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Dayang Chem (Hangzhou) Co.,Ltd.

img _fcksavedurl="/UserAppearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:It is an important raw material and intermediate used in Organic Synthesis, Phar

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

(2R,4R)-4-Methylpiperidine-2-carboxylic acid, CAS No.:74892-81-2 Name (2R,4R)-4-Methylpiperidine-2-carboxylic acid Synonyms (2R,4R)-4-Methylpipecolinic acid Molecular Structure Molecular Formula C7H13NO2 Molec

(2R,4R)-4-Methylpiperidine-2-carboxylic acid, CAS No.:74892-81-2

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

(2R,4R)-4-Methylpiperidine-2-carboxylic acid Basic information Product Name: (2R,4R)-4-Methylpiperidine-2-carboxylic acid Synonyms: (2R,4R)-4-METHYLPIPERIDINE-2-CAR

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2R,4R)-4-Methylpiperidine-2-Carboxylicacid

Cas:74892-81-2

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM_(2R,4R)-4-Methylpiperidine-2-carboxylic acid 74892-81-2

Cas:74892-81-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 74892-81-2 with best quality

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

(2R,4R)-4-Methylpiperidine-2-carboxylic acid CAS74892-81-2

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(2R,4R)-4-Methylpiperidine-2-carboxylic acid 74892-81-2

Cas:74892-81-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

(2R,4R)-4-Methylpiperidine-2-carboxylic acid 74892-81-2

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $100.0 / 120.0

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

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Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

(2R,4R)-4-methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Nantong Noatic Bio-Pharm Technology Co.,Ltd

We are manufacturer of this product and can supply good quality and competitive price , the purity over 98.0%, this product has been in massive production for years , so its process and quality always keep stable and its price is very competitive .

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Product Name: (2R,4R)-4-Methylpiperidine-2-carboxylic acid Synonyms: (2R,4R)-4-METHYLPIPERIDINE-2-CARBOXYLIC ACID;(2R,4R)-4-Methylpipecolinic acid;2-…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Other

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Hebei Lead Bio-Chemicals Co., Ltd.

Hebei Lead Bio-Chemicals Co., Ltd. established in 2006, devolved in resurching, manufacturing and supplying of pharmaceuticals,food ingredients, cosmetics,health care products, Chinese herb, plant extracts and some fine chemicals,is one of leading gr

The China supplier of Argatroban Intermediate Cas:74892-81-2

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Manufacturers

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2R,4R)-4-Methylpiperidine-2-carboxylic acid cas no. 74892-81-2 95%%

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:White to yellow Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(2R,4R)-4-Methyl-2-piperidinecarboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(2R,4R)-4-Methylpiperidine-2-carboxylic acid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

(2R,4R)-4-Methylpiperidine-2-Carboxylicacid

Cas:74892-81-2

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

(4R,8R,10R)-8-methyl-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1-one

(4R,8R,10R)-8-methyl-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1-one

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
With hydrogen; palladium dihydroxide In ethanol98%
With hydrogen; palladium dihydroxide In ethanol for 2h;98%
C22H25NO2

C22H25NO2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Stage #1: C22H25NO2 With hydrogen; [Rh(NBD)(PPh3)2]PF6 In ethanol at 50℃; under 760.051 Torr; for 4h;
Stage #2: With palladium hydroxide, 20 wt% on carbon; hydrogen In ethanol; water at 23℃; under 760.051 Torr; for 5h;
86%
(2R,4S)-2-amino-6-methoxy-4-methyl-6-oxohexanoic acid

(2R,4S)-2-amino-6-methoxy-4-methyl-6-oxohexanoic acid

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
With potassium borohydride In water at 1 - 60℃; for 3.5h;83.1%
(2R,4R)-N-(tert-butoxycarbonyl)-4-methylpipecolic acid
154002-73-0

(2R,4R)-N-(tert-butoxycarbonyl)-4-methylpipecolic acid

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃; for 2h;74%
C10H19NO2

C10H19NO2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NaHCO3 / methanol / 16 h / 60 °C
2: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
3: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
4: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
5: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
6: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
7: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(2R,3R)-N-allyl-N-(tert-butoxycarbonyl)-3-amino-5-methyl-5-hexen-1,2-diol

(2R,3R)-N-allyl-N-(tert-butoxycarbonyl)-3-amino-5-methyl-5-hexen-1,2-diol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
2: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
3: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
4: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
5: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
6: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(+)-(2R)-N-allyl-N-(tert-butoxycarbonyl)-2-amino-4-methyl-4-pentenaldehyde

