We are manufacturer of this product and can supply good quality and competitive price , the purity over 98.0%, this product has been in massive production for years , so its process and quality always keep stable and its price is very competitive .
Cas:74892-82-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:74892-82-3
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:74892-82-3
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryEthyl (2R,4R)-4-methyl-2-piperidinecarboxylate CAS No.:74892-82-3 Name Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate Molecular Structure Molecular Formula C9H17NO2 Molecular Weight 171.24 CAS Registry Number
Cas:74892-82-3
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:74892-82-3
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:74892-82-3
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:74892-82-3
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:74892-82-3
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:74892-82-3
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla
Cas:74892-82-3
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:74892-82-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryEthyl (2R,4R)-4-methyl-2-piperidinecarboxylate CAS:74892-82-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
Cas:74892-82-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:74892-82-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:74892-82-3
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:74892-82-3
Min.Order:0 Metric Ton
Negotiable
Type:Other
inquiryEthyl (2R,4R)-4-methyl-2-piperidinecarboxylateAppearance:Solid Storage:keep in dry and ventilated place Package:according to customers' requirements Application:intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or C
Cas:74892-82-3
Min.Order:1 Gram
Negotiable
Type:Other
inquirySuperior quality, moderate price & quick delivery. Appearance:White crystalline powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:10g/bag,or as your request Application:For medicine , pesticide interm
Cas:74892-82-3
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryChemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k
Cas:74892-82-3
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:74892-82-3
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryHebei Lead Bio-Chemicals Co., Ltd. established in 2006, devolved in resurching, manufacturing and supplying of pharmaceuticals,food ingredients, cosmetics,health care products, Chinese herb, plant extracts and some fine chemicals,is one of leading gr
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:74892-82-3
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Trading Company
inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryISO/factory/goodqualityAppearance:White to yellow Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Manufacturers
inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
Cas:74892-82-3
Min.Order:0
Negotiable
Type:Other
inquiryShanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is
Cas:74892-82-3
Min.Order:100 Kilogram
FOB Price: $100.0 / 150.0
Type:Other
inquiryethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In water; ethyl acetate at 15 - 20℃; for 1h; | 88% |
ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With 10% palladium hydroxide on charcoal; hydrogen In ethanol at 20℃; under 760.051 Torr; for 4h; | 45% |
With palladium 10% on activated carbon; hydrogen; iron(II) oxalate; acetic acid In ethanol at 30℃; under 3750.38 Torr; for 4h; Reagent/catalyst; Autoclave; | 345 g |
(2R,4R)-4-Methyl-1-((R)-1-phenyl-ethyl)-piperidine-2-carboxylic acid ethyl ester
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With hydrogen; palladium hydroxide - carbon In ethanol under 760 Torr; Ambient temperature; |
(6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 2: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme |
isoprene
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: TFA, H2O / dimethylformamide / 30 h / Ambient temperature 2: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 3: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme |
ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (SP, S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; bis(norbornadiene)rhodium(l)tetrafluoroborate; methanesulfonic acid; hydrogen / ethanol / 18 h / 90 °C / 7500.75 Torr / Autoclave 2: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 4 h / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 3 % platinum on carbon; hydrogen / ethyl acetate / 48 h / 20 °C / 760.05 Torr 2: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 4 h / 20 °C / 760.05 Torr View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In water; ethyl acetate at 20℃; for 1h; |
4-methylpiperidin
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: acetic acid; sodium hypochlorite / water / 2 h / 0 - 10 °C 1.2: 0 - 20 °C 2.1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 3.1: water; dichloromethane / 0 - 20 °C 4.1: hydrogenchloride / water / 20 - 60 °C 5.1: thionyl chloride / 0 °C / Reflux 6.1: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 7.1: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
2,3,4,5-tetrahydro-4-methylpyridine
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 2: water; dichloromethane / 0 - 20 °C 3: hydrogenchloride / water / 20 - 60 °C 4: thionyl chloride / 0 °C / Reflux 5: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 6: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: water; dichloromethane / 0 - 20 °C 2: hydrogenchloride / water / 20 - 60 °C 3: thionyl chloride / 0 °C / Reflux 4: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 5: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 20 - 60 °C 2: thionyl chloride / 0 °C / Reflux 3: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 4: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
A
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
