 deg C, 15 min, 2) 0 deg C, 1.5 h; Yield given. Multistep reaction;
Stage #1: 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine In dichloromethane at -10℃; for 0.5h; Inert atmosphere;
Stage #2: With iodine In dichloromethane at -10 - 0℃; for 2h;
24.8 g
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

diphenyldisulfane
882-33-7

diphenyldisulfane

Methyl 2-phenylsulphenyl-3-oxo-4-aza-5α-androstan-17β-carboxylate
141057-70-7

Methyl 2-phenylsulphenyl-3-oxo-4-aza-5α-androstan-17β-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane38%
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate
103335-41-7

methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate

Conditions
ConditionsYield
With bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane 20 deg C, 4 h. then 110 deg C, 18 h.; Yield given;
With benzeneseleninic anhydride In chlorobenzene for 4h; Heating;49.5 g
With 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In toluene at 25 - 110℃; for 12h; Product distribution / selectivity; Inert atmosphere;
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-thioxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylic acid methyl ester

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-thioxo-hexadecahydro-indeno[5,4-f]quinoline-7-carboxylic acid methyl ester

Conditions
ConditionsYield
With Lawessons reagent In dichloromethane for 10h; Ambient temperature; Yield given;
oxalyl dichloride
79-37-8

oxalyl dichloride

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

C22H29NO5

C22H29NO5

Conditions
ConditionsYield
Stage #1: oxalyl dichloride; 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester With pyridine In dichloromethane at -45 - -35℃; for 0.166667h;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at -10℃; for 0.75h;
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

dihydro-finasteride
98319-24-5

dihydro-finasteride

Conditions
ConditionsYield
With hydrogenchloride; n-butyllithium; tert-butylamine In tetrahydrofuran; n-heptane; water11.2 g (99.7%)
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 50 - 55 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide / methanol
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

methyl iodide
74-88-4

methyl iodide

methyl-3-oxo-4-methyl-4-aza-5α-androstane-17β-carboxylate
86283-81-0

methyl-3-oxo-4-methyl-4-aza-5α-androstane-17β-carboxylate

Conditions
ConditionsYield
With sodium chloride In N-methyl-acetamide; mineral oil
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid
104239-97-6

3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / toluene / 12 h / 25 - 110 °C / Inert atmosphere
2.1: sulfuric acid / 3 h / 20 - 30 °C
2.2: 1.5 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

3-oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid chloride

3-oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / toluene / 12 h / 25 - 110 °C / Inert atmosphere
2.1: sulfuric acid / 3 h / 20 - 30 °C
2.2: 1.5 h / 0 - 5 °C
3.1: thionyl chloride / dichloromethane / 0.5 h / 25 - 30 °C / Inert atmosphere
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

dutasteride

dutasteride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / toluene / 12 h / 25 - 110 °C / Inert atmosphere
2.1: sulfuric acid / 3 h / 20 - 30 °C
2.2: 1.5 h / 0 - 5 °C
3.1: thionyl chloride / dichloromethane / 0.5 h / 25 - 30 °C / Inert atmosphere
4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 25 - 30 °C
4.2: 12 h / 40 - 42 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: triethylamine / acetonitrile / 4 h / -7 - -5 °C / Inert atmosphere
4.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -15 - -8 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.25 h / -20 °C
4.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / 76 - 78 °C
View Scheme
Multi-step reaction with 4 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C
4.1: boron trifluoride diethyl etherate / tetrahydrofuran / 13 h / 0 - 65 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 0.33 h / 25 °C
1.2: 50 °C
2.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2.2: 0 - 5 °C / Inert atmosphere
3.1: sodium hydrogencarbonate; Oxone / water; acetone / 30 °C
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

(5α,17β)-3-oxo-4-azaandrost-1-ene-17-(ethoxycarbonyl)carboxylate
1416955-22-0

(5α,17β)-3-oxo-4-azaandrost-1-ene-17-(ethoxycarbonyl)carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: triethylamine / acetonitrile / 4 h / -7 - -5 °C / Inert atmosphere
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

C20H29NO5S
1260388-53-1

C20H29NO5S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.25 h / -20 °C
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

C24H35NO4
1169835-66-8

C24H35NO4

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
1.2: 2 h / -10 - 0 °C
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.33 h / -15 °C
2.2: 2 h / 50 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

C25H40N2O2

C25H40N2O2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 50 - 55 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

N-phenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide

N-phenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 50 - 55 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid cyclohexylamide
133216-45-2

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid cyclohexylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol / 50 - 55 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide
3: N,O-bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 90 - 95 °C
View Scheme
3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester
73671-92-8

3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester

N-phenyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide

N-phenyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol / 50 - 55 °C
2: benzotriazol-1-ol; dicyclohexyl-carbodiimide
3: N,O-bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 90 - 95 °C
View Scheme

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