(+)-(2R)-N-allyl-N-(tert-butoxycarbonyl)-2-amino-4-methyl-4-pentenaldehyde

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
2: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
3: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
4: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
5: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(2R)-N-allyl-N-(tert-butoxycarbonyl)-2-amino-4-methyl-4-penten-1-ol
954379-06-7

(2R)-N-allyl-N-(tert-butoxycarbonyl)-2-amino-4-methyl-4-penten-1-ol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
2: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
3: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
4: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(N-(tert-butoxycarbonyl)-(6R)-1,2,3,6-tetrahydro-4-methylpyridine-2-yl)methanol
954379-07-8

(N-(tert-butoxycarbonyl)-(6R)-1,2,3,6-tetrahydro-4-methylpyridine-2-yl)methanol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
2: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
3: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(N-(tert-butoxycarbonyl)-(2R,4R)-4-methylpiperidine-2-yl)methanol
173369-02-3

(N-(tert-butoxycarbonyl)-(2R,4R)-4-methylpiperidine-2-yl)methanol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
2: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
((2S,3S)-3-(2-methylallyl)oxiran-2-yl)methanol
954378-99-5

((2S,3S)-3-(2-methylallyl)oxiran-2-yl)methanol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LiClO4 / 16 h / 40 °C
2: NaHCO3 / methanol / 16 h / 60 °C
3: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
4: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
5: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
6: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
7: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
8: 74 percent / aq. HCl / methanol / 2 h / 20 °C
View Scheme
(4R,10R)-8-methylene-4-phenyloctahydropyrido[2,1-c][1,4]oxazin-1-ol
194796-77-5

(4R,10R)-8-methylene-4-phenyloctahydropyrido[2,1-c][1,4]oxazin-1-ol

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 85 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / 1.5 h / -50 - 20 °C
2: 74 percent / H2 / PtO2 / ethyl acetate / 0.25 h
3: 98 percent / H2 / Pd(OH)2 / ethanol / 2 h
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / (COCl)2, DMSO, Et3N / -50 - 0 °C
2: H2 / PtO2 / ethyl acetate
3: 98 percent / H2 / Pd(OH)2 / ethanol
View Scheme
(4R,9aR)-8-methylene-4-phenyl-hexahydropyrido[2,1-c][1,4]oxazin-1-one
194796-78-6

(4R,9aR)-8-methylene-4-phenyl-hexahydropyrido[2,1-c][1,4]oxazin-1-one

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / H2 / PtO2 / ethyl acetate / 0.25 h
2: 98 percent / H2 / Pd(OH)2 / ethanol / 2 h
View Scheme
Multi-step reaction with 2 steps
1: H2 / PtO2 / ethyl acetate
2: 98 percent / H2 / Pd(OH)2 / ethanol
View Scheme
(R)-3-methyl-γ-butyrolactone
65284-00-6

(R)-3-methyl-γ-butyrolactone

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: methanol / 5 h / 80 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C / Inert atmosphere
2.2: 0.5 h / -60 - 20 °C
3.1: ethanolamine / water / 6.5 h / 60 - 80 °C
4.1: sodium hydroxide / 2.5 h / Reflux
5.1: pyrrole aldehyde / water / 24 h / 37 °C / pH 8
6.1: sulfuric acid / 3 h / 0 - 20 °C
7.1: potassium borohydride / water / 3.5 h / 1 - 60 °C
View Scheme
(S)-methyl-3-hydroxy-2-methylpropanoate
147915-53-5

(S)-methyl-3-hydroxy-2-methylpropanoate

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -60 °C / Inert atmosphere
1.2: 0.5 h / -60 - 20 °C
2.1: ethanolamine / water / 6.5 h / 60 - 80 °C
3.1: sodium hydroxide / 2.5 h / Reflux
4.1: pyrrole aldehyde / water / 24 h / 37 °C / pH 8
5.1: sulfuric acid / 3 h / 0 - 20 °C
6.1: potassium borohydride / water / 3.5 h / 1 - 60 °C
View Scheme
(R)-3-Methyl-4-oxo-butyric acid methyl ester
125137-08-8

(R)-3-Methyl-4-oxo-butyric acid methyl ester

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid
74892-81-2

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ethanolamine / water / 6.5 h / 60 - 80 °C
2: sodium hydroxide / 2.5 h / Reflux
3: pyrrole aldehyde / water / 24 h / 37 °C / pH 8
4: sulfuric acid / 3 h / 0 - 20 °C
5: potassium borohydride / water / 3.5 h / 1 - 60 °C
View Scheme

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