B
ethyl (2S,4S)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With potassium carbonate In water; ethyl acetate at 15 - 20℃; for 1.08333h; Overall yield = 85 %; Overall yield = 29.4 g; | A n/a B n/a |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 2: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / 0 °C / Reflux 2: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 3: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
1,2,3,4-tetrahydro-3-methyl-8-quinolinesulfonyl chloride
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: N-Boc-N'-nitro-L-arginine; ethyl (2R-trans)-4-methylpiperidine-2-carboxylate With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In chloroform at -30℃; for 2h; Stage #2: 1,2,3,4-tetrahydro-3-methyl-8-quinolinesulfonyl chloride In chloroform at 20℃; for 3h; Temperature; | 87.5% |
Boc-Orn(Z)-OH
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(2R,4R)-1-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.75h; Acylation; | 86% |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
5-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4,4-difluoro-pentanoic acid
(2R,4R)-1-((S)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4,4-difluoro-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; Acylation; | 84% |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-butyric acid
Conditions | Yield |
---|---|
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; Acylation; | 79% |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: N2-(3-methyl-8-quinolinesulfonyl)-NG-nitro-L-arginine With trichlorophosphate In tetrahydrofuran at -30℃; for 2h; Reflux; Stage #2: ethyl (2R-trans)-4-methylpiperidine-2-carboxylate In tetrahydrofuran for 2h; | 72.6% |
Boc-Asp(OtBu)-OH
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
With N-ethylmorpholine;; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(2R,4R)-1-((S)-2-Amino-5-benzyloxycarbonylamino-pentanoyl)-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / 1-ethyl-3-(3-dimethylamino)propyl carbodiimide hydrochloride; HOBt; 4-methylmorpholine / dimethylformamide / 0.75 h / 20 °C 2: 100 percent / TFA / 1 h / 0 - 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 86 percent / 1-ethyl-3-(3-dimethylamino)propyl carbodiimide hydrochloride; HOBt; 4-methylmorpholine / dimethylformamide / 0.75 h / 20 °C 2: 100 percent / TFA / 1 h / 0 - 20 °C 3: 75 percent / Et3N / CH2Cl2 / 2.75 h / 20 °C 4: 92 percent / H2 / Pd black / ethanol / 72 h / 760 Torr View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 86 percent / 1-ethyl-3-(3-dimethylamino)propyl carbodiimide hydrochloride; HOBt; 4-methylmorpholine / dimethylformamide / 0.75 h / 20 °C 2: 100 percent / TFA / 1 h / 0 - 20 °C 3: 75 percent / Et3N / CH2Cl2 / 2.75 h / 20 °C 4: 92 percent / H2 / Pd black / ethanol / 72 h / 760 Torr 5: 100 percent / NH4OAc / methanol / 24 h / 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 86 percent / 1-ethyl-3-(3-dimethylamino)propyl carbodiimide hydrochloride; HOBt; 4-methylmorpholine / dimethylformamide / 0.75 h / 20 °C 2: 100 percent / TFA / 1 h / 0 - 20 °C 3: 75 percent / Et3N / CH2Cl2 / 2.75 h / 20 °C 4: 92 percent / H2 / Pd black / ethanol / 72 h / 760 Torr 5: 100 percent / NH4OAc / methanol / 24 h / 20 °C 6: 40 percent / H2NOH / methanol / 2 h / 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(2R,4R)-1-[(S)-5-Benzyloxycarbonylamino-2-(3-methyl-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86 percent / 1-ethyl-3-(3-dimethylamino)propyl carbodiimide hydrochloride; HOBt; 4-methylmorpholine / dimethylformamide / 0.75 h / 20 °C 2: 100 percent / TFA / 1 h / 0 - 20 °C 3: 75 percent / Et3N / CH2Cl2 / 2.75 h / 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4-ethylmorpholine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide 2: p-toluenesulfonic acid monohydrate / acetonitrile / 8 h / Ambient temperature View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(2R,4R)-1-[(S)-3-Carboxy-2-(naphthalene-2-sulfonylamino)-propionyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 4-ethylmorpholine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide 2: p-toluenesulfonic acid monohydrate / acetonitrile / 8 h / Ambient temperature 3: aq. NaHCO3 / dioxane 4: HCl / ethyl acetate / 5 h / Ambient temperature View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
(2R,4R)-1-[(S)-3-tert-Butoxycarbonyl-2-(naphthalene-2-sulfonylamino)-propionyl]-4-methyl-piperidine-2-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 4-ethylmorpholine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide 2: p-toluenesulfonic acid monohydrate / acetonitrile / 8 h / Ambient temperature 3: aq. NaHCO3 / dioxane View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 4-ethylmorpholine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide 2: p-toluenesulfonic acid monohydrate / acetonitrile / 8 h / Ambient temperature 3: aq. NaHCO3 / dioxane 4: HCl / ethyl acetate / 5 h / Ambient temperature 5: 4-ethylmorpholine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethyletoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl (2R-trans)-4-methylpiperidine-2-carboxylate With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In ethyl acetate at -10℃; for 1.5h; Stage #2: ethyl (2R-trans)-4-methylpiperidine-2-carboxylate In ethyl acetate at -10 - 10℃; |
Boc-Arg(NO2)-OH
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
ethyl (2R,4R)-1-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Stage #1: Boc-Arg(NO2)-OH With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In ethyl acetate at -10 - -5℃; for 1.5h; Stage #2: ethyl (2R-trans)-4-methylpiperidine-2-carboxylate In ethyl acetate at -5 - 10℃; | 85 g |
Boc-Arg(NO2)-OH
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methyl-morpholine / ethyl acetate / 1.5 h / -10 - -5 °C 1.2: -5 - 10 °C 2.1: hydrogenchloride / ethanol / 15 - 20 °C View Scheme |